{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:38:55Z","timestamp":1782124735968,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":5550,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1093\/jn\/137.12.2686","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T07:43:26Z","timestamp":1516175006000},"page":"2686-2690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Retinoic Acid Modulates Hepatic Iron Homeostasis in Rats by Attenuating the RNA-Binding Activity of Iron Regulatory Proteins ,"],"prefix":"10.1016","volume":"137","author":[{"given":"Stacy E.","family":"Schroeder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju B.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Schalinske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/137.12.2686_bib1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1001\/jama.1926.02680070022006","article-title":"The relation of anemia, primary and secondary, to vitamin A deficiency","volume":"87","author":"Koessler","year":"1926","journal-title":"J Am Med Assoc"},{"key":"10.1093\/jn\/137.12.2686_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/ajcn\/66.1.177","article-title":"Weekly micronutrient supplementation to build iron stores in female Indonesian adolescents","volume":"66","author":"Angeles-Agdeppa","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib3","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/oxfordjournals.aje.a115231","article-title":"A prevalence study of vitamin A deficiency and xerophthalmia in northeastern Thailand","volume":"129","author":"Bloem","year":"1989","journal-title":"Am J Epidemiol"},{"key":"10.1093\/jn\/137.12.2686_bib4","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/ajcn\/85.5.1375","article-title":"Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women","volume":"85","author":"Graham","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1749-6632.1980.tb21327.x","article-title":"Vitamin A deficiency and abnormal metabolism of iron","volume":"355","author":"Hodges","year":"1980","journal-title":"Ann N Y Acad Sci"},{"key":"10.1093\/jn\/137.12.2686_bib6","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/jn\/130.5.1291","article-title":"Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats","volume":"130","author":"Jang","year":"2000","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/jn\/135.1.27","article-title":"Low vitamin A intake affects milk iron level and iron transporters in rat mammary gland and liver","volume":"135","author":"Kelleher","year":"2005","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/ajcn\/30.7.1175","article-title":"Vitamin A deficiency and anemia in Central American children","volume":"30","author":"Majia","year":"1977","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jn\/109.1.129","article-title":"Role of vitamin A in the absorption, retention, and distribution of iron in the rat","volume":"109","author":"Mejia","year":"1979","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0955-2863(00)00070-X","article-title":"Indicators of erythrocyte formation and degradation in rats with either vitamin A or iron deficiency","volume":"11","author":"Roodenburg","year":"2000","journal-title":"J Nutr Biochem"},{"key":"10.1093\/jn\/137.12.2686_bib11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1079\/BJN19960165","article-title":"Supplemental vitamin A enhances the recovery from iron deficiency in rats with chronic vitamin A deficiency","volume":"75","author":"Roodenburg","year":"1996","journal-title":"Br J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1079\/BJN19940176","article-title":"Comparison between time-dependent changes in iron metabolism of rats as induced by marginal deficiency of either vitamin A or iron","volume":"71","author":"Roodenburg","year":"1994","journal-title":"Br J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib13","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/jn\/129.6.1223","article-title":"Iron deficiency in young rats alters the distribution of vitamin A between plasma and liver and between hepatic retinol and retinyl esters","volume":"129","author":"Rosales","year":"1999","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.ejcn.1601320","article-title":"The anemia of vitamin A deficiency: epidemiology and pathogenesis","volume":"56","author":"Semba","year":"2002","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib15","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1079\/BJN19930173","article-title":"Iron status in rats fed on diets containing marginal amounts of vitamin A","volume":"70","author":"Sijtsma","year":"1993","journal-title":"Br J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib16","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1093\/jn\/132.12.3607","article-title":"Iron deficiency and marginal vitamin A deficiency affect growth, hematological indices and the regulation of iron metabolism genes in rats","volume":"132","author":"Strube","year":"2002","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/ajcn\/51.1.76","article-title":"Vitamin A intervention: short-term effects of a single, oral, massive dose on iron metabolism","volume":"51","author":"Bloem","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0167-4889(92)90043-B","article-title":"Effect of iron and retinoic acid on the control of transferrin receptor and ferritin in the human promonocytic cell line U937","volume":"1133","author":"Iturralde","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"10.1093\/jn\/137.12.2686_bib19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/sj.ejcn.1600684","article-title":"Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh","volume":"53","author":"Kolsteren","year":"1999","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/ajcn\/36.1.87","article-title":"The effect of vitamin A fortification of sugar on iron metabolism in preschool children of