{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:16:32Z","timestamp":1756995392266},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1968,11,1]],"date-time":"1968-11-01T00:00:00Z","timestamp":-36806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1968,11]]},"DOI":"10.1093\/jn\/96.3.327","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T08:07:46Z","timestamp":1516262866000},"page":"327-336","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["RNA Polymerase Activities and other Aspects of Hepatic Protein Synthesis during Early Protein Depletion in the Rat"],"prefix":"10.1016","volume":"96","author":[{"given":"Carolyn","family":"Shaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis Charles","family":"Fillios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/96.3.327_bib1","first-page":"157","article-title":"Fine structural changes produced in rat liver by partial starvation","volume":"45","author":"Herdson","year":"1964","journal-title":"Amer. J. Pathol"},{"key":"10.1093\/jn\/96.3.327_bib2","first-page":"353","article-title":"Ultra- structural changes produced by protein and related deficiencies in the rat liver","volume":"45","author":"Svoboda","year":"1964","journal-title":"Amer. J. Pathol"},{"key":"10.1093\/jn\/96.3.327_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1113\/jphysiol.1947.sp004204","article-title":"The effects of changes in dietary protein on the composition and structure of the liver cell","volume":"106","author":"Kosterlitz","year":"1947","journal-title":"J. Physiol. (London)"},{"key":"10.1093\/jn\/96.3.327_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jn\/73.3.199","article-title":"Response of the liver to prolonged protein depletion. I. Liver weight, nitrogen, and deoxyribonucleic acid","volume":"73","author":"Williams","year":"1961","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/96.3.327_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jn\/85.1.73","article-title":"Response of the liver to prolonged protein depletion. V. Neutral glycerides and cholesterol; production of fatty livers by certain amino acids fed in a protein-free ration","volume":"85","author":"Williams","year":"1965","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/96.3.327_bib6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/0006-3002(53)90097-3","article-title":"The effect of level of energy intake on the metabolism of ribonucleic acid and phospholipin in different parts of the liver cell","volume":"11","author":"Wikramanayake","year":"1953","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/96.3.327_bib7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0021-9258(19)50919-X","article-title":"The effect of diet on the rate of loss of labeled amino acid from tissue proteins","volume":"195","author":"Solomon","year":"1952","journal-title":"J. BioL Chem"},{"key":"10.1093\/jn\/96.3.327_bib8","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/1841875a0","article-title":"Effect of protein depletion on the distribution of protein synthesis","volume":"184","author":"Waterlow","year":"1959","journal-title":"Nature"},{"key":"10.1093\/jn\/96.3.327_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3181\/00379727-107-26601","article-title":"Incorporation of S35 from L-methionine in tumor-bearing and protein-depleted rats","volume":"107","author":"Wannemacher","year":"1961","journal-title":"Proc. Soc. Exp. BioL Med"},{"key":"10.1093\/jn\/96.3.327_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/jn\/81.4.427","article-title":"Dietary protein level and the turnover rate of tissue proteins in rats","volume":"81","author":"Muramatsu","year":"1963","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/96.3.327_bib11","first-page":"398","article-title":"General aspects of the regulation of protein metabolism by diet and hormones. Mammalian Protein Metabolism","author":"Munro","year":"1964"},{"key":"10.1093\/jn\/96.3.327_bib12","first-page":"85","article-title":"Effect of protein depletion on ribonucleic acid metabolism in rat liver","volume":"2","author":"Girija","year":"1965","journal-title":"Indian J. Biochem"},{"key":"10.1093\/jn\/96.3.327_bib13","first-page":"531","article-title":"Evidence for two DNA-dependent RNA polymerase activities in isolated rat liver nuclei","volume":"87","author":"Widnell","year":"1964","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/96.3.327_bib14","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1042\/bj0980604","article-title":"Ribonucleic acid synthesis during early action of thyroid hormones","volume":"98","author":"Tata","year":"1966","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/96.3.327_bib15","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0021-9258(17)41275-0","article-title":"A comparison of methods for the estimation of nucleic acids","volume":"164","author":"Schneider","year":"1946","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/96.3.327_bib16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/jn\/85.4.319","article-title":"Effect of protein uptake on RNA metabolism in liver cell nuclei of the rat","volume":"85","author":"Munro","year":"1965","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/96.3.327_bib17","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1073\/pnas.46.8.1020","article-title":"Enzymatic incorporation of ribonucleoside triphosphates into the interpolynucleotide linkages of ribonucleic acid","volume":"46","author":"Weiss","year":"1960","journal-title":"Proc. Nat. Acad. Sci"},{"key":"10.1093\/jn\/96.3.327_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/jn\/95.3.349","article-title":"Hepatic RNA metabolism in male and female obese rats fed cholesterol","volume":"95","author":"Fillios","year":"1968","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/96.3.327_bib19","first-page":"616","article-title":"Polysome profiles obtained from mammalian tissues by an improved procedure. Biochim","volume":"138","author":"Drysdale","year":"1967","journal-title":"Biophys. Acta"},{"key":"10.1093\/jn\/96.3.327_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0021-9258(18)55763-X","article-title":"Uptake of radioactive alanine in vitro in the proteins of rat liver