{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:29:29Z","timestamp":1792441769185,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":8017,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.1093\/jn\/131.3.841s","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T14:01:46Z","timestamp":1516370506000},"page":"841S-845S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Regulation of Branched-Chain \u03b1-Keto Acid Dehydrogenase Kinase Expression in Rat Liver"],"prefix":"10.1016","volume":"131","author":[{"given":"Robert A.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Shimomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/131.3.841S_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/jn\/130.2.139","article-title":"Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation","volume":"130","author":"Anthony","year":"2000","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/131.3.841S_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/bj3440047","article-title":"Evidence that pyruvate dehydrogenase kinase belongs to the ATPase\/kinase superfamily","volume":"344","author":"Bowker-Kinley","year":"1999","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib3","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1016\/S0021-9258(18)61164-0","article-title":"Purification and properties of the catalytic subunit of the branched-chain \u03b1-keto acid dehydrogenase phosphatase from bovine kidney mitochondria","volume":"262","author":"Damuni","year":"1987","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.3.841S_bib4","doi-asserted-by":"crossref","first-page":"19861","DOI":"10.1074\/jbc.270.34.19861","article-title":"Expression and characterization of branched-chain alpha-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase?","volume":"270","author":"Davie","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.3.841S_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-1119(98)00182-6","article-title":"Murine branched chain alpha-ketoacid dehydrogenase kinase; cDNA cloning, tissue distribution, and temporal expression during embryonic development","volume":"212","author":"Doering","year":"1998","journal-title":"Gene"},{"key":"10.1093\/jn\/131.3.841S_bib6","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/jn\/108.11.1767","article-title":"Diet-hormone interrelationships in the rat","volume":"108","author":"Edozien","year":"1978","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/131.3.841S_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/bj2370285","article-title":"Effects of low protein diet and starvation on the activity of branched-chain 2-oxoacid dehydrogenase kinase in rat liver and heart","volume":"237","author":"Espinal","year":"1986","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj2250509","article-title":"Purification and properties of a protein activator of phosphorylated branched-chain 2-oxo acid dehydrogenase complex","volume":"225","author":"Espinal","year":"1985","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.nu.04.070184.002205","article-title":"Branched-chain amino acid metabolism","volume":"4","author":"Harper","year":"1984","journal-title":"Annu. Rev. Nutr"},{"key":"10.1093\/jn\/131.3.841S_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0065-2571(96)00009-X","article-title":"Studies on the regulation of the mitochondrial \u03b1-ketoacid dehydrogenase complexes and their kinases","volume":"37","author":"Harris","year":"1997","journal-title":"Adv. Enzyme Regul"},{"key":"10.1093\/jn\/131.3.841S_bib11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0065-2571(94)00020-4","article-title":"A new family of protein kinases\u2014the mitochondrial protein kinases","volume":"35","author":"Harris","year":"1995","journal-title":"Adv. Enzyme Regul"},{"key":"10.1093\/jn\/131.3.841S_bib12","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/0003-9861(85)90531-4","article-title":"Physiological covalent regulation of rat liver branched-chain \u03b1-ketoacid dehydrogenase","volume":"243","author":"Harris","year":"1985","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/131.3.841S_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0065-2571(90)90021-S","article-title":"Regulation of the branched chain \u03b1-keto acid dehyrogenase and elucidation of a molecular basis for maple syrup urine disease","volume":"30","author":"Harris","year":"1990","journal-title":"Adv. Enzyme Regul"},{"key":"10.1093\/jn\/131.3.841S_bib14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/bj3130603","article-title":"Structural organization of the rat branched-chain 2-oxo-acid dehydrogenase kinase gene and partial characterization of the promoter-regulatory region","volume":"313","author":"Huang","year":"1996","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1042\/bj3340713","article-title":"Mechanism for basal expression of rat mitochondrial branched-chain-2-oxo-acid dehydrogenase kinase","volume":"334","author":"Huang","year":"1998","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/bj3390503","article-title":"Down-regulation of rat mitochondrial branched-chain 2-oxoacid dehydrogenase kinase gene expression by glucocorticoids","volume":"339","author":"Huang","year":"1999","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib17","doi-asserted-by":"crossref","first-page":"15681","DOI":"10.1016\/S0021-9258(19)49589-6","article-title":"Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues","volume":"267","author":"Hutson","year":"1992","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.3.841S_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/bj2060103","article-title":"Pyruvate dehydrogenase kinase\/activator in rat heart mitochondria. Assay. effect of starvation, and effect of protein-synthesis inhibitors in starvation","volume":"206","author":"Kerbey","year":"1982","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1042\/bj3270449","article-title":"Gender difference in regulation of branched-chain amino acid catabolism","volume":"327","author":"Kobayashi","year":"1997","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3177\/jnsv.45.303","article-title":"Hepatic branched-chain \u03b1-keto acid dehydrogenase complex in female rats: activation by exercise and starvation","volume":"45","author":"Kobayashi","year":"1999","journal-title":"J. Nutr. Sci. Vitaminol"},{"key":"10.1093\/jn\/131.3.841S_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/abbi.1999.1635","article-title":"Experimental hyperthyroidism causes inactivation of the branched-chain \u03b1-ketoacid dehydrogenase complex in rat liver","volume":"375","author":"Kobayashi","year":"2000","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/131.3.841S_bib22","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.1999.277.4.E685","article-title":"Inverse