{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:23:33Z","timestamp":1785867813893,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":6950,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1093\/jn\/134.2.348","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T06:32:53Z","timestamp":1516602773000},"page":"348-356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":170,"title":["Low Dose Daily Iron Supplementation Improves Iron Status and Appetite but Not Anemia, whereas Quarterly Anthelminthic Treatment Improves Growth, Appetite and Anemia in Zanzibari Preschool Children"],"prefix":"10.1016","volume":"134","author":[{"given":"Hababu M.","family":"Chway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Montresor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Tielsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jape Khatib","family":"Jape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Albonico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Savioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Stoltzfus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/134.2.348_bib1","unstructured":"Levin, H. M., Pollitt, E., Galloway, R. & McGuire, J. (1994) Micronutrient deficiency disorders. In: Disease Control Priorities in Developing Countries (Jamison, D. T. & Mosley, W. H., eds.). Oxford University Press, New York, NY."},{"key":"10.1093\/jn\/134.2.348_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/jn\/130.2.254","article-title":"Variations in dietary iron alter brain iron metabolism in developing rats","volume":"130","author":"Pinero","year":"2000","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib3","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1093\/jn\/127.12.2282","article-title":"In vivo dopamine metabolism is altered in iron-deficient anemic rats","volume":"127","author":"Nelson","year":"1997","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1467-8624.1998.tb06130.x","article-title":"Behavior of infants with iron-deficiency anemia","volume":"69","author":"Lozoff","year":"1998","journal-title":"Child Dev"},{"key":"10.1093\/jn\/134.2.348_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1753-4887.1997.tb06463.x","article-title":"Psychomotor development and behavior in iron-deficient anemic infants","volume":"55","author":"de Andraca","year":"1997","journal-title":"Nutr. Rev"},{"key":"10.1093\/jn\/134.2.348_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0140-6736(93)92477-B","article-title":"Reversal of developmental delays in iron-deficient anaemic infants treated with iron [see comments]","volume":"341","author":"Idjradinata","year":"1993","journal-title":"Lancet"},{"key":"10.1093\/jn\/134.2.348_bib7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0140-6736(92)91719-O","article-title":"Effect of blood transfusion on survival among children in a Kenyan hospital [see comments]","volume":"340","author":"Lackritz","year":"1992","journal-title":"Lancet"},{"key":"10.1093\/jn\/134.2.348_bib8","unstructured":"Stoltzfus, R. J. & Dreyfuss, M. L. (1998) Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia. ILSI Press, Washington, DC."},{"key":"10.1093\/jn\/134.2.348_bib9","unstructured":"Warren, K. S., Bundy, D.A.P., Anderson, R. M., Davis, A. R., Henderson, D. A., Jamison, D. T., Prescott, N. & Senft, A. (1993) Helminth infection. In: Disease Control Priorities in Developing Countries (Jamison, D. T., Mosley, W. H., Measham, A. R. & Bobadilla,. JL., eds.), pp. 131\u2013160. Oxford University Press, New York, NY."},{"key":"10.1093\/jn\/134.2.348_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0035-9203(92)90215-X","article-title":"Intestinal parasitic infections: a soluble health problem","volume":"86","author":"Savioli","year":"1992","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"10.1093\/jn\/134.2.348_bib11","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/bmj.320.7251.1697","article-title":"Effects of treatment for intestinal helminth infection on growth and cognitive performance in children: systematic review of randomised trials","volume":"320","author":"Dickson","year":"2000","journal-title":"Br. Med. J"},{"key":"10.1093\/jn\/134.2.348_bib12","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/bmj.323.7326.1389","article-title":"Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study","volume":"323","author":"Stoltzfus","year":"2001","journal-title":"Br. Med. J"},{"key":"10.1093\/jn\/134.2.348_bib13","unstructured":"World Health Organization (1994) Bench aids for the diagnosis of intestinal parasites. WHO, Geneva, Switzerland."