{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:30:24Z","timestamp":1783380624491,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":6766,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1093\/jn\/134.8.1958","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T06:53:18Z","timestamp":1516603998000},"page":"1958-1963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Vitamin A Deficiency Impairs Fetal Islet Development and Causes Subsequent Glucose Intolerance in Adult Rats"],"prefix":"10.1016","volume":"134","author":[{"given":"Kimberly A.","family":"Matthews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Rhoten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry K.","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Chertow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/134.8.1958_bib1","doi-asserted-by":"crossref","unstructured":"Falkner, S. & Ostberg, Y. (1977) Comparative morphology of the pancreatic islets in animals. In: The Diabetic Pancreas (Volk, B. & Wellmann, K., eds.), pp. 15\u201319. Plenum Press, New York, NY.","DOI":"10.1007\/978-1-4684-2325-9_2"},{"key":"10.1093\/jn\/134.8.1958_bib2","doi-asserted-by":"crossref","unstructured":"Hellerstrom, C. (1977) Growth patterns of pancreatic islets in animals. In: The Diabetic Pancreas (Volk, B. & Wellmann, K., eds.), pp. 61\u201397. Plenum Press, New York, NY.","DOI":"10.1007\/978-1-4684-2325-9_3"},{"key":"10.1093\/jn\/134.8.1958_bib3","unstructured":"Mangelsdorf, D. J., Umesono Kazuhiko, U. & Evans, R. M. (1994) The retinoid receptors. In: The Retinoids (Sporn, M. B., Roberts, A. B. & Goodman, D., eds.), pp. 319\u2013349. Raven Press, New York, NY."},{"key":"10.1093\/jn\/134.8.1958_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1101\/gad.859401","article-title":"Intercellular signals regulating pancreas development and function","volume":"15","author":"Kim","year":"2001","journal-title":"Genes Dev"},{"key":"10.1093\/jn\/134.8.1958_bib5","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1242\/dev.127.11.2317","article-title":"Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages","volume":"127","author":"Herrera","year":"2000","journal-title":"Development"},{"key":"10.1093\/jn\/134.8.1958_bib6","unstructured":"Gudas, L., Sporn, M. B. & Roberts, A. B. (1994) Cellular biology and biochemistry of the retinoids. In: The Retinoids: Biology, Chemistry and Medicine (Sporn, M. B., Roberts, A. B. & Goodman, D., eds.), pp. 443\u2013520. Raven Press, New York, NY."},{"key":"10.1093\/jn\/134.8.1958_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/1043-2760(93)90048-J","article-title":"Peroxisome proliferator-activated receptors: a link between endocrinology and nutrition","volume":"4","author":"Keller","year":"1993","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1093\/jn\/134.8.1958_bib8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0960-0760(95)00094-G","article-title":"Developmental roles of the retinoic acid receptors","volume":"53","author":"Lohnes","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol"},{"key":"10.1093\/jn\/134.8.1958_bib9","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1242\/dev.125.16.3235","article-title":"A conserved retinoic acid responsive element in the murine Hoxb-1 gene is required for expression in the developing gut","volume":"125","author":"Huang","year":"1998","journal-title":"Development"},{"key":"10.1093\/jn\/134.8.1958_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/(SICI)1097-0177(199912)216:4\/5<469::AID-DVDY15>3.0.CO;2-3","article-title":"Retinoic acid is essential for Shh\/Hoxd signaling during rat limb outgrowth but not for limb initiation","volume":"216","author":"Power","year":"1999","journal-title":"Dev. Dyn"},{"key":"10.1093\/jn\/134.8.1958_bib11","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.98.3.1001","article-title":"Identification of a calcium-regulated insulinoma cell phosphoprotein as an islet cell keratin","volume":"98","author":"Schubart","year":"1984","journal-title":"J. Cell Biol"},{"key":"10.1093\/jn\/134.8.1958_bib12","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1101\/gad.11.13.1662","article-title":"Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development","volume":"11","author":"Sander","year":"1997","journal-title":"Genes Dev"},{"key":"10.1093\/jn\/134.8.1958_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1432-0436.1998.6240187.x","article-title":"Retinoic acid mediates Pax6 expression during in vitro differentiation of embryonic stem cells","volume":"62","author":"Gajovic","year":"1997","journal-title":"Differentiation"},{"key":"10.1093\/jn\/134.8.1958_bib14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.7326\/0003-4819-130-4-199902160-00019","article-title":"The fetal origins of type 2 diabetes mellitus","volume":"130","author":"Barker","year":"1999","journal-title":"Ann. Intern. Med"},{"key":"10.1093\/jn\/134.8.1958_bib15","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/diab.38.12.1544","article-title":"Cytoplasmic retinoid-binding proteins and retinoid effects on insulin release in RINm5F beta-cells","volume":"38","author":"Chertow","year":"1989","journal-title":"Diabetes"},{"key":"10.1093\/jn\/134.8.1958_bib16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI112778","article-title":"Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets","volume":"79","author":"Chertow","year":"1987","journal-title":"J. Clin. Investig"},{"key":"10.1093\/jn\/134.8.1958_bib17","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0026-0495(97)90009-3","article-title":"Retinoid-X receptors and the effects of 9-cis-retinoic acid on insulin secretion from RINm5F cells","volume":"46","author":"Chertow","year":"1997","journal-title":"Metabolism"},{"key":"10.1093\/jn\/134.8.1958_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00006676-199708000-00003","article-title":"Effects of all-trans-retinoic acid (ATRA) and retinoic acid receptor (RAR) expression on secretion, growth, and apoptosis of insulin- secreting