{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:48:22Z","timestamp":1694753302281},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":6152,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1093\/jn\/136.4.1017","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T06:33:07Z","timestamp":1516084387000},"page":"1017-1020","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reduced Ornithine Transcarbamylase Activity Does Not Impair Ureagenesis in Otc Mice"],"prefix":"10.1016","volume":"136","author":[{"given":"Juan C","family":"Marini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Garlick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/136.4.1017_bib1","series-title":"The metabolic and molecular bases of inherited disease.","article-title":"Urea cycle enzymes","author":"Brusilow","year":"2001"},{"key":"10.1093\/jn\/136.4.1017_bib2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/oxfordjournals.jhered.a108500","article-title":"A new allele of the sparse fur gene in the mouse","volume":"65","author":"Doolittle","year":"1974","journal-title":"J Hered."},{"key":"10.1093\/jn\/136.4.1017_bib3","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1073\/pnas.86.11.4142","article-title":"The spf-ash mouse: A missense mutation in the ornithine transcarbamylase gene also causes aberrant mRNA splicing","volume":"86","author":"Hodges","year":"1989","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1093\/jn\/136.4.1017_bib4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.6623083","article-title":"Biogenesis of ornithine transcarbamylase in spfash mutant mice: two cytoplasmic precursors, one mitochondrial enzyme","volume":"222","author":"Rosenberg","year":"1983","journal-title":"Science."},{"key":"10.1093\/jn\/136.4.1017_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0167-4781(88)90128-5","article-title":"Compared expression levels of ornithine transcarbamylase and carbamylphosphate Synthetase in liver and small-intestine of normal and mutant mice","volume":"950","author":"Dubois","year":"1988","journal-title":"Biochim Biophys Acta."},{"key":"10.1093\/jn\/136.4.1017_bib6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0167-4838(82)90136-4","article-title":"Ornithine transcarbamylase deficiencies in human males. kinetic and immunochemical classification","volume":"704","author":"Briand","year":"1982","journal-title":"Biochim Biophys Acta."},{"key":"10.1093\/jn\/136.4.1017_bib7","first-page":"743","article-title":"The sparse fur mouse as a model for gene therapy in ornithine carbamoyltransferase deficiency","volume":"2","author":"Batshaw","year":"1995","journal-title":"Gene Ther."},{"key":"10.1093\/jn\/136.4.1017_bib8","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ymthe.2004.05.036","article-title":"Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus","volume":"10","author":"Mian","year":"2004","journal-title":"Mol Ther."},{"key":"10.1093\/jn\/136.4.1017_bib9","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/(SICI)1097-0231(19991115)13:21<2080::AID-RCM755>3.0.CO;2-O","article-title":"Quantitation of blood and plasma amino acids using isotope dilution electron impact gas chromatography\/mass spectrometry with U-(13)C amino acids as internal standards","volume":"13","author":"Calder","year":"1999","journal-title":"Rapid Commun Mass Spectrom."},{"key":"10.1093\/jn\/136.4.1017_bib10","first-page":"40","article-title":"Non-surgical alternatives to invasive procedures in mice","author":"Marini","year":"2006","journal-title":"Lab Anim."},{"key":"10.1093\/jn\/136.4.1017_bib11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/jn\/136.1.202","article-title":"In vivo urea kinetic studies in conscious mice","volume":"136","author":"Marini","year":"2006","journal-title":"J Nutr."},{"key":"10.1093\/jn\/136.4.1017_bib12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1177\/0148607183007006582","article-title":"Total parenteral nutrition in the mouse: development of a technique","volume":"7","author":"Sitren","year":"1983","journal-title":"J Parenter Enteral Nutr."},{"key":"10.1093\/jn\/136.4.1017_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1023\/A:1005315531630","article-title":"Symptomatic ornithine carbamoyltransferase deficiency (point mutation H202P) with normal in vitro activity","volume":"21","author":"Staudt","year":"1998","journal-title":"J Inherit Metab Dis."},{"key":"10.1093\/jn\/136.4.1017_bib14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1023\/A:1005397329395","article-title":"Mutation of ornithine transcarbamylase (H136R) in a girl with severe intermittent orotic aciduria but normal enzyme activity","volume":"20","author":"Vella","year":"1997","journal-title":"J Inherit Metab Dis."