{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:01:19Z","timestamp":1790060479700,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":5754,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1093\/jn\/137.5.1132","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T07:17:03Z","timestamp":1516173423000},"page":"1132-1136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Dietary Selenium Affects Homocysteine Metabolism Differently in Fisher-344 Rats and CD-1 Mice ,4"],"prefix":"10.1016","volume":"137","author":[{"given":"Eric O.","family":"Uthus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/137.5.1132_bib1","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1093\/jn\/130.12.2903","article-title":"Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon","volume":"130","author":"Davis","year":"2000","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3181\/00379727-167-41130","article-title":"Evidence for an impairment in the conversion of methionine to cysteine in selenium-deficient chick","volume":"167","author":"Bunk","year":"1981","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1093\/jn\/137.5.1132_bib3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/jn\/114.3.606","article-title":"Selenium deficiency and transsulfuration in the chick","volume":"114","author":"Halpin","year":"1984","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib4","doi-asserted-by":"crossref","first-page":"10668","DOI":"10.1016\/S0021-9258(18)33874-2","article-title":"Effect of selenium deficiency and vitamin E deficiency on glutathione metabolism in isolated rat hepatocytes","volume":"257","author":"Hill","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.5.1132_bib5","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1093\/jn\/132.6.1122","article-title":"Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status","volume":"132","author":"Uthus","year":"2002","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib6","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib7","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/BTER:109:3:201","article-title":"Differential effects of dietary selenium (Se) and folate on methyl metabolism in liver and colon of rats","volume":"109","author":"Uthus","year":"2006","journal-title":"Biol Trace Elem Res"},{"key":"10.1093\/jn\/137.5.1132_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF02783797","article-title":"Mineral status in selenium-deficient rats compared to selenium-sufficient rats fed vitamin-free casein-based or torula yeast-based diet","volume":"37","author":"Zhu","year":"1993","journal-title":"Biol Trace Elem Res"},{"key":"10.1093\/jn\/137.5.1132_bib10","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1093\/jn\/135.11.2627","article-title":"Selenium bioavailability from buckwheat bran in rats fed a modified AIN-93G torula yeast-based diet","volume":"135","author":"Reeves","year":"2005","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0271-5317(96)00062-0","article-title":"Selenium contents of food purchased in North Dakota","volume":"16","author":"Finley","year":"1996","journal-title":"Nutr Res"},{"key":"10.1093\/jn\/137.5.1132_bib12","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1093\/jn\/137.5.1132_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0009-8981(96)06325-5","article-title":"Hyperhomocysteinemia induced by folic acid deficiency and methionine load\u2013applications of a modified HPLC method","volume":"252","author":"Durand","year":"1996","journal-title":"Clin Chim Acta"},{"key":"10.1093\/jn\/137.5.1132_bib14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0003-2697(84)90140-4","article-title":"A rapid high-performance liquid chromatographic procedure for the simultaneous determination of methionine, ethionine, S-adenosylmethionine, S-adenosylethionine, and the natural polyamines in rat tissues","volume":"140","author":"Wagner","year":"1984","journal-title":"Anal Biochem"},{"key":"10.1093\/jn\/137.5.1132_bib15","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0021-9258(18)96205-8","article-title":"Transsulfuration in mammals. The methionine-sparing action of cysteine","volume":"242","author":"Finkelstein","year":"1967","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.5.1132_bib16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0305-0491(85)90278-0","article-title":"Comparative studies on the methionine synthesis in sheep and rat tissues","volume":"80","author":"Xue","year":"1985","journal-title":"Comp Biochem Physiol B"},{"key":"10.1093\/jn\/137.5.1132_bib17","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1073\/pnas.81.12.3631","article-title":"Glycine N-methyltransferase is a folate binding protein of rat liver cytosol","volume":"81","author":"Cook","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/jn\/137.5.1132_bib18","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1093\/jn\/119.4.612","article-title":"Effect of dietary methylgroup deficiency on one-carbon metabolism in rats","volume":"119","author":"Cook","year":"1989","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib19","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.6.10.986","article-title":"Real-time