{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:23:55Z","timestamp":1791393835034,"version":"4.3.3"},"reference-count":14,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":8628,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1093\/jn\/129.7.1451s","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T08:15:20Z","timestamp":1519200920000},"page":"1451S-1453S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["Controlled Trial of Oligofructose in the Management of Irritable Bowel Syndrome"],"prefix":"10.1016","volume":"129","author":[{"given":"J.O.","family":"Hunter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Tuffnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/129.7.1451S_bib1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(82)92782-9","article-title":"Food intolerance: a major factor in the pathogenesis of irritable bowel syndrome","volume":"2","author":"Alun Jones","year":"1982","journal-title":"Lancet"},{"key":"10.1093\/jn\/129.7.1451S_bib2","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.3109\/01443618409075757","article-title":"The aetiological role of antibiotic prophylaxis with hysterectomy in irritable bowel syndrome","volume":"5","author":"Alun Jones","year":"1984","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1093\/jn\/129.7.1451S_bib3","first-page":"16a","article-title":"Microbiological studies on food intolerance","volume":"43","author":"Bayliss","year":"1984","journal-title":"Proc. Nutr. Soc."},{"key":"10.1093\/jn\/129.7.1451S_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2036.1987.tb00633.x","article-title":"Idiopathic slow transit constipation: whole gut transit times, measured by a new simplified method, are not shortened by opiate antagonists","volume":"1","author":"Fotherby","year":"1987","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1093\/jn\/129.7.1451S_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/gut.32.4.439","article-title":"Probiotics in human medicine","volume":"32","author":"Fuller","year":"1991","journal-title":"Gut"},{"key":"10.1093\/jn\/129.7.1451S_bib6","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0016-5085(95)90192-2","article-title":"Selective stimulation of bifidobacter in the human colon by oligofructose and inulin","volume":"108","author":"Gibson","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/129.7.1451S_bib7","first-page":"A62","article-title":"Enterococcus faecium strain PR88\u2014an effective probiotic","volume":"38","author":"Hunter","year":"1996","journal-title":"Gut"},{"key":"10.1093\/jn\/129.7.1451S_bib8","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0140-6736(98)02146-1","article-title":"Abnormal colonic fermentation in irritable bowel syndrome","volume":"352","author":"King","year":"1998","journal-title":"Lancet"},{"key":"10.1093\/jn\/129.7.1451S_bib9","first-page":"A64","article-title":"Do symptoms improve with quality of life in IBS?","volume":"40","author":"King","year":"1997","journal-title":"Gut"},{"key":"10.1093\/jn\/129.7.1451S_bib10","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/ajcn\/65.5.1397","article-title":"Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons","volume":"65","author":"Kleessen","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/129.7.1451S_bib11","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0140-6736(97)05276-8","article-title":"Irritable bowel syndrome","volume":"350","author":"Maxwell","year":"1997","journal-title":"Lancet"},{"key":"10.1093\/jn\/129.7.1451S_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-4453(94)94871-2","article-title":"Irritable bowel syndrome\u2014post salmonella infection","volume":"29","author":"McKendrick","year":"1994","journal-title":"J. Infection"},{"key":"10.1093\/jn\/129.7.1451S_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/jn\/128.1.11","article-title":"Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics","volume":"128","author":"Roberfroid","year":"1998","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/129.7.1451S_bib14","first-page":"S5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum. Nutr. Clin. Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662302117X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662302117X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/129\/7\/1451S\/24023375\/4w06t9s1451.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T01:03:31Z","timestamp":1686618211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002231662302117X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["S002231662302117X"],"URL":"https:\/\/doi.org\/10.1093\/jn\/129.7.1451s","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1999,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Controlled Trial of Oligofructose in the Management of Irritable Bowel Syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/129.7.1451S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}