},{"key":"10.1093\/jn\/136.4.1017_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/bj2570251","article-title":"Altered enzyme activities and citrulline synthesis in liver mitochondria from ornithine carbamoyltransferase-deficient sparse-fur ash mice","volume":"257","author":"Cohen","year":"1989","journal-title":"Biochem J."},{"key":"10.1093\/jn\/136.4.1017_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0925-4439(94)00007-D","article-title":"Importance of ornithine transcarbamylase (OTC) deficiency in small intestine for urinary orotic acid excretion: analysis of OTC-deficient spf-ash mice with OTC transgene","volume":"1270","author":"Saheki","year":"1995","journal-title":"Biochim Biophys Acta."},{"key":"10.1093\/jn\/136.4.1017_bib17","doi-asserted-by":"crossref","first-page":"2791S","DOI":"10.1093\/jn\/134.10.2791S","article-title":"Renal arginine metabolism","volume":"134","author":"Brosnan","year":"2004","journal-title":"J Nutr."},{"key":"10.1093\/jn\/136.4.1017_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-4439(99)00048-4","article-title":"Aberrations of ammonia metabolism in ornithine carbamoyltransferase-deficient spf-ash mice and their prevention by treatment with urea cycle intermediate amino acids and an ornithine aminotransferase inactivator","volume":"1455","author":"Li","year":"1999","journal-title":"Biochim Biophys Acta."},{"key":"10.1093\/jn\/136.4.1017_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000059860","article-title":"No increase of ornithine concentration in the liver of ornithine transcarbamylase-deficient spf-ash mice following intraperitoneal injection of ammonium chloride","volume":"121","author":"Saheki","year":"1997","journal-title":"Contrib Nephrol."},{"key":"10.1093\/jn\/136.4.1017_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF01996075","article-title":"Protection against lethal ammonia intoxication - synergism between endogenous ornithine and L\u2013carnitine","volume":"9","author":"Sarhan","year":"1994","journal-title":"Metab Brain Dis."},{"key":"10.1093\/jn\/136.4.1017_bib21","first-page":"G290","article-title":"Mechanism of arginine protection against ammonia intoxication in the rat","volume":"247","author":"Goodman","year":"1984","journal-title":"Am J Physiol."},{"key":"10.1093\/jn\/136.4.1017_bib22","article-title":"Synthesis of the urea by means of isolated hepatocytes from Spf-Ash mice (mutation for ornithine transcarbamylase)","volume":"10","author":"Rabier","year":"1984","journal-title":"Diabetes Metab."},{"key":"10.1093\/jn\/136.4.1017_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0020-711X(85)90146-6","article-title":"Does ornithine stimulate carbamoylphosphate synthetase?","volume":"17","author":"Banko","year":"1985","journal-title":"Int J Biochem."},{"key":"10.1093\/jn\/136.4.1017_bib24","doi-asserted-by":"crossref","first-page":"10248","DOI":"10.1016\/S0021-9258(19)70456-6","article-title":"The effects of ornithine on mitochondrial carbamyl-phosphate synthesis","volume":"255","author":"Cohen","year":"1980","journal-title":"J Biol Chem."},{"key":"10.1093\/jn\/136.4.1017_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1432-1033.1982.tb05909.x","article-title":"Activity of carbamoyl-phosphate synthetase (ammonia) in isolated rat-liver mitochondria - cycling of carbamoyl phosphate in the absence of ornithine","volume":"124","author":"Lof","year":"1982","journal-title":"Eur J Biochem."},{"key":"10.1093\/jn\/136.4.1017_bib26","doi-asserted-by":"crossref","first-page":"14684","DOI":"10.1016\/S0021-9258(18)77356-0","article-title":"Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice","volume":"265","author":"Jones","year":"1990","journal-title":"J Biol Chem."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622081895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622081895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/136\/4\/1017\/23893646\/1017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T13:06:51Z","timestamp":1686575211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622081895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0022316622081895"],"URL":"https:\/\/doi.org\/10.1093\/jn\/136.4.1017","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Ornithine Transcarbamylase Activity Does Not Impair Ureagenesis in Otcspf-ash Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/136.4.1017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}