{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:07:02Z","timestamp":1774426022295,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":5579,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1093\/jn\/137.11.2481","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T07:43:53Z","timestamp":1516175033000},"page":"2481-2484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Disappearance of Cobalamin Absorption Testing: A Critical Diagnostic Loss"],"prefix":"10.1016","volume":"137","author":[{"given":"Ralph","family":"Carmel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/137.11.2481_bib1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0002-9343(79)90646-6","article-title":"Aspects of vitamin B12 and folate metabolism in malabsorption syndrome","volume":"67","author":"Lindenbaum","year":"1979","journal-title":"Am J Med"},{"key":"10.1093\/jn\/137.11.2481_bib2","series-title":"Modern nutrition in health and disease","first-page":"482","article-title":"Cobalamin (vitamin B12)","author":"Carmel","year":"2006"},{"key":"10.1093\/jn\/137.11.2481_bib3","series-title":"The megaloblastic anaemias","author":"Chanarin","year":"1979"},{"key":"10.1093\/jn\/137.11.2481_bib4","first-page":"23","article-title":"Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies","volume":"5","author":"Carmel","year":"2006","journal-title":"Curr Hematol Rep"},{"key":"10.1093\/jn\/137.11.2481_bib5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0016-5085(73)80002-2","article-title":"Impaired assimilation of egg Co57 vitamin B12 in patients with hypochlorhydria and achlorhydria and after gastric resection","volume":"64","author":"Doscherholmen","year":"1973","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/137.11.2481_bib6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0950-3536(05)80224-0","article-title":"Malabsorption of food cobalamin","volume":"8","author":"Carmel","year":"1995","journal-title":"Baillieres Clin Haematol"},{"key":"10.1093\/jn\/137.11.2481_bib7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/ajcn\/66.4.750","article-title":"Cobalamin, the stomach, and aging","volume":"66","author":"Carmel","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.11.2481_bib8","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/gut.47.5.638","article-title":"Heterogeneity of gastric histology and function in food cobalamin malabsorption: absence of atrophic gastritis and achlorhydria in some patients with severe malabsorption","volume":"47","author":"Cohen","year":"2000","journal-title":"Gut"},{"key":"10.1093\/jn\/137.11.2481_bib9","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0016-5085(91)90731-Y","article-title":"Reversal of protein-bound vitamin B12 malabsorption with antibiotics in atrophic gastritis","volume":"101","author":"Suter","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/137.11.2481_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1572-0241.2001.03453.x","article-title":"Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis","volume":"96","author":"Carmel","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1093\/jn\/137.11.2481_bib11","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archinte.1996.00040041097008","article-title":"Prevalence of undiagnosed pernicious anemia in the elderly","volume":"156","author":"Carmel","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1093\/jn\/137.11.2481_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.med.51.1.357","article-title":"Current concepts in cobalamin deficiency","volume":"51","author":"Carmel","year":"2000","journal-title":"Annu Rev Med"},{"key":"10.1093\/jn\/137.11.2481_bib13","first-page":"541","article-title":"Tests for pernicious anemia: the \u201cSchilling test.\u201d","volume":"58","author":"Fairbanks","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"10.1093\/jn\/137.11.2481_bib14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0002-9343(83)91064-1","article-title":"Relapses after interruption of cyanocobalamin therapy in patients with pernicious anemia","volume":"74","author":"Savage","year":"1983","journal-title":"Am J Med"},{"key":"10.1093\/jn\/137.11.2481_bib15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ajcn\/68.2.328","article-title":"Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects","volume":"68","author":"van Asselt","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.11.2481_bib16","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1532-5415.1996.tb01866.x","article-title":"Free and protein-bound cobalamin absorption in healthy middle-aged and older subjects","volume":"44","author":"van Asselt","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"10.1093\/jn\/137.11.2481_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1096-8652(199809)59:1<42::AID-AJH8>3.0.CO;2-#","article-title":"Food-bound B12 absorption and serum total homocysteine in patients with low serum B12 levels","volume":"59","author":"Miller","year":"1998","journal-title":"Am J Hematol"},{"key":"10.1093\/jn\/137.11.2481_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-2796.1997.tb00005.x","article-title":"Schilling and protein-bound cobalamin absorption tests are poor instruments for diagnosing cobalamin malabsorption","volume":"241","author":"Lindgren","year":"1997","journal-title":"J Intern Med"},{"key":"10.1093\/jn\/137.11.2481_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/jn\/137.2.373","article-title":"Very low oral doses of vitamin B-12 increase serum concentrations in elderly subjects with food-bound vitamin B-12 malabsorption","volume":"137","author":"Blacher","year":"2007","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.11.2481_bib20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/gut.41.4.475","article-title":"Prospective evaluation of protein-bound vitamin B12 (cobalamin) malabsorption in the elderly using trout flesh labeled in vivo with 57Co-cobalamin","volume":"41","author":"Aimone-Gastin","year":"1997","journal-title":"Gut"},{"key":"10.1093\/jn\/137.11.2481_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0002-9343(01)00792-6","article-title":"Oral cobalamin therapy for the treatment of patients with food cobalamin malabsorption","volume":"111","author":"Andr\u00e8s","year":"2001","journal-title":"Am J Med"},{"key":"10.1093\/jn\/137.11.2481_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-2257.2003.00515.x","article-title":"Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients","volume":"25","author":"Andr\u00e8s","year":"2003","journal-title":"Clin Lab Haematol"},{"key":"10.1093\/jn\/137.11.2481_bib23","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.amjmed.2005.02.026","article-title":"Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment","volume":"118","author":"Andr\u00e8s","year":"2005","journal-title":"Am J Med"},{"key":"10.1093\/jn\/137.11.2481_bib24","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1373\/clinchem.2003.025916","article-title":"Recombinant human intrinsic factor expressed in plants is suitable for use in measurement of vitamin B12","volume":"49","author":"Bor","year":"2003","journal-title":"Clin Chem"},{"key":"10.1093\/jn\/137.11.2481_bib25","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1073\/pnas.0601251103","article-title":"Human vitamin B12 absorption measured by accelerator mass spectrometry using specifically labeled 14C-cobalamin","volume":"103","author":"Carkeet","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/jn\/137.11.2481_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/00365510310002013","article-title":"Health technology assessment in clinical biochemistry. Methylmalonic acid: a Danish showcase","volume":"63","author":"Hvas","year":"2003","journal-title":"Scand J Clin Lab Invest"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622094329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622094329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/137\/11\/2481\/23901589\/2481.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T20:22:00Z","timestamp":1686601320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622094329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0022316622094329"],"URL":"https:\/\/doi.org\/10.1093\/jn\/137.11.2481","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Disappearance of Cobalamin Absorption Testing: A Critical Diagnostic Loss","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/137.11.2481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}