{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:39:19Z","timestamp":1780382359482,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1992,6]]},"DOI":"10.1093\/jn\/122.6.1232","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T14:59:07Z","timestamp":1515164347000},"page":"1232-1241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cephaloridine Nephrotoxicity is Potentiated by Selenium Deficiency but not Copper Deficiency in Rats"],"prefix":"10.1016","volume":"122","author":[{"given":"Sandra E.","family":"Kays","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne A.","family":"Crowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1093\/jn\/122.6.1232_bib1","first-page":"110","article-title":"Cephaloridine, cephalothin and the kidney.","volume":"1","author":"Foord","year":"1975","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1093\/jn\/122.6.1232_bib2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0041-008X(91)90178-H","article-title":"Cephaloridine-induced biochemical changes and cytotoxicity in suspensions of rabbit isolated proximal tubules.","volume":"109","author":"Rush","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1093\/jn\/122.6.1232_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-3565(25)13371-5","article-title":"The renal mitochondrial toxicity of cephalosporins: specificity of the effect on anionic substrate uptake.","volume":"252","author":"Tune","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1093\/jn\/122.6.1232_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0041-008X(83)90246-6","article-title":"Lipid peroxidation: a possible mechanism of cephaloridine-induced nephrotoxicity.","volume":"67","author":"Kuo","year":"1983","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1093\/jn\/122.6.1232_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0041-008X(86)90303-0","article-title":"Biochemical mechanisms of cephaloridine nephrotoxicity: time and concentration dependence of peroxidative injury.","volume":"83","author":"Goldstein","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1093\/jn\/122.6.1232_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0005-2760(85)90014-1","article-title":"Cephaloridine-induced lipid peroxidation initiated by reactive oxygen species as a possible mechanism of cephaloridine nephrotoxicity.","volume":"834","author":"Cojocel","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/122.6.1232_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1079\/PNS19870003","article-title":"Free radical mechanisms in relation to tissue injury.","volume":"46","author":"Slater","year":"1987","journal-title":"Proc. Nutr. Soc."},{"key":"10.1093\/jn\/122.6.1232_bib8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0163-7258(90)90073-B","article-title":"Protection against free radical injury by selenoenzymes.","volume":"45","author":"Burk","year":"1990","journal-title":"Pharmacol. & Ther."},{"key":"10.1093\/jn\/122.6.1232_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0041-008X(82)90052-7","article-title":"Depletion of renal glutathione content and nephrotoxicity of cephaloridine in rabbits, rats and mice.","volume":"63","author":"Kuo","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1093\/jn\/122.6.1232_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-5793(80)80195-5","article-title":"Oxygen free-radicals and lipid peroxidation: inhibition by the protein caeruloplasmin.","volume":"112","author":"Gutteridge","year":"1980","journal-title":"FEBS Lett."},{"key":"10.1093\/jn\/122.6.1232_bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/jn\/121.3.355","article-title":"Changes in Cu,Zn-superoxide dismutase, cytochrome c oxidase, glutathione peroxidase and glutathione transferase activities in copper-deficient mice and rats.","volume":"121","author":"Prohaska","year":"1991","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/122.6.1232_bib12","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/jn\/109.9.1570","article-title":"Changes in activity of the Cu,Zn-superoxide dismutase enzyme in tissues of the rat with changes in dietary copper.","volume":"109","author":"Paynter","year":"1979","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/122.6.1232_bib13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02989255","article-title":"Interaction between dietary carbohydrate and copper nutriture on lipid peroxidation in rat tissues.","volume":"6","author":"Fields","year":"1984","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1093\/jn\/122.6.1232_bib14","first-page":"134","article-title":"Effects of copper deficiency on carbon tetrachloride-induced lipid peroxidation.","volume":"109","author":"Lawrence","year":"1987","journal-title":"J. Lab. Clin. Med."},{"key":"10.1093\/jn\/122.6.1232_bib15","series-title":"In: Trace Elements in Man and Animals","first-page":"39","article-title":"The effects of copper deficiency on lipid peroxidation in rat liver microsomes.","author":"Davies","year":"1985"},{"key":"10.1093\/jn\/122.6.1232_bib16","series-title":"In: Enzymatic Basis of Detoxification","first-page":"333","article-title":"Glutathione peroxidase.","author":"Wendel","year":"1980"},{"key":"10.1093\/jn\/122.6.1232_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jcp.1041230106","article-title":"Selenium deficiency in cultured adrenocortical cells: Restoration of glutathione peroxidase and resistance to hydroperoxides on addition of selenium.","volume":"123","author":"Hornsby","year":"1985","journal-title":"J. Cell. Physiol."},{"key":"10.1093\/jn\/122.6.1232_bib18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/jn\/116.7.1225","article-title":"Development of anemia in copper-deficient rats fed high levels of dietary iron and sucrose.","volume":"116","author":"Johnson","year":"1986","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/122.6.1232_bib19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/ac60233a025","article-title":"Fluorimetric determination of selenium in biological material with 2,3-diaminonaphthalene.","volume":"38","author":"Watkinson","year":"1966","journal-title":"Anal. Chem."