{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:36:59Z","timestamp":1790267819330,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":7221,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1093\/jn\/133.5.1554s","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T11:31:22Z","timestamp":1519731082000},"page":"1554S-1556S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Iron and Copper Interactions in Development and the Effect on Pregnancy Outcome"],"prefix":"10.1016","volume":"133","author":[{"given":"Lorraine","family":"Gambling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Danzeisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Fosset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette S.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Dunford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Kaila S.","family":"Srai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry J.","family":"McArdle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/133.5.1554S_bib1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00003081-199509000-00004","article-title":"Iron deficiency anemia in pregnancy","volume":"38","author":"Schwartz","year":"1995","journal-title":"Clin. Obstet. Gynecol"},{"key":"10.1093\/jn\/133.5.1554S_bib2","doi-asserted-by":"crossref","first-page":"257S","DOI":"10.1093\/ajcn\/72.1.257S","article-title":"Iron requirements in pregnancy and strategies to meet them","volume":"72","author":"Bothwell","year":"2000","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/133.5.1554S_bib3","doi-asserted-by":"crossref","first-page":"1280S","DOI":"10.1093\/ajcn\/71.5.1280s","article-title":"Anemia and iron deficiency: effects on pregnancy outcome","volume":"71","author":"Allen","year":"2000","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/133.5.1554S_bib4","first-page":"886","article-title":"The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight Br","volume":"98","author":"Godfrey","year":"1991","journal-title":"J. Obstet. Gynaecol"},{"key":"10.1093\/jn\/133.5.1554S_bib5","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1093\/jn\/130.11.2821","article-title":"Chronic marginal iron intakes during early development in mice result in persistent changes in dopamine metabolism and myelin composition","volume":"130","author":"Kwik-Uribe","year":"2000","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/133.5.1554S_bib6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/ajcn\/41.5.1032","article-title":"Zinc and copper nutrition in human pregnancy: a longitudinal study in normal primigravidae and in primigravidae at risk of delivering a growth retarded baby","volume":"41","author":"Tuttle","year":"1985","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/133.5.1554S_bib7","doi-asserted-by":"crossref","unstructured":"Linder, M. (1991) The Biochemistry of Copper. Plenum Press, New York.","DOI":"10.1007\/978-1-4757-9432-8"},{"key":"10.1093\/jn\/133.5.1554S_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/sj.ejcn.1600781","article-title":"Trace element transfer from the mother to the newborn\u2013investigations on triplets of colostrum, maternal and umbilical cord sera","volume":"53","author":"Krachler","year":"1999","journal-title":"Eur. J. Clin. Nutr"},{"key":"10.1093\/jn\/133.5.1554S_bib9","doi-asserted-by":"crossref","first-page":"1003S","DOI":"10.1093\/ajcn\/67.5.1003S","article-title":"Effect of copper deficiency on prenatal development and pregnancy outcome","volume":"67","author":"Keen","year":"1998","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/133.5.1554S_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0143-4004(96)90030-2","article-title":"Placental copper transport in the rat. II: Effect of maternal copper deficiency","volume":"17","author":"Wapnir","year":"1996","journal-title":"Placenta"},{"key":"10.1093\/jn\/133.5.1554S_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0167-4889(95)00123-6","article-title":"Copper uptake by cultured trophoblast cells isolated from human term placenta","volume":"1269","author":"Tong","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/133.5.1554S_bib12","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jn\/122.6.1260","article-title":"The accumulation of copper by microvillar vesicles isolated from human placenta","volume":"122","author":"McArdle","year":"1992","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/133.5.1554S_bib13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3181\/00379727-203-43619","article-title":"Ceruloplasmin and copper transport during the latter part of gestation in the rat","volume":"203","author":"Lee","year":"1993","journal-title":"Proc. Soc. Exp. Biol. Med"},{"key":"10.1093\/jn\/133.5.1554S_bib14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-4165(95)00084-O","article-title":"Characterisation of the copper uptake mechanism and isolation of the ceruloplasmin receptor\/copper transporter in human placental vesicles","volume":"1245","author":"Hilton","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/133.5.1554S_bib15","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1073\/pnas.96.19.10812","article-title":"Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux","volume":"96","author":"Harris","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1093\/jn\/133.5.1554S_bib16","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1073\/pnas.94.14.7481","article-title":"hCTR1: a human gene for copper uptake identified by complementation in yeast","volume":"94","author":"Zhou","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1093\/jn\/133.5.1554S_bib17","doi-asserted-by":"crossref","first-page":"6836","DOI":"10.1073\/pnas.111057298","article-title":"The copper transporter CTR1 provides an essential function in mammalian embryonic development","volume":"98","author":"Kuo","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1093\/jn\/133.5.1554S_bib18","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1073\/pnas.111058698","article-title":"Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development","volume":"98","author":"Lee","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1093\/jn\/133.5.1554S_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-4615-4859-1_9","article-title":"Developmental expression of the mouse mottled and toxic milk genes","volume":"448","author":"Kuo","year":"1999","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1093\/jn\/133.5.1554S_bib20","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/hmg\/8.9.1665","article-title":"Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation","volume":"8","author":"Buiakova","year":"1999","journal-title":"Hum. Mol. Genet"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622159079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622159079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/133\/5\/1554S\/24181143\/1554s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T21:24:44Z","timestamp":1686605084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622159079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["S0022316622159079"],"URL":"https:\/\/doi.org\/10.1093\/jn\/133.5.1554s","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2003,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron and Copper Interactions in Development and the Effect on Pregnancy Outcome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/133.5.1554S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}