{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:15:33Z","timestamp":1789665333907,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1996,4,1]],"date-time":"1996-04-01T00:00:00Z","timestamp":828316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":9814,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1996,4]]},"DOI":"10.1093\/jn\/126.4.825","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T10:18:23Z","timestamp":1519208303000},"page":"825-833","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Transgenic Mice That Overexpress Metallothionein-I Resist Dietary Zinc Deficiency"],"prefix":"10.1016","volume":"126","author":[{"given":"Tim","family":"Dalton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Palmiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen K.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/126.4.825_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1432-1033.1987.tb13545.x","article-title":"Regulation of the ontogeny of rat liver metallothionein mRNA by zinc.","volume":"166","author":"Andrews","year":"1987","journal-title":"Eur. J. Biochem."},{"key":"10.1093\/jn\/126.4.825_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1242\/dev.100.3.463","article-title":"Metallothionein gene regulation in the preimplantation rabbit blastocyst.","volume":"100","author":"Andrews","year":"1987","journal-title":"Development"},{"key":"10.1093\/jn\/126.4.825_bib3","first-page":"193","article-title":"Regulation of metallothionein gene expression.","volume":"14","author":"Andrews","year":"1990","journal-title":"Prog. Food Nutr. Sci."},{"key":"10.1093\/jn\/126.4.825_bib4","series-title":"Metallothionein 01: Biological Roles and Medical Implications","first-page":"351","article-title":"Cell-specific expression and regulation of the mouse metallothionein-I and -II genes in the reproductive tract and pre-implantation embryo","author":"Andrews","year":"1993"},{"key":"10.1093\/jn\/126.4.825_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.nu.05.070185.000355","article-title":"Zinc and reproduction.","volume":"5","author":"Apgar","year":"1985","journal-title":"Annu. Rev. Nutr."},{"key":"10.1093\/jn\/126.4.825_bib6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/BF01952862","article-title":"Zinc, copper and selenium in reproduction.","volume":"50","author":"Bedwal","year":"1994","journal-title":"Experientia"},{"key":"10.1093\/jn\/126.4.825_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0076-6879(91)05080-F","article-title":"Nutritional and physiologic significance of me- tallothionein.","volume":"205","author":"Bremner","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1093\/jn\/126.4.825_bib8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1079\/BJN19930084","article-title":"Functional capacity of the residual lymphocytes from zinc-deficient adult mice.","volume":"69","author":"Cook Mills","year":"1993","journal-title":"Br. J. Nutr."},{"key":"10.1093\/jn\/126.4.825_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1152\/physrev.1985.65.2.238","article-title":"Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin.","volume":"65","author":"Cousins","year":"1985","journal-title":"Physiol. Rev."},{"key":"10.1093\/jn\/126.4.825_bib10","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1093\/nar\/22.23.5016","article-title":"Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor\/antioxidant response element and metal response promoter elements.","volume":"22","author":"Dalton","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1093\/jn\/126.4.825_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1289\/ehp.9610468","article-title":"Analysis of the effects of over-expression of metal- lothionein-I in transgenic mice on the reproductive toxicology of cadmium.","volume":"104","author":"Dalton","year":"1995","journal-title":"Environ. Health Perspec."},{"key":"10.1093\/jn\/126.4.825_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0076-6879(91)05089-E","article-title":"Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay.","volume":"205","author":"Eaton","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1093\/jn\/126.4.825_bib13","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1021\/bi00380a020","article-title":"Isolation of full- length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning.","volume":"26","author":"Han","year":"1987","journal-title":"Biochemistry"},{"key":"10.1093\/jn\/126.4.825_bib14","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1073\/pnas.88.21.9671","article-title":"Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport.","volume":"88","author":"Hempe","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1093\/jn\/126.4.825_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/tera.1420040211","article-title":"Teratogenic effects of short-term and transitory zinc deficiency in rats.","volume":"4","author":"Hurley","year":"1971","journal-title":"Teratology"},{"key":"10.1093\/jn\/126.4.825_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/taap.1995.1155","article-title":"Characterization of me- tallothionein-I transgenic mice.","volume":"133","author":"Iszard","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1093\/jn\/126.4.825_bib17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0076-6879(91)05145-L","article-title":"Overview of metallothionein.","volume":"205","author":"Kagi","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1093\/jn\/126.4.825_bib18","doi-asserted-by":"crossref","unstructured":"Lee, D. K., Fu, K., Liang, L., Dalton, T., Palmiter, R. D. & Andrews, G. K. (1996) Transgenic mouse blastocysts that over-express metallothionein-I resist cadmium toxicity in vitro. Mol. Reprod. De- vel. (in press).","DOI":"10.1002\/(SICI)1098-2795(199602)43:2<158::AID-MRD4>3.0.CO;2-Q"},{"key":"10.1093\/jn\/126.4.825_bib19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1073\/pnas.91.2.584","article-title":"Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.","volume":"91","author":"Masters","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1093\/jn\/126.4.825_bib20","first-page":"275","article-title":"The pancreas and zinc homeostasis.","volume":"116","author":"McClain","year":"1990","journal-title":"J. Lab. Clin. Med."},{"key":"10.1093\/jn\/126.4.825_bib21","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.4049\/jimmunol.148.6.1699","article-title":"Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period.","volume":"148","author":"McMaster","year":"1992","journal-title":"J. Immunol."},{"key":"10.1093\/jn\/126.4.825_bib22","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1093\/nar\/12.18.7035","article-title":"Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.","volume":"12","author":"Melton","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1093\/jn\/126.4.825_bib23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/jn\/119.4.639","article-title":"Zinc uptake by basolateral membrane vesicles from rat small intestine.","volume":"119","author":"Oestreicher","year":"1989","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/126.4.825_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0300-483X(82)90037-3","article-title":"The induced synthesis of metallothionein in various tissues of rats in response to metals. II Influence of zinc status and specific effect on pancreatic metallothionein.","volume":"23","author":"Onosaka","year":"1982","journal-title":"Toxicology"},{"key":"10.1093\/jn\/126.4.825_bib25","first-page":"5266","article-title":"Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.","volume":"13","author":"Palmiter","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1093\/jn\/126.4.825_bib26","series-title":"Metallothionein III: Biological Roles and Medical Implications","first-page":"399","article-title":"Metallothionein genes and their regulation in transgenic mice","author":"Palmiter","year":"1993"},{"key":"10.1093\/jn\/126.4.825_bib27","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/j.1460-2075.1995.tb07042.x","article-title":"Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.","volume":"14","author":"Palmiter","year":"1995","journal-title":"EMBO J."},{"key":"10.1093\/jn\/126.4.825_bib28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1042\/bj3080543","article-title":"Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression.","volume":"308","author":"Philcox","year":"1995","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/126.4.825_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","article-title":"The biochemical basis of zinc physiology.","volume":"73","author":"Vallee","year":"1993","journal-title":"Physiol. Rev."},{"issue":"suppl. 2","key":"10.1093\/jn\/126.4.825_bib30","first-page":"5","article-title":"Zinc: health effects and research priorities for the 1990s.","volume":"102","author":"Walsh","year":"1994","journal-title":"Environ. Health Perspect."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622014870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622014870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/126\/4\/825\/24073287\/jn1260040825.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T13:22:39Z","timestamp":1686576159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622014870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["S0022316622014870"],"URL":"https:\/\/doi.org\/10.1093\/jn\/126.4.825","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1996,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transgenic Mice That Overexpress Metallothionein-I Resist Dietary Zinc Deficiency","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/126.4.825","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}