{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:46:56Z","timestamp":1785394016528,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":7941,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1093\/jn\/131.5.1427","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T14:25:10Z","timestamp":1516371910000},"page":"1427-1432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Tumor Suppressor Protein p53 mRNA and Subcellular Localization Are Altered by Changes in Cellular Copper in Human Hep G2 Cells"],"prefix":"10.1016","volume":"131","author":[{"given":"Vijaya S.","family":"Narayanan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A.","family":"Fitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy W.","family":"Levenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/131.5.1427_bib1","doi-asserted-by":"crossref","first-page":"952S","DOI":"10.1093\/ajcn\/67.5.952S","article-title":"Essentiality of copper in humans","volume":"67","author":"Uauy","year":"1998","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/131.5.1427_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/10409238709083738","article-title":"Aspects of the structure, function, and applications of superoxide dismutase","volume":"22","author":"Bannister","year":"1987","journal-title":"CRC Crit. Rev. Biochem"},{"key":"10.1093\/jn\/131.5.1427_bib3","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1046\/j.1471-4159.1999.721580.x","article-title":"Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-deficient Mo(vbr) mice","volume":"72","author":"Kunz","year":"1999","journal-title":"J. Neurochem"},{"key":"10.1093\/jn\/131.5.1427_bib4","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1126\/science.7652554","article-title":"Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A","volume":"269","author":"Tsukihara","year":"1995","journal-title":"Science (Washington, DC)"},{"key":"10.1093\/jn\/131.5.1427_bib5","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1093\/jn\/129.12.2147","article-title":"Copper deficiency alters rat dopamine \u03b2-monooxygenase mRNA and activity","volume":"129","author":"Prohaska","year":"1999","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/131.5.1427_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/nbdi.1999.0250","article-title":"The role of copper in neurodegenerative disease","volume":"6","author":"Waggoner","year":"1999","journal-title":"Neurobiol. Dis"},{"key":"10.1093\/jn\/131.5.1427_bib7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1442-200x.1999.01095.x","article-title":"Clinical manifestations and treatment of Menkes disease and its variants","volume":"41","author":"Kodama","year":"1999","journal-title":"Pediatr. Int"},{"key":"10.1093\/jn\/131.5.1427_bib8","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1067\/mpd.2000.103355","article-title":"Zinc-induced anemia and neutropenia in an adolescent","volume":"135","author":"Porea","year":"2000","journal-title":"J. Pediatr"},{"key":"10.1093\/jn\/131.5.1427_bib9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/biof.5520100406","article-title":"Cardiovascular effects of dietary copper deficiency","volume":"10","author":"Saari","year":"1999","journal-title":"Biofactors"},{"key":"10.1093\/jn\/131.5.1427_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ng1293-327","article-title":"The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene","volume":"5","author":"Bull","year":"1993","journal-title":"Nat. Genet"},{"key":"10.1093\/jn\/131.5.1427_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ng1293-344","article-title":"The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene","volume":"5","author":"Tanzi","year":"1993","journal-title":"Nat. Genet"},{"key":"10.1093\/jn\/131.5.1427_bib12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/ng0894-541","article-title":"The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene","volume":"7","author":"Wu","year":"1994","journal-title":"Nat. Genet"},{"key":"10.1093\/jn\/131.5.1427_bib13","doi-asserted-by":"crossref","first-page":"1087S","DOI":"10.1093\/ajcn\/67.5.1087S","article-title":"Wilson disease and canine copper toxicosis","volume":"67","author":"Brewer","year":"1998","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/131.5.1427_bib14","first-page":"G311","article-title":"Genetic disorders of membrane transport. IV. Wilson's disease and Menkes disease","volume":"276","author":"Schaefer","year":"1999","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/131.5.1427_bib15","first-page":"323","article-title":"Wilson's disease: a new gene and an animal model for an old disease","volume":"43","author":"Cuthbert","year":"1995","journal-title":"J. Investig. Med"},{"key":"10.1093\/jn\/131.5.1427_bib16","doi-asserted-by":"crossref","unstructured":"Scheinberg, I. H. (1978) A