{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:58:34Z","timestamp":1787313514325,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1994,6,1]],"date-time":"1994-06-01T00:00:00Z","timestamp":770428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1994,6]]},"DOI":"10.1093\/jn\/124.6.853","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T05:23:29Z","timestamp":1519190609000},"page":"853-860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Food-Grade Silicon Dioxide is Hypocholesterolemic in the Diet of Cholesterol-Fed Rats"],"prefix":"10.1016","volume":"124","author":[{"given":"Michael R","family":"Peluso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara O","family":"Schneeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/124.6.853_bib1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","article-title":"Enzymatic determination of total serum cholesterol","volume":"20","author":"Allain","year":"1974","journal-title":"Clin. Chem"},{"key":"10.1093\/jn\/124.6.853_bib2","first-page":"387","article-title":"Plasma and liver cholesterol concentrations in mice fed semipurified diets differing in the amount of cholesterol and type of fat","volume":"56","author":"Beynen","year":"1986","journal-title":"Int. J. Vitam. Nutr. Res"},{"key":"10.1093\/jn\/124.6.853_bib3","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1172\/JCI110714","article-title":"Role of apolipoprotein E-containing lipoproteins in abetalipoproteinemia","volume":"70","author":"Blum","year":"1982","journal-title":"J. Clin. Invest"},{"key":"10.1093\/jn\/124.6.853_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0005-2760(90)90205-C","article-title":"Hepatic uptake and processing of free cholesterol from different lipoproteins with and without sodium taurocholate administration","volume":"1045","author":"Bravo","year":"1990","journal-title":"An in vivo study in the rat. Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/124.6.853_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02409409","article-title":"Silicon: a requirement in bone formation independent of vitamin Di","volume":"33","author":"Carlisle","year":"1981","journal-title":"Calcif. Tissue Int"},{"key":"10.1093\/jn\/124.6.853_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/jn\/112.2.241","article-title":"Effects of garlic on lipid metabolism in rats fed cholesterol or lard","volume":"112","author":"Chi","year":"1982","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib7","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1016\/S0021-9258(18)32716-9","article-title":"Bile acid secretion by cultured rat hepatocytes","volume":"258","author":"Davis","year":"1983","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/124.6.853_bib8","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/ajcn\/31.7.1188","article-title":"Relationship of metal metabolism to vascular disease mortality rates in Texas","volume":"31","author":"Dawson","year":"1978","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0022-2275(20)35372-4","article-title":"Rat plasma lipoproteins and apolipoproteins in experimental hypothyroidism","volume":"22","author":"Dory","year":"1981","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/124.6.853_bib10","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/jn\/119.8.1100","article-title":"Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats","volume":"119","author":"Ebihara","year":"1989","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0009-8981(68)90041-7","article-title":"A colorimetrie method for estimating serum triglycerides","volume":"22","author":"Fletcher","year":"1968","journal-title":"Clin. Chim. Acta"},{"key":"10.1093\/jn\/124.6.853_bib12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0002-9149(92)90980-D","article-title":"Role of water-soluble dietary fiber in the management of elevated plasma cholesterol in healthy subjects","volume":"69","author":"Haskell","year":"1992","journal-title":"Am. J. Cardiol"},{"key":"10.1093\/jn\/124.6.853_bib13","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0022-2275(20)38276-6","article-title":"Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat","volume":"30","author":"Heuman","year":"1989","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/124.6.853_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/jn\/120.4.353","article-title":"Effect of viscous indigestible polysaccha-rides on pancreatic-biliary secretion and digestive organs in rats","volume":"120","author":"Ikegami","year":"1990","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib15","series-title":"The Chemistry of Silica: Solubility, Polymerization, Colloid and Surface Properties, and Biochemistry","first-page":"42","year":"1979"},{"key":"10.1093\/jn\/124.6.853_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jsfa.2740320417","article-title":"The silica content of plant polysaccharides","volume":"32","author":"Khalil","year":"1981","journal-title":"J. Sci. Food Agric"},{"key":"10.1093\/jn\/124.6.853_bib17","first-page":"959","article-title":"Effects of silicon on the 3H-cholesterol level of serum, aorta, cardiac and hepatic tissues of young turkeys","volume":"12","author":"Ki","year":"1984","journal-title":"IRCS Med. Sci"},{"key":"10.1093\/jn\/124.6.853_bib18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF02537341","article-title":"Dietary fiber supplements: effects on serum and