{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:47:30Z","timestamp":1793789250177,"version":"4.6.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":5579,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1093\/jn\/137.11.2346","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T07:44:29Z","timestamp":1516175069000},"page":"2346-2350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Loss-of-Function Mutation in Carotenoid 15,15\u00b4-Monooxygenase Identified in a Patient with Hypercarotenemia and Hypovitaminosis A"],"prefix":"10.1016","volume":"137","author":[{"given":"Annika","family":"Lindqvist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sharvill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis E.","family":"Sharvill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/137.11.2346_bib1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.149.3686.879","article-title":"Biosynthesis of vitamin A with rat intestinal enzymes","volume":"149","author":"Goodman","year":"1965","journal-title":"Science"},{"key":"10.1093\/jn\/137.11.2346_bib2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1073\/pnas.54.5.1364","article-title":"The enzymatic cleavage of \u03b2-carotene into vitamin A by soluble enzymes of rat liver and intestine","volume":"54","author":"Olson","year":"1965","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/jn\/137.11.2346_bib3","series-title":"The retinoids","first-page":"232","article-title":"Retinol and retinoic acid metabolism","author":"Blaner","year":"1994"},{"key":"10.1093\/jn\/137.11.2346_bib4","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1172\/JCI105468","article-title":"The intestinal absorption and metabolism of vitamin A and \u03b2-carotene in man","volume":"45","author":"Goodman","year":"1966","journal-title":"J Clin Invest"},{"key":"10.1093\/jn\/137.11.2346_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/00365516709090648","article-title":"Studies on the intestinal absorption of radioactive \u03b2-carotene and vitamin A in man. Conversion of \u03b2-carotene into vitamin A","volume":"19","author":"Blomstrand","year":"1967","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1093\/jn\/137.11.2346_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/ajcn\/48.2.298","article-title":"Bioavailability of \u03b2-carotene in humans","volume":"48","author":"Dimitrov","year":"1988","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 3","key":"10.1093\/jn\/137.11.2346_bib7","first-page":"S32","article-title":"Absorption of \u03b2-carotene and other carotenoids in humans and animal models","volume":"50","author":"van Vliet","year":"1996","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/jn\/137.11.2346_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.nutr.18.1.19","article-title":"Bioavailability and bioconversion of carotenoids","volume":"18","author":"Castenmiller","year":"1998","journal-title":"Annu Rev Nutr"},{"key":"10.1093\/jn\/137.11.2346_bib9","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/clinchem\/20.12.1578","article-title":"Transport of \u03b2-carotene in serum of individuals with carotenemia","volume":"20","author":"Matthews-Roth","year":"1974","journal-title":"Clin Chem"},{"key":"10.1093\/jn\/137.11.2346_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0022-2275(20)34917-8","article-title":"The transport of \u03b1-tocopherol and \u03b2-carotene in human blood","volume":"17","author":"Bjornson","year":"1976","journal-title":"J Lipid Res"},{"key":"10.1093\/jn\/137.11.2346_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/ajcn\/67.1.81","article-title":"Effect of menstrual cycle phase on the concentration of individual carotenoids in lipoproteins of premenopausal women: a controlled dietary study","volume":"67","author":"Forman","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.11.2346_bib12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/002215540405200407","article-title":"Cell type-specific expression of \u03b2-carotene 15,15\u00b4-mono-oxygenase in human tissues","volume":"52","author":"Lindqvist","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"10.1093\/jn\/137.11.2346_bib13","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1096\/fasebj.3.8.2656356","article-title":"Biological actions of carotenoids","volume":"3","author":"Bendich","year":"1989","journal-title":"FASEB J"},{"key":"10.1093\/jn\/137.11.2346_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nm1097-1061","article-title":"Clinical research and the human condition: moving from observation to practice","volume":"3","author":"Sommer","year":"1997","journal-title":"Nat Med"},{"key":"10.1093\/jn\/137.11.2346_bib15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.7326\/0003-4819-48-2-219","article-title":"Observations on carotenemia","volume":"48","author":"Cohen","year":"1958","journal-title":"Ann