{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:42:08Z","timestamp":1773420128329,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":6918,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1093\/jn\/134.3.517","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T06:41:46Z","timestamp":1516603306000},"page":"517-521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Ferroportin-1 Is Not Upregulated in Copper-Deficient Mice"],"prefix":"10.1016","volume":"134","author":[{"given":"Jayong","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Wessling-Resnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Prohaska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/134.3.517_bib1","doi-asserted-by":"crossref","unstructured":"Linder, M. C. (1991) Biochemistry of Copper. Plenum Press, New York, NY.","DOI":"10.1007\/978-1-4757-9432-8"},{"key":"10.1093\/jn\/134.3.517_bib2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.nutr.22.012502.114457","article-title":"Ceruloplasmin metabolism and function","volume":"22","author":"Hellman","year":"2002","journal-title":"Annu. Rev. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib3","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1073\/pnas.96.19.10812","article-title":"Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux","volume":"96","author":"Harris","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1093\/jn\/134.3.517_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0925-4439(02)00165-5","article-title":"Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice","volume":"1588","author":"Yamamoto","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/134.3.517_bib5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/35001596","article-title":"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter","volume":"403","author":"Donovan","year":"2000","journal-title":"Nature (Lond.)"},{"key":"10.1093\/jn\/134.3.517_bib6","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M000713200","article-title":"A novel mammalian iron-regulated protein involved in intracellular iron metabolism","volume":"275","author":"Abboud","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/134.3.517_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","article-title":"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation","volume":"5","author":"McKie","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1093\/jn\/134.3.517_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/90038","article-title":"A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis","volume":"28","author":"Njajou","year":"2001","journal-title":"Nat. Genet"},{"key":"10.1093\/jn\/134.3.517_bib9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1172\/JCI200113468","article-title":"Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene","volume":"108","author":"Montosi","year":"2001","journal-title":"J. Clin. Investig"},{"key":"10.1093\/jn\/134.3.517_bib10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1182\/blood-2001-11-0132","article-title":"Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)","volume":"100","author":"Devalia","year":"2002","journal-title":"Blood"},{"key":"10.1093\/jn\/134.3.517_bib11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1182\/blood-2002-03-0693","article-title":"A valine deletion of ferroportin 1: a common mutation in hemochromatosis type 4","volume":"100","author":"Roetto","year":"2002","journal-title":"Blood"},{"key":"10.1093\/jn\/134.3.517_bib12","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1053\/gast.2001.24033","article-title":"Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload","volume":"120","author":"Zoller","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/134.3.517_bib13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/ng1152","article-title":"Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis","volume":"34","author":"Muckenthaler","year":"2003","journal-title":"Nat. Genet"},{"key":"10.1093\/jn\/134.3.517_bib14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1079-9796(03)00136-0","article-title":"Expression of ferroportin in hemochromatosis liver","volume":"31","author":"Adams","year":"2003","journal-title":"Blood Cells Mol. Dis"},{"key":"10.1093\/jn\/134.3.517_bib15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0140-6736(03)12602-5","article-title":"Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis","volume":"361","author":"Bridle","year":"2003","journal-title":"Lancet"},{"key":"10.1093\/jn\/134.3.517_bib16","first-page":"A379","article-title":"Copper enhances ferroportin1 mRNA and protein levels in the murine macrophage J774 cell line","volume":"17","author":"Chung","year":"2003","journal-title":"FASEB J"},{"key":"10.1093\/jn\/134.3.517_bib17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-5793(02)03253-2","article-title":"Effects of copper on the expression of metal transporters in human intestinal Caco-2 cells","volume":"527","author":"Tennant","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1093\/jn\/134.3.517_bib18","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jn\/107.7.1340","article-title":"Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies","volume":"107","year":"1977","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib19","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/jn\/110.8.1726","article-title":"Second report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies","volume":"110","year":"1980","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib20","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/jn\/123.7.1226","article-title":"Persistent