genetic defect in the transport of ceruloplasmin-copper from blood to bile as the possible pathogenesis of Wilson\u2019s disease. In: Transport by Proteins (Blauer, G. & Sund, H., eds.), pp. 311\u2013321. Walter de Gruyter, Berlin, Germany.","DOI":"10.1515\/9783111710013-022"},{"key":"10.1093\/jn\/131.5.1427_bib17","first-page":"252","article-title":"A case of adult chronic copper self-intoxication resulting in cirrhosis","volume":"4","author":"O'Donohue","year":"1999","journal-title":"Eur. J. Med. Res"},{"key":"10.1093\/jn\/131.5.1427_bib18","doi-asserted-by":"crossref","first-page":"1069S","DOI":"10.1093\/ajcn\/67.5.1069S","article-title":"Manifestations of copper excess","volume":"67","author":"Bremner","year":"1998","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/131.5.1427_bib19","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/carcin\/20.6.1091","article-title":"Hepatic hyperplasia and cancer in rats: alterations in copper metabolism","volume":"20","author":"Eagon","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1093\/jn\/131.5.1427_bib20","first-page":"200","article-title":"The LEC rat: a model for human hepatitis, liver cancer, and much more","volume":"144","author":"Mori","year":"1994","journal-title":"Am. J. Pathol"},{"key":"10.1093\/jn\/131.5.1427_bib21","first-page":"229","article-title":"Pathobiology of copper-induced injury in Bedlington terriers: ultrastructural and microanalytical studies","volume":"10","author":"Haywood","year":"1996","journal-title":"Anal. Cell. Pathol"},{"key":"10.1093\/jn\/131.5.1427_bib22","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nm0598-588","article-title":"Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1\/Fas) mediated apoptosis","volume":"4","author":"Strand","year":"1998","journal-title":"Nat. Med"},{"key":"10.1093\/jn\/131.5.1427_bib23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/jcpa.1998.0282","article-title":"Macrophage populations and apoptotic cells in the liver before spontaneous hepatitis in Long Evans Cinnamon (LEC) rats","volume":"120","author":"Yamate","year":"1999","journal-title":"J. Comp. Pathol"},{"key":"10.1093\/jn\/131.5.1427_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/(SICI)1096-9896(199710)183:2<177::AID-PATH909>3.0.CO;2-E","article-title":"UV but not gamma-irradiation induces specific transcriptional activity of p53 in primary hepatocytes","volume":"183","author":"Bellamy","year":"1997","journal-title":"J. Pathol"},{"key":"10.1093\/jn\/131.5.1427_bib25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/oxfordjournals.jbchem.a021639","article-title":"Analysis of IFN-gamma-induced cell cycle arrest and cell death in hepatocytes","volume":"121","author":"Kano","year":"1997","journal-title":"J. Biochem"},{"key":"10.1093\/jn\/131.5.1427_bib26","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1093\/carcin\/17.10.2157","article-title":"Abnormal accumulation of copper in LEC rat liver induces expression of p53 and nuclear matrix-bound p21(waf 1\/cip 1)","volume":"17","author":"Obata","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1093\/jn\/131.5.1427_bib27","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/282615a0","article-title":"Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line","volume":"286","author":"Aden","year":"1979","journal-title":"Nature (Lond.)"},{"key":"10.1093\/jn\/131.5.1427_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.5.1427_bib29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem"},{"key":"10.1093\/jn\/131.5.1427_bib30","unstructured":"Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Extraction, purification, and analysis of messenger RNA from eukaryotic cells. In: Molecular Cloning, A Laboratory Manual, pp.7.37\u20137.52. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"10.1093\/jn\/131.5.1427_bib31","unstructured":"Chazotte, B. (1998) Nonimmunological fluorescent labeling of cellular structures. In: Cells: A Laboratory Manual (Spector, D., Goldman, R. & Leinwand, L., eds.), pp. 101.1\u2013101.22. Cold Spring Harbor Laboratory Press, Plainview, NY."},{"key":"10.1093\/jn\/131.5.1427_bib32","unstructured":"McNamara, G. (1998) Introduction to immunofluorescence microscopy. In: Cells: A Laboratory Manual (Spector, D., Goldman, R. & Leinwand, L., eds.), pp.102.1\u2013102.13. Cold Spring Harbor Laboratory Press, Plainview, NY."