alterations of BCKA dehydrogenase activity in cardiac and skeletal muscles of diabetic rats","volume":"277","author":"Lombardo","year":"1999","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1093\/jn\/131.3.841S_bib23","first-page":"40","article-title":"Posttranscriptional alterations in protein masses of hepatic branched-chain keto acid dehydrogenase and its associated kinase in diabetes","volume":"110","author":"Lombardo","year":"1998","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"10.1093\/jn\/131.3.841S_bib24","doi-asserted-by":"crossref","first-page":"14393","DOI":"10.1016\/S0021-9258(17)38731-8","article-title":"Transcriptional and post-transcriptional regulation of L-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose","volume":"260","author":"Noguchi","year":"1985","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.3.841S_bib25","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1172\/JCI109791","article-title":"Leucine oxidation and protein turnover in clofibrate-induced muscle protein degradation in rats","volume":"65","author":"Paul","year":"1980","journal-title":"J. Clin. Invest"},{"key":"10.1093\/jn\/131.3.841S_bib26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/bj3170411","article-title":"Alteration in gene expression of branched chain keto acid dehydrogenase kinase but not in gene expression of its substrate in the liver of clofibrate-treated rats","volume":"317","author":"Paul","year":"1996","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0003-9861(84)90362-X","article-title":"Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain \u03b1-ketoacid dehydrogenase kinase in vitro and in perfused rat heart","volume":"231","author":"Paxton","year":"1984","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/131.3.841S_bib28","doi-asserted-by":"crossref","first-page":"29720","DOI":"10.1016\/S0021-9258(18)43940-3","article-title":"Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase","volume":"269","author":"Popov","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.3.841S_bib29","doi-asserted-by":"crossref","first-page":"26602","DOI":"10.1016\/S0021-9258(19)74354-3","article-title":"Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases","volume":"268","author":"Popov","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.3.841S_bib30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/abbi.1995.1022","article-title":"Dietary control and tissue specific expression of branched-chain \u03b1-ketoacid dehydrogenase kinase","volume":"316","author":"Popov","year":"1995","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/131.3.841S_bib31","doi-asserted-by":"crossref","first-page":"13127","DOI":"10.1016\/S0021-9258(18)42179-5","article-title":"Branched-chain \u03b1-ketoacid dehydrogenase kinase: molecular cloning, expression, and sequence similarity with histidine protein kinases","volume":"267","author":"Popov","year":"1992","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.3.841S_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1210\/jcem-39-1-191","article-title":"The effect of starvation on the concentration and binding of thyroxine and triiodothyronine in serum and on the response to TRH","volume":"39","author":"Portnay","year":"1974","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1093\/jn\/131.3.841S_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-5793(92)81056-R","article-title":"Purification and partial characterization of rat liver pyruvate dehydrogenase kinase activator protein (free pyruvate dehydrogenase kinase)","volume":"308","author":"Priestman","year":"1992","journal-title":"FEBS Lett"},{"key":"10.1093\/jn\/131.3.841S_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/bj3490195","article-title":"Pyruvate dehydrogenase kinase from Arabidopsis thaliana: a protein histidine kinase that phosphorylates serine residues","volume":"349","author":"Thelen","year":"2000","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib35","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/jn\/109.7.1321","article-title":"Characteristics of thyroid function in experimental protein malnutrition","volume":"109","author":"Tulp","year":"1979","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/131.3.841S_bib36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/jn\/111.2.252","article-title":"Influence of diet composition on serum T3 concentration, hepatic mitochondrial metabolism and shuttle system activity in rats","volume":"111","author":"Tyzbir","year":"1981","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/131.3.841S_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abbi.2000.1946","article-title":"Starvation increases amount of pyruvate dehydrogenase kinase in several mammalian tissues","volume":"381","author":"Wu","year":"2000","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/131.3.841S_bib38","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2337\/diabetes.48.8.1593","article-title":"Mechanism responsible for inactivation of the skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes","volume":"48","author":"Wu","year":"1999","journal-title":"Diabetes"},{"key":"10.1093\/jn\/131.3.841S_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/bj3290197","article-title":"Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase 4 in rat heart","volume":"329","author":"Wu","year":"1998","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/bj2850167","article-title":"Effects of clofibric acid on the activity and activity state of the hepatic branched-chain 2-oxo acid dehydrogenase complex","volume":"285","author":"Zhao","year":"1992","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/131.3.841S_bib41","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1006\/abbi.1994.1063","article-title":"Effect of dietary protein on the liver content and subunit composition of the branched chain \u03b1-ketoacid dehydrogenase complex","volume":"308","author":"Zhao","year":"1994","journal-title":"Arch. Biochem. Biophys"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662214753X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662214753X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/131\/3\/841S\/24004757\/4w03010s841.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T19:49:40Z","timestamp":1686599380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002231662214753X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["S002231662214753X"],"URL":"https:\/\/doi.org\/10.1093\/jn\/131.3.841s","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2001,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of Branched-Chain \u03b1-Keto Acid Dehydrogenase Kinase Expression in Rat Liver","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/131.3.841S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}