{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:47:58Z","timestamp":1759146478101},"reference-count":28,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":8098,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1093\/jn\/130.12.3059","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T13:41:52Z","timestamp":1516369312000},"page":"3059-3062","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lysosomal Enzyme Activities Are Decreased in the Retina and Their Circadian Rhythms Are Different from Those in the Pineal Gland of Rats Fed an \u03b1-Linolenic Acid\u2013Restricted Diet"],"prefix":"10.1016","volume":"130","author":[{"given":"Atsushi","family":"Ikemoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Fukuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/130.12.3059_bib1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000423565","article-title":"The accretion of docosahexaenoic acid in the retina","volume":"75","author":"Anderson","year":"1994","journal-title":"World Rev. Nutr. Diet"},{"key":"10.1093\/jn\/130.12.3059_bib2","unstructured":"Bazan, N. G. (1990) Supply of n-3 polyunsaturated fatty acids and their significance in the central nervous system. In: Nutrition and the Brain (Wurtman, R. J. & Wurtman, J. J., eds.), vol. 8, pp. 1\u201324. Raven Press, New York, NY."},{"key":"10.1093\/jn\/130.12.3059_bib3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/0005-2760(82)90301-0","article-title":"High content of 22:6 (docosahexaenoate) and active [2-3H]glycerol metabolism of phosphatidic acid from photoreceptor membranes","volume":"712","author":"Bazan","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/130.12.3059_bib4","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol"},{"key":"10.1093\/jn\/130.12.3059_bib5","first-page":"1659","article-title":"Retinal photoreceptor-pigment epithelium interactions","volume":"26","author":"Bok","year":"1985","journal-title":"Investig. Ophthalmol. Vis. Sci"},{"key":"10.1093\/jn\/130.12.3059_bib6","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1093\/jn\/119.12.1880","article-title":"The effects of dietary \u03b1-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats","volume":"119","author":"Bourre","year":"1989","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/130.12.3059_bib7","first-page":"1464","article-title":"A mannose receptor is involved in retinal phagocytosis","volume":"32","author":"Boyle","year":"1991","journal-title":"Investig. Ophthalmol. Vis. Sci"},{"key":"10.1093\/jn\/130.12.3059_bib8","doi-asserted-by":"crossref","first-page":"28458","DOI":"10.1074\/jbc.271.45.28458","article-title":"Selective transcription factor induction in retinal pigment epithelial cells during photoreceptor phagocytosis","volume":"271","author":"Ershov","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/130.12.3059_bib9","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1471-4159.1993.tb03620.x","article-title":"Effect of an n-3 fatty acid-deficient diet on the adenosine-dependent melatonin release in cultured rat pineal","volume":"61","author":"Gazzah","year":"1993","journal-title":"J. Neurochem"},{"key":"10.1093\/jn\/130.12.3059_bib10","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/S0022-2275(20)35351-7","article-title":"Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo","volume":"34","author":"Green","year":"1993","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/130.12.3059_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0022-2275(20)40751-5","article-title":"Effect of a high linoleate and a high \u03b1-linolenate diet on general behavior and drug sensitivity in mice","volume":"34","author":"Nakashima","year":"1993","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/130.12.3059_bib12","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1073\/pnas.83.11.4021","article-title":"Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys","volume":"83","author":"Neuringer, M, Connor","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/130.12.3059_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1210\/edrv-12-2-151","article-title":"Pineal melatonin: cell biology of its synthesis and of its physiological interactions","volume":"12","author":"Reiter","year":"1991","journal-title":"Endocr. Rev"},{"key":"10.1093\/jn\/130.12.3059_bib14","doi-asserted-by":"crossref","first-page":"20536","DOI":"10.1074\/jbc.271.34.20536","article-title":"Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36","volume":"271","author":"Ryeom","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/130.12.3059_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0005-2760(91)90252-D","article-title":"Fatty acid composition of the rat pineal gland. Dietary