{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:58:28Z","timestamp":1793732308306,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":9268,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1093\/jn\/127.10.2030","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T04:14:29Z","timestamp":1519186469000},"page":"2030-2038","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":205,"title":["Regional Brain Iron, Ferritin and Transferrin Concentrations during Iron Deficiency and Iron Repletion in Developing Rats"],"prefix":"10.1016","volume":"127","author":[{"given":"Keith M.","family":"Erikson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo J.","family":"Pinero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Beard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/127.10.2030_bib1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jn\/107.7.1340","article-title":"American Institute of Nutrition Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies","volume":"107","year":"1977","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/127.10.2030_bib2","doi-asserted-by":"crossref","unstructured":"Arosio, P., Levi, S., Santambroagio, P., Cozzi, A., Luzzago, A., Casareni, G. & Albertini, A. (1991) Structural and functional studies of human ferritin H and L chains. In: Biotechnology of Plasma Proteins (Albertini, A., Lenfant, C. L., Mannucci, P. M. & Sixma, J. J., eds.). Curr. Studies Hematol. Blood Transf. Basel Karger 58: 127 \u2013 139.","DOI":"10.1159\/000419350"},{"issue":"suppl","key":"10.1093\/jn\/127.10.2030_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0091-3057(82)90509-3","article-title":"Nutritional Fe and dopamine binding sites in the rat brain","volume":"17","author":"Ashkenazi","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1093\/jn\/127.10.2030_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1471-4159.1991.tb02130.x","article-title":"Expression of transferrin mRNA in the CNS of normal and Jimpy mice","volume":"57","author":"Barlett","year":"1991","journal-title":"J Neurochem."},{"key":"10.1093\/jn\/127.10.2030_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev.nu.10.070190.001025","article-title":"Iron deficiency","volume":"10","author":"Baynes","year":"1990","journal-title":"Annu. Rev. Nutr."},{"key":"10.1093\/jn\/127.10.2030_bib6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0091-3057(94)90323-9","article-title":"Altered monoamine metabolism in caudate-putamen of iron deficient rats","volume":"48","author":"Beard","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1093\/jn\/127.10.2030_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1753-4887.1993.tb03096.x","article-title":"Iron in the brain","volume":"51","author":"Beard","year":"1993","journal-title":"Nutr. Rev."},{"key":"10.1093\/jn\/127.10.2030_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/cne.903380108","article-title":"Ferritin, transferrin and iron in normal and aged rat brains","volume":"337","author":"Benkovic","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1093\/jn\/127.10.2030_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0736-5748(86)90019-5","article-title":"Long term consequences of early iron deficiency on dopaminergic neurotransmission","volume":"4","author":"Ben-Shachar","year":"1986","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1093\/jn\/127.10.2030_bib10","series-title":"Handbook of Chemical Neuroanatomy, Vol. 2: Classical Transmitters in the CNS, Part I","article-title":"Dopamine-containing systems in the CNS In:","author":"Bjorklund","year":"1984"},{"key":"10.1093\/jn\/127.10.2030_bib11","first-page":"E380","article-title":"Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats","volume":"264","author":"Borel","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1093\/jn\/127.10.2030_bib12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/10408399609527748","article-title":"Iron and thermoregulation: a review","volume":"36","author":"Brigham","year":"1996","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1093\/jn\/127.10.2030_bib13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0955-2863(95)00074-A","article-title":"Abnormal rat brain metabolism in iron deficiency anemia","volume":"6","author":"Chen","year":"1995","journal-title":"Nutr. Biochem."},{"key":"10.1093\/jn\/127.10.2030_bib14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/jn\/125.6.1529","article-title":"Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats","volume":"125","author":"Chen","year":"1995","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/127.10.2030_bib15","series-title":"Iron and Human Disease","first-page":"365","article-title":"Proteins of iron regulation in the brain in Alzheimer\u2019s disease In:","author":"Connor","year":"1992"},{"key":"10.1093\/jn\/127.10.2030_bib16","series-title":"Progress in Iron Research","first-page":"229","article-title":"Iron regulation in the brain at the cell and molecular level In:","author":"Connor","year":"1994"},{"key":"10.1093\/jn\/127.10.2030_bib17","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1002\/ana.410320710","article-title":"Iron regulation in the brain: histochemical, biochemical, and molecular considerations","volume":"32","author":"Connor","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1093\/jn\/127.10.2030_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jnr.490310214","article-title":"Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer\u2019s disease","volume":"31","author":"Connor","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1093\/jn\/127.10.2030_bib19","series-title":"Iron,","first-page":"105","author":"Cook","year":"1980"},{"key":"10.1093\/jn\/127.10.2030_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-8993(92)91652-U","article-title":"Iron and transferrin uptake in brain and cerebrospinal fluid in the rat","volume":"592","author":"Crowe","year":"1992","journal-title":"Brain Res."