{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:39:42Z","timestamp":1791221982942,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":5426,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1093\/jn\/138.4.653","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T07:54:02Z","timestamp":1516175642000},"page":"653-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Strain Differences in Mice Highlight the Role of DNA Damage in Neoplasia Induced by Low Dietary Folate"],"prefix":"10.1016","volume":"138","author":[{"given":"Erin","family":"Knock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K.","family":"Lawrance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Rozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/138.4.653_bib1","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1158\/0008-5472.CAN-06-2477","article-title":"Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c","volume":"66","author":"Knock","year":"2006","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/138.4.653_bib2","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","article-title":"Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage","volume":"94","author":"Blount","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/jn\/138.4.653_bib3","series-title":"MTHFR polymorphisms and disease","first-page":"78","article-title":"The molecular dynamics of abnormal folate metabolism and DNA methylation implications for disease susceptibility and progression","author":"James","year":"2004"},{"key":"10.1093\/jn\/138.4.653_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0009-8981(02)00174-2","article-title":"Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker","volume":"322","author":"Wu","year":"2002","journal-title":"Clin Chim Acta"},{"key":"10.1093\/jn\/138.4.653_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"10.1093\/jn\/138.4.653_bib6","first-page":"1249","article-title":"A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer","volume":"63","author":"Heijmans","year":"2003","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/138.4.653_bib7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1093\/jn\/138.4.653_bib8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2307\/3571354","article-title":"The response of twenty-seven inbred strains of mice to daily doses of whole-body x-irradiation","volume":"20","author":"Roderick","year":"1963","journal-title":"Radiat Res"},{"key":"10.1093\/jn\/138.4.653_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2307\/3577229","article-title":"Extrapolation of the relative risk of radiogenic neoplasms across mouse strains and to man","volume":"114","author":"Storer","year":"1988","journal-title":"Radiat Res"},{"key":"10.1093\/jn\/138.4.653_bib10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/carcin\/bgi205","article-title":"Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice","volume":"27","author":"Suzuki","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1093\/jn\/138.4.653_bib11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/ajcn\/82.1.188","article-title":"Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice","volume":"82","author":"Li","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/138.4.653_bib12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1096\/fj.02-0456fje","article-title":"Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency","volume":"17","author":"Schwahn","year":"2003","journal-title":"FASEB J"},{"key":"10.1093\/jn\/138.4.653_bib13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1042\/BJ20030822","article-title":"Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency","volume":"382","author":"Schwahn","year":"2004","journal-title":"Biochem J"},{"key":"10.1093\/jn\/138.4.653_bib14","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1093\/jn\/138.4.653_bib15","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/jn\/136.7.1774","article-title":"Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart","volume":"136","author":"Li","year":"2006","journal-title":"J Nutr"},{"key":"10.1093\/jn\/138.4.653_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0009-8981(96)06325-5","article-title":"Hyperhomocysteinemia induced by folic acid deficiency and methionine load\u2013applications of a modified HPLC method","volume":"252","author":"Durand","year":"1996","journal-title":"Clin Chim Acta"},{"key":"10.1093\/jn\/138.4.653_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/carcin\/24.1.39","article-title":"Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice","volume":"24","author":"Trasler","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1093\/jn\/138.4.653_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2184.1993.tb00328.x","article-title":"A simplified HPLC method for simultaneously quantifying ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues","volume":"26","author":"Cross","year":"1993","journal-title":"Cell Prolif"},{"key":"10.1093\/jn\/138.4.653_bib19","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1172\/JCI113343","article-title":"Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry","volume":"81","author":"Stabler","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1093\/jn\/138.4.653_bib20","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/0026-0495(87)90043-6","article-title":"Homocysteinemia due to folate deficiency","volume":"36","author":"Kang","year":"1987","journal-title":"Metabolism"},{"key":"10.1093\/jn\/138.4.653_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4161\/cc.3.1.595","article-title":"Many fingers on the mitotic trigger: post-translational regulation of the Cdc25C phosphatase","volume":"3","author":"Hutchins","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1093\/jn\/138.4.653_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1535-6108(02)00061-2","article-title":"Altered methylation patterns in cancer cell genomes: cause or consequence?","volume":"1","author":"Baylin","year":"2002","journal-title":"Cancer Cell"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622096341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622096341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/138\/4\/653\/23904874\/653.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T20:22:59Z","timestamp":1686601379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622096341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0022316622096341"],"URL":"https:\/\/doi.org\/10.1093\/jn\/138.4.653","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Strain Differences in Mice Highlight the Role of DNA Damage in Neoplasia Induced by Low Dietary Folate","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/138.4.653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}