},{"key":"10.1093\/jn\/134.2.348_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0035-9203(85)90329-3","article-title":"Rapid evaluation of malaria parasite density and standardization of thick smear examination for epidemiological investigations","volume":"79","author":"Trape","year":"1985","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"10.1093\/jn\/134.2.348_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/ajcn\/61.1.26","article-title":"Validity and epidemiology of reported poor appetite among Peruvian infants from a low-income, periurban community","volume":"61","author":"Brown","year":"1995","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib16","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/jn\/130.7.1724","article-title":"Malaria, hookworms and recent fever are related to anemia and iron status indicators in 0- to 5-y old Zanzibari children and these relationships change with age","volume":"130","author":"Stoltzfus","year":"2000","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib17","unstructured":"Diggle, P. J., Liang, K. Y. & Zeger, S. L. (1994) Analysis of Longitudinal Data. Clavendon Press, Oxford, UK."},{"key":"10.1093\/jn\/134.2.348_bib18","first-page":"443","article-title":"The effects of malnutrition on child mortality in developing countries","volume":"73","author":"Pelletier","year":"1995","journal-title":"Bull. World Health Org"},{"key":"10.1093\/jn\/134.2.348_bib19","unstructured":"World Health Organization Expert Committee (1995) Physical Status: The Use and Interpretation of Anthropometry. WHO Technical Report Series no. 854, World Health Organization, Geneva, Switzerland."},{"key":"10.1093\/jn\/134.2.348_bib20","doi-asserted-by":"crossref","first-page":"697S","DOI":"10.1093\/jn\/131.2.697S","article-title":"Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs","volume":"131","author":"Stoltzfus","year":"2001","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ije\/28.3.591","article-title":"A controlled evaluation of two school-based anthelminthic chemotherapy regimens on intensity of intestinal helminth infections","volume":"28","author":"Albonico","year":"1999","journal-title":"Int. J. Epidemiol"},{"key":"10.1093\/jn\/134.2.348_bib22","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0035-9203(94)90174-0","article-title":"A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris and hookworm infections","volume":"88","author":"Albonico","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"10.1093\/jn\/134.2.348_bib23","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0140-6736(97)04229-3","article-title":"Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants","volume":"350","author":"Menendez","year":"1997","journal-title":"Lancet"},{"key":"10.1093\/jn\/134.2.348_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/02724936.1989.11748589","article-title":"The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children","volume":"9","author":"Smith","year":"1989","journal-title":"Ann. Trop. Paediatr"},{"key":"10.1093\/jn\/134.2.348_bib25","unstructured":"Adam, Z. (1997) Iron Supplementation and Malaria: a Randomized, Placebo-Controlled Field Trial in Rural Ethiopia. Doctoral thesis, London School of Tropical Medicine and Hygiene, London, UK."},{"key":"10.1093\/jn\/134.2.348_bib26","unstructured":"Verhoef, J. (2001) Iron deficiency and malaria as determinants of anaemia and African children. Doctoral thesis, Universal Press, Veenendaal, the Netherlands."},{"key":"10.1093\/jn\/134.2.348_bib27","unstructured":"National Research Council (1989) Recommended Dietary Allowances, 10th ed. National Academy Press, Washington, DC."},{"key":"10.1093\/jn\/134.2.348_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0035-9203(02)90303-2","article-title":"Is the exclusion of children under 24 months from anthelmintic treatment justifiable?","volume":"96","author":"Montresor","year":"2002","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"10.1093\/jn\/134.2.348_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/156482659902000203","article-title":"Interventions to improve intake of complementary foods by infants 6\u201312 months of age in developing countries: impact on growth and on the prevalence of malnutrition and potential contribution to child survival","volume":"20","author":"Caulfield","year":"1999","journal-title":"Food Nutr. Bull"},{"key":"10.1093\/jn\/134.2.348_bib30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/4.4.815","article-title":"Ascariasis: nutritional implications","volume":"4","author":"Schultz","year":"1982","journal-title":"Rev. Infect. Dis"},{"key":"10.1093\/jn\/134.2.348_bib31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/4.4.763","article-title":"Intestinal physiology and parasitic diseases","volume":"4","author":"Rosenberg","year":"1982","journal-title":"Rev. Infect. Dis"},{"key":"10.1093\/jn\/134.2.348_bib32","unstructured":"Crompton, D.W.T. & Stephenson, L. S. (1990) Hookworm infection, nutritional status and productivity. In: Hookworm Disease: Current Status and New Directions (Schad, G. A. & Warren, K. S., eds.), pp. 231\u2013264. Taylor & Francis, New York, NY."