{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:01:31Z","timestamp":1775318491725,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1994,10]]},"DOI":"10.1093\/jn\/124.2.241","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T03:50:56Z","timestamp":1739332256000},"page":"241-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin C Deficiency Causes Hematological and Skeletal Abnormalities during Fetal Development in Swine"],"prefix":"10.1016","volume":"124","author":[{"given":"Inger","family":"Wegger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birthe","family":"Palludan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/124.2.241_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0143-4004(86)80026-1","article-title":"Importance of vitamin C in maintenance of the normal amnion: an experimental study","volume":"7","author":"Aplin","year":"1986","journal-title":"Placenta"},{"key":"10.1093\/jn\/124.2.241_bib2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0021-9258(18)73884-2","article-title":"A method for the determination of small quantities of ascorbic acid and dehydroascorbic acid in turbid and colored solutions in the presence of other reducing substances","volume":"126","author":"Bessey","year":"1938","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/124.2.241_bib3","series-title":"In: The Biochemistry and Physiology of Bone, Vol. II, Physiology and Pathology","first-page":"231","article-title":"Vitamin C and bone","author":"Bourne","year":"1972"},{"key":"10.1093\/jn\/124.2.241_bib4","series-title":"A Textbook of Pathology","author":"Boyd","year":"1970"},{"key":"10.1093\/jn\/124.2.241_bib5","first-page":"401","article-title":"Incidence of premature rupture of membranes in pregnant women with low leukocyte levels of vitamin C","volume":"45","author":"Casanueva","year":"1991","journal-title":"Eut. J. Clin. Nutr"},{"key":"10.1093\/jn\/124.2.241_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.nu.06.070186.002053","article-title":"The biochemical functions of ascorbic acid","volume":"6","author":"Englard","year":"1986","journal-title":"Annu. Rev. Nutr"},{"key":"10.1093\/jn\/124.2.241_bib7","series-title":"Deficiency Disease","author":"Folks","year":"1958"},{"key":"10.1093\/jn\/124.2.241_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0306-3356(21)00529-X","article-title":"Antepartum haemorrhage","volume":"9","author":"Green-Thompson","year":"1982","journal-title":"Clin. Obstet. Gynaecol"},{"issue":"Suppl. 289","key":"10.1093\/jn\/124.2.241_bib9","first-page":"3","article-title":"Autoradiographic studies on the distribution of C14-labelled ascorbic acid and dehydroascorbic acid","volume":"70","author":"Hammarstr\u00f6m","year":"1966","journal-title":"Acta Physiol. Scand"},{"key":"10.1093\/jn\/124.2.241_bib10","first-page":"163","article-title":"Vitamin-C-Konzentrationen in maternalem Plasma, Fruchtwasser, Nabelschnurblut, im Plasma des Neugeborenen und in Kolostrum, transitorischer und reifer Frauen- milch","volume":"22","author":"Heinz-Erian","year":"1987","journal-title":"Paediatr. Paedol"},{"key":"10.1093\/jn\/124.2.241_bib11","series-title":"In: Ascorbic Acid in Domestic Animals","first-page":"3","article-title":"General aspects of ascorbic acid function and metabolism","author":"Hornig","year":"1984"},{"key":"10.1093\/jn\/124.2.241_bib12","series-title":"In: Modern Nutrition in Health and Disease","first-page":"417","article-title":"Ascorbic acid","author":"Hornig","year":"1988"},{"key":"10.1093\/jn\/124.2.241_bib13","first-page":"223","article-title":"Autoradiographic distribution of (1-14C) ascorbic acid and (1-14C) dehydroascorbic acid in male guinea pigs after intravenous injection","volume":"42","author":"Hornig","year":"1972","journal-title":"Int. J. Vitam. Nutr. Res"},{"key":"10.1093\/jn\/124.2.241_bib14","first-page":"511","article-title":"Tissue distribution of labelled material in vitamin C-deficient guinea pigs after intravenous injection of (1-14C) ascorbic acid or (1-14C) dehydroascorbic acid","volume":"42","author":"Hornig","year":"1972","journal-title":"Int. J. Vitam. Nutr. Res"},{"key":"10.1093\/jn\/124.2.241_bib15","first-page":"115","article-title":"Plasma vitamin C and pro-thrombin concentration in pregnancy and in threatened, spontaneous and habitual abortion","volume":"76","author":"Javert","year":"1943","journal-title":"Surg. Gynecol. & Obstet"},{"key":"10.1093\/jn\/124.2.241_bib16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/BF03546713","article-title":"Congenital