{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:46:18Z","timestamp":1791333978501,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":8533,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1999,10]]},"DOI":"10.1093\/jn\/129.10.1761","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T08:21:34Z","timestamp":1519201294000},"page":"1761-1764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Cellular Import of Cobalamin (Vitamin B-12)"],"prefix":"10.1016","volume":"129","author":[{"given":"Bellur","family":"Seetharam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Bose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/129.10.1761_bib1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/6831","article-title":"Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anemia 1","volume":"21","author":"Aminioff","year":"1999","journal-title":"Nat. Genet"},{"key":"10.1093\/jn\/129.10.1761_bib2","doi-asserted-by":"crossref","first-page":"26497","DOI":"10.1074\/jbc.272.42.26497","article-title":"Characterization of an epithelial 460 kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds to receptor associated protein","volume":"272","author":"Birn","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib3","doi-asserted-by":"crossref","first-page":"16163","DOI":"10.1074\/jbc.273.26.16163","article-title":"Brefeldin A (BFA) inhibits the basolateral membrane delivery and dimerization of transcobalamin in human intestinal epithelial Caco-2 cells","volume":"273","author":"Bose","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib4","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1074\/jbc.272.6.3538","article-title":"Bipolar functional expression of transcobalamin II receptor in human intestinal polarized Caco-2 cells","volume":"272","author":"Bose","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib5","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.1074\/jbc.271.20.11718","article-title":"Dimerization of transcobalamin II-receptor: requirement of a structurally ordered lipid bilayer","volume":"271","author":"Bose","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib6","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1074\/jbc.271.8.4195","article-title":"In vitro and in vivo inactivation of transcobalamin II-receptor by its antiserum","volume":"271","author":"Bose","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib7","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1042\/bj3100923","article-title":"Regulation of expression of transcobalamin II-receptor in the rat","volume":"310","author":"Bose","year":"1995","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/129.10.1761_bib8","doi-asserted-by":"crossref","first-page":"20920","DOI":"10.1074\/jbc.272.33.20920","article-title":"Effect of disulfide bonds of transcobalamin II-receptor on its activity and basolateral targeting in human intestinal epithelial Caco-2 cells","volume":"272","author":"Bose","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0076-6879(97)81034-8","article-title":"Purification, membrane expression, and interactions of transcobalamin II receptor","volume":"281","author":"Bose","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1093\/jn\/129.10.1761_bib10","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1074\/jbc.270.14.8152","article-title":"Membrane expression and interactions of human transcobalamin II receptor","volume":"270","author":"Bose","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib11","first-page":"717","article-title":"Transcobalamin II-receptor imaging via radiolabeled diethyl-triaminepentaacetate cobalamin analogs","volume":"38","author":"Collins","year":"1997","journal-title":"J. Nucl. Med"},{"key":"10.1093\/jn\/129.10.1761_bib12","series-title":"Metabolic Basis of Inherited Disease","first-page":"3111","article-title":"Inherited disorders of cobalamin transport and metabolism","author":"Fenton","year":"1995"},{"key":"10.1093\/jn\/129.10.1761_bib13","doi-asserted-by":"crossref","first-page":"20180","DOI":"10.1074\/jbc.273.32.20180","article-title":"Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line","volume":"273","author":"Fiskerstrand","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib14","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1016\/S0021-9258(20)64349-6","article-title":"Defective brush border expression of intrinsic factor cobalamin receptor in inherited selective intestinal cobalamin malabsorption","volume":"266","author":"Fyfe","year":"1991","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0888-7543(91)90329-D","article-title":"Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11","volume":"10","author":"Hewittt","year":"1991","journal-title":"Genomics"},{"key":"10.1093\/jn\/129.10.1761_bib16","series-title":"Biomedicine and Physiology of Vitamin B 12","first-page":"293","article-title":"Synthesis and recycling of the transcobalamin II receptor","author":"Jacobsen","year":"1990"},{"key":"10.1093\/jn\/129.10.1761_bib17","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/9504","article-title":"The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprptein A-I receptor facilitating endocytosis of high-density lipoprotein","volume":"5","author":"Kozyarki","year":"1999","journal-title":"Nat. Med"},{"key":"10.1093\/jn\/129.10.1761_bib18","doi-asserted-by":"crossref","first-page":"20540","DOI":"10.1074\/jbc.274.29.20540","article-title":"Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding","volume":"274","author":"Kristiansen","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib19","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/hmg\/3.10.1835","article-title":"Identification