Guatemala","volume":"36","author":"Mejia","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/ajcn\/48.3.595","article-title":"Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron","volume":"48","author":"Mejia","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0955-2863(95)00180-8","article-title":"Vitamin A status affects the efficacy of iron repletion in rats with mild iron deficiency","volume":"7","author":"Roodenburg","year":"1996","journal-title":"J Nutr Biochem"},{"key":"10.1093\/jn\/137.12.2686_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0271-5317(05)80017-X","article-title":"Impact of vitamin A supplementation on hematological indicators of iron metabolism and protein status in children","volume":"12","author":"Semba","year":"1992","journal-title":"Nutr Res"},{"key":"10.1093\/jn\/137.12.2686_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/1028415021000056041","article-title":"Effect of retinoic acid on ferritin H expression during brain development and neuronal differentiation","volume":"6","author":"Vanlandingham","year":"2003","journal-title":"Nutr Neurosci"},{"key":"10.1093\/jn\/137.12.2686_bib25","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1146\/annurev.nutr.20.1.627","article-title":"Iron regulatory proteins and the molecular control of mammalian iron metabolism","volume":"20","author":"Eisenstein","year":"2000","journal-title":"Annu Rev Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib26","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/jn\/128.12.2295","article-title":"Iron regulatory proteins, iron responsive elements and iron homeostasis","volume":"128","author":"Eisenstein","year":"1998","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib27","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1093\/jn\/133.11.3392","article-title":"Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells","volume":"133","author":"Rowling","year":"2003","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib28","first-page":"A1500","article-title":"Retinoic acid decreases the RNA binding activity of hepatic iron regulatory proteins","volume":"19","author":"Schroeder","year":"2005","journal-title":"FASEB J"},{"key":"10.1093\/jn\/137.12.2686_bib29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1093\/jn\/137.12.2686_bib30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/jn\/128.3.525","article-title":"Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver","volume":"128","author":"Chen","year":"1998","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/jn\/127.2.238","article-title":"Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver","volume":"127","author":"Chen","year":"1997","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib32","doi-asserted-by":"crossref","first-page":"27363","DOI":"10.1016\/S0021-9258(19)74258-6","article-title":"Iron-responsive element-binding protein. Phosphorylation by protein kinase C","volume":"268","author":"Eisenstein","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.12.2686_bib33","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1074\/jbc.271.12.7168","article-title":"Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells","volume":"271","author":"Schalinske","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.12.2686_bib34","first-page":"649","article-title":"A study on reaction mechanism of sodium lauryl sulfate-hemoglobin, Part 1","volume":"40","author":"Hamaguchi","year":"1992","journal-title":"Rinsho Byori"},{"key":"10.1093\/jn\/137.12.2686_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0009-9120(82)91069-4","article-title":"New method for hemoglobin determination by using sodium lauryl sulfate (SLS)","volume":"15","author":"Oshiro","year":"1982","journal-title":"Clin Biochem"},{"key":"10.1093\/jn\/137.12.2686_bib36","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/ajcn\/54.4.723","article-title":"Assessment of dietary determinants of non-heme iron absorption in humans and rats","volume":"54","author":"Reddy","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib37","first-page":"219","article-title":"Use of the modified relative dose response assay in rats and its application to humans for the measurement of vitamin A status","volume":"44","author":"Tanumihardjo","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/jn\/137.12.2686_bib38","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1074\/jbc.273.13.7588","article-title":"Regulation of iron regulatory protein 1 during hypoxia and hypoxia\/reoxygenation","volume":"273","author":"Hanson","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.12.2686_bib39","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/abbi.1995.1019","article-title":"Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake","volume":"316","author":"Martins","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1093\/jn\/137.12.2686_bib40","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/j.1460-2075.1995.tb07291.x","article-title":"Rapid response to oxidative stress mediated by iron regulatory proteins","volume":"14","author":"Pantopoulos","year":"1995","journal-title":"EMBO J"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622094706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622094706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/137\/12\/2686\/23900317\/2686.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T20:58:34Z","timestamp":1686603514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622094706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0022316622094706"],"URL":"https:\/\/doi.org\/10.1093\/jn\/137.12.2686","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinoic Acid Modulates Hepatic Iron Homeostasis in Rats by Attenuating the RNA-Binding Activity of Iron Regulatory Proteins,","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/137.12.2686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}