{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:33:30Z","timestamp":1791092010409,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":9145,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1998,2]]},"DOI":"10.1093\/jn\/128.2.463s","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T08:23:46Z","timestamp":1519201426000},"page":"463S-466S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Aldehyde Dehydrogenases in the Generation of Retinoic Acid in the Developing Vertebrate: A Central Role of the Eye ,"],"prefix":"10.1016","volume":"128","author":[{"given":"Ursula C.","family":"Dr\u00e4ger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McCaffery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/128.2.463S_bib1","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1074\/jbc.271.16.9526","article-title":"Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression","volume":"271","author":"Ang","year":"1996","journal-title":"J Biol. Chem"},{"key":"10.1093\/jn\/128.2.463S_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0168-9525(91)90423-N","article-title":"Hox gene activation by retinoic acid","volume":"7","author":"Boncinelli","year":"1991","journal-title":"Trends Genet"},{"key":"10.1093\/jn\/128.2.463S_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0014-4835(88)90049-8","article-title":"Opsin, G-protein and 48-kd protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light\/dark cycling of mRNAs","volume":"47","author":"Bowes","year":"1988","journal-title":"Exp Eye Res"},{"key":"10.1093\/jn\/128.2.463S_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/1350-9462(94)00001-Y","article-title":"Circadian rhythmicity in vertebrate retinas: regulation by a photoreceptor oscillator","volume":"14","author":"Cahill","year":"1995","journal-title":"Prog Retinal Eye Res"},{"key":"10.1093\/jn\/128.2.463S_bib5","doi-asserted-by":"crossref","first-page":"10056","DOI":"10.1073\/pnas.89.21.10056","article-title":"Retinoic acid is enriched in Hensen\u2019s node and is developmentally regulated in the early chicken embryo","volume":"89","author":"Chen","year":"1992","journal-title":"Proc Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/128.2.463S_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/dbio.1994.1008","article-title":"A concentration gradient of retinoids in the early Xenopus laevis embryo","volume":"161","author":"Chen","year":"1994","journal-title":"Dev Biol"},{"key":"10.1093\/jn\/128.2.463S_bib7","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1073\/pnas.91.8.3067","article-title":"The retinoid X receptor ligand, 9-cis-retinoic acid, is a potential regulator of early Xenopus development","volume":"91","author":"Creech Kraft","year":"1994","journal-title":"Proc Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/128.2.463S_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0925-4773(94)90023-X","article-title":"Developmental expression of murine retinoid X receptor (RXR) genes","volume":"45","author":"Doll\u00e9","year":"1994","journal-title":"Mech Dev"},{"key":"10.1093\/jn\/128.2.463S_bib9","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1242\/dev.110.4.1133","article-title":"Retinoic acid receptors and cellular retinoid binding proteins I. A systematic study of their differential pattern of transcription during mouse organogenesis","volume":"110","author":"Doll\u00e9","year":"1990","journal-title":"Development"},{"key":"10.1093\/jn\/128.2.463S_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-4615-1965-2_24","article-title":"Retinoic-acid synthesis in the developing spinal cord","volume":"372","author":"Dr\u00e4ger","year":"1995","journal-title":"Adv Exp. Med. Biol"},{"key":"10.1093\/jn\/128.2.463S_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1350-9462(96)00029-8","article-title":"Retinoic acid and development of the retina","volume":"16","author":"Dr\u00e4ger","year":"1997","journal-title":"Prog Retina Eye Res"},{"key":"10.1093\/jn\/128.2.463S_bib12","doi-asserted-by":"crossref","first-page":"12221","DOI":"10.1021\/bi961176+","article-title":"Involvement of alcohol dehydrogenase, short-chain dehydrogenase\/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis","volume":"35","author":"Duester","year":"1996","journal-title":"Biochemistry"},{"key":"10.1093\/jn\/128.2.463S_bib13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/340140a0","article-title":"Retinoic acid causes an anteroposterior transformation in the developing central nervous system","volume":"340","author":"Durston","year":"1989","journal-title":"Nature (Lond)"},{"key":"10.1093\/jn\/128.2.463S_bib14","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0014-4835(91)90114-T","article-title":"Levels of mRNA encoding proteins of the cGMP cascade as a function of light environment","volume":"53","author":"Farber","year":"1991","journal-title":"Exp Eye Res"},{"key":"10.1093\/jn\/128.2.463S_bib15","series-title":"In: The Retinoids: Biology, Chemistry, and