{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:53:43Z","timestamp":1784966023631,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1965,3,1]],"date-time":"1965-03-01T00:00:00Z","timestamp":-152668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1965,3]]},"DOI":"10.1093\/jn\/85.3.297","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T10:21:36Z","timestamp":1516616496000},"page":"297-304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Thiamine Requirement in the Adult Human as Measured by Urinary Excretion of Thiamine Metabolites"],"prefix":"10.1016","volume":"85","author":[{"given":"Z.Z.","family":"Ziporin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.T.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.P.","family":"Waring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.E.","family":"Sauberlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/85.3.297_bib1","first-page":"433","article-title":"Further observations on induced thiamine (vitamin B1) deficiency and thiamine requirement of man: preliminary report","volume":"16","author":"Williams","year":"1941","journal-title":"Proc. Staff Meetings Mayo Clinic"},{"key":"10.1093\/jn\/85.3.297_bib2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00000441-194204000-00013","article-title":"Studies of the B vitamins in the human subject. V. The normal requirement for thiamine; some factors influencing its utilization and excretion","volume":"203","author":"Elsom","year":"1942","journal-title":"Am. J. Med. Sci."},{"key":"10.1093\/jn\/85.3.297_bib3","first-page":"323","article-title":"The level of vitamin B-complex in the diet at which detectable symptoms of deficiency occur in man","volume":"2","author":"Foltz","year":"1944","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/85.3.297_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jn\/32.1.1","article-title":"A comparison of thiamine synthesis and excretion in human subjects on synthetic and natural diets","volume":"32","author":"Hathaway","year":"1946","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/jn\/31.2.187","article-title":"Thiamine excretions and blood levels of young women on diets containing varying levels of the B vitamins with some observations on niacin and pantothenic acid","volume":"32","author":"Oldham","year":"1946","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/ajplegacy.1945.144.1.5","article-title":"Experimental studies on man with a restricted intake of the B vitamins","volume":"144","author":"Keys","year":"1945","journal-title":"Am. J. Physiol."},{"key":"10.1093\/jn\/85.3.297_bib7","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1001\/archinte.1942.00200170003001","article-title":"Induced thiamine (vitamin B1) deficiency and the requirement of man. Further observations","volume":"69","author":"Williams","year":"1942","journal-title":"Arch. Int. Med."},{"key":"10.1093\/jn\/85.3.297_bib8","first-page":"1049","article-title":"Influence of various levels of thiamine intake on physiologic response. 2. Urinary excretion of thiamine","volume":"24","author":"Daum","year":"1948","journal-title":"J. Am. Dietet. A."},{"key":"10.1093\/jn\/85.3.297_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/jn\/48.3.297","article-title":"Thiamine metabolism of women on controlled diets. 1. Daily urinary thiamine excretion and its relation to creatinine excretion","volume":"48","author":"Louhi","year":"1952","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0021-9258(17)30902-X","article-title":"Statistical evaluation of the thiamine and pyramin excretions of normal young men on controlled intakes of thiamine","volume":"168","author":"Mickelsen","year":"1947","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/85.3.297_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/jn\/85.3.287","article-title":"Excretion of thiamine and its metabolites in the urine of young adult males receiving restricted intakes of the vitamin","volume":"85","author":"Ziporin","year":"1965","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/jn\/71.3.273","article-title":"The effect of thiamine deficiency on the activity of erythrocyte hemolysate transketolase","volume":"71","author":"Brin","year":"1960","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib13","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1056\/NEJM196209202671204","article-title":"Clinical application of blood transketolase determinations","volume":"267","author":"Dreyfus","year":"1962","journal-title":"New Eng. J. Med."},{"key":"10.1093\/jn\/85.3.297_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/jn\/24.2.131","article-title":"Thiamine clearance as an index of nutritional status","volume":"24","author":"Melnick","year":"1942","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/jn\/18.6.593","article-title":"A quantitative chemical study of the urinary excretion of thiamine by normal individuals","volume":"18","author":"Melnick","year":"1939","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3181\/00379727-44-11367P","article-title":"A test proposed to measure vitamin B1 saturation in humans","volume":"44","author":"Pollack","year":"1940","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1093\/jn\/85.3.297_bib17","first-page":"787","article-title":"Induced vitamin B1 deficiency in human subjects","volume":"14","author":"Williams","year":"1939","journal-title":"Proc. Staff Meetings Mayo Clinic"},{"key":"10.1093\/jn\/85.3.297_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jn\/26.4.399","article-title":"The performance of normal young men on controlled thiamine intakes","volume":"26","author":"Keys","year":"1943","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0002-8223(21)29753-8","article-title":"Influence of various levels of thiamine intake on physiologic response. VII. Thiamine requirements and their implications","volume":"25","author":"Daum","year":"1949","journal-title":"J. Am. Dietet. A."