{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:53:49Z","timestamp":1761746029580,"version":"3.37.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1995,12]]},"DOI":"10.1093\/jn\/125.12.2999","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T03:46:10Z","timestamp":1739331970000},"page":"2999-3010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Supplemental Nutrition with Ornithine \u03b1-Ketoglutarate in Rats with Cancer-Associated Cachexia: Surgical Treatment of the Tumor Improves Efficacy of Nutritional Support"],"prefix":"10.1016","volume":"125","author":[{"given":"Thierry","family":"Le Bricon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Cynober","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine J.","family":"Field","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vickie E.","family":"Baracos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/125.12.2999_bib1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jn\/107.7.1340","article-title":"Report of the American Institution of Nutrition ad hoc committee on standards for nutritional studies","volume":"107","year":"1977","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/125.12.2999_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00000658-199202000-00003","article-title":"The effects of glutamine-enriched parenteral nutrition on tumor growth and host tissues","volume":"215","author":"Austgen","year":"1992","journal-title":"Ann. Surg."},{"article-title":"The Kjeldahl Method for Organic Nitrogen","year":"1965","author":"Bradstreet","key":"10.1093\/jn\/125.12.2999_bib3"},{"key":"10.1093\/jn\/125.12.2999_bib4","first-page":"613","article-title":"Statistics Today, p","author":"Byrkit","year":"1987"},{"key":"10.1093\/jn\/125.12.2999_bib5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0024-3205(88)90627-3","article-title":"Reduction of tumor growth following treatment with a glutamine antimetabolite","volume":"42","author":"Chance","year":"1988","journal-title":"Life Sci."},{"key":"10.1093\/jn\/125.12.2999_bib6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00000658-199306000-00007","article-title":"Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney","volume":"217","author":"Chen","year":"1993","journal-title":"Ann. Surg."},{"key":"10.1093\/jn\/125.12.2999_bib7","first-page":"2698","article-title":"Effects of branched chain amino acid-enriched total parenteral nutrition on amino acid utilization in rats bearing Yoshida sarcoma","volume":"48","author":"Crosby","year":"1988","journal-title":"Cancer Res."},{"key":"10.1093\/jn\/125.12.2999_bib8","first-page":"313","article-title":"Ornithine alpha-ketoglutarate in nutritional support","volume":"7","author":"Cynober","year":"1991","journal-title":"Nutrition"},{"key":"10.1093\/jn\/125.12.2999_bib9","doi-asserted-by":"crossref","unstructured":"Cynober, L. (1994) Can arginine and ornithine support gut function? Gut 3: (suppl. 1) S42-S45.","DOI":"10.1136\/gut.35.1_Suppl.S42"},{"key":"10.1093\/jn\/125.12.2999_bib10","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/bj1920719","article-title":"A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine","volume":"192","author":"Garlick","year":"1980","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/125.12.2999_bib11","doi-asserted-by":"crossref","unstructured":"Hammarqvist, F., Wemerman, J. & Vinnars, E. (1990) Effects of an amino acid solution enriched with either branched chain amino acids or ornithine a-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle. Br. J. Surg. 77:214\u2013218.","DOI":"10.1002\/bjs.1800770227"},{"key":"10.1093\/jn\/125.12.2999_bib12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/bjs.1800790707","article-title":"Nutrition and malignant disease: implications for surgical practice","volume":"79","author":"Heys","year":"1992","journal-title":"Br. J. Surg."},{"key":"10.1093\/jn\/125.12.2999_bib13","first-page":"23","article-title":"Altered tissue amino acid levels in traumatized, growing rats due to omithine-a-ketoglutarate supplemented oral diet","volume":"6","author":"Jeevanandam","year":"1991","journal-title":"J. Clin. Nutr. Gastroenterol."},{"key":"10.1093\/jn\/125.12.2999_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0022-4804(90)90066-B","article-title":"Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth","volume":"48","author":"Klimberg","year":"1990","journal-title":"J. Surg. Res."},{"key":"10.1093\/jn\/125.12.2999_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00808086","article-title":"Effect of alanylglutamine-enriched infusion on tumor growth and cellular immune function in rats","volume":"1","author":"Kweon","year":"1991","journal-title":"Amino Acids"},{"key":"10.1093\/jn\/125.12.2999_bib16","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0026-0495(94)90274-7","article-title":"Ornithine aketoglutarate (OKG) limits muscle protein breakdown without stimulating tumor growth in rats bearing Yoshida ascites hepatoma","volume":"43","author":"Le Bricon","year":"1994","journal-title":"Metabolism"},{"key":"10.1093\/jn\/125.12.2999_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0261-5614(85)90037-8","article-title":"Nitrogen sparing effect of Ornicetil in the immediate postoperative state: clinical biochemistry and nitrogen balance","volume":"4","author":"Leander","year":"1985","journal-title":"Clin. Nutr."