ascorbic acid deficiency in pigs","volume":"24","author":"Jensen","year":"1983","journal-title":"Acta Vet. Scand"},{"key":"10.1093\/jn\/124.2.241_bib17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0002-9378(85)90703-3","article-title":"Collagen types in normal and prematurely ruptured amniotic membranes","volume":"153","author":"Kanayama","year":"1985","journal-title":"Am. J. Obstet. Gynecol"},{"key":"10.1093\/jn\/124.2.241_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(08)60060-6","article-title":"Ascorbic acid in endocrine systems","volume":"42","author":"Levine","year":"1985","journal-title":"Vitam. Horm"},{"key":"10.1093\/jn\/124.2.241_bib19","series-title":"Variationer i askorbinsyrekoncentrationen i plasma og vaev (Danish)","article-title":"Studier over askorbinsyres betydning for svin","author":"Lund","year":"1980"},{"key":"10.1093\/jn\/124.2.241_bib20","first-page":"48","article-title":"Ascorbic acid metabolism in swine Studies on ascorbic acid content in blood, milk and tissues (Danish, English summary)","volume":"23","author":"Lund","year":"1980","journal-title":"R. Vet. Agric. Univ. Steril. Res. Inst. Annu. Rep"},{"key":"10.1093\/jn\/124.2.241_bib21","series-title":"The Embryonic Pig. A Chronological Account","author":"Marrable","year":"1971"},{"key":"10.1093\/jn\/124.2.241_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF01952551","article-title":"A rat mutant unable to synthesize vitamin C","volume":"40","author":"Mizushima","year":"1984","journal-title":"Experientia"},{"key":"10.1093\/jn\/124.2.241_bib23","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1139\/o90-173","article-title":"Cellular functions of ascorbic acid","volume":"68","author":"Padh","year":"1990","journal-title":"Biochem. Cell Biol"},{"key":"10.1093\/jn\/124.2.241_bib24","first-page":"239","article-title":"The influence of ascorbic acid status on boar performance","author":"Palludan","year":"1988","journal-title":"Proc. 10th Int. Pig Vet. Soc. Congr."},{"key":"10.1093\/jn\/124.2.241_bib25","doi-asserted-by":"crossref","first-page":"1135S","DOI":"10.1093\/ajcn\/54.6.1135s","article-title":"Ascorbate requirement for hydroxylation and secretion of procollagen: relation to inhibition of collagen synthesis in scurvy","volume":"54","author":"Peterkofsky","year":"1991","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/124.2.241_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1079\/PNS19920029","article-title":"The transport of vitamin C and effects of disease","volume":"51","author":"Schorah","year":"1992","journal-title":"Proc. Nutr. Soc"},{"key":"10.1093\/jn\/124.2.241_bib27","first-page":"151","article-title":"Evaluation of antenatal and perinatal vitamin C status in pregnancies threatened with prematurity","volume":"16","author":"Sharma","year":"1988"},{"key":"10.1093\/jn\/124.2.241_bib28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000391416","article-title":"Bone pathology in experimental malnutrition","volume":"5","author":"Steward","year":"1965","journal-title":"World Rev. Nutr. Diet"},{"key":"10.1093\/jn\/124.2.241_bib29","first-page":"429","article-title":"Ascorbic acid in swine nutrition: pre-, neo- and postnatal aspects","author":"Wegger","year":"1986","journal-title":"Proc. 9th Int. Pig Vet. Soc. Congr."},{"key":"10.1093\/jn\/124.2.241_bib30","series-title":"In: Ascorbic Acid in Domestic Animals","first-page":"60","article-title":"Distribution of 14C-ascorbic acid in normal and vitamin C deficient pigs","author":"Wegger","year":"1992"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623057334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623057334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:20:02Z","timestamp":1739359202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623057334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["S0022316623057334"],"URL":"https:\/\/doi.org\/10.1093\/jn\/124.2.241","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1994,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin C Deficiency Causes Hematological and Skeletal Abnormalities during Fetal Development in Swine","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/124.2.241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1994 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}