},{"key":"10.1093\/jn\/134.2.348_bib33","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/jn\/124.6.906","article-title":"Do the differences between the amino acid compositions of acute-phase and muscle proteins have a bearing on nitrogen loss in traumatic states?","volume":"124","author":"Reeds","year":"1994","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib34","unstructured":"Solomons, N. W., Mazariegos, M., Vettorazzi, C., Valdez, C., Grazioso, C., Romero-Abal, M. E. & Caballero, B. (1994) Growth Faltering, Protein Metabolism and Immunostimulation: New Speculations on the Nature of the Relationship with Notes from Observations and Analyses in Guatemala. Application of Stable Isotope Tracer Methods to Studies of Amino Acid, Protein and Energy Metabolism in Malnourished Populations of Developing Countries, pp. 115\u2013126. IAEA, Vienna, Austria."},{"key":"10.1093\/jn\/134.2.348_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1054\/npep.1999.0048","article-title":"Interleukins and tumor necrosis factor as inhibitors of food intake","volume":"33","author":"Langhans","year":"1999","journal-title":"Neuropeptides"},{"key":"10.1093\/jn\/134.2.348_bib36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1749-6632.1998.tb08324.x","article-title":"Cytokine-induced anorexia. Behavioral, cellular, and molecular mechanisms","volume":"856","author":"Plata-Salaman","year":"1998","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1093\/jn\/134.2.348_bib37","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/jir.1998.18.555","article-title":"Proinflammatory cytokines lowering erythropoietin production","volume":"18","author":"Jelkmann","year":"1998","journal-title":"J. Interferon Cytokine Res"},{"key":"10.1093\/jn\/134.2.348_bib38","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/rheumatology\/36.9.950","article-title":"Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade","volume":"36","author":"Davis","year":"1997","journal-title":"Br. J. Rheumatol"},{"key":"10.1093\/jn\/134.2.348_bib39","unstructured":"Willett, W. (1990) Nutritional Epidemiology. Oxford University Press, New York, NY."},{"key":"10.1093\/jn\/134.2.348_bib40","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0035-9203(91)90242-Q","article-title":"A controlled chemotherapeutic intervention trial on the relationship between Ascaris lumbricoides infection and malnutrition in children","volume":"85","author":"Thein-Hlaing","year":"1991","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"10.1093\/jn\/134.2.348_bib41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0140-6736(77)90119-2","article-title":"Effect of periodic deworming on nutritional status of ascaris-infested preschool children receiving supplementary food","volume":"ii","author":"Gupta","year":"1977","journal-title":"Lancet"},{"key":"10.1093\/jn\/134.2.348_bib42","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1093\/ajcn\/34.11.2508","article-title":"Single dose piperazine therapy for Ascaris lumbricoides: an unsuccessful method of promoting growth","volume":"34","author":"Greenberg","year":"1981","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib43","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/03014469400003322","article-title":"An 18-month study of the effect of periodic anthelminthic treatment on the growth and nutritional status of pre-school children in Bangladesh","volume":"21","author":"Rousham","year":"1994","journal-title":"Ann. Hum. Biol"},{"key":"10.1093\/jn\/134.2.348_bib44","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/ajcn\/32.7.1545","article-title":"Ascariasis and malnutrition. A study in urban Ethiopian children","volume":"32","author":"Freij","year":"1979","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ajcn\/36.1.79","article-title":"Effect of periodic antiascaris and antigiardia treatment on nutritional status of preschool children","volume":"36","author":"Gupta","year":"1982","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.2.348_bib46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/tropej\/28.1.41","article-title":"Ascaris and malnutrition in a group of Brazilian children\u2013a follow-up study","volume":"28","author":"Kloetzel","year":"1982","journal-title":"J. Trop. Pediatr"},{"key":"10.1093\/jn\/134.2.348_bib47","first-page":"1320","article-title":"Vitamin A supplementation but not deworming improves growth of malnourished preschool children in eastern Zaire","volume":"128","author":"Donnen","year":"1998","journal-title":"Am. J. Clin. Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623026391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623026391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/134\/2\/348\/24009881\/z4w00204000348.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T17:02:32Z","timestamp":1686589352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623026391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0022316623026391"],"URL":"https:\/\/doi.org\/10.1093\/jn\/134.2.348","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low Dose Daily Iron Supplementation Improves Iron Status and Appetite but Not Anemia, whereas Quarterly Anthelminthic Treatment Improves Growth, Appetite and Anemia in Zanzibari Preschool Children","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/134.2.348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}