},{"key":"10.1093\/jn\/125.12.2999_bib18","first-page":"602","article-title":"Energy substrate utilization of freshly isolated Morris hepatoma 7777 cells","volume":"48","author":"Mares-Perlman","year":"1988","journal-title":"Cancer Res."},{"key":"10.1093\/jn\/125.12.2999_bib19","series-title":"In Vivo Body Composition Studies","first-page":"67","article-title":"Tissue loss during severe wasting in lung cancer patients","author":"Preston","year":"1987"},{"key":"10.1093\/jn\/125.12.2999_bib20","first-page":"1","article-title":"Functional and metabolic changes in intestinal mucosa of rats after enteral administration of ornithine a-ketoglutarate salt, J","volume":"10","author":"Raul","year":"1995","journal-title":"Parent. Enteral Nutr."},{"key":"10.1093\/jn\/125.12.2999_bib21","doi-asserted-by":"crossref","unstructured":"Strelkov, A. B. S., Fields, A. L. A. & Baracos, V. E. (1989) Effect of systemic inhibition of prostaglandin production on protein metabolism in tumor bearing rats. Am. ). Physiol. 257: C261-C269.","DOI":"10.1152\/ajpcell.1989.257.2.C261"},{"key":"10.1093\/jn\/125.12.2999_bib22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/0148607185009004428","article-title":"Evaluation of the effect of arginine-enriched amino acid solution on tumor growth.)","volume":"9","author":"Tachibana","year":"1985","journal-title":"Parent. Enteral Nutr."},{"key":"10.1093\/jn\/125.12.2999_bib23","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0021-9258(19)68081-6","article-title":"Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? J","volume":"257","author":"Tischler","year":"1982","journal-title":"Biol. Chem."},{"key":"10.1093\/jn\/125.12.2999_bib24","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/0148607191015005517","article-title":"Action of enterally administered ornithine \u03b1-ketoglutarate on protein breakdown in skeletal muscle and liver of the burned rat","volume":"15","author":"Vaubourdolle","year":"1991","journal-title":"J. Parent. Enteral Nutr."},{"key":"10.1093\/jn\/125.12.2999_bib25","first-page":"183","article-title":"Fate of enterally administered ornithine in healthy animals: interaction with \u03b1-ketoglutarate","volume":"5","author":"Vaubourdolle","year":"1989","journal-title":"Nutrition"},{"key":"10.1093\/jn\/125.12.2999_bib26","first-page":"213","article-title":"Nitrogen sparing effect of Omicetil in the immediate postoperative period","volume":"6","author":"Versterberg","year":"1987","journal-title":"II. Muscle and plasma amino acids. Clin. Nutr."},{"key":"10.1093\/jn\/125.12.2999_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0026-0495(89)90144-3","article-title":"Glutamine and ornithine \u03b1-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma","volume":"38","author":"Wemerman","year":"1989","journal-title":"Metabolism"},{"key":"10.1093\/jn\/125.12.2999_bib28","first-page":"917","article-title":"The gut: a central organ after surgical stress","volume":"104","author":"Wilmore","year":"1988","journal-title":"Surgery"},{"key":"10.1093\/jn\/125.12.2999_bib29","doi-asserted-by":"crossref","unstructured":"Wu, G., Field, C. J. & Marliss, E. B. (1991) Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph node lymphocytes. Am. J. Physiol. 260: E141-E147.","DOI":"10.1152\/ajpendo.1991.260.1.E141"},{"key":"10.1093\/jn\/125.12.2999_bib30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/1097-0142(19920101)69:1<261::AID-CNCR2820690144>3.0.CO;2-Y","article-title":"Tumor and host response to arginine and branched chain amino acid-enriched total parenteral nutrition","volume":"69","author":"Ye","year":"1992","journal-title":"Cancer"},{"key":"10.1093\/jn\/125.12.2999_bib31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/0148607192016006505","article-title":"Ornithine \u03b1-ketoglutarate and glutamine supplementation during refeeding of food-deprived rats","volume":"16","author":"Ziegler","year":"1992","journal-title":"J. Parent. Enteral Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622018351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622018351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:21:34Z","timestamp":1739359294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622018351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["S0022316622018351"],"URL":"https:\/\/doi.org\/10.1093\/jn\/125.12.2999","relation":{},"ISSN":["0022-3166"],"issn-type":[{"type":"print","value":"0022-3166"}],"subject":[],"published":{"date-parts":[[1995,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Supplemental Nutrition with Ornithine \u03b1-Ketoglutarate in Rats with Cancer-Associated Cachexia: Surgical Treatment of the Tumor Improves Efficacy of Nutritional Support","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/125.12.2999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1995 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}