fractions","volume":"195","author":"Siekevitz","year":"1952","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/96.3.327_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/96.3.327_bib22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0005-2787(65)90025-0","article-title":"The estimation of ribonucleic acid using ultraviolet absorption measurements","volume":"108","author":"Fleck","year":"1965","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/96.3.327_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/206093a0","article-title":"An improved method for the estimation of deoxyribonucleic acid","volume":"206","author":"Giles","year":"1963","journal-title":"Nature"},{"key":"10.1093\/jn\/96.3.327_bib24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0079-6603(08)60529-2","article-title":"Tlie nature and biosynthesis of nuclear ribonucleic acid","volume":"6","author":"Georgiev","year":"1967","journal-title":"Prog. Nucl. Acid Res. Mol. Biol"},{"key":"10.1093\/jn\/96.3.327_bib25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1042\/bj0530460","article-title":"The deoxyribonucleic acid content of the rat cell nucleus and its use in expressing the results of tissue analysis, with particular reference to the composition of liver tissue","volume":"53","author":"Thomson","year":"1953","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/96.3.327_bib26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0014-4827(62)90153-2","article-title":"Radiouatographic studies with methionine-*H and cytidine-sH on protein deficiency in mice and rats with special reference to liver cells","volume":"26","author":"Stenram","year":"1962","journal-title":"Exp. Cell Res"},{"key":"10.1093\/jn\/96.3.327_bib27","first-page":"220","article-title":"The nucleolus and the synthesis of ribosomes","volume":"6","author":"Perry","year":"1967","journal-title":"Prog. Nucl. Acid Res. Mol. Biol"},{"key":"10.1093\/jn\/96.3.327_bib28","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/0024-3205(67)90025-2","article-title":"Effect of protein deprivation on soluble and \u201caggregate\u201d RNA polymerase in rat liver","volume":"6","author":"Mandel","year":"1967","journal-title":"Life Sci"},{"key":"10.1093\/jn\/96.3.327_bib29","first-page":"42","article-title":"Characterization of the product of the RNA polymerase of isolated rat liver nuclei","volume":"95","author":"Widnell","year":"1965","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/96.3.327_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0026-0495(66)90026-6","article-title":"Liver RNA polymerase activity in genetically obese and lean rats fed cholesterol","volume":"15","author":"Fillios","year":"1966","journal-title":"Metabolism"},{"key":"10.1093\/jn\/96.3.327_bib31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/jn\/84.2.173","article-title":"Activity of amino acid activating enzymes in tissues from protein-depleted rats","volume":"84","author":"Gaetani","year":"1964","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/96.3.327_bib32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/jn\/83.3.186","article-title":"Effect of protein intake on the ribonucleic acid of liver cell sap","volume":"83","author":"Munro","year":"1964","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/96.3.327_bib33","first-page":"219","article-title":"Incorporation of amino acids by the protein of the postmicrosomal fraction of rat liver","volume":"87","author":"Hird","year":"1964","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/96.3.327_bib34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0024-3205(66)90017-8","article-title":"The influence of protein intake on RNA and protein synthesis in rat liver","volume":"5","author":"Mandel","year":"1966","journal-title":"Life Sci"},{"key":"10.1093\/jn\/96.3.327_bib35","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.150.3696.628","article-title":"Protein synthesis in rat liver: Influence of amino acids in diet on microsomes and polysomes","volume":"150","author":"Fleck","year":"1965","journal-title":"Science"},{"key":"10.1093\/jn\/96.3.327_bib36","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0006-291X(67)80068-8","article-title":"The influence of tryptophan on hepatic polyribosomes and protein synthesis in fasted mice","volume":"27","author":"Sidransky","year":"1967","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/96.3.327_bib37","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1126\/science.146.3645.766","article-title":"Protein synthesis enhanced in the liver of rats force-fed a threonine-devoid diet","volume":"146","author":"Sidransky","year":"1964","journal-title":"Science"},{"key":"10.1093\/jn\/96.3.327_bib38","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1152\/ajplegacy.1965.208.5.882","article-title":"Effects of dietary lipids on hepatic protein synthesis and lipid metabolism in the rat","volume":"208","author":"Saito","year":"1965","journal-title":"Amer, J. Physiol"},{"key":"10.1093\/jn\/96.3.327_bib39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/jn\/96.1.46","article-title":"Changes in cholesterol concentrations in rough and smooth endoplasmic reticulum and polysomal profiles in rats fed cholesterol","volume":"96","author":"Pronczuk","year":"1968","journal-title":"J. Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623050885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623050885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/96\/3\/327\/24057723\/jn0960030327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T20:08:38Z","timestamp":1686859718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623050885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,11]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1968,11]]}},"alternative-id":["S0022316623050885"],"URL":"https:\/\/doi.org\/10.1093\/jn\/96.3.327","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1968,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNA Polymerase Activities and other Aspects of Hepatic Protein Synthesis during Early Protein Depletion in the Rat","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/96.3.327","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1968 American Institute of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}