of two mutant alleles of transcobalamin II in an affected family","volume":"3","author":"Li","year":"1994","journal-title":"Hum. Mol. Genet"},{"key":"10.1093\/jn\/129.10.1761_bib20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1006\/bbrc.1994.2577","article-title":"Nonsense mutations in human transcobalmin II deficiency","volume":"204","author":"Li","year":"1994","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/129.10.1761_bib21","first-page":"28170","article-title":"A 69-base pair fragment derived from human transcobalamin II promoter is sufficient for high bidirectional activity in the absence of TATA box and an initiator element in transfected cells","volume":"273","author":"Li","year":"1998","journal-title":"Role of an E box in transcriptional activity. J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0167-4781(93)90264-E","article-title":"Isolation and sequence analysis of variant forms of human transcobalamin II","volume":"1172","author":"Li","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/129.10.1761_bib23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj3010585","article-title":"Expression of transcobalamin II mRNA in human tissues and cultured fibroblasts form normal and TC II deficient patients","volume":"301","author":"Li","year":"1994","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/129.10.1761_bib24","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1006\/bbrc.1995.1402","article-title":"Genomic organization of human transcobalamin II gene: comparison to human intrinsic factor and transcobalamin I","volume":"208","author":"Li","year":"1995","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/129.10.1761_bib25","doi-asserted-by":"crossref","first-page":"16104","DOI":"10.1074\/jbc.273.26.16104","article-title":"Characterization of the human transcobalamin II promoter: a proximal GC\/GT box is a dominant negative element","volume":"273","author":"Li","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib26","first-page":"6374","article-title":"The intrinsic factor, cubilin, is assembled into trimers via coiled-coil \u03b1-helix. J. Biol.Chem","volume":"274","author":"Lindblom","year":"1999"},{"key":"10.1093\/jn\/129.10.1761_bib27","doi-asserted-by":"crossref","first-page":"26559","DOI":"10.1016\/S0021-9258(19)74349-X","article-title":"Use of transgeneic mice to study the regulation of gene expression in the parietal cell lineage of gastric units","volume":"268","author":"Lorenz","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib28","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1074\/jbc.273.9.5235","article-title":"The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin binding peripheral protein with homology to developmental proteins","volume":"273","author":"Moestrup","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib29","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1016\/S0021-9258(20)89528-3","article-title":"The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I","volume":"266","author":"Platica","year":"1991","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/129.10.1761_bib30","series-title":"Physiology of the Gastrointestinal Tract","first-page":"1997","article-title":"Gastric intrinsic factor and cobalamin absorption","author":"Seetharam","year":"1994"},{"key":"10.1093\/jn\/129.10.1761_bib31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.nutr.19.1.173","article-title":"Receptor-mediated endocytosis of cobalamin (vitamin B12)","volume":"19","author":"Seetharam","year":"1999","journal-title":"Annu. Rev. Nutr"},{"key":"10.1093\/jn\/129.10.1761_bib32","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1172\/JCI119411","article-title":"Identification of rat yolk sac target protein of teratogenic antibodies, gp280 as intrinsic factor-cobalamin receptor","volume":"99","author":"Seetharam","year":"1997","journal-title":"J. Clin. Investig"},{"key":"10.1093\/jn\/129.10.1761_bib33","article-title":"Transcobalamin II and its cell surface receptor","author":"Seetharam","year":"1999","journal-title":"Vitam. Horm"},{"key":"10.1093\/jn\/129.10.1761_bib34","series-title":"Advances in Thomas Addison\u2019s Disease, vol. II","first-page":"293","article-title":"Intrinsic factor-cobalamin receptor, an overview","author":"Seetharam","year":"1994"},{"key":"10.1093\/jn\/129.10.1761_bib35","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/S0021-9258(18)50044-2","article-title":"The intrinsic factor in receptor binding site is located in the amino terminal portion of IF","volume":"267","author":"Tang","year":"1992","journal-title":"J. Biol. Chem"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623021612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623021612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/129\/10\/1761\/24056018\/4w109901761.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T15:28:57Z","timestamp":1686583737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623021612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["S0022316623021612"],"URL":"https:\/\/doi.org\/10.1093\/jn\/129.10.1761","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1999,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular Import of Cobalamin (Vitamin B-12)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/129.10.1761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}