},{"key":"10.1093\/jn\/127.10.2030_bib21","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/jn\/107.6.1075","article-title":"Brain iron in the rat: extremely slow turnover in normal rats may explain long-lasting effects of early iron deficiency","volume":"107","author":"Dallman","year":"1977","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/127.10.2030_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0006-8993(94)91436-2","article-title":"Histological analysis of selected brain regions of hypotransferrinemic mice","volume":"635","author":"Dickinson","year":"1994","journal-title":"Brain Res."},{"key":"10.1093\/jn\/127.10.2030_bib23","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/jn\/126.3.693","article-title":"Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development","volume":"126","author":"Felt","year":"1996","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/127.10.2030_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0306-4522(96)00607-0","article-title":"Regional distribution of iron, transferrin ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains","volume":"79","author":"Focht","year":"1997","journal-title":"Neuroscience"},{"key":"10.1093\/jn\/127.10.2030_bib25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0006-8993(92)91334-B","article-title":"Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson\u2019s disease: a LAMMA study","volume":"593","author":"Good","year":"1992","journal-title":"Brain Res."},{"key":"10.1093\/jn\/127.10.2030_bib26","series-title":"Brain Iron: Neurochemistry and Behavioural Aspects","first-page":"1","article-title":"The distribution of iron in the brain In:","author":"Hill","year":"1988"},{"key":"10.1093\/jn\/127.10.2030_bib27","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1073\/pnas.82.13.4553","article-title":"TfR in rat brain: neuropeptide-like pattern and relationship to iron distribution","volume":"82","author":"Hill","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1093\/jn\/127.10.2030_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(92)91193-I","article-title":"Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer\u2019s disease","volume":"585","author":"Kalaria","year":"1992","journal-title":"Brain Res."},{"key":"10.1093\/jn\/127.10.2030_bib29","first-page":"241","article-title":"Bioevaluation of dietary iron in growing rats. I. Relationship between the iron level in a milk powder diet and the response of growing rats","volume":"10","author":"Koivistoinen","year":"1968","journal-title":"Nutr. Dieta"},{"key":"10.1093\/jn\/127.10.2030_bib30","first-page":"709","article-title":"Transferrin and iron in normal, Alzheimer\u2019s disease and Parkinson\u2019s disease brain regions","volume":"63","author":"Loeffler","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/127.10.2030_bib31","first-page":"23","article-title":"Behavioral aspects of iron deficiency","volume":"14","author":"Lozoff","year":"1986","journal-title":"Prog. Hematol."},{"key":"10.1093\/jn\/127.10.2030_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0968-0004(83)90217-7","article-title":"Iron uptake and utilization by mammalian cells. I. Cellular uptake of transferrin and iron","volume":"8","author":"Octave","year":"1983","journal-title":"Trends Biochem. Sci."},{"key":"10.1093\/jn\/127.10.2030_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jnr.490310304","article-title":"Transferrin receptor expression in myelin deficient (md) rats","volume":"31","author":"Roskams","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1093\/jn\/127.10.2030_bib34","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1046\/j.1471-4159.1994.63020709.x","article-title":"Iron, transferrin, and ferritin in the rat brain during development and aging","volume":"63","author":"Roskams","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/127.10.2030_bib35","series-title":"Principles and Procedures of Statistics.","author":"Steel","year":"1980"},{"key":"10.1093\/jn\/127.10.2030_bib36","series-title":"Aspects of the Blood-brain Barrier.","author":"Van Gelder","year":"1995"},{"key":"10.1093\/jn\/127.10.2030_bib37","doi-asserted-by":"crossref","first-page":"607S","DOI":"10.1093\/ajcn\/50.3.607","article-title":"Putative biological mechanisms on the effects of iron deficiency on brain biochemistry","volume":"50","author":"Youdim","year":"1989","journal-title":"Am. J. Clin. Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623016140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623016140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/127\/10\/2030\/24022220\/2030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T05:50:27Z","timestamp":1758347427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623016140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0022316623016140"],"URL":"https:\/\/doi.org\/10.1093\/jn\/127.10.2030","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional Brain Iron, Ferritin and Transferrin Concentrations during Iron Deficiency and Iron Repletion in Developing Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/127.10.2030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}