{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:27:27Z","timestamp":1767842847127,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":6363,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1093\/jn\/135.9.2206","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T06:25:07Z","timestamp":1516083907000},"page":"2206-2211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Phlorizin Administration Increases Hepatic Gluconeogenic Enzyme mRNA Abundance but Not Feed Intake in Late-Lactation Dairy Cows1-3"],"prefix":"10.1016","volume":"135","author":[{"given":"Barry J.","family":"Bradford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/135.9.2206_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev.nutr.25.050304.092704","article-title":"The cow as a model to study food intake regulation","volume":"25","author":"Allen","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"10.1093\/jn\/135.9.2206_bib2","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.2527\/1996.74123029x","article-title":"Integration of regulatory signals controlling forage intake in ruminants","volume":"74","author":"Forbes","year":"1996","journal-title":"J. Anim. Sci."},{"key":"10.1093\/jn\/135.9.2206_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-1838(87)90129-9","article-title":"Evidence for a vagally mediated satiety signal derived from hepatic fatty acid oxidation","volume":"18","author":"Langhans","year":"1987","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1093\/jn\/135.9.2206_bib4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0899-9007(99)00125-2","article-title":"Control of food intake by fatty acid oxidation and ketogenesis","volume":"15","author":"Scharrer","year":"1999","journal-title":"Nutrition"},{"key":"10.1093\/jn\/135.9.2206_bib5","first-page":"R610","article-title":"Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM","volume":"274","author":"Koch","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1093\/jn\/135.9.2206_bib6","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/jn\/133.4.1094","article-title":"Intraruminal infusion of propionate alters feeding behavior and decreases energy intake of lactating dairy cows","volume":"133","author":"Oba","year":"2003","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/135.9.2206_bib7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1113\/expphysiol.1988.sp003174","article-title":"The roles of hepatic nerves in the reduction of food intake as a consequence of intraportal sodium propionate administration in sheep","volume":"73","author":"Anil","year":"1988","journal-title":"Q. J. Exp. Physiol."},{"key":"10.1093\/jn\/135.9.2206_bib8","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3168\/jds.S0022-0302(02)74255-0","article-title":"Effects of abomasal vegetable oil infusion on splanchnic nutrient metabolism in lactating dairy cows","volume":"85","author":"Benson","year":"2002","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1079\/PNS2003286","article-title":"Cross talk between physical activity and appetite control: does physical activity stimulate appetite?","volume":"62","author":"Blundell","year":"2003","journal-title":"Proc. Nutr. Soc."},{"key":"10.1093\/jn\/135.9.2206_bib10","first-page":"241","article-title":"A meta-analysis review of the effects of recombinant bovine somatotropin. 1. Methodology and effects on production","volume":"67","author":"Dohoo","year":"2003","journal-title":"Can. J. Vet. Res."},{"key":"10.1093\/jn\/135.9.2206_bib11","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1242\/jeb.204.11.1925","article-title":"Limits to sustained energy intake. I. Lactation in the laboratory mouse Mus musculus","volume":"204","author":"Johnson","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1093\/jn\/135.9.2206_bib12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3168\/jds.S0022-0302(74)84948-9","article-title":"Effects of phlorizin on glucose kinetics in the bovine","volume":"57","author":"Young","year":"1974","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib13","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2527\/jas1988.6651194x","article-title":"Follicular phase gonadotropin secretion in cyclic postpartum beef cows with phlorizin-induced hypoglycemia","volume":"66","author":"Rutter","year":"1988","journal-title":"J. Anim. Sci."