{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:30:26Z","timestamp":1783380626039,"version":"3.54.6"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":8221,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1093\/jn\/130.8.1958","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T13:11:52Z","timestamp":1516367512000},"page":"1958-1962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Metabolic Availability of Vitamin A Is Decreased at the Onset of Diabetes in BB Rats"],"prefix":"10.1016","volume":"130","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter T.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan K.","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.C.","family":"Tsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/130.8.1958_bib1","doi-asserted-by":"crossref","unstructured":"American Diabetes Assoc. (1996) Nutrition recommendations and principles for people with diabetes mellitus. Diabetes Care 19 (suppl. 1): S16\u2013S19.","DOI":"10.2337\/diacare.19.1.S16"},{"key":"10.1093\/jn\/130.8.1958_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/ajcn\/50.2.329","article-title":"Serum vitamin A and retinol-binding protein in patients with insulin-dependent diabetes mellitus","volume":"50","author":"Basu","year":"1989","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/130.8.1958_bib3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/ajcn\/34.9.1655","article-title":"The effect of severe zinc deficiency on serum levels of albumin, transferrin, and prealbumin in man","volume":"34","author":"Bates","year":"1981","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/130.8.1958_bib4","unstructured":"Blaner, W. S. & Olson, J. A. (1994) Retinol and retinol acid metabolism. In: The Retinoids: Biology, Chemistry and Medicine (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), pp. 229\u2013256. Raven Press, New York, NY."},{"key":"10.1093\/jn\/130.8.1958_bib5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/jn\/106.4.563","article-title":"Vitamin A metabolism during the repletion of zinc deficient rats","volume":"106","author":"Brown","year":"1976","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/130.8.1958_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0003-2670(01)83632-1","article-title":"The determination of zinc in blood plasma by atomic absorption spectrometry","volume":"94","author":"Butrimovitz","year":"1977","journal-title":"Anal. Chim. Acta"},{"key":"10.1093\/jn\/130.8.1958_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI112778","article-title":"Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets","volume":"79","author":"Chertow","year":"1987","journal-title":"J. Clin. Investig"},{"key":"10.1093\/jn\/130.8.1958_bib8","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/0026-0495(94)90016-7","article-title":"Hyperzincuria in individuals with insulin-dependent diabetes mellitus: concurrent zinc status and the effect of high-dose zinc supplementation","volume":"42","author":"Cunningham","year":"1994","journal-title":"Metabolism"},{"key":"10.1093\/jn\/130.8.1958_bib9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2337\/diacare.20.1.84","article-title":"Increased urinary albumin and retinol-binding protein in type 1 diabetes","volume":"20","author":"Durbey","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1093\/jn\/130.8.1958_bib10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/hep.1840160222","article-title":"Spontaneously diabetic biobreeding rats and impairment of bile acid-independent bile flow and increased biliary bilirubin, calcium and lipid secretion","volume":"16","author":"Gonzalez","year":"1992","journal-title":"Hepatology"},{"key":"10.1093\/jn\/130.8.1958_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/cs0940189","article-title":"Carotenoids, retinol and tocopherols in patients with insulin-dependent diabetes mellitus and their immediate relatives","volume":"94","author":"Granado","year":"1998","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1093\/jn\/130.8.1958_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0005-2760(93)90058-H","article-title":"Enzymes catalysing the hydrolysis of retinyl esters","volume":"1170","author":"Harrison","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/130.8.1958_bib13","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2337\/diacare.11.10.780","article-title":"Hyperzincuria in type I diabetes women: relationship to measures of glycemic control, renal function, and tissue catabolism","volume":"11","author":"Heise","year":"1988","journal-title":"Diabetes Care"},{"key":"10.1093\/jn\/130.8.1958_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0009-8981(80)90465-9","article-title":"Determination of zinc in serum and urine by atomic absorption spectrophotometry; relationship between serum levels of zinc and proteins in 104 normal subjects","volume":"105","author":"Kiilerich","year":"1980","journal-title":"Clin. Chim. Acta"},{"issue":"suppl.","key":"10.1093\/jn\/130.8.1958_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2337\/diab.31.1.S7","article-title":"Spontaneous