regional changes in brain copper, cuproenzymes and catecholamines following perinatal copper deficiency in mice","volume":"123","author":"Prohaska","year":"1993","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/jn\/121.3.355","article-title":"Changes in Cu, Zn-superoxide dismutase, cytochrome c oxidase, glutathione peroxidase and glutathione transferase activities in copper-deficient mice and rats","volume":"121","author":"Prohaska","year":"1991","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib22","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1182\/blood-2003-04-1250","article-title":"Iron loading and erythrophagocytosis increase ferroportin1 (FPN1) expression in J774 macrophages","volume":"102","author":"Knutson","year":"2003","journal-title":"Blood"},{"key":"10.1093\/jn\/134.3.517_bib23","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1093\/nar\/19.14.3998","article-title":"36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO","volume":"19","author":"Laborda","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"10.1093\/jn\/134.3.517_bib24","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0168-8278(03)00408-2","article-title":"The role of the iron responsive element in the control of ferroportin1\/IREG1\/MTP1 gene expression","volume":"39","author":"Lymboussaki","year":"2003","journal-title":"J. Hepatol"},{"key":"10.1093\/jn\/134.3.517_bib25","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1146\/annurev.nutr.20.1.627","article-title":"Iron regulatory proteins and the molecular control of mammalian iron metabolism","volume":"20","author":"Eisenstein","year":"2000","journal-title":"Annu. Rev. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/jn\/133.1.28","article-title":"Copper deficiency induces the upregulation of the copper chaperone for Cu\/Zn superoxide dismutase in weanling male rats","volume":"133","author":"Bertinato","year":"2003","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0003-9861(03)00364-3","article-title":"Metallochaperone for Cu, Zn-superoxide dismutase (CCS) protein but not mRNA is higher in organs from copper-deficient mice and rats","volume":"417","author":"Prohaska","year":"2003","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/134.3.517_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0021-9258(18)76165-6","article-title":"The action of copper in iron metabolism","volume":"98","author":"Elvehjem","year":"1932","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/134.3.517_bib29","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1172\/JCI105891","article-title":"Iron metabolism in copper-deficient swine","volume":"47","author":"Lee","year":"1968","journal-title":"J. Clin. Investig"},{"key":"10.1093\/jn\/134.3.517_bib30","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1152\/ajplegacy.1973.224.3.514","article-title":"Effects of iron on copper metabolism and copper on iron metabolism in rats","volume":"224","author":"Owen","year":"1973","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/134.3.517_bib31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1079\/BJN19830136","article-title":"Hepatic iron accumulation in copper-deficient rats","volume":"50","author":"Williams","year":"1983","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-291X(83)90441-2","article-title":"The effect of copper chelating drugs on liver iron mobilization in the adult rat","volume":"113","author":"Cohen","year":"1983","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/134.3.517_bib33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0955-2863(90)90015-D","article-title":"Effect of dietary copper deficiency on the distribution of dopamine and norepinephrine in mice and rats","volume":"1","author":"Prohaska","year":"1990","journal-title":"J. Nutr. Biochem"},{"key":"10.1093\/jn\/134.3.517_bib34","first-page":"G311","article-title":"Genetic disorders of membrane transport. IV. Wilson's disease and Menkes disease","volume":"276","author":"Schaefer","year":"1999","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/134.3.517_bib35","doi-asserted-by":"crossref","first-page":"1527S","DOI":"10.1093\/jn\/133.5.1527S","article-title":"Genetic defects in copper metabolism","volume":"133","author":"Shim","year":"2003","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.517_bib36","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1182\/blood-2003-02-0347","article-title":"Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency","volume":"102","author":"Chen","year":"2003","journal-title":"Blood"},{"key":"10.1093\/jn\/134.3.517_bib37","doi-asserted-by":"crossref","unstructured":"Yang, F., Wang, X., Haile, D. J., Piantadosi, C. A. & Ghio, A. J. (2002) Iron increases expression of iron-export protein MTP1 in lung cells. Am. J. Physiol. 283:L932\u2013L939.","DOI":"10.1152\/ajplung.00114.2002"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623026688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623026688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/134\/3\/517\/24008510\/z4w00304000517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T22:41:03Z","timestamp":1686609663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623026688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0022316623026688"],"URL":"https:\/\/doi.org\/10.1093\/jn\/134.3.517","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroportin-1 Is Not Upregulated in Copper-Deficient Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/134.3.517","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}