},{"key":"10.1093\/jn\/135.9.2206_bib14","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3168\/jds.S0022-0302(93)77399-3","article-title":"Effects of decreased availability of glucose for dairy cows","volume":"76","author":"Amaral-Phillips","year":"1993","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib15","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3168\/jds.S0022-0302(93)77492-5","article-title":"Continuous computer acquisition of feed and water intake, chewing reticular motility, and ruminal pH of cattle","volume":"76","author":"Dado","year":"1993","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1210\/jcem-35-3-463","article-title":"Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma","volume":"35","author":"Ensinck","year":"1972","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1093\/jn\/135.9.2206_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1507\/endocrj.44.133","article-title":"Inhibition of GH releasing factor (GRF)-induced GH secretion by intraruminal infusion of volatile fatty acids (VFA) in sheep","volume":"44","author":"Matsunaga","year":"1997","journal-title":"Endocr. J."},{"key":"10.1093\/jn\/135.9.2206_bib18","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.3168\/jds.S0022-0302(91)78551-2","article-title":"Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition","volume":"74","author":"Van Soest","year":"1991","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib19","series-title":"Forage Fiber Analysis (Apparatus, Reagents, Procedures, and Some Applications)","article-title":"Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition","author":"Goering","year":"1970"},{"key":"10.1093\/jn\/135.9.2206_bib20","first-page":"783","article-title":"More powerful peroxide Kjeldahl digestion method","volume":"70","author":"Hach","year":"1987","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"10.1093\/jn\/135.9.2206_bib21","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/jsfa.2740361018","article-title":"An improved enzymatic method for the determination of native and modified starch","volume":"36","author":"Karkalas","year":"1985","journal-title":"J. Sci. Food Agric."},{"key":"10.1093\/jn\/135.9.2206_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3168\/jds.S0022-0302(86)80368-X","article-title":"Effect of chronic growth hormone treatment on responses to epinephrine and thyrotropin-releasing hormone in lactating cows","volume":"69","author":"McCutcheon","year":"1986","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib23","unstructured":"LUX Fluorogenic Primers. www.invitrogen.com\/lux. [Last accessed Jan. 6, 2005]."},{"key":"10.1093\/jn\/135.9.2206_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-1759(03)00223-0","article-title":"A method for the absolute quantification of cDNA using real-time PCR","volume":"278","author":"Whelan","year":"2003","journal-title":"J. Immunol. Methods"},{"key":"10.1093\/jn\/135.9.2206_bib25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1152\/physiolgenomics.00108.2001","article-title":"Cloning and characterization of bovine cytosolic and mitochondrial PEPCK during transition to lactation","volume":"11","author":"Agca","year":"2002","journal-title":"Physiol. Genomics"},{"key":"10.1093\/jn\/135.9.2206_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1093\/jn\/135.9.2206_bib27","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1146\/annurev.ph.54.030192.004321","article-title":"Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis","volume":"54","author":"Pilkis","year":"1992","journal-title":"Annu. Rev. Physiol."},{"key":"10.1093\/jn\/135.9.2206_bib28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.nutr.19.1.379","article-title":"Regulation of glucose production by the liver","volume":"19","author":"Nordlie","year":"1999","journal-title":"Annu. Rev. Nutr."},{"key":"10.1093\/jn\/135.9.2206_bib29","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1093\/jn\/118.11.1366","article-title":"Kinetics of metabolism of glucose, propionate and CO2 in steers as affected by injecting phlorizin and feeding propionate","volume":"118","author":"Veenhuizen","year":"1988","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/135.9.2206_bib30","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3168\/jds.S0022-0302(00)74989-7","article-title":"Changes in mRNA expression for gluconeogenic enzymes in liver of dairy cattle during the transition to lactation","volume":"83","author":"Greenfield","year":"2000","journal-title":"J. Dairy Sci."},{"issue":"Pt. 1","key":"10.1093\/jn\/135.9.2206_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3400001","article-title":"Structure, function and regulation of pyruvate carboxylase","volume":"340","author":"Jitrapakdee","year":"1999","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/135.9.2206_bib32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3168\/jds.S0022-0302(99)75338-5","article-title":"Regulation of messenger ribonucleic acid expression for gluconeogenic enzymes during glucagon infusions into lactating cows","volume":"82","author":"She","year":"1999","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib33","first-page":"217","article-title":"Effects of glucagon on activities of hepatic enzymes in sheep","volume":"64","author":"Brockman","year":"1974","journal-title":"Cornell Vet"},{"key":"10.1093\/jn\/135.9.2206_bib34","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3168\/jds.S0022-0302(01)74499-2","article-title":"Rumen undegradable protein, rumen-protected choline and mRNA expression for enzymes in gluconeogenesis and ureagenesis in periparturient dairy cows","volume":"84","author":"Hartwell","year":"2001","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2527\/jas1987.641283x","article-title":"Gluconeogenesis in isolated lamb hepatocytes","volume":"64","author":"Looney","year":"1987","journal-title":"J. Anim. Sci."