modifications","volume":"1081","author":"Sarda","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/130.12.3059_bib16","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1073\/pnas.86.8.2903","article-title":"Membrane docosahexaenoate is supplied to the developing brain and retina by the liver","volume":"86","author":"Scott","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/130.12.3059_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1203\/00006450-199011000-00014","article-title":"Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-weight neonates","volume":"28","author":"Uauy","year":"1990","journal-title":"Pediatr. Res"},{"key":"10.1093\/jn\/130.12.3059_bib18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0006-8993(87)90457-4","article-title":"Pineal and retinal lysosomal enzyme rhythms","volume":"417","author":"Vaughan","year":"1987","journal-title":"Brain Res"},{"key":"10.1093\/jn\/130.12.3059_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/dev.420270705","article-title":"Brain and behavioral effects of dietary n-3 deficiency in mice: a three generational study","volume":"27","author":"Wainwright","year":"1994","journal-title":"Dev. Psychobiol"},{"key":"10.1093\/jn\/130.12.3059_bib20","unstructured":"Watanabe, I., Aonuma, H., Kaneko, S. & Okuyama, H. (1993) Effect of a high linoleate and high a-linolenate diets on size distribution of phagosomes in retinal pigment epithelium. In: Advances in Polyunsaturated Fatty Acid Research (Yasugi, T., Nakamura, H. & Soma, M., eds.), pp. 269\u2013272. Elsevier Science Publishers, Amsterdam, The Netherlands."},{"key":"10.1093\/jn\/130.12.3059_bib21","first-page":"563","article-title":"Effect of dietary \u03b1-linolenate\/linoleate balance on the lipid composition and electroretinographic responses in rats","volume":"62","author":"Watanabe","year":"1987","journal-title":"Adv. Biosci"},{"key":"10.1093\/jn\/130.12.3059_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02522413","article-title":"The effect of docosahexaenoic acid on the electroretinogram of the guinea pig","volume":"31","author":"Weisinger","year":"1996","journal-title":"Lipids"},{"key":"10.1093\/jn\/130.12.3059_bib23","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.1145197","article-title":"Visual membranes: specificity of fatty acid precursors for the electrical response to illumination","volume":"188","author":"Wheeler","year":"1975","journal-title":"Science (Washington, DC)"},{"key":"10.1093\/jn\/130.12.3059_bib24","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0022-2275(20)38463-7","article-title":"Effect of the dietary \u03b1-linolenate\/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions","volume":"29","author":"Yamamoto","year":"1988","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/130.12.3059_bib25","doi-asserted-by":"crossref","first-page":"B17","DOI":"10.1093\/geronj\/46.1.B17","article-title":"Effect of the high \u03b1-linolenate diet on the learning ability of aged rats","volume":"46","author":"Yamamoto","year":"1991","journal-title":"J. Gerontol"},{"key":"10.1093\/jn\/130.12.3059_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0022-2275(20)38713-7","article-title":"Effect of the dietary \u03b1-linolenate\/linoleate balance on lipid compositions and learning ability of rats","volume":"28","author":"Yamamoto","year":"1987","journal-title":"J. Lipid Res"},{"key":"10.1093\/jn\/130.12.3059_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.33.1.61","article-title":"The renewal of photoreceptor cell outer segments","volume":"33","author":"Young","year":"1967","journal-title":"J. Cell. Biol"},{"key":"10.1093\/jn\/130.12.3059_bib28","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1093\/jn\/129.11.2074","article-title":"Dietary docosahexaenoic acid-enriched phospholipids normalize urinary melatonin excretion in adult (n-3) polyunsaturated fatty acid-deficient rats","volume":"129","author":"Zaouali-Ajina","year":"1999","journal-title":"J. Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622147103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622147103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/130\/12\/3059\/24016189\/4w120003059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T23:45:14Z","timestamp":1686613514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622147103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["S0022316622147103"],"URL":"https:\/\/doi.org\/10.1093\/jn\/130.12.3059","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2000,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosomal Enzyme Activities Are Decreased in the Retina and Their Circadian Rhythms Are Different from Those in the Pineal Gland of Rats Fed an \u03b1-Linolenic Acid\u2013Restricted Diet","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/130.12.3059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}