{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:46:55Z","timestamp":1784774815992,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":7011,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1093\/jn\/133.12.4252","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T06:13:15Z","timestamp":1516601595000},"page":"4252-4255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["A Plant Food\u2013Based Diet Modifies the Serum \u03b2-Sitosterol Concentration in Hyperandrogenic Postmenopausal Women"],"prefix":"10.1016","volume":"133","author":[{"given":"Paola","family":"Muti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif B.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Sch\u00fcnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol S.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Hovey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo L.","family":"Freudenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yow-Wu B.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bellati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Berrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/133.12.4252_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0002-8223(21)05668-6","article-title":"Sterol content of foods of plant of origin","volume":"73","author":"Weihrauch","year":"1978","journal-title":"J. Am. Diet Assoc"},{"key":"10.1093\/jn\/133.12.4252_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/01635589209514203","article-title":"The role of dietary phytosterols in colon carcinogenesis","volume":"18","author":"Venketeshewer","year":"1992","journal-title":"Nutr. Cancer"},{"key":"10.1093\/jn\/133.12.4252_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0009-8981(05)80004-X","article-title":"Effects of unsaturated and saturated dietary plant sterols on their serum contents","volume":"205","author":"Vanhancen","year":"1992","journal-title":"Clin. Chim. Acta"},{"key":"10.1093\/jn\/133.12.4252_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/01635589809514709","article-title":"\u03b2-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells","volume":"32","author":"von Holtz","year":"1998","journal-title":"Nutr. Cancer"},{"key":"10.1093\/jn\/133.12.4252_bib5","first-page":"403","article-title":"Protective effects of plant sterols against chemically induced colon tumors in rats","volume":"40","author":"Raicht","year":"1980","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/133.12.4252_bib6","first-page":"541","article-title":"Inhibition of growth and stimulation of apoptosis by \u03b2-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture","volume":"5","author":"Awad","year":"2000","journal-title":"Int. J. Mol. Med"},{"key":"10.1093\/jn\/133.12.4252_bib7","first-page":"821","article-title":"Dietary phytosterols inhibit the growth and metastasis of MDA-MB-231 human breast cancer cells grown in SCID mice","volume":"20","author":"Awad","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1093\/jn\/133.12.4252_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00008469-200112000-00005","article-title":"In vitro and in vivo (SCID mice) effect of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells","volume":"10","author":"Awad","year":"2001","journal-title":"Europ. J. Cancer Prev"},{"key":"10.1093\/jn\/133.12.4252_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0024-3205(95)00263-6","article-title":"Dietary phytosterols: a review of metabolism, benefits and side effects","volume":"57","author":"Ling","year":"1995","journal-title":"Life Sci"},{"key":"10.1093\/jn\/133.12.4252_bib10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/jnci\/83.8.541","article-title":"The role of soy products in reducing the risk of cancer","volume":"83","author":"Messina","year":"1991","journal-title":"J. Natl. Cancer Inst"},{"key":"10.1093\/jn\/133.12.4252_bib11","unstructured":"Potter, J. D. & Steinmetz, K. (1996) Vegetables, fruits and phytoestrogens as preventive agents. In: Principles of Chemioprevention (Stewart, B.W., McGregor, D. & Kleihues, P. eds.), pp. 61\u201390. IARC Scientific Publications, Lyon, France."},{"key":"10.1093\/jn\/133.12.4252_bib12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/jnci\/88.6.340","article-title":"Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients","volume":"88","author":"Freudenheim","year":"1996","journal-title":"J. Natl. Cancer Inst"},{"key":"10.1093\/jn\/133.12.4252_bib13","first-page":"733S","article-title":"The evidence for soybean products as cancer preventive agents J","volume":"125","author":"Kennedy","year":"1995","journal-title":"Nutr"},{"key":"10.1093\/jn\/133.12.4252_bib14","first-page":"606","article-title":"Breast cancer and endogenous sex hormones in postmenopausal women: a collaborative re-analysis of data on 650 cases and 1700 controls from nine prospective studies","volume":"94","year":"2002","journal-title":"J. Natl. Cancer Inst"},{"key":"10.1093\/jn\/133.12.4252_bib15","first-page":"345","article-title":"Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial","volume":"8","author":"Berrino","year":"1999","journal-title":"Cancer Epidemiol. Biomark. Prev"},{"key":"10.1093\/jn\/133.12.4252_bib16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/jnci\/88.5.291","article-title":"Serum sex steroids levels after menopause and subsequent breast cancer","volume":"88","author":"Berrino","year":"1996","journal-title":"J. Natl. Cancer Inst"},{"issue":"Suppl. 