{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:43:13Z","timestamp":1790872993447,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1993,6,1]],"date-time":"1993-06-01T00:00:00Z","timestamp":738892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1993,6,1]],"date-time":"1993-06-01T00:00:00Z","timestamp":738892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1993,6]]},"DOI":"10.1093\/jn\/123.6.1168","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T03:54:17Z","timestamp":1739332457000},"page":"1168-1172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Elevated Neuropeptide Y in the Arcuate Nucleus of Young Obese Zucker Rats May Contribute to the Development of Their Overeating"],"prefix":"10.1016","volume":"123","author":[{"given":"Bernard","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlette","family":"Burlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Bazin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Burlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/123.6.1168_bib1","first-page":"123","article-title":"Hypothalamic control of food intake in rats and cats","volume":"24","author":"Anand","year":"1940","journal-title":"Yale J. Biol. Med"},{"key":"10.1093\/jn\/123.6.1168_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0006-8993(85)90730-9","article-title":"An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat","volume":"331","author":"Bai","year":"1985","journal-title":"Brain Res"},{"key":"10.1093\/jn\/123.6.1168_bib3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/jn\/120.7.806","article-title":"Hyperphagia in obesity is associated with a central peptidergic dysregulation","volume":"120","author":"Beck","year":"1990","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/123.6.1168_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0031-9384(90)90107-F","article-title":"Hypothalamic neuropeptide YNPYin obese Zucker rats: implications in feeding and sexual behaviors","volume":"47","author":"Beck","year":"1990","journal-title":"Physiol.Behav"},{"key":"10.1093\/jn\/123.6.1168_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(90)91664-3","article-title":"Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status","volume":"528","author":"Beck","year":"1990","journal-title":"Brain Res"},{"key":"10.1093\/jn\/123.6.1168_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0143-4179(90)90036-X","article-title":"Influence of diet composition on food intake and hypothalamic neuropeptide YNPYin the rat","volume":"17","author":"Beck","year":"1990","journal-title":"Neuropeptides"},{"key":"10.1093\/jn\/123.6.1168_bib7","first-page":"44","article-title":"Cholecystokinine, neurotensine et corticotropin-releasing factor: trois importants peptides anorexigenes","volume":"53","author":"Beck","year":"1992","journal-title":"Ann. Endocrinol"},{"key":"10.1093\/jn\/123.6.1168_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0304-3940(92)90045-9","article-title":"Early modification of neuropeptide Y but not of neurotensin in the suprachiasmatic nucleus of the obese Zucker rat","volume":"136","author":"Beck","year":"1992","journal-title":"Neurosci. Lett"},{"key":"10.1093\/jn\/123.6.1168_bib9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00001756-199207000-00006","article-title":"Specific hypothalamic neuropeptide Y variation with diet parameters in rats with food choice","volume":"3","author":"Beck","year":"1992","journal-title":"Neuroreport"},{"key":"10.1093\/jn\/123.6.1168_bib10","first-page":"295","article-title":"Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behavior of obese Zucker rats","volume":"16","author":"Beck","year":"1992","journal-title":"Int. J. Obesity"},{"key":"10.1093\/jn\/123.6.1168_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0165-0173(87)90004-X","article-title":"The dorsomedial hypothalamic nucleus revisited: 1986 update","volume":"12","author":"Bemardis","year":"1987","journal-title":"Brain Res. Rev"},{"key":"10.1093\/jn\/123.6.1168_bib12","first-page":"148","article-title":"The Zucker-fatty rat: a review","volume":"36","author":"Bray","year":"1977","journal-title":"Fed. Proc"},{"key":"10.1093\/jn\/123.6.1168_bib13","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0306-4522(85)90260-X","article-title":"The anatomy of neuropeptide Y-containing neurons in rat brain","volume":"15","author":"Chronwall","year":"1985","journal-title":"Neuroscience"},{"key":"10.1093\/jn\/123.6.1168_bib14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1210\/endo-115-1-427","article-title":"Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats","volume":"115","author":"Clark","year":"1984","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/123.6.1168_bib15","first-page":"107","article-title":"Neuropeptide YNPY)-induced suppression of male sexual behavior: neural loci","author":"Clark","year":"1986","journal-title":"First International Congress of Neuroendocrinology San Francisco, CA"},{"key":"10.1093\/jn\/123.6.1168_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3001478","article-title":"Multiple range and multiple F tests","volume":"11","author":"Duncan","year":"1955","journal-title":"Biometrics"},{"key":"10.1093\/jn\/123.6.1168_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0306-4522(84)90036-8","article-title":"Differential coexistence of neuropeptide YNPY)-like immunoreactivity with catecholamines in the central nervous system of the rat","volume":"11","author":"Everitt","year":"1984","journal-title":"Neuroscience"},{"key":"10.1093\/jn\/123.6.1168_bib18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0006-8993(87)90325-8","article-title":"Double-labeling of neuropeptide Y-immunoreactive neurons which project from the geniculate to the suprachiasmatic nucleus","volume":"410","author":"Harrington","year":"1987","journal-title":"Brain Res"},{"key":"10.1093\/jn\/123.6.1168_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ar.1090780203","article-title":"Hypothalamic lesions and adiposity in the","volume":"78","author":"Hetherington","year":"1940","journal-title":"rat. Anat. Rec"},{"key":"10.1093\/jn\/123.6.1168_bib20","series-title":"In: Progress in Comparative Endocrinology","first-page":"257","article-title":"Colocalization of messenger substances with special reference to the hypothalamic arcuate and paraventricular