{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:20:19Z","timestamp":1791688819059,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":8628,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1093\/jn\/129.7.1478s","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T08:12:29Z","timestamp":1519200749000},"page":"1478S-1482S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Possible Mechanisms by Which Pro- and Prebiotics Influence Colon Carcinogenesis and Tumor Growth"],"prefix":"10.1016","volume":"129","author":[{"given":"Bandaru S.","family":"Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/129.7.1478S_bib1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2362.1990.tb01848.x","article-title":"Ras oncogenes: their role in neoplasia","volume":"20","author":"Barbacid","year":"1990","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1093\/jn\/129.7.1478S_bib2","first-page":"142","article-title":"Effect of Lactobacillus acidophilus and Bifidobacterium bifidum on rectal cell kinetics and fecal pH","volume":"23","author":"Biasco","year":"1991","journal-title":"Ital. J. Gastroenterol."},{"key":"10.1093\/jn\/129.7.1478S_bib3","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.3168\/jds.S0022-0302(90)79033-9","article-title":"Antimutagenic activity of milk fermented by Streptococcus thermophilus and Lactobacillus bulgaricus","volume":"73","author":"Bodana","year":"1990","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/129.7.1478S_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jn\/127.1.130","article-title":"Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and micorflora in rats","volume":"127","author":"Campbell","year":"1997","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/129.7.1478S_bib5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ijc.2910520222","article-title":"Effects of short-chain fatty acids on growth and differentiation of the human colon cancer cell line HT 29","volume":"52","author":"Gamet","year":"1992","journal-title":"Int. J. Cancer"},{"key":"10.1093\/jn\/129.7.1478S_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0167-5699(94)90139-2","article-title":"Surface-bound cytokines: a possible effector mechanism in bacterial immunity?","volume":"15","author":"George","year":"1994","journal-title":"Immunol. Today"},{"key":"10.1093\/jn\/129.7.1478S_bib7","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0016-5085(95)90192-2","article-title":"Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin","volume":"108","author":"Gibson","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/129.7.1478S_bib8","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","article-title":"Dietary modulation of the human colon microbiota: introducing the concept of prebiotics","volume":"125","author":"Gibson","year":"1995","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/129.7.1478S_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jnci\/64.2.263","article-title":"Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats","volume":"64","author":"Goldin","year":"1980","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1093\/jn\/129.7.1478S_bib10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ijc.2910550329","article-title":"Sodium butyrate induces apoptosis in human colonic tumor cell lines in p53-independent pathway: implications for possible role of dietary fiber in the prevention of large bowel cancer","volume":"55","author":"Hague","year":"1993","journal-title":"Int. J. Cancer"},{"key":"10.1093\/jn\/129.7.1478S_bib11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/ajcn\/49.4.675","article-title":"Prophylactic and therapeutic aspects of fermented milk","volume":"49","author":"Hitchins","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/129.7.1478S_bib12","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1093\/jnci\/84.24.1887","article-title":"Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies","volume":"84","author":"Howe","year":"1992","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1093\/jn\/129.7.1478S_bib13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2183\/pjab.56.382","article-title":"Chemical synthesis of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a potent mutagen isolated from broiled fish","volume":"56B","author":"Kasai","year":"1980","journal-title":"Proc. Jpn. Acad."},{"key":"10.1093\/jn\/129.7.1478S_bib14","first-page":"841","article-title":"Relative expression of wild-type and activated Ki-ras2 oncogene in colorectal carcinomas","volume":"3","author":"Kotsinas","year":"1993","journal-title":"Int. J. Oncol."},{"key":"10.1093\/jn\/129.7.1478S_bib15","first-page":"163","article-title":"Antitumor effect of Bifidobacterium infantis in mice","volume":"69","author":"Kohwi","year":"1978","journal-title":"Gann"},{"key":"10.1093\/jn\/129.7.1478S_bib16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3181\/00379727-207-43817","article-title":"Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial \u03b2-glucuronidase","volume":"207","author":"Kulkarni","year":"1994","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1093\/jn\/129.7.1478S_bib17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/jnci\/77.3.633","article-title":"Consumption of dairy produce and alcohol in a case-control study of breast cancer","volume":"77","author":"Le","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1093\/jn\/129.7.1478S_bib18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00008469-199208000-00002","article-title":"Lactobacilli, anticarcinogenic activities and human intestinal microflora","volume":"1","author":"Lidbeck","year":"1992","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1093\/jn\/129.7.1478S_bib19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1056\/NEJM198407123110202","article-title":"Ornithine decarboxylase as biological marker in familial colonic polyps","volume":"311","author":"Luk","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1093\/jn\/129.7.1478S_bib20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/jnci\/81.6.421","article-title":"Effects of timing of administration and dose of difluoromethylornithine on rat colonic