{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:46:29Z","timestamp":1787741189440,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":9546,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1997,1]]},"DOI":"10.1093\/jn\/127.1.70","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T03:52:03Z","timestamp":1519185123000},"page":"70-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Parenteral Zinc Supplementation in Adult Humans during the Acute Phase Response Increases the Febrile Response , ,"],"prefix":"10.1016","volume":"127","author":[{"given":"Carol L.","family":"Braunschweig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryfran","family":"Sowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra S.","family":"Kovacevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen M.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"August","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/127.1.70_bib1","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/eji.1830171004","article-title":"Production of hybridoma growth factor by human monocytes","volume":"17","author":"Aarden","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"10.1093\/jn\/127.1.70_bib2","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/ajcn\/30.8.1236","article-title":"Magnitude of the host nutritional responses to infection","volume":"30","author":"Beisel","year":"1977","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/127.1.70_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-3083.1980.tb00095.x","article-title":"Differential role of Zn in antigen- and mitogen-induced lymphokine production","volume":"12","author":"Bendtzen","year":"1980","journal-title":"Scand. J. Immunol."},{"key":"10.1093\/jn\/127.1.70_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-3083.1982.tb00624.x","article-title":"Role of Zn and other divalent metal ions in human lymphokine production in vitro","volume":"15","author":"Bendtzen","year":"1982","journal-title":"Scand. J. Immunol."},{"key":"10.1093\/jn\/127.1.70_bib5","series-title":"Zinc in Human Biology","first-page":"129","article-title":"Biochemical pathologies of zinc deficiency","author":"Clegg","year":"1989"},{"key":"10.1093\/jn\/127.1.70_bib6","unstructured":"Cody, R. P. & Smith, J. K. (1991) Applied Statistics and the SAS Programming Language, 3rd ed., pp. 129\u2013131. Prentice Hall, Englewood Cliffs, NJ."},{"key":"10.1093\/jn\/127.1.70_bib7","first-page":"57","article-title":"The role of zinc in endotoxin fever","volume":"61","author":"Cossack","year":"1991","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1093\/jn\/127.1.70_bib8","first-page":"238","article-title":"Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin","volume":"65","author":"Cousins","year":"1985","journal-title":"Physiol. Ref."},{"key":"10.1093\/jn\/127.1.70_bib9","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1096\/fasebj.2.13.2458983","article-title":"Tissue specific regulation of zinc metabolism and metallothionein gene by interleukin 1","volume":"2","author":"Cousins","year":"1988","journal-title":"FASEB J."},{"key":"10.1093\/jn\/127.1.70_bib10","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00000658-199204000-00009","article-title":"Cytokine serum level during severe sepsis in human IL-6 as a marker of severity","volume":"215","author":"Damas","year":"1992","journal-title":"Ann. Surg."},{"key":"10.1093\/jn\/127.1.70_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/ajcn\/41.2.285","article-title":"Effect of zinc intake on copper excretion and retention in men","volume":"41","author":"Festa","year":"1985","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/127.1.70_bib12","series-title":"Parenteral Nutrition: Clinical Nutrition","first-page":"533","article-title":"Parenteral nutrition in the septic patient","author":"Freund","year":"1986"},{"key":"10.1093\/jn\/127.1.70_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0035-9203(88)90245-3","article-title":"The effects of malnutrition in the metabolism of children","volume":"82","author":"Golden","year":"1988","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1093\/jn\/127.1.70_bib14","series-title":"Trace Elements in Human and Animal Nutrition","first-page":"1","article-title":"Zinc","author":"Hambidge","year":"1986"},{"key":"10.1093\/jn\/127.1.70_bib15","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/jn\/121.9.1389","article-title":"Intestinal metallothonein gene expression and zinc absorption in rats are zinc-responsive but refractory to dexamethasone and interleukin 1\u03b1","volume":"121","author":"Hempe","year":"1991","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/127.1.70_bib16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2527\/jas1983.571106x","article-title":"Effect of dietary zinc levels on the growth and development of the GILT","volume":"57","author":"Hill","year":"1983","journal-title":"J. Anim. Sci."