1","key":"10.1093\/jn\/133.12.4252_bib17","doi-asserted-by":"crossref","first-page":"s6","DOI":"10.1093\/ije\/26.suppl_1.S6","article-title":"The EPIC study: rationale and study design. European Prospective Investigation into Cancer and Nutrition","volume":"26","author":"Riboli","year":"1997","journal-title":"Int. J. Epidemiol"},{"key":"10.1093\/jn\/133.12.4252_bib18","unstructured":"Salvini, S., Parpinel, M., Gnagnarella, P., Maisonnueve, P. & Turrini, A. (1998) Banca di composizione degli alimenti per studi epidemiologici in Italia.Istituto Europeo di Oncologia Milan, Italy."},{"key":"10.1093\/jn\/133.12.4252_bib19","unstructured":"Rinaldi, S., Minuit, G. J., Bellati, C., Filieri, R., Berrino, F. & Secreto, G. (1998) Precision and accuracy of a rapid method for measuring urinary isoflavonoids. In: Symposium on Phytoesterogen Research Methods (Setchell, K.D.R.Barnes, S. eds.) Tucson, AZ."},{"key":"10.1093\/jn\/133.12.4252_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00008469-200106000-00007","article-title":"Variation analysis in plasma \u03b2-sitosterol and campesterol measurements in premenopausal women","volume":"10","author":"Li","year":"2001","journal-title":"Eur. J. Cancer Prev"},{"key":"10.1093\/jn\/133.12.4252_bib21","first-page":"1","article-title":"Energy and protein requirements. Report of a joint FAO\/WHO\/UNU Expert Consultation","volume":"724","year":"1998","journal-title":"WHO Tech. Report Ser"},{"key":"10.1093\/jn\/133.12.4252_bib22","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1093\/jn\/130.9.2127","article-title":"Phytosterols as anticancer dietary components; evidence and mechanism of action","volume":"130","author":"Awad","year":"2000","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/133.12.4252_bib23","first-page":"471","article-title":"\u03b2-sitosterol inhibits the growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle","volume":"18","author":"Awad","year":"1998","journal-title":"Anticancer Res"},{"key":"10.1093\/jn\/133.12.4252_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-4157(93)90001-5","article-title":"Sphingolipid breakdown products: antiproliferative and tumor suppressor lipids","volume":"1154","author":"Hannun","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/133.12.4252_bib25","doi-asserted-by":"crossref","first-page":"30701","DOI":"10.1074\/jbc.270.51.30701","article-title":"Role of ceramide in cellular senescence","volume":"270","author":"Venable","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/133.12.4252_bib26","first-page":"691","article-title":"Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modular by apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation","volume":"55","author":"Ohta","year":"1995","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/133.12.4252_bib27","first-page":"2797","article-title":"\u03b2-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids","volume":"16","author":"Awad","year":"1996","journal-title":"Anticancer Res"},{"key":"10.1093\/jn\/133.12.4252_bib28","first-page":"3034","article-title":"Phytosterols and cholesterol in malignant and benign breast tumors","volume":"37","author":"Mellies","year":"1977","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/133.12.4252_bib29","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1210\/jcem-30-2-174","article-title":"Circulating phytosterol in normal females, lactating mothers, and breast cancer patients","volume":"30","author":"Haddad","year":"1970","journal-title":"J. Clin. Endocr"},{"key":"10.1093\/jn\/133.12.4252_bib30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0024-3205(00)00665-2","article-title":"Pharmacological properties of plant sterols: in vivo and in vitro observations","volume":"67","author":"Mogadashian","year":"2000","journal-title":"Life Sci"},{"key":"10.1093\/jn\/133.12.4252_bib31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1207\/S15327914NC3602_14","article-title":"Peanuts as a source of \u03b2-sitosterol, a sterol with anticancer properties","volume":"36","author":"Awad","year":"2000","journal-title":"Nutr. Cancer"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622161973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622161973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/133\/12\/4252\/24019330\/z4w01203004252.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T21:03:28Z","timestamp":1686603808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622161973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0022316622161973"],"URL":"https:\/\/doi.org\/10.1093\/jn\/133.12.4252","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Plant Food\u2013Based Diet Modifies the Serum \u03b2-Sitosterol Concentration in Hyperandrogenic Postmenopausal Women","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/133.12.4252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}