},{"key":"10.1093\/jn\/135.9.2206_bib36","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/jn\/122.suppl_3.838","article-title":"Ruminant hepatic metabolism of volatile fatty acids, lactate and pyruvate","volume":"122","author":"Armentano","year":"1992","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/135.9.2206_bib37","series-title":"Aspects of Digestive Physiology in Ruminants","first-page":"238","article-title":"Propionate metabolism: a new interpretation","author":"Steinhour","year":"1988"},{"key":"10.1093\/jn\/135.9.2206_bib38","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1016\/S0021-9258(18)96422-7","article-title":"Pyruvate and propionate metabolism in lactating cows. Effect of butyrate on pyruvate metabolism","volume":"241","author":"Black","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/135.9.2206_bib39","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.2527\/1999.7771940x","article-title":"Substrate utilization for hepatic gluconeogenesis is altered by increased glucose demand in ruminants","volume":"77","author":"Overton","year":"1999","journal-title":"J. Anim. Sci."},{"key":"10.1093\/jn\/135.9.2206_bib40","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0749-0720(15)30799-4","article-title":"Lipid nutrition","volume":"7","author":"Emery","year":"1991","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1093\/jn\/135.9.2206_bib41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0003-9861(92)90055-2","article-title":"Role of endogenous fatty acids in the control of hepatic gluconeogenesis","volume":"292","author":"Gonzalez-Manchon","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1093\/jn\/135.9.2206_bib42","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2337\/diabetes.51.2.276","article-title":"Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin","volume":"51","author":"Huang","year":"2002","journal-title":"Diabetes"},{"key":"10.1093\/jn\/135.9.2206_bib43","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3168\/jds.S0022-0302(92)77974-0","article-title":"Interactions between gluconeogenesis and fatty acid oxidation in isolated sheep hepatocytes","volume":"75","author":"Chow","year":"1992","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1079\/BJN19830094","article-title":"Whole-body metabolism of glucose and lactate in productive sheep and cows","volume":"50","author":"Baird","year":"1983","journal-title":"Br. J. Nutr."},{"key":"10.1093\/jn\/135.9.2206_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/bj1860047","article-title":"Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cows in vivo in relation to lactation and nutrient supply","volume":"186","author":"Baird","year":"1980","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/135.9.2206_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1079\/BJN19830095","article-title":"Tissue glucose and lactate metabolism and interconversions in pregnant and lactating sheep","volume":"50","author":"van der Walt","year":"1983","journal-title":"Br. J. Nutr."},{"key":"10.1093\/jn\/135.9.2206_bib47","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.3168\/jds.S0022-0302(00)75030-2","article-title":"Effects of diet on short-term regulation of feed intake by lactating dairy cattle","volume":"83","author":"Allen","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.1093\/jn\/135.9.2206_bib48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.physbeh.2004.01.007","article-title":"Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats","volume":"81","author":"Horn","year":"2004","journal-title":"Physiol. Behav."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622104025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622104025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/135\/9\/2206\/23894460\/z4w00905002206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T23:53:21Z","timestamp":1686614001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622104025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0022316622104025"],"URL":"https:\/\/doi.org\/10.1093\/jn\/135.9.2206","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phlorizin Administration Increases Hepatic Gluconeogenic Enzyme mRNA Abundance but Not Feed Intake in Late-Lactation Dairy Cows","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/135.9.2206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}