},{"key":"10.1093\/jn\/131.5.1427_bib33","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1093\/jn\/130.7.1688","article-title":"Expression of the p53 tumor suppressor gene is up-regulated by depletion of intracellular zinc in HepG2 cells","volume":"130","author":"Reaves","year":"2000","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/131.5.1427_bib34","first-page":"G907","article-title":"Pleiotropic effect of LEC mutation: a rodent model of Wilson's disease","volume":"266","author":"Schilsky","year":"1994","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/131.5.1427_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0091-679X(08)61921-4","article-title":"Anatomical methods in cell death","volume":"46","author":"Kerr","year":"1995","journal-title":"Methods Cell Biol"},{"key":"10.1093\/jn\/131.5.1427_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0167-4781(98)00092-X","article-title":"Distinct mechanisms of site-specific DNA damage induced by endogenous reductants in the presence of iron(III) and copper(II)","volume":"1399","author":"Oikawa","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/131.5.1427_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0041-008X(91)90048-J","article-title":"Interaction of copper with DNA and antagonism by other metals","volume":"110","author":"Sagripanti","year":"1991","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1093\/jn\/131.5.1427_bib38","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1016\/S0021-9258(18)38132-8","article-title":"Mutation spectrum of copper-induced DNA damage","volume":"266","author":"Tkeshelashvili","year":"1991","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/131.5.1427_bib39","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/0016-5085(94)90822-2","article-title":"Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis","volume":"107","author":"Sokol","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/131.5.1427_bib40","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(92)90562-Q","article-title":"Regulation of the specific DNA binding function of p53","volume":"71","author":"Hupp","year":"1992","journal-title":"Cell"},{"key":"10.1093\/jn\/131.5.1427_bib41","first-page":"27","article-title":"Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)\/Cu(I) redox mechanism","volume":"10","author":"Hainaut","year":"1995","journal-title":"Oncogene"},{"key":"10.1093\/jn\/131.5.1427_bib42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/bies.950170606","article-title":"Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage","volume":"17","author":"Cox","year":"1995","journal-title":"Bioessays"},{"key":"10.1093\/jn\/131.5.1427_bib43","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1126\/science.286.5449.2507","article-title":"Pharmacological rescue of mutant p53 conformation and function","volume":"286","author":"Foster","year":"1999","journal-title":"Science (Washington, DC)"},{"key":"10.1093\/jn\/131.5.1427_bib44","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.1659741","article-title":"Tumor suppressor genes","volume":"254","author":"Weinberg","year":"1991","journal-title":"Science (Washington, DC)"},{"key":"10.1093\/jn\/131.5.1427_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/356215a0","article-title":"Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours","volume":"356","author":"Donehower","year":"1992","journal-title":"Nature (Lond.)"},{"key":"10.1093\/jn\/131.5.1427_bib46","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt","year":"1994","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/131.5.1427_bib47","first-page":"901","article-title":"A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone\/myo-inositol and chemotherapeutic agents taxol or adriamycin","volume":"60","author":"Zhang","year":"2000","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/131.5.1427_bib48","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/01635589709514631","article-title":"Alterations of rat hepatoma cell genomes induced by copper deficiency","volume":"29","author":"Renault","year":"1997","journal-title":"Nutr. Cancer"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622138150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622138150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/131\/5\/1427\/24013151\/4w050101427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T19:06:52Z","timestamp":1686596812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622138150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["S0022316622138150"],"URL":"https:\/\/doi.org\/10.1093\/jn\/131.5.1427","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2001,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor Suppressor Protein p53 mRNA and Subcellular Localization Are Altered by Changes in Cellular Copper in Human Hep G2 Cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/131.5.1427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}