},{"key":"10.1093\/jn\/85.3.297_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/jn\/24.2.139","article-title":"Vitamin B1 (thiamine) requirement of man","volume":"24","author":"Melnick","year":"1942","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/jn\/66.2.173","article-title":"Thiamine requirement of eight adolescent boys, as estimated from urinary thiamine excretion","volume":"66","author":"Dick","year":"1958","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1172\/JCI101709","article-title":"Studies of thiamine metabolism in man. 1. Thiamine balance. The normal requirement of vitamin B1 and the role of fecal thiamine in human nutrition","volume":"25","author":"Alexander","year":"1946","journal-title":"J. Clin. Invest."},{"key":"10.1093\/jn\/85.3.297_bib23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/jn\/27.6.435","article-title":"A study of the riboflavin and thiamine requirement of children of preschool age","volume":"27","author":"Oldham","year":"1944","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-2697(62)90037-4","article-title":"A method for determining the metabolites of thiamine in urine","volume":"3","author":"Ziporin","year":"1962","journal-title":"Analyt. Biochem."},{"key":"10.1093\/jn\/85.3.297_bib25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jama.1943.02840460017005","article-title":"The biosynthesis of thiamine in man and its implications in human nutrition","volume":"123","author":"Najjar","year":"1943","journal-title":"J.A.M.A."},{"key":"10.1093\/jn\/85.3.297_bib26","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1152\/ajplegacy.1947.148.3.618","article-title":"Effects in young men consuming restricted quantities of B-complex vitamins and proteins, and changes associated with supplementation","volume":"148","author":"Berryman","year":"1947","journal-title":"Am. J. Physiol."},{"key":"10.1093\/jn\/85.3.297_bib27","first-page":"109","article-title":"The excretion of B-complex vitamins by normal adults on a restricted intake","volume":"11","author":"Denko","year":"1946","journal-title":"Arch. Biochem."},{"key":"10.1093\/jn\/85.3.297_bib28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/jn\/47.2.275","article-title":"Effect of oral administration of streptomycin on urinary excretion of B vitamins in man","volume":"47","author":"Sarett","year":"1952","journal-title":"J. Nutrition"},{"key":"10.1093\/jn\/85.3.297_bib29","first-page":"100","article-title":"The absorption, destruction, and excretion of orally administered thiamine by human subjects","volume":"11","author":"Friedemann","year":"1948","journal-title":"Gastroenterology"},{"key":"10.1093\/jn\/85.3.297_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0021-9258(17)41112-4","article-title":"The influence of pyrimidines upon the urinary excretion of thiamine and pyramin","volume":"171","author":"Caster","year":"1947","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/85.3.297_bib31","series-title":"The Biochemistry of the B Vitamins","first-page":"690","author":"Williams","year":"1950"},{"key":"10.1093\/jn\/85.3.297_bib32","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1021\/ja01580a054","article-title":"Thiamine metabolism. 1. The metabolism of thiazole-2-C14 thiamine in the rat","volume":"79","author":"Iacono","year":"1957","journal-title":"J. Am. Chem. Soc."},{"key":"10.1093\/jn\/85.3.297_bib33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1073\/pnas.26.6.412","article-title":"The course of thiamine metabolism in man as indicated by the use of radioactive sulfur","volume":"26","author":"Borsook","year":"1940","journal-title":"Proc. Nat. Acad. Sci."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623145846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623145846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/85\/3\/297\/23287406\/jn0850030297.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T02:35:57Z","timestamp":1686623757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623145846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1965,3]]}},"alternative-id":["S0022316623145846"],"URL":"https:\/\/doi.org\/10.1093\/jn\/85.3.297","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1965,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiamine Requirement in the Adult Human as Measured by Urinary Excretion of Thiamine Metabolites","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/85.3.297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1965 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}