{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:54:13Z","timestamp":1769457253350,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1988,5]]},"DOI":"10.1093\/jn\/118.5.598","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T14:42:42Z","timestamp":1515163362000},"page":"598-603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["A Modified Relative Dose-Response Assay Employing 3,4-Didehydroretinol (Vitamin A2) in Rats"],"prefix":"10.1016","volume":"118","author":[{"given":"Sherry A.","family":"Tanumihardjo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/118.5.598_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/jn\/109.5.778","article-title":"Response of plasma levels of vitamin A to a dose of vitamin A as an indicator of hepatic vitamin A reserves in rats.","volume":"109","author":"LOERCH","year":"1979","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/ajcn\/40.6.1281","article-title":"Assessment of marginal vitamin A deficiency in Brazilian children using the relative dose response procedure.","volume":"40","author":"FLORES","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/ajcn\/39.6.898","article-title":"Relation of the relative dose response to liver concentrations of vitamin A in generally well-nourished surgical patients.","volume":"39","author":"AM\u00c9D\u00c9E-MANESME","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/ajcn\/46.2.286","article-title":"Vitamin A relative dose response test: validation by intravenous injection in children with liver disease.","volume":"46","author":"AM\u00c9D\u00c9E-MANESME","year":"1987","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/ajcn\/45.4.704","article-title":"Recommended dietary intakes (RDI) of vitamin A in humans.","volume":"45","author":"OLSON","year":"1987","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(86)91157-8","article-title":"Impact of vitamin A supplementation on childhood mortality.","volume":"1","author":"SOMMER","year":"1986","journal-title":"Lancet"},{"key":"10.1093\/jn\/118.5.598_bib7","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/ajcn\/40.5.1090","article-title":"Increased risk of respiratory disease and diarrhea in children with pre-existing mild vitamin A deficiency.","volume":"40","author":"SOMMER","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/ajcn\/23.8.1037","article-title":"Liver stores of vitamin A in a normal population dying suddenly or rapidly from unnatural causes in New York City.","volume":"23","author":"UNDERWOOD","year":"1970","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/ajcn\/27.8.883","article-title":"Plasma and liver concentrations of vitamin A in normal population of urban Thai.","volume":"27","author":"SUTHUTVORAVOOT","year":"1974","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib10","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/S0021-9258(19)45460-4","article-title":"Regulation of retinol binding protein metabolism by vitamin A status in the rat.","volume":"247","author":"MUTO","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/118.5.598_bib11","first-page":"127","article-title":"Use of 3,4-didehydroretinol to assess vitamin A status in rats.","volume":"57","author":"TANUMIHARDJO","year":"1987","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1093\/jn\/118.5.598_bib12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0021-9258(19)51170-X","article-title":"Biological activity of pure vitamin A2.","volume":"183","author":"SHANTZ","year":"1950","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/118.5.598_bib13","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1042\/bst0140950","article-title":"3,4-Didehydroretinol (vitamin A2) has vitamin A activity in the rat without conversion to retinol.","volume":"14","author":"WILSON","year":"1986","journal-title":"Biochem. Soc. Trans."},{"key":"10.1093\/jn\/118.5.598_bib14","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1042\/bj0520542","article-title":"Studies in vitamin A. 21. Retinene2 and vitamin A2.","volume":"52","author":"CAMA","year":"1952","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/118.5.598_bib15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0042-6989(69)90120-5","article-title":"Visual pigments of the vitamin A-deficient rat following vitamin A2 administration.","volume":"9","author":"YOSHIKAMI","year":"1969","journal-title":"Vision Res."},{"key":"10.1093\/jn\/118.5.598_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0042-6989(71)90183-0","article-title":"Visual pigments of the vitamin A-deficient thyroidectomized rat following vitamin A2 administration.","volume":"11","author":"PEARLMAN","year":"1971","journal-title":"Vision Res."},{"key":"10.1093\/jn\/118.5.598_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1079\/BJN19860044","article-title":"Metabolism of dehy-droretinyl ester in white leghorn chicks.","volume":"55","author":"GOSWAMI","year":"1986","journal-title":"Br. J. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib18","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/S0040-4039(01)85279-5","article-title":"Preparation and properties of 4-oxo-retinoic acid and its methylester.","volume":"18","author":"BARUA","year":"1972","journal-title":"Tetrahedron Lett."},{"key":"10.1093\/jn\/118.5.598_bib19","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/jn\/117.5.874","article-title":"A marginal vitamin A status alters the distribution of vitamin A among parenchymal and stellate cells in rat liver.","volume":"117","author":"BATRES","year":"1987","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib20","series-title":"Experimental and Surgical Technique in the Rat","first-page":"50","author":"WAYNFORTH","year":"1980"},{"key":"10.1093\/jn\/118.5.598_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-4347(00)80698-2","article-title":"Separation of retinyl esters by non-aqueous reversed-phase high-performance liquid chromatography.","volume":"378","author":"FURR","year":"1986","journal-title":"J. Chromatogr."},{"key":"10.1093\/jn\/118.5.598_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0083-6729(08)60014-X","article-title":"Metabolism of vitamin A and determination of vitamin A status.","volume":"32","author":"RIETZ","year":"1974","journal-title":"Vitam. Horm. (NY)"},{"key":"10.1093\/jn\/118.5.598_bib23","first-page":"1439","article-title":"Serum levels of vitamin A and carotenoids as reflectors of nutritional status.","volume":"73","author":"OLSON","year":"1984","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1093\/jn\/118.5.598_bib24","first-page":"9","article-title":"Hyperbolic regression analysis for kinetics, electrophoresis, ELISA, RIA, Bradford, Lowry, and other applications.","volume":"3","author":"STUDNICKA","year":"1987","journal-title":"Comp. Appl. Biosci."},{"key":"10.1093\/jn\/118.5.598_bib25","series-title":"Proceedings of the Third FAOB Congress on Biochemistry","first-page":"84","article-title":"Determination of vitamin A status by using vitamin A2.","author":"THAITAWEE","year":"1983"},{"key":"10.1093\/jn\/118.5.598_bib26","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/jn\/117.8.1410","article-title":"Vitamin A status needed to maintain vitamin A concentrations in nonhe-patic tissues of the pregnant rat.","volume":"117","author":"WALLINGFORD","year":"1987","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib27","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/archopht.1984.01040031131040","article-title":"Detection of ocular surface abnormalities in experimental vitamin A deficiency.","volume":"102","author":"HATCHELL","year":"1984","journal-title":"Arch. Ophthalmol."},{"key":"10.1093\/jn\/118.5.598_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/archopht.1986.01050140091027","article-title":"Detection of early xerophthalmia by impression cytology.","volume":"104","author":"WITTPENN","year":"1986","journal-title":"Arch. Ophthalmol."},{"key":"10.1093\/jn\/118.5.598_bib29","series-title":"Vitamin A Deficiency and Its Control","first-page":"177","article-title":"Clinical aspects of vitamin A deficiency.","author":"WITTPENN","year":"1984"},{"key":"10.1093\/jn\/118.5.598_bib30","first-page":"1335","article-title":"The in vivo kinetic pattern of ingested tetradeu-terated vitamin A in the serum of an adult human.","volume":"46","author":"FURR","year":"1987","journal-title":"Fed. Proc."},{"key":"10.1093\/jn\/118.5.598_bib31","first-page":"xxxvii","article-title":"Potential of vitamin A analogs as tests of liver vitamin A status in the rat.","volume":"116","author":"BURRI","year":"1986","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib32","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/ajcn\/34.9.1961","article-title":"Evaluation of a rapid test of dark adaptation.","volume":"34","author":"VINTON","year":"1981","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/118.5.598_bib33","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/ajcn\/43.6.940","article-title":"Evaluation of rose bengal staining test and rapid dark-adaptation test for the field assessment of vitamin A status of preschool children in Southern Brazil.","volume":"43","author":"FAVARO","year":"1986","journal-title":"Am. J. Clin. Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622169166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622169166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/118\/5\/598\/23984980\/jn1180050598.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T20:10:34Z","timestamp":1686600634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622169166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["S0022316622169166"],"URL":"https:\/\/doi.org\/10.1093\/jn\/118.5.598","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1988,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Modified Relative Dose-Response Assay Employing 3,4-Didehydroretinol (Vitamin A2) in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/118.5.598","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1988 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}