autoimmune diabetes mellitus in the BB rat","volume":"31","author":"Like","year":"1982","journal-title":"Diabetes"},{"key":"10.1093\/jn\/130.8.1958_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1039\/AN9921700141","article-title":"Rapid and simple method for the determination of copper, manganese and zinc in rat liver by direct flame atomic absorption spectrometry","volume":"117","author":"Luterotti","year":"1992","journal-title":"Analyst"},{"key":"10.1093\/jn\/130.8.1958_bib17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00004836-198006000-00004","article-title":"Severe zinc deficiency presenting with acrodermatitis during hyperalimention: diagnosis, pathogenesis and treatment","volume":"2","author":"McClain","year":"1980","journal-title":"J. Clin. Gastroenterol"},{"key":"10.1093\/jn\/130.8.1958_bib18","first-page":"148","article-title":"Zinc deficiency reduces hepatic cellular retinol-binding protein in rats","volume":"62","author":"Mobarhan","year":"1992","journal-title":"Int. J. Vitam. Nutr. Res"},{"key":"10.1093\/jn\/130.8.1958_bib19","first-page":"45","article-title":"Immunologic and genetic studies of diabetes in the BB rat","volume":"9","author":"Parfrey","year":"1989","journal-title":"Critical Rev. Immunol"},{"key":"10.1093\/jn\/130.8.1958_bib20","first-page":"3399","article-title":"Streptozotocin-induced hyperglycemia in rats: analysis of complement activity after streptozotocin administration","volume":"27","author":"Perloff","year":"1995","journal-title":"Transplant. Proc"},{"key":"10.1093\/jn\/130.8.1958_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s001250050762","article-title":"Ontogenic changes in proglucogan mRNA in BB diabetes prone and normal rats weaned onto a chow diet","volume":"40","author":"Reimer","year":"1997","journal-title":"Diabetologia"},{"key":"10.1093\/jn\/130.8.1958_bib22","unstructured":"Scott, F. W. (1994) Food, diabetes, and immunology. In: Diet, Nutrition and Immunity (Forse, R. A., Bell, S. J., Blackburn, G. L. & Kabbash, L. G., eds.), pp. 73\u201395. CRC Press, Boca Raton, FL."},{"key":"10.1093\/jn\/130.8.1958_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00000658-198107000-00008","article-title":"Impaired wound healing in streptozotocin diabetes. Prevention by supplemental vitamin A","volume":"194","author":"Seifer","year":"1981","journal-title":"Ann. Surg"},{"key":"10.1093\/jn\/130.8.1958_bib24","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.1980.tb21328.x","article-title":"The vitamin A-zinc connection: a review","volume":"355","author":"Smith","year":"1980","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1093\/jn\/130.8.1958_bib25","first-page":"692","article-title":"The effect of zinc deficiency on the metabolism of retinol-binding protein in the rat","volume":"84","author":"Smith","year":"1974","journal-title":"J. Lab. Clin. Med"},{"key":"10.1093\/jn\/130.8.1958_bib26","unstructured":"Soprano, D. B. & Blaner, W. S. (1994) Plasma retinol-binding protein. In: The Retinoids: Biology, Chemistry and Medicine (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), pp. 257\u2013281. Raven Press, New York, NY."},{"key":"10.1093\/jn\/130.8.1958_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3164\/jcbn.19.165","article-title":"Effect of insulin treatment or zinc supplementation on vitamin A status in streptozotocin-induced diabetic rats","volume":"19","author":"Tuitoek","year":"1996","journal-title":"J. Clin. Biochem. Nutr"},{"key":"10.1093\/jn\/130.8.1958_bib28","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1079\/BJN19960095","article-title":"Streptozotocin-induced diabetes lowers retinol-binding protein and transthyretin concentrations in rats","volume":"76","author":"Tuitoek","year":"1996","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/130.8.1958_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1079\/BJN19960164","article-title":"Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A","volume":"75","author":"Tuitoek","year":"1996","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/130.8.1958_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)06818-8","article-title":"Diabetes mellitus-induced alterations of hepatobiliary function","volume":"47","author":"Watkins","year":"1995","journal-title":"Pharmacol Rev"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622143622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622143622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/130\/8\/1958\/24004560\/4w080001958.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T22:56:20Z","timestamp":1751237780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622143622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S0022316622143622"],"URL":"https:\/\/doi.org\/10.1093\/jn\/130.8.1958","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Metabolic Availability of Vitamin A Is Decreased at the Onset of Diabetes in BB Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/130.8.1958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}