carcinogenesis","volume":"81","author":"Luk","year":"1989","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1093\/jn\/129.7.1478S_bib21","first-page":"5270","article-title":"Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions","volume":"51","author":"McLellan","year":"1991","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/129.7.1478S_bib22","first-page":"1744","article-title":"Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA","volume":"51","author":"Mukhopadhyay","year":"1991","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/129.7.1478S_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3835(94)90023-X","article-title":"Butyrate as a differentiating agent: pharmacokinetics, analogues and current status","volume":"78","author":"Newmark","year":"1994","journal-title":"Cancer Lett"},{"key":"10.1093\/jn\/129.7.1478S_bib24","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/1097-0142(19930915)72:6<1949::AID-CNCR2820720626>3.0.CO;2-W","article-title":"Effect of LC9018 combined with radiation therapy on carcinoma of the uterine cervix","volume":"72","author":"Okawa","year":"1993","journal-title":"Cancer"},{"key":"10.1093\/jn\/129.7.1478S_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/canjclin.47.1.5","article-title":"Cancer Statistics, 1997","volume":"47","author":"Parker","year":"1997","journal-title":"CA-Cancer J. Clin."},{"key":"10.1093\/jn\/129.7.1478S_bib26","series-title":"DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells","first-page":"45","article-title":"Investigation of sequence specificity in DNA alkylation and repair using oligodeoxynucleotide substrate","author":"Pegg","year":"1989"},{"key":"10.1093\/jn\/129.7.1478S_bib27","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/1097-0142(19870915)60:6<1275::AID-CNCR2820600619>3.0.CO;2-I","article-title":"Polyamine biosynthetic activity in normal and neoplastic human colorectal tissue","volume":"60","author":"Porter","year":"1987","journal-title":"Cancer (Phila.)"},{"key":"10.1093\/jn\/129.7.1478S_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jcb.240501111","article-title":"Aberrant crypts in human colonic mucosa: putative preneoplastic lesions","volume":"16G","author":"Pretlow","year":"1992","journal-title":"J. Cell. Biochem."},{"key":"10.1093\/jn\/129.7.1478S_bib29","first-page":"559","article-title":"Dietary fiber and colon cancer: animal model studies","volume":"6","author":"Reddy","year":"1995","journal-title":"Prev. Med."},{"key":"10.1093\/jn\/129.7.1478S_bib30","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/0016-5085(92)91704-8","article-title":"Effect of dietary fiber on colonic bacterial enzymes and bile acids in relation to colon cancer","volume":"102","author":"Reddy","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/129.7.1478S_bib31","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/carcin\/18.7.1371","article-title":"Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition","volume":"18","author":"Reddy","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1093\/jn\/129.7.1478S_bib32","first-page":"3914","article-title":"Inhibitory effect of Bifidobacterium longum on colon, mammary and liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen","volume":"53","author":"Reddy","year":"1993","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/129.7.1478S_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1248\/bpb.18.148","article-title":"Analysis of antitumor properties of effector cells stimulated with a cell wall preparation (WPG) of Bifidobacterium infantis","volume":"18","author":"Sekine","year":"1995","journal-title":"Biol. Pharm. Bull."},{"key":"10.1093\/jn\/129.7.1478S_bib34","first-page":"405","article-title":"Effect of chemopreventive agents on intermediate biomarkers during different stages of azoxymethane-induced colon carcinogenesis","volume":"1","author":"Singh","year":"1992","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1093\/jn\/129.7.1478S_bib35","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/carcin\/18.4.833","article-title":"Bifidobacterium longum, a lactic acid-producing intestinal microflora inhibit colon cancer and modulate the intermediate biomarkers of colon carcinogenesis","volume":"18","author":"Singh","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1093\/jn\/129.7.1478S_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00051672","article-title":"A review of vegetables, fruits, and cancer. 1. Epidemiology","volume":"2","author":"Steinmetz","year":"1991","journal-title":"Cancer Causes Control"},{"key":"10.1093\/jn\/129.7.1478S_bib37","series-title":"Origins of Human Cancer","first-page":"1561","article-title":"Mutagen-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled foods","author":"Sugimura","year":"1977"},{"key":"10.1093\/jn\/129.7.1478S_bib38","series-title":"Xenobiotics and Cancer","first-page":"279","article-title":"Heterocyclic amines produced in cooked food: unavailable zenobiotics","author":"Sugimura","year":"1991"},{"key":"10.1093\/jn\/129.7.1478S_bib39","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/carcin\/14.9.1777","article-title":"K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis","volume":"14","author":"Vivona","year":"1993","journal-title":"Carcinogenesis (Lond.)"},{"key":"10.1093\/jn\/129.7.1478S_bib40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2672.1993.tb02790.x","article-title":"Effect of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine","volume":"75","author":"Wang","year":"1993","journal-title":"J. Appl. Bacteriol."},{"key":"10.1093\/jn\/129.7.1478S_bib41","first-page":"355","article-title":"Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat","volume":"5","author":"Wargovich","year":"1996","journal-title":"Cancer Epidemiol. Biomark. Prev."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623023271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623023271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/129\/7\/1478S\/24023586\/4w06t9s1478.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T01:03:56Z","timestamp":1686618236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623023271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["S0022316623023271"],"URL":"https:\/\/doi.org\/10.1093\/jn\/129.7.1478s","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1999,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible Mechanisms by Which Pro- and Prebiotics Influence Colon Carcinogenesis and Tumor Growth","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/129.7.1478S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}