quantitative PCR","volume":"6","author":"Heid","year":"1996","journal-title":"Genome Res"},{"key":"10.1093\/jn\/137.5.1132_bib20","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/jn\/132.2.292","article-title":"Dietary selenium and azadeoxycytidine treatment affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells","volume":"132","author":"Davis","year":"2002","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0955-2863(90)90070-2","article-title":"Methionine metabolism in mammals","volume":"1","author":"Finkelstein","year":"1990","journal-title":"J Nutr Biochem"},{"key":"10.1093\/jn\/137.5.1132_bib22","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0003-9861(85)90019-0","article-title":"Effect of selenium deficiency on the disposition of plasma glutathione","volume":"240","author":"Hill","year":"1985","journal-title":"Arch Biochem Biophys"},{"key":"10.1093\/jn\/137.5.1132_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/jn\/117.1.99","article-title":"Effect of selenium depletion and repletion on plasma glutathione and glutathione-dependent enzymes in the rat","volume":"117","author":"Hill","year":"1987","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0304-4165(87)90051-1","article-title":"Influence of selenium deficiency on glutathione disulfide metabolism in isolated perfused rat heart","volume":"923","author":"Hill","year":"1987","journal-title":"Biochim Biophys Acta"},{"key":"10.1093\/jn\/137.5.1132_bib25","doi-asserted-by":"crossref","first-page":"33766","DOI":"10.1074\/jbc.M504604200","article-title":"Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/137.5.1132_bib26","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/jn\/136.6.1493","article-title":"Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice","volume":"136","author":"Collinsova","year":"2006","journal-title":"J Nutr"},{"key":"10.1093\/jn\/137.5.1132_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jnutbio.2003.10.005","article-title":"Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level","volume":"15","author":"Lee","year":"2004","journal-title":"J Nutr Biochem"},{"key":"10.1093\/jn\/137.5.1132_bib28","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1055\/s-2007-978982","article-title":"Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone","volume":"29","author":"Aida","year":"1997","journal-title":"Horm Metab Res"},{"key":"10.1093\/jn\/137.5.1132_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/cs0910079","article-title":"Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy humans","volume":"91","author":"Loehrer","year":"1996","journal-title":"Clin Sci (Lond)"},{"key":"10.1093\/jn\/137.5.1132_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1357-2725(97)00105-2","article-title":"Structure, function and physiological role of glycine N-methyltransferase","volume":"30","author":"Ogawa","year":"1998","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1093\/jn\/137.5.1132_bib31","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0006-291X(85)80006-1","article-title":"Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism","volume":"127","author":"Wagner","year":"1985","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1093\/jn\/137.5.1132_bib32","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.1021\/bi970159x","article-title":"The homodimeric form of glycine N-methyltransferase acts as a polycyclic aromatic hydrocarbon-binding receptor","volume":"36","author":"Bhat","year":"1997","journal-title":"Biochemistry"},{"key":"10.1093\/jn\/137.5.1132_bib33","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1158\/0008-5472.CAN-03-3726","article-title":"Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway","volume":"64","author":"Chen","year":"2004","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/137.5.1132_bib34","first-page":"640","article-title":"Alteration of glycine N-methyltransferase activity in fetal, adult, and tumor tissues","volume":"35","author":"Heady","year":"1975","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/137.5.1132_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02256001","article-title":"Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies","volume":"10","author":"Liu","year":"2003","journal-title":"J Biomed Sci"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622091994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622091994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/137\/5\/1132\/23898997\/1132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T22:31:34Z","timestamp":1686609094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622091994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0022316622091994"],"URL":"https:\/\/doi.org\/10.1093\/jn\/137.5.1132","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Selenium Affects Homocysteine Metabolism Differently in Fisher-344 Rats and CD-1 Mice,4","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/137.5.1132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}