},{"key":"10.1093\/jn\/122.6.1232_bib20","series-title":"In: Methods in Enzymatic Analysis","first-page":"118","article-title":"Lactate dehydrogenase.","author":"Vassault","year":"1983"},{"key":"10.1093\/jn\/122.6.1232_bib21","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/jama.1963.03060120063023","article-title":"Urinary alkaline phosphatase activity II: An analytical validation of the assay method.","volume":"185","author":"Amador","year":"1963","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/jn\/122.6.1232_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0009-8981(76)90147-9","article-title":"Rapid colorimetric assay of \u03b2-galactosidase and n-acetyl-\u03b2-glucosaminidase in human urine.","volume":"73","author":"Maruhn","year":"1976","journal-title":"Clin. Chim. Acta"},{"key":"10.1093\/jn\/122.6.1232_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jn\/113.1.55","article-title":"Platelet glutathione peroxidase activity as an index of selenium status in rats.","volume":"113","author":"Levander","year":"1983","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/122.6.1232_bib24","series-title":"In: Methods in Enzymatic Analysis","first-page":"569","article-title":"Sorbitol dehydrogenase.","author":"Gerlach","year":"1974"},{"key":"10.1093\/jn\/122.6.1232_bib25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ajcn\/47.1.96","article-title":"Adverse effects of high dietary iron and ascorbic acid on copper status in copper-deficient and copper-adequate rats.","volume":"47","author":"Johnson","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/122.6.1232_bib26","series-title":"In: Laboratory Diagnosis of Kidney Diseases","first-page":"100","article-title":"Measurement of urea in serum and urine and the estimation of urea clearance.","author":"De la Huerga","year":"1970"},{"key":"10.1093\/jn\/122.6.1232_bib27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation.","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1093\/jn\/122.6.1232_bib28","series-title":"In: Handbook of Methods for Oxygen Radical Research","first-page":"203","article-title":"Lipid peroxidation.","author":"Aust","year":"1985"},{"key":"10.1093\/jn\/122.6.1232_bib29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent.","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/122.6.1232_bib30","series-title":"SAS User's Guide.","year":"1979"},{"key":"10.1093\/jn\/122.6.1232_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0891-5849(89)90160-3","article-title":"On the participation of higher oxidation states of iron and copper in Fenton reaction.","volume":"6","author":"Sutton","year":"1989","journal-title":"Free Radical Biol. & Med."},{"key":"10.1093\/jn\/122.6.1232_bib32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1042\/bj2540519","article-title":"Free-radical generation by copper ions and hydrogen peroxide.","volume":"254","author":"Simpson","year":"1988","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/122.6.1232_bib33","doi-asserted-by":"crossref","first-page":"10282","DOI":"10.1016\/S0021-9258(18)67521-0","article-title":"The involvement of iron in lipid peroxidation.","volume":"261","author":"Braughler","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/122.6.1232_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02798591","article-title":"The role of dietary copper, manganese, selenium and vitamin E in lipid peroxidation in tissues of the rat.","volume":"2","author":"Paynter","year":"1980","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1093\/jn\/122.6.1232_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0021-9258(17)38265-0","article-title":"Peroxide removal by selenium-dependent and selenium-inde-pendent glutathione peroxidases in hemoglobin-free perfused rat liver.","volume":"253","author":"Burk","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/122.6.1232_bib36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/bj2480539","article-title":"The effects of selenium and copper deficiencies on glutathione S-transferase and glutathione peroxidase in rat liver.","volume":"248","author":"Arthur","year":"1987","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/122.6.1232_bib37","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1016\/0006-2952(84)90637-3","article-title":"Differential changes of glutathione S-transferase activity by dietary selenium.","volume":"33","author":"Masukawa","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1093\/jn\/122.6.1232_bib38","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/jn\/120.9.1068","article-title":"Effect of dietary homocysteine on copper status in rats.","volume":"120","author":"Brown","year":"1990","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/122.6.1232_bib39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3181\/00379727-187-42634","article-title":"Copper deficiency and tissue glutathione concen-tration in the rat.","volume":"187","author":"Allen","year":"1988","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1093\/jn\/122.6.1232_bib40","first-page":"294","article-title":"Influence of copper nutrition on gentamicin nephrotoxicity in rats.","volume":"9","author":"Kays","year":"1990","journal-title":"Magnesium Trace Elem."},{"key":"10.1093\/jn\/122.6.1232_bib41","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0271-5317(05)80674-8","article-title":"Cardiovascular but not renal effects of copper deficiency are inhibited by dimethyl sulfoxide.","volume":"10","author":"Saari","year":"1990","journal-title":"Nutr. Res."},{"key":"10.1093\/jn\/122.6.1232_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ajcn\/39.2.289","article-title":"The interaction of type of dietary carbohydrates with copper deficiency.","volume":"39","author":"Fields","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/122.6.1232_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0021-9975(87)90039-9","article-title":"Kidney lesions in copper-deficient rats.","volume":"97","author":"Fell","year":"1987","journal-title":"J. Comp. Path."},{"key":"10.1093\/jn\/122.6.1232_bib44","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/jn\/116.12.2453","article-title":"Effect of selenium defi-ciency on the chronic toxicity of adriamycin in rats.","volume":"116","author":"Chen","year":"1986","journal-title":"J. Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623046564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623046564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/122\/6\/1232\/23131823\/jn1220061232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T11:15:04Z","timestamp":1751195704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623046564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["S0022316623046564"],"URL":"https:\/\/doi.org\/10.1093\/jn\/122.6.1232","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1992,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cephaloridine Nephrotoxicity is Potentiated by Selenium Deficiency but not Copper Deficiency in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/122.6.1232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1992 American Institute of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}