{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:00:26Z","timestamp":1793246426039,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":6918,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1093\/jn\/134.3.580","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T06:33:03Z","timestamp":1516602783000},"page":"580-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["The Short-Term Bioavailabilities of [6S]-5-Methyltetrahydrofolate and Folic Acid Are Equivalent in Men"],"prefix":"10.1016","volume":"134","author":[{"given":"Kristina","family":"Pentieva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Strain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"McKillop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edel","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"McPartlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/134.3.580_bib1","first-page":"8781","article-title":"Food standards: amendment of standards of identify for enriched grain products to require addition of folic acid: final rule, (21 CFR Parts 136, 137 and 139)","volume":"61","year":"1996","journal-title":"Fed. Regist"},{"issue":"Part I","key":"10.1093\/jn\/134.3.580_bib2","first-page":"1509","article-title":"Regulations amending the Food and Drug Regulations, Schedule No. 1066","volume":"131","year":"1997","journal-title":"Canada Gazette"},{"key":"10.1093\/jn\/134.3.580_bib3","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"Br. Med. J"},{"key":"10.1093\/jn\/134.3.580_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jn\/130.2.129","article-title":"Folate and carcinogenesis: an integrated scheme","volume":"130","author":"Choi","year":"2000","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib5","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N. Engl. J. Med"},{"key":"10.1093\/jn\/134.3.580_bib6","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1093\/jn\/131.12.3277","article-title":"Folic acid fortification increases red blood cell folate concentrations in the Framingham study","volume":"131","author":"Choumenkovitch","year":"2001","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib7","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1001\/jama.285.23.2981","article-title":"Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects","volume":"285","author":"Honein","year":"2001","journal-title":"J. Am. Med. Assoc"},{"key":"10.1093\/jn\/134.3.580_bib8","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(02)11994-5","article-title":"Association of neural tube defects and folic acid food fortification in Canada","volume":"360","author":"Ray","year":"2002","journal-title":"Lancet"},{"key":"10.1093\/jn\/134.3.580_bib9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1056\/NEJM196106292642604","article-title":"Folic acid therapy and spinal cord degeneration in pernicious anemia","volume":"264","author":"Baldwin","year":"1961","journal-title":"N. Engl. J. Med"},{"key":"10.1093\/jn\/134.3.580_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.0954-6820.1962.tb07176.x","article-title":"Metabolic effects and diagnostic value of small doses of folic acid and B12 in megaloblastic anemias","volume":"172","author":"Hansen","year":"1962","journal-title":"Acta Med. Scand"},{"key":"10.1093\/jn\/134.3.580_bib11","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/ajcn\/65.6.1790","article-title":"Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements","volume":"65","author":"Kelly","year":"1997","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2141.1970.tb01447.x","article-title":"Intestinal absorption of reduced folate compounds in man","volume":"18","author":"Perry","year":"1970","journal-title":"Br. J. Haematol"},{"key":"10.1093\/jn\/134.3.580_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/ajcn\/75.2.275","article-title":"5, 10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women","volume":"75","author":"Fohr","year":"2002","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0140-6736(81)90650-4","article-title":"The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia","volume":"2","author":"Scott","year":"1981","journal-title":"Lancet"},{"key":"10.1093\/jn\/134.3.580_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0016-5085(73)80033-2","article-title":"Ingestion and absorption of naturally occurring pteroylmonoglutamates (folates) in man","volume":"64","author":"Brown","year":"1973","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/134.3.580_bib16","unstructured":"Eprova, A. G. (2000) Metafolin: scientific review. Internet: http:\/\/www.metafolin.com [accessed June 2003]."},{"key":"10.1093\/jn\/134.3.580_bib17","first-page":"124","article-title":"Effect of folic acid preload on the bioequivalence of [6S]-5-methyltetrahydrofolate and folic acid in healthy volunteers","volume":"26","author":"Prinz-Langenohl","year":"2003","journal-title":"J. Inherit. Metab. Dis"},{"key":"10.1093\/jn\/134.3.580_bib18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1079\/BJN2003908","article-title":"Single oral doses of 13C forms of pteroylmonoglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short-term kinetics of labelled and unlabelled folates in plasma: potential problems in interpretation of folate bioavailability studies","volume":"90","author":"Wright","year":"2003","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib19","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1093\/jn\/132.11.3353","article-title":"Increases in blood folate indices are similar in women of childbearing age supplemented with [6S]-5-methyltetrahydrofolate and folic acid","volume":"132","author":"Venn","year":"2002","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/ajcn\/77.3.658","article-title":"Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study","volume":"77","author":"Venn","year":"2003","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib21","unstructured":"Knoll, Aktiengesellshaft (1999) Method of separating the enantiomers of 5-methyltetrahydrofolic acid. Patent number: EP 0 612 322 B1."