liver lipids and on liver phospholipid composition in rats","volume":"23","author":"Kritchevsky","year":"1988","journal-title":"Lipids"},{"key":"10.1093\/jn\/124.6.853_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0003-2697(66)90246-6","article-title":"Quantitative estimation of proteins by elec-trophoresis in agarose gel containing antibodies","volume":"15","author":"Laurell","year":"1966","journal-title":"Anal. Biochem"},{"key":"10.1093\/jn\/124.6.853_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF02535238","article-title":"An improved procedure for bile acid extraction and purification and tissue distribution in the rat","volume":"24","author":"Locket","year":"1989","journal-title":"Lipids"},{"key":"10.1093\/jn\/124.6.853_bib21","first-page":"693","article-title":"Fatty acids and lipid peroxidation during experimental atheroma","volume":"6","author":"Loeper","year":"1984","journal-title":"Silicon's action. Pathol. Biol"},{"key":"10.1093\/jn\/124.6.853_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin-phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/124.6.853_bib23","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/jn\/120.9.1037","article-title":"Effects of diets rich in fermentable carbohydrates on plasma lipoprotein levels and on lipoprotein catabolism in rats","volume":"120","author":"Mazur","year":"1990","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib24","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/jn\/118.12.1455","article-title":"Soluble oat fiber tends to normalize lipoprotein composition in cholesterol-fed rats","volume":"118","author":"Ney","year":"1988","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib25","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/ajcn\/49.5.832","article-title":"Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose of high-amylose cornstarch","volume":"49","author":"Reiser","year":"1989","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib26","series-title":"In: Silicon Biochemistry. Ciba Foundation Symposium 121","first-page":"90","article-title":"Silica in higher plants","author":"Sangster","year":"1986"},{"key":"10.1093\/jn\/124.6.853_bib27","series-title":"In: Silicon and Siliceous Structures in Biological Systems","first-page":"383","article-title":"Ultrastructure of silicon deposits in higher plants","author":"Sangster","year":"1981"},{"key":"10.1093\/jn\/124.6.853_bib28","series-title":"In: Dietary Fiber","first-page":"157","article-title":"Macronutrient absorption","author":"Schneeman","year":"1990"},{"key":"10.1093\/jn\/124.6.853_bib29","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/jn\/110.3.584","article-title":"Changes in small intestinal digestive enzyme activity and bile acids with dietary cellulose","volume":"110","author":"Schneeman","year":"1980","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/124.6.853_bib30","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0140-6736(77)91945-6","article-title":"Silicon, fibre, and atherosclerosis","volume":"1","author":"Schwarz","year":"1977","journal-title":"Lancet"},{"key":"10.1093\/jn\/124.6.853_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0009-8981(75)90194-1","article-title":"Determination of faecal bile acids by an enzymic method","volume":"64","author":"Sheltawy","year":"1975","journal-title":"Clin. Chim. Acta"},{"key":"10.1093\/jn\/124.6.853_bib32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1248\/bpb1978.14.371","article-title":"Effects of dietary konjac mannan on serum and liver cholesterol levels and biliary bile acid composition in hamsters","volume":"14","author":"Shimizu","year":"1991","journal-title":"J. Pharmacobio-Dyn"},{"key":"10.1093\/jn\/124.6.853_bib33","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S0022-2275(20)38217-1","article-title":"Regulation of hepatic cholesterol ester hydrolase and acyl-coenzyme Axholesterol acyltransferase in the rat","volume":"30","author":"Stone","year":"1989","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/124.6.853_bib34","series-title":"In: Dietary Fiber in Health and Disease","first-page":"193","article-title":"Modification of bile acid spectrum by dietary fiber","author":"Story","year":"1982"},{"key":"10.1093\/jn\/124.6.853_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jn\/74.1.87","article-title":"Beneficial effects of pectin in prevention of hypercholesterolemia and increase in liver cholesterol in cholesterol-fed rats","volume":"74","author":"Wells","year":"1961","journal-title":"J. Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623058157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623058157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/124\/6\/853\/23954694\/jn1240060853.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T20:34:12Z","timestamp":1686602052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623058157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["S0022316623058157"],"URL":"https:\/\/doi.org\/10.1093\/jn\/124.6.853","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1994,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Food-Grade Silicon Dioxide is Hypocholesterolemic in the Diet of Cholesterol-Fed Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/124.6.853","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1994 American Institute of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}