RINm5F cells","volume":"15","author":"Chertow","year":"1997","journal-title":"Pancreas"},{"key":"10.1093\/jn\/134.8.1958_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-4899-2575-6_15","article-title":"The function of vitamin A in cellular growth and differentiation, and its roles during pregnancy and lactation","volume":"352","author":"Ross","year":"1994","journal-title":"Adv. Exp. Med. Biol"},{"key":"10.1093\/jn\/134.8.1958_bib20","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/jn\/123.8.1435","article-title":"Dietary vitamin A restriction produces marginal vitamin A status in young rats","volume":"123","author":"Gardner","year":"1993","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.8.1958_bib21","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/jn\/100.9.1049","article-title":"Biological activity of 25-hydroxyergocalciferol in rats","volume":"100","author":"Suda","year":"1970","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/134.8.1958_bib22","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1210\/endo.136.7.7789343","article-title":"Presence of nerve growth factor and its receptors in an in vitro model of islet cell development: implication in normal islet morphogenesis","volume":"136","author":"Kanaka-Gantenbein","year":"1995","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/134.8.1958_bib23","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1210\/endo.138.4.5069","article-title":"Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat","volume":"138","author":"Scaglia","year":"1997","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/134.8.1958_bib24","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/jcem-25-10-1375","article-title":"Coated charcoal immunoassay of insulin","volume":"25","author":"Herbert","year":"1965","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"10.1093\/jn\/134.8.1958_bib25","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1172\/JCI104130","article-title":"Immunoassay of endogenous plasma insulin in man","volume":"39","author":"Yalow","year":"1960","journal-title":"J. Clin. Investig"},{"key":"10.1093\/jn\/134.8.1958_bib26","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1093\/emboj\/16.13.3955","article-title":"Axial (HNF3beta) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter","volume":"16","author":"Chang","year":"1997","journal-title":"EMBO J"},{"key":"10.1093\/jn\/134.8.1958_bib27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1242\/dev.105.4.787","article-title":"XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm","volume":"105","author":"Wright","year":"1989","journal-title":"Development"},{"key":"10.1093\/jn\/134.8.1958_bib28","first-page":"105","article-title":"Ontogeny of the pancreatic islet parenchymal cells in the rabbit\u2014an immunohistochemical and ultrastructural study with particular regard to the earliest appearance of argyrophil insulin-immunoreactive cells","volume":"5","author":"Titlbach","year":"1987","journal-title":"Diabetes Res"},{"key":"10.1093\/jn\/134.8.1958_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2337\/diab.32.4.293","article-title":"A quantitative immunofluorescent study of the endocrine cell populations in the developing human pancreas","volume":"32","author":"Stefan","year":"1983","journal-title":"Diabetes"},{"key":"10.1093\/jn\/134.8.1958_bib30","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1292\/jvms1939.48.769","article-title":"Immunocytochemical studies on the development of the pancreatic islet cells in the domestic fowl","volume":"48","author":"Mikami","year":"1986","journal-title":"Nippon Juigaku Zasshi"},{"key":"10.1093\/jn\/134.8.1958_bib31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00006676-199407000-00005","article-title":"Pancreatic islet cell reaggregation systems: efficiency of cell reassociation and endocrine cell topography of rat islet-like aggregates","volume":"9","author":"Matta","year":"1994","journal-title":"Pancreas"},{"key":"10.1093\/jn\/134.8.1958_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/endo-123-1-113","article-title":"Altered differentiated cell surface properties of transformed (RINm5F) compared with native adult rat pancreatic B cells","volume":"123","author":"Halban","year":"1988","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/134.8.1958_bib33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0026-0495(96)90282-6","article-title":"Retinoic acid receptor transcripts and effects of retinol and retinoic acid on glucagon secretion from rat islets and glucagon-secreting cell lines","volume":"45","author":"Chertow","year":"1996","journal-title":"Metabolism"},{"key":"10.1093\/jn\/134.8.1958_bib34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1749-6632.1993.tb26140.x","article-title":"Vitamin A status of low-income pregnant women in Iowa as assessed by the modified relative dose-response","volume":"678","author":"Duitsman","year":"1993","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1093\/jn\/134.8.1958_bib35","doi-asserted-by":"crossref","first-page":"517S","DOI":"10.1093\/ajcn\/59.2.517S","article-title":"Maternal vitamin A status and its importance in infancy and early childhood","volume":"59","author":"Underwood","year":"1994","journal-title":"Am. J. Clin. Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623029784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623029784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/134\/8\/1958\/24007486\/z4w00804001958.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T23:19:47Z","timestamp":1751239187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623029784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0022316623029784"],"URL":"https:\/\/doi.org\/10.1093\/jn\/134.8.1958","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin A Deficiency Impairs Fetal Islet Development and Causes Subsequent Glucose Intolerance in Adult Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/134.8.1958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}