{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T13:40:07Z","timestamp":1751204407101,"version":"3.41.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1987,2,1]],"date-time":"1987-02-01T00:00:00Z","timestamp":539136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1987,2]]},"DOI":"10.1093\/jn\/117.2.286","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T09:15:53Z","timestamp":1515402953000},"page":"286-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of the Flavin-Containing Monooxygenase in Guinea Pigs by Ascorbic Acid and Food Restriction"],"prefix":"10.1016","volume":"117","author":[{"given":"Joanne I.","family":"Brodfuehrer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent G.","family":"Zannoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/117.2.286_bib1","series-title":"Enzymatic Basis of Detoxification","first-page":"201","article-title":"Microsomal flavin-containing monooxygenase: oxygenation of nucleophilic nitrogen and sulfur compounds","author":"Ziegler","year":"1980"},{"key":"10.1093\/jn\/117.2.286_bib2","first-page":"33","article-title":"Organic sulfur substrates for the microsomal flavin-containing monooxygenase","volume":"3","author":"Poulsen","year":"1981","journal-title":"Rev. Biochem. Toxicol"},{"key":"10.1093\/jn\/117.2.286_bib3","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.7403873","article-title":"Flavin adenine dinucleotide-dependent monooxygenase: its role in the sulfoxidation of pesticides in mammals","volume":"209","author":"Hajjar","year":"1980","journal-title":"Science"},{"key":"10.1093\/jn\/117.2.286_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0003-9861(73)90641-3","article-title":"The N-oxidation of alkylhydrazines catalyzed by the microsomal mixed-function amine oxidase","volume":"158","author":"Prough","year":"1973","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/117.2.286_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0300-483X(84)90154-9","article-title":"Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide","volume":"31","author":"Chiele","year":"1984","journal-title":"Toxicology"},{"key":"10.1093\/jn\/117.2.286_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0968-0004(77)90042-1","article-title":"Protein disulfide bond synthesis: a possible intracellular mechanism","volume":"2","author":"Ziegler","year":"1977","journal-title":"Trends Biochem. Sci"},{"key":"10.1093\/jn\/117.2.286_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0006-291X(64)90322-5","article-title":"Formation of an intermediate N-oxide in the oxidative demethylation of N,N-dimethylaniline catalyzed by liver microsomes","volume":"15","author":"Ziegler","year":"1954","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/117.2.286_bib8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0026-895X(25)14211-9","article-title":"Hamster hepatic nuclear mixed-function amine oxidase: location and specific activity","volume":"18","author":"Patton","year":"1980","journal-title":"Mol. Pharmacol"},{"key":"10.1093\/jn\/117.2.286_bib9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0026-895X(25)15179-1","article-title":"Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenase in various hog, mouse, rat, rabbit, dog and human tissues","volume":"22","author":"DAnnan","year":"1982","journal-title":"Mol. Pharmacol"},{"key":"10.1093\/jn\/117.2.286_bib10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0006-291X(84)80342-3","article-title":"Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzyme","volume":"125","author":"Williams","year":"1984","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/117.2.286_bib11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0006-2952(86)90360-6","article-title":"Ascorbic acid deficiency and the flavin-containing monooxygenase","volume":"35","author":"Brodfuehrer","year":"1986","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/117.2.286_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0006-2944(74)90093-3","article-title":"A rapid micromethod for the determination of ascorbic acid in plasma and tissue","volume":"11","author":"Zannoni","year":"1974","journal-title":"Biochem. Med"},{"key":"10.1093\/jn\/117.2.286_bib13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurements with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/117.2.286_bib14","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide binding pigment of liver microsomes","volume":"239","author":"Omura","year":"1964","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/117.2.286_bib15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0022-3565(25)32238-X","article-title":"Metabolic activation and detoxification of bromobenzene leading to cytotoxicity","volume":"214","author":"Lau","year":"1980","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1093\/jn\/117.2.286_bib16","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1016\/S0021-9258(19)76934-8","article-title":"Tyrosyluria resulting from inhibition of p-hydroxyphenylpyruvic acid oxidase in vitamin C-deficient guinea pigs","volume":"235","author":"Zannoni","year":"1960","journal-title":"J. Biol. Chem"},{"year":"1970","series-title":"Statistics with Applications to the Biological Health Sciences","author":"Remington","key":"10.1093\/jn\/117.2.286_bib17"},{"key":"10.1093\/jn\/117.2.286_bib18","first-page":"264","article-title":"Effects on hepatic microsomal N- and C-oxygenation of aromatic amines by in vivo corticosteroid or aminofluorene treatment, diet, or stress","volume":"28","author":"Arrhenius","year":"1968","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/117.2.286_bib19","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/S0021-9258(18)96105-3","article-title":"Studies on the regulation of tyrosine aminotransferase in rats","volume":"242","author":"Grossman","year":"1967","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/117.2.286_bib20","series-title":"Ascorbic Acid: Chemistry, Metabolism, and Uses","first-page":"349","article-title":"Biochemical functions of ascorbic acid in drug metabolism","author":"Zannoni","year":"1982"},{"key":"10.1093\/jn\/117.2.286_bib21","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/ajcn\/32.2.418","article-title":"Hospital malnutrition. A prospective evaluation of general medical patients during the course of hospitalization","volume":"32","author":"Weinsier","year":"1979","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/117.2.286_bib22","series-title":"Ascorbic Acid: Chemistry, Metabolism and Uses","first-page":"375","article-title":"Nutritional and health aspects of ascorbic acid","author":"Brin","year":"1982"},{"key":"10.1093\/jn\/117.2.286_bib23","unstructured":"Calabrese, E. J. (1980) Human requirements for vitamin C. In: Nutrition and Environmental Health, Vol. 1. The Vitamins pp. 262-266, John Wiley & Sons, New York."},{"key":"10.1093\/jn\/117.2.286_bib24","unstructured":"Calabrese, E. J. (1980) Common drugs and medication. In: Nutrition and Environmental Health, Vol. 1. The Vitamins, pp. 419-424, John Wiley & Sons, New York."},{"key":"10.1093\/jn\/117.2.286_bib25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(71)91441-3","article-title":"Effect of aspirin injestion on ascorbic acid levels in rheumatoid arthritis","volume":"1","author":"Sahud","year":"1971","journal-title":"Lancet"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623081075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623081075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/117\/2\/286\/23197091\/jn1170020286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T13:24:56Z","timestamp":1751203496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623081075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,2]]}},"alternative-id":["S0022316623081075"],"URL":"https:\/\/doi.org\/10.1093\/jn\/117.2.286","relation":{},"ISSN":["0022-3166"],"issn-type":[{"type":"print","value":"0022-3166"}],"subject":[],"published":{"date-parts":[[1987,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of the Flavin-Containing Monooxygenase in Guinea Pigs by Ascorbic Acid and Food Restriction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/117.2.286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1987 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}