},{"key":"10.1093\/jn\/134.3.580_bib22","unstructured":"Department of Health (1991) Report on Health and Social Subjects 41. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. The Stationary Office, London, UK."},{"key":"10.1093\/jn\/134.3.580_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0076-6879(97)81007-5","article-title":"Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method","volume":"281","author":"Molloy","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1093\/jn\/134.3.580_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/clinchem\/45.4.569a","article-title":"Fully automated measurement of total homocysteine in plasma and serum on the Abbott IMx analyzer","volume":"45","author":"Leino","year":"1999","journal-title":"Clin. Chem"},{"key":"10.1093\/jn\/134.3.580_bib25","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/jcp.44.7.592","article-title":"Microbiological assay for vitamin B12 performed in 96-well microtitre plates","volume":"44","author":"Kelleher","year":"1991","journal-title":"J. Clin. Pathol"},{"key":"10.1093\/jn\/134.3.580_bib26","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/jnci\/82.10.806","article-title":"Polymerase chain reaction and analysis of cancer cell markers","volume":"82","author":"Kawasaki","year":"1990","journal-title":"J. Natl. Cancer Inst"},{"key":"10.1093\/jn\/134.3.580_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"56","author":"Frosst","year":"1995","journal-title":"Nat. Genet"},{"key":"10.1093\/jn\/134.3.580_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/jf960497p","article-title":"Food folate assay with protease, \u03b1-amylase, and conjugase treatments","volume":"45","author":"Tamura","year":"1997","journal-title":"J. Agric. Food Chem"},{"key":"10.1093\/jn\/134.3.580_bib29","unstructured":"Altman, D. (1991) Serial measurements. In: Practical Statistics for Medical Research (Altman, D., eds.), pp. 426\u2013433. Chapman & Hall, London, UK."},{"key":"10.1093\/jn\/134.3.580_bib30","unstructured":"Mason, J. (1990) Intestinal transport of monoglutamyl folates in mammalian systems. In: Folic Acid Metabolism in Health and Disease (Picciano, M. F., Stokstad, E.L.R. & Gregory, J. F. eds.), pp. 47\u201363. Willey-Liss, New York, NY."},{"key":"10.1093\/jn\/134.3.580_bib31","first-page":"1","article-title":"Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects","volume":"41","year":"1992","journal-title":"Morbid. Mortal. Wkly Rep"},{"key":"10.1093\/jn\/134.3.580_bib32","unstructured":"Department of Health (1992) Report from an expert advisory group. Folic acid and the prevention of neural tube defects. HM Stationary Office, London, UK."},{"key":"10.1093\/jn\/134.3.580_bib33","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/ajcn\/55.6.1147","article-title":"Relative bioavailability of deuterium-labeled monoglutamyl tetrahydrofolates and folic acid in human subjects","volume":"55","author":"Gregory","year":"1992","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib34","first-page":"207","article-title":"Methodological aspects in vitamin bioavailability testing","volume":"7","author":"Pietrzik","year":"1990","journal-title":"J. Micronutr. Anal"},{"key":"10.1093\/jn\/134.3.580_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0308-8146(00)00116-3","article-title":"Total folate in enriched cereal-grain products in the United States following fortification","volume":"70","author":"Rader","year":"2000","journal-title":"Food Chem"},{"key":"10.1093\/jn\/134.3.580_bib36","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1093\/jn\/132.9.2792","article-title":"Folic acid intake from fortification in United States exceeds predictions","volume":"132","author":"Choumenkovitch","year":"2002","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/ajcn\/77.1.221","article-title":"Effect of food fortification on folic acid intake in the United States","volume":"77","author":"Quinlivan","year":"2003","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/134.3.580_bib38","unstructured":"Holland, B., Welch, A. A., Unwin, I. D., Buss, D. H., Paul, A. A. & Southgate, D.A.T. (1991) McCance and Widdowson's The Composition of Foods, 5th ed. Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food, Cambridge, UK."},{"key":"10.1093\/jn\/134.3.580_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.nu.12.070192.001431","article-title":"Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease","volume":"12","author":"Kang","year":"1992","journal-title":"Annu. Rev. Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623026780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623026780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/134\/3\/580\/24008145\/z4w00304000580.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T22:41:39Z","timestamp":1686609699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623026780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0022316623026780"],"URL":"https:\/\/doi.org\/10.1093\/jn\/134.3.580","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Short-Term Bioavailabilities of [6S]-5-Methyltetrahydrofolate and Folic Acid Are Equivalent in Men","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/134.3.580","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}