Medicine","first-page":"443","article-title":"Cellular biology and biochemistry of the retinoids","author":"Gudas","year":"1994"},{"key":"10.1093\/jn\/128.2.463S_bib16","first-page":"228","article-title":"The relation of maternal vitamin A deficiency to microphthalmia in pigs","volume":"33","author":"Hale","year":"1937","journal-title":"Texas State J Med"},{"key":"10.1093\/jn\/128.2.463S_bib17","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1073\/pnas.89.17.8293","article-title":"Retinoic acid\u2013induced duplication of the zebrafish retina","volume":"89","author":"Hyatt","year":"1992","journal-title":"Proc Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/128.2.463S_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1242\/dev.122.1.195","article-title":"Retinoic acid establishes ventral retinal characteristics","volume":"122","author":"Hyatt","year":"1996","journal-title":"Development"},{"key":"10.1093\/jn\/128.2.463S_bib19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/350585a0","article-title":"Expression of the homeobox Hox-4 genes and the specification of position in chick limb development","volume":"350","author":"Izpisua-Belmonte","year":"1991","journal-title":"Nature (Lond)"},{"key":"10.1093\/jn\/128.2.463S_bib20","series-title":"Developmental Neurobiology","author":"Jacobson","year":"1991"},{"key":"10.1093\/jn\/128.2.463S_bib21","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(94)90274-7","article-title":"Genetic analysis of RXR\u03b1 developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis","volume":"78","author":"Kastner","year":"1994","journal-title":"Cell"},{"key":"10.1093\/jn\/128.2.463S_bib22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/337454a0","article-title":"Circadian rhythm and light regulate opsin mRNA in rod photoreceptors","volume":"337","author":"Korenbrot","year":"1989","journal-title":"Nature (Lond)"},{"key":"10.1093\/jn\/128.2.463S_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/10409239209082565","article-title":"Aldehyde dehydrogenases and their role in carcinogenesis","volume":"27","author":"Lindahl","year":"1992","journal-title":"Crit Rev. Biochem. Molec. Biol"},{"key":"10.1093\/jn\/128.2.463S_bib24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: the second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1093\/jn\/128.2.463S_bib25","series-title":"In: The Retinoids: Biology, Chemistry, and Medicine","first-page":"319","article-title":"The retinoid receptors","author":"Mangelsdorf","year":"1994"},{"key":"10.1093\/jn\/128.2.463S_bib26","doi-asserted-by":"crossref","first-page":"7286","DOI":"10.1073\/pnas.91.15.7286","article-title":"Retinoic acid is necessary for development of the ventral retina in zebrafish","volume":"91","author":"Marsh-Armstrong","year":"1994","journal-title":"Proc Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/128.2.463S_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00357756","article-title":"Retinoic acid in the anteroposterior patterning of the zebrafish trunk","volume":"205","author":"Marsh-Armstrong","year":"1995","journal-title":"Roux\u2019s Arch Dev. Biol"},{"key":"10.1093\/jn\/128.2.463S_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-4615-2904-0_20","article-title":"Retinoic acid synthesis in the developing retina","volume":"328","author":"McCaffery","year":"1993","journal-title":"Adv Exp. Med. Biol"},{"key":"10.1093\/jn\/128.2.463S_bib29","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1073\/pnas.91.15.7194","article-title":"Hotspots of retinoic acid synthesis in the developing spinal cord","volume":"91","author":"McCaffery","year":"1994","journal-title":"Proc Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/128.2.463S_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.115.2.371","article-title":"Asymmetrical retinoic acid synthesis in the dorso-ventral axis of the retina","volume":"115","author":"McCaffery","year":"1992","journal-title":"Development"},{"key":"10.1093\/jn\/128.2.463S_bib31","doi-asserted-by":"crossref","first-page":"12570","DOI":"10.1073\/pnas.93.22.12570","article-title":"Light-mediated retinoic acid production","volume":"93","author":"McCaffery","year":"1996","journal-title":"Proc Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/128.2.463S_bib32","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1006\/dbio.1993.1197","article-title":"Changing patterns of the retinoic acid system in the developing retina","volume":"158","author":"McCaffery","year":"1993","journal-title":"Dev Biol"},{"key":"10.1093\/jn\/128.2.463S_bib33","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1242\/dev.112.3.693","article-title":"Aldehyde dehydrogenase is a positional marker in the retina","volume":"112","author":"McCaffery","year":"1991","journal-title":"Development"},{"key":"10.1093\/jn\/128.2.463S_bib34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/jnr.490380414","article-title":"Light-dependent regulation of the