Intern Med"},{"key":"10.1093\/jn\/137.11.2346_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000254405","article-title":"Etat keratodermique avec taux serique abaisse de la vitamine A et hypercarotinemie","volume":"132","author":"Frenk","year":"1965","journal-title":"Dermatologica"},{"key":"10.1093\/jn\/137.11.2346_bib17","first-page":"605","article-title":"Familial hypercarotinaemia and hypovitaminosis A","volume":"63","author":"Sharvill","year":"1970","journal-title":"Proc R Soc Med"},{"key":"10.1093\/jn\/137.11.2346_bib18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1001\/archpedi.1971.02100150052002","article-title":"Failure of enzymic cleavage of \u03b2-carotene. The cause of vitamin A deficiency in a child","volume":"121","author":"McLaren","year":"1971","journal-title":"Am J Dis Child"},{"key":"10.1093\/jn\/137.11.2346_bib19","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2133.1982.tb04546.x","article-title":"Metabolic carotenaemia","volume":"106","author":"Monk","year":"1982","journal-title":"Br J Dermatol"},{"key":"10.1093\/jn\/137.11.2346_bib20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2340\/00015555757071","article-title":"Metabolic carotenemia and carotenoderma in a child","volume":"75","author":"Svensson","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"10.1093\/jn\/137.11.2346_bib21","doi-asserted-by":"crossref","first-page":"23942","DOI":"10.1074\/jbc.M202756200","article-title":"Biochemical properties of purified recombinant human \u03b2-carotene 15,15\u00b4-monooxygenase","volume":"277","author":"Lindqvist","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.11.2346_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0076-6879(96)66024-8","article-title":"Using CLUSTAL for multiple sequence alignments","volume":"266","author":"Higgins","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1093\/jn\/137.11.2346_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/geno.2000.6476","article-title":"Cloning and characterization of a human \u03b2,\u03b2-carotene-15,15\u00b4-dioxygenase that is highly expressed in retinal pigment epithelium","volume":"72","author":"Yan","year":"2001","journal-title":"Genomics"},{"key":"10.1093\/jn\/137.11.2346_bib24","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1096\/fj.02-0690fje","article-title":"Identification of \u03b2-carotene 15,15\u00b4-monooxygenase as a peroxisome proliferator-activated receptor target gene","volume":"17","author":"Boulanger","year":"2003","journal-title":"FASEB J"},{"key":"10.1093\/jn\/137.11.2346_bib25","doi-asserted-by":"crossref","first-page":"29217","DOI":"10.1074\/jbc.M500409200","article-title":"Key role of conserved histidines in recombinant mouse \u03b2-carotene 15,15\u00b4-monooxygenase-1 activity","volume":"280","author":"Poliakov","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.11.2346_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1126\/science.1108965","article-title":"The structure of a retinal-forming carotenoid oxygenase","volume":"308","author":"Kloer","year":"2005","journal-title":"Science"},{"key":"10.1093\/jn\/137.11.2346_bib27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0009-2797(00)00221-0","article-title":"Subunit communication in tetrameric class 2 human liver aldehyde dehydrogenase as the basis for half-of-the-site reactivity and the dominance of the oriental subunit in a heterotetramer","volume":"130\u2013132","author":"Weiner","year":"2001","journal-title":"Chem Biol Interact"},{"key":"10.1093\/jn\/137.11.2346_bib28","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1172\/JCI113875","article-title":"Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant","volume":"83","author":"Crabb","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1093\/jn\/137.11.2346_bib29","series-title":"The metabolic and molecular bases of inherited disease","first-page":"2991","article-title":"Disorders of heme biosynthesis: X-linked sideroblastic anemia and porphyrias","author":"Anderson","year":"2001"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622094111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622094111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/137\/11\/2346\/23900942\/2346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T15:28:12Z","timestamp":1693495692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622094111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0022316622094111"],"URL":"https:\/\/doi.org\/10.1093\/jn\/137.11.2346","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss-of-Function Mutation in Carotenoid 15,15\u00b4-Monooxygenase Identified in a Patient with Hypercarotenemia and Hypovitaminosis A","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/137.11.2346","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}