},{"key":"10.1093\/jn\/127.1.70_bib17","series-title":"Modern Nutrition in Health and Disease","first-page":"214","article-title":"Zinc","author":"King","year":"1994"},{"key":"10.1093\/jn\/127.1.70_bib18","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/clinchem\/20.12.1564","article-title":"Standardization of serum ceruloplasmin concentrations in international enzyme units with o-dianisdine dihydro chloride as substrates","volume":"20","author":"Lehmann","year":"1974","journal-title":"Clin. Chem."},{"key":"10.1093\/jn\/127.1.70_bib19","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0016-5085(91)90539-W","article-title":"Elevation of serum IL-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis","volume":"101","author":"Lesser","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/127.1.70_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jcp.1040950114","article-title":"In vitro and in vivo actions of zinc ion affecting cellular substances which influence host metabolic response to inflammation","volume":"95","author":"Mapes","year":"1978","journal-title":"J. Cell. Physiol."},{"key":"10.1093\/jn\/127.1.70_bib21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0140-6736(87)91413-9","article-title":"Serum levels of interleukin-6 and acute phase response","volume":"2","author":"Nijsten","year":"1987","journal-title":"Lancet"},{"key":"10.1093\/jn\/127.1.70_bib22","doi-asserted-by":"crossref","unstructured":"O\u2019Dell, B. L. & Reeves, P. G. (1989) Zinc status and food intake. In: Zinc in Human Biology (Mills, C. F., ed.), pp. 183\u2013220. International Life Science Institute, London, England.","DOI":"10.1007\/978-1-4471-3879-2_11"},{"key":"10.1093\/jn\/127.1.70_bib23","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1001\/jama.1978.03290200044019","article-title":"Hypocupremia induced by zinc therapy in adults","volume":"240","author":"Prasad","year":"1978","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/jn\/127.1.70_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0171-2985(87)80073-6","article-title":"Heavy-metal mitogenesis: Zn and Hg induce cellular cytotoxicity and interferon production in murine T lymphocytes","volume":"175","author":"Reardon","year":"1987","journal-title":"Immunobiology"},{"key":"10.1093\/jn\/127.1.70_bib25","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/0006-291X(75)90822-0","article-title":"Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis","volume":"64","author":"Richards","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1093\/jn\/127.1.70_bib26","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1073\/pnas.87.8.3137","article-title":"Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures","volume":"87","author":"Schroeder","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1093\/jn\/127.1.70_bib27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0008-8749(90)90330-T","article-title":"Differential effects of copper and zinc on human peripheral blood monocyte cytokine secretion","volume":"126","author":"Scuderi","year":"1990","journal-title":"Cell. Immunol."},{"key":"10.1093\/jn\/127.1.70_bib28","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1001\/jama.1979.03290450049024","article-title":"Guidelines for essential trace element preparations for parenteral use. A statement by an expert panel","volume":"241","author":"Shils","year":"1979","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/jn\/127.1.70_bib29","first-page":"643","article-title":"Impaired thermoregulation in cold exposed zinc deficient rats","volume":"24","author":"Topping","year":"1981","journal-title":"Nutr. Rep. Int."},{"key":"10.1093\/jn\/127.1.70_bib30","unstructured":"Turnlund, J. R. (1994) Copper. In: Modern Nutrition in Health and Disease (Shils, M. E., Olson, J.A. & Shike, M., eds.), vol. 1, 8th ed., pp. 231\u2013241. Lea and Fibiger, Philadelphia PA."},{"key":"10.1093\/jn\/127.1.70_bib31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1136\/gut.33.9.1264","article-title":"Role of interleukin-6 in acute pancreatitis. Comparison with C-reactive protein and phospholipase A","volume":"22","author":"Viedma","year":"1992","journal-title":"Gut"},{"key":"10.1093\/jn\/127.1.70_bib32","unstructured":"Weinsier, R. L. & Morgan, S. L. (1993) Nutrition support. In: Fundamentals of Clinical Nutrition (Weinsier, R. L. & Morgan, S. L., eds.), pp. 158. Mosby, St Louis, MO."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622073059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622073059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/127\/1\/70\/24023218\/70.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T05:49:18Z","timestamp":1758347358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622073059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["S0022316622073059"],"URL":"https:\/\/doi.org\/10.1093\/jn\/127.1.70","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parenteral Zinc Supplementation in Adult Humans during the Acute Phase Response Increases the Febrile Response,,","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/127.1.70","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}