transcriptional activity of the mammalian gene for arrestin","volume":"38","author":"McGinnis","year":"1994","journal-title":"J Neurosci. Res"},{"key":"10.1093\/jn\/128.2.463S_bib35","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1523\/JNEUROSCI.17-19-07441.1997","article-title":"Retinoic acid in the developing chick retina","volume":"17","author":"Mey","year":"1997","journal-title":"J Neurosci"},{"key":"10.1093\/jn\/128.2.463S_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0925-4773(96)00653-3","article-title":"Restricted expression and retinoic acid\u2013induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development","volume":"62","author":"Niederreither","year":"1997","journal-title":"Mech Dev"},{"key":"10.1093\/jn\/128.2.463S_bib37","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1242\/dev.115.2.449","article-title":"The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis","volume":"115","author":"Oro","year":"1992","journal-title":"Development"},{"key":"10.1093\/jn\/128.2.463S_bib38","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1126\/science.7914031","article-title":"Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans","volume":"265","author":"Quiring","year":"1994","journal-title":"Science"},{"key":"10.1093\/jn\/128.2.463S_bib39","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/exer.1996.0139","article-title":"Control of Drosophila opsin gene expression by carotenoids and retinoic acid: Northern and Western analyses","volume":"63","author":"Picking","year":"1996","journal-title":"Exp Eye Res"},{"key":"10.1093\/jn\/128.2.463S_bib40","series-title":"In: The Retinoids: Biology, Chemistry, and Medicine","first-page":"351","article-title":"Retinoids in photosensitive systems","author":"Saari","year":"1994"},{"key":"10.1093\/jn\/128.2.463S_bib41","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/346763a0","article-title":"Sequential activation of Hox2 homeobox genes by retinoic acid in human embryonal carcinoma cells","volume":"346","author":"Simeone","year":"1990","journal-title":"Nature (Lond)"},{"key":"10.1093\/jn\/128.2.463S_bib42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1073\/pnas.50.4.703","article-title":"Chemoaffinity in the orderly growth of nerve fiber patterns and connections","volume":"50","author":"Sperry","year":"1963","journal-title":"Proc Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/128.2.463S_bib43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/exer.1993.1113","article-title":"Increased expression of chloramphenicol acetyltransferase by carotenoid and retinoid replacement in Drosophila opsin promotor fusion stocks","volume":"57","author":"Sun","year":"1993","journal-title":"Exp Eye Res"},{"key":"10.1093\/jn\/128.2.463S_bib44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fasebj.11.4.9068616","article-title":"Retinoic acid increases arrestin mRNA levels in the mouse retina","volume":"11","author":"Wagner","year":"1997","journal-title":"FASEB J"},{"key":"10.1093\/jn\/128.2.463S_bib45","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/219800a0","article-title":"The molecular basis of visual excitation","volume":"219","author":"Wald","year":"1968","journal-title":"Nature (Lond)"},{"key":"10.1093\/jn\/128.2.463S_bib46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1001\/archopht.1946.00890200155008","article-title":"Congenital malformations induced in rats by maternal vitamin A deficiency I. Defects of the eye","volume":"35","author":"Warkany","year":"1946","journal-title":"Arch Ophthalmol"},{"key":"10.1093\/jn\/128.2.463S_bib47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0165-3806(96)00038-7","article-title":"Influence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesis","volume":"93","author":"Yamamoto","year":"1996","journal-title":"Dev Brain Res"},{"key":"10.1093\/jn\/128.2.463S_bib48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1432-1033.1996.0015h.x","article-title":"Molecular identification of a major retinoic-acid synthesizing enzyme: a retinaldehyde-specific dehydrogenase","volume":"240","author":"Zhao","year":"1996","journal-title":"Eur J. Biochem"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623017546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623017546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/128\/2\/463S\/24025195\/463s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T21:55:14Z","timestamp":1735250114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623017546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["S0022316623017546"],"URL":"https:\/\/doi.org\/10.1093\/jn\/128.2.463s","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1998,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aldehyde Dehydrogenases in the Generation of Retinoic Acid in the Developing Vertebrate: A Central Role of the Eye,","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/128.2.463S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}