nuclei","author":"Hdkfelt","year":"1990"},{"key":"10.1093\/jn\/123.6.1168_bib21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0006-8993(90)90045-D","article-title":"Diurnal rhythm of neuropeptide Y-like immunoreactivity in the suprachiasmatic, arcuate and paraventricular nuclei and other hypothalamic sites","volume":"536","author":"Jhanwar-Uniyal","year":"1990","journal-title":"Brain Res"},{"key":"10.1093\/jn\/123.6.1168_bib22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0022-2275(20)38098-6","article-title":"Inguinal fat pad weight plotted versus body weight as a method of genotype identification in 16 day-old Zucker rats","volume":"23","author":"Lavau","year":"1982","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/123.6.1168_bib23","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(81)90366-8","article-title":"Hypothalamic paraventricular nucleus lesion produces overeating and obesity in the rat","volume":"27","author":"Leibowitz","year":"1981","journal-title":"Physiol.Behav"},{"key":"10.1093\/jn\/123.6.1168_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/123.6.1168_bib25","first-page":"2783","article-title":"Organization and function of a central nervous system circadian oscillator: the suprachiasmatic nucleus","volume":"42","author":"Moore","year":"1983","journal-title":"Fed. Proc"},{"key":"10.1093\/jn\/123.6.1168_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1210\/edrv-8-3-256","article-title":"Neuropeptide regulation of appetite and weight","volume":"8","author":"Morley","year":"1987","journal-title":"Endocr. Rev"},{"key":"10.1093\/jn\/123.6.1168_bib27","first-page":"R599","article-title":"Effect of neuropeptide Y on ingestive behaviors in the rat","volume":"252","author":"Morley","year":"1987","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/123.6.1168_bib28","series-title":"Guide for the Care and Use of Laboratory Animals Pub no. 85-23(rev.)","year":"1985"},{"key":"10.1093\/jn\/123.6.1168_bib29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0006-8993(73)90290-4","article-title":"Isolated removal of hypothalamic or other brain nuclei of the rat","volume":"59","author":"Palkovits","year":"1973","journal-title":"Brain Res"},{"key":"10.1093\/jn\/123.6.1168_bib30","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0091-3057(91)90066-B","article-title":"Hypothermia and feeding induced simultaneously in rats by perfusion of neuropeptide Y in preoptic area","volume":"39","author":"Roscoe","year":"1991","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1093\/jn\/123.6.1168_bib31","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/0196-9781(88)90191-X","article-title":"Bilateral neural transections at the level of mesencephalon increase food intake and reduce latency to onset of feeding in response to neuropeptide Y","volume":"9","author":"Sahu","year":"1989","journal-title":"Peptides"},{"key":"10.1093\/jn\/123.6.1168_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/cne.902410203","article-title":"Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus","volume":"241","author":"Sawchenko","year":"1985","journal-title":"J. Comp. Neurol"},{"key":"10.1093\/jn\/123.6.1168_bib33","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/0196-9781(86)90149-X","article-title":"Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity","volume":"7","author":"Stanley","year":"1986","journal-title":"Peptides"},{"key":"10.1093\/jn\/123.6.1168_bib34","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1016\/0024-3205(84)90032-8","article-title":"Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus","volume":"35","author":"Stanley","year":"1984","journal-title":"Life Sci"},{"key":"10.1093\/jn\/123.6.1168_bib35","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1073\/pnas.82.11.3940","article-title":"Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior","volume":"82","author":"Stanley","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/123.6.1168_bib36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0195-6663(87)80015-6","article-title":"Circadian regulation of feeding in rats: suprachiasmatic versus ventromedial hypothalamic nuclei","volume":"9","author":"Stoynev","year":"1987","journal-title":"Appetite"},{"issue":"suppl. 3","key":"10.1093\/jn\/123.6.1168_bib37","first-page":"43","article-title":"Neuropeptide Y stimulation of food intake in the Zucker rat","volume":"15","author":"Stricker-Krongrad","year":"1991","journal-title":"Int. J. Obesity"},{"key":"10.1093\/jn\/123.6.1168_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2220\/biomedres.12.249","article-title":"Immunohistochemical study of the neuropeptide-Y immunoreactivity in the paraventricular and the preoptic area of the rat following experimental lesions","volume":"12","author":"Ueda","year":"1991","journal-title":"Biomed. Res"},{"key":"10.1093\/jn\/123.6.1168_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1172\/JCI114425","article-title":"Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein","volume":"85","author":"Valet","year":"1990","journal-title":"J. Clin. Invest"},{"key":"10.1093\/jn\/123.6.1168_bib40","first-page":"443","article-title":"Genetic obesity in rats","volume":"22","author":"York","year":"1973","journal-title":"II. The effects of food restriction on the metabolism of adipose tissue Metabolism"},{"key":"10.1093\/jn\/123.6.1168_bib41","first-page":"41N","article-title":"Effets d'un traitement chronique au neuropeptide Y chez le rat Zucker normal","volume":"53","author":"Zarjevski","year":"1992","journal-title":"Ann. Endocrinol"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623009409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623009409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:19:32Z","timestamp":1739359172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623009409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["S0022316623009409"],"URL":"https:\/\/doi.org\/10.1093\/jn\/123.6.1168","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1993,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated Neuropeptide Y in the Arcuate Nucleus of Young Obese Zucker Rats May Contribute to the Development of Their Overeating","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/123.6.1168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1993 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}