{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:34:02Z","timestamp":1787646842349,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":8437,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1093\/jn\/130.1.15","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T09:40:40Z","timestamp":1519033240000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":116,"title":["The Traditional Plant Treatment, Sambucus nigra (elder), Exhibits Insulin-Like and Insulin-Releasing Actions In Vitro"],"prefix":"10.1016","volume":"130","author":[{"given":"Alison M.","family":"Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser H.A.","family":"Abdel-Wahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/130.1.15_bib1","first-page":"63","article-title":"Effect of PHA-B fraction of Agaricus bisporus lectin on insulin release and 45Ca2+ uptake by islets of Langerhans in vitro","volume":"21","author":"Ahmad","year":"1984","journal-title":"Acta Diabetologia"},{"key":"10.1093\/jn\/130.1.15_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF02582088","article-title":"Effect of age on Agaricus bisporus PHA-B stimulated insulin release and 45Ca2+ uptake in vitro by islets of Langerhans","volume":"21","author":"Ahmad","year":"1984","journal-title":"Acta Diabetologia"},{"key":"10.1093\/jn\/130.1.15_bib3","unstructured":"Atkinson, M. (1979) Herbs for your Health. New York: Dalesman Books."},{"key":"10.1093\/jn\/130.1.15_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2337\/diacare.12.8.553","article-title":"Traditional treatments for diabetes","volume":"12","author":"Bailey","year":"1989","journal-title":"Diabetes Care"},{"key":"10.1093\/jn\/130.1.15_bib5","unstructured":"Bailey, C. J. & Flatt, P. R. (1995) Development of antidiabetic drugs. In: Drugs, Diet and Disease. vol. 2, Mechanistic Approaches to Diabetes. (Ioannides, C. & Flatt, P. R., eds.). pp. 279 \u2013326, Chichester: Ellis Horwood Ltd."},{"key":"10.1093\/jn\/130.1.15_bib6","first-page":"212","article-title":"Effect of metformin on glucose metabolism in mouse soleus muscle","volume":"12","author":"Bailey","year":"1986","journal-title":"Diab\u00e8te et Metabolisme"},{"key":"10.1093\/jn\/130.1.15_bib7","unstructured":"Chiej, R. (1988) The Macdonald Encyclopedia of Medicinal Plants. pp. 360 \u2013 361, London, Macdonald & Co. Ltd."},{"key":"10.1093\/jn\/130.1.15_bib8","unstructured":"Dunne, M. J., Harding, E. A., Jaggar, J. H., Ayton, B. J. & Squires, P. E. (1994) Endogenous and chemical activators of ATP-regulated potassium channels in insulin-secreting cells: possible mechanisms and physiological significance. In: Frontiers of Insulin Secretion and Pancreatic B-Cell Research. (Flatt, P. R. & Lenzen, S., eds.). pp. 153\u2013159, London: Smith-Gordon."},{"key":"10.1093\/jn\/130.1.15_bib9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.271.5250.813","article-title":"PKC-Dependent stimulation of exocytosis by sulfonylureas in pancreatic \u03b2-cells","volume":"271","author":"Eliasson","year":"1996","journal-title":"Science"},{"key":"10.1093\/jn\/130.1.15_bib10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2337\/diab.24.8.705","article-title":"Effect of lectins on hormone release from isolated rat islets of Langerhans","volume":"24","author":"Ewart","year":"1975","journal-title":"Diabetes"},{"key":"10.1093\/jn\/130.1.15_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF00252768","article-title":"Abnormal plasma glucose and insulin responses in heterozygous lean (ob\/+) mice","volume":"20","author":"Flatt","year":"1981","journal-title":"Diabetologia"},{"key":"10.1093\/jn\/130.1.15_bib12","first-page":"157","article-title":"New perspective on the actions of sulphonylureas and hyperglycemic sulphonamides on the pancreatic \u03b2-cell","volume":"20","author":"Flatt","year":"1994","journal-title":"Diab\u00e8te et Metabolisme"},{"key":"10.1093\/jn\/130.1.15_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1079\/PNS19970051","article-title":"Nature's own pharmacy: the diabetes perspective","volume":"56","author":"Gray","year":"1997","journal-title":"Proc. Nutr. Soc"},{"key":"10.1093\/jn\/130.1.15_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1079\/BJN19970150","article-title":"Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne)","volume":"78","author":"Gray","year":"1997","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/130.1.15_bib15","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1093\/jn\/128.12.2319","article-title":"Pancreatic and extra-pancreatic actions of the traditional anti-diabetic plant, Eucalyptus globulus (eucalyptus)","volume":"128","author":"Gray","year":"1998","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/130.1.15_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1677\/joe.0.1570259","article-title":"Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom)","volume":"157","author":"Gray","year":"1998","journal-title":"J. Endocrin"},{"key":"10.1093\/jn\/130.1.15_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0007114598001834","article-title":"Actions of the traditional antidiabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion","volume":"80","author":"Gray","year":"1998","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/130.1.15_bib18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1017\/S0007114599000392","article-title":"Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander)","volume":"81","author":"Gray","year":"1999","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/130.1.15_bib19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1677\/joe.0.1600409","article-title":"Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe)","volume":"160","author":"Gray","year":"1999","journal-title":"J. Endocrin"},{"key":"10.1093\/jn\/130.1.15_bib20","unstructured":"Herman, W. H. & Crofford, O. B. (1997) The relationship between diabetic control and complications. In: Textbook of diabetes. (Pickup, J. C. & Williams, G., eds.). pp. 41.1\u2013 41.11, Oxford: Blackwell Scientific."},{"key":"10.1093\/jn\/130.1.15_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/026119298701500104","article-title":"A comparison of in vitro cytotoxicity assays and their application to water samples","volume":"15","author":"Hunt","year":"1987","journal-title":"Altern. Lab. Anim"},{"key":"10.1093\/jn\/130.1.15_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2337\/diab.44.1.67","article-title":"A novel insulin secretagogue is a phosphodiesterase inhibitor","volume":"44","author":"Leibowitz","year":"1995","journal-title":"Diabetes"},{"key":"10.1093\/jn\/130.1.15_bib23","unstructured":"Lust, J. (1986) The Herb Book. pp. 179, Reading: Cox and Wyman Ltd."},{"key":"10.1093\/jn\/130.1.15_bib24","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/diab.45.8.1132","article-title":"Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion","volume":"45","author":"McClenaghan","year":"1996","journal-title":"Diabetes"},{"key":"10.1093\/jn\/130.1.15_bib25","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0196-9781(97)00201-5","article-title":"Effects of non-glycated and glycated glucagon-like peptide-1(7\u201336) amide on glucose metabolism in isolated mouse abdominal muscle","volume":"18","author":"O'Harte","year":"1997","journal-title":"Peptides"},{"key":"10.1093\/jn\/130.1.15_bib26","unstructured":"Palaiseul, J. (1983) Grandmother\u2019s Secrets. Her Green Guide to Health from Plants. pp. 107\u2013110, Reading: Cox & Wyman Ltd."},{"key":"10.1093\/jn\/130.1.15_bib27","first-page":"346","article-title":"Effect of metformin on peripheral insulin sensitivity in non-insulin dependent diabetes mellitus","volume":"12","author":"Prager","year":"1986","journal-title":"Diab\u00e8te et Metabolisme"},{"key":"10.1093\/jn\/130.1.15_bib28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s001250050706","article-title":"The pancreatic B-cell as a fuel sensor: an electrophysiologist's viewpoint","volume":"40","author":"Rorsman","year":"1997","journal-title":"Diabetologia"},{"key":"10.1093\/jn\/130.1.15_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF01223617","article-title":"The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release","volume":"16","author":"Sharp","year":"1979","journal-title":"Diabetologia"},{"key":"10.1093\/jn\/130.1.15_bib30","first-page":"95","article-title":"Flavenoid and carbohydrate contents of Sambucus nigra grown in Egypt","volume":"13","author":"Shoaib","year":"1972","journal-title":"Egyp. J. Pharm. Sci"},{"key":"10.1093\/jn\/130.1.15_bib31","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1079\/PNS19910077","article-title":"Traditional dietary adjuncts for the treatment of diabetes mellitus","volume":"50","author":"Swanston-Flatt","year":"1991","journal-title":"Proc. Nutr. Soc"},{"key":"10.1093\/jn\/130.1.15_bib32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1055\/s-0028-1097541","article-title":"The constituents of Sambucus nigra: The lipophilic components of the flowers","volume":"31","author":"Willuhn","year":"1997","journal-title":"Planta Medica"},{"key":"10.1093\/jn\/130.1.15_bib33","unstructured":"World Health Organization. (1980) Second Report of the WHO Expert Committee on Diabetes Mellitus. Technical report series 646. pp. 66, Geneva: World Health Organization, 1980."},{"key":"10.1093\/jn\/130.1.15_bib34","unstructured":"Yada, T. (1994) Action mechanisms of amino acids in pancreatic B-cells. In: Frontiers of Insulin Secretion and Pancreatic B-cell Research. (Flatt, P. R. & Lenzen, S., eds.). pp. 129 \u2013135, London: Smith-Gordon."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622143294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622143294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/130\/1\/15\/24007521\/4w010000015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T12:52:54Z","timestamp":1686574374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622143294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0022316622143294"],"URL":"https:\/\/doi.org\/10.1093\/jn\/130.1.15","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Traditional Plant Treatment, Sambucus nigra (elder), Exhibits Insulin-Like and Insulin-Releasing Actions In Vitro","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/130.1.15","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}