{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:24:16Z","timestamp":1759541056237},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1969,10,1]],"date-time":"1969-10-01T00:00:00Z","timestamp":-7948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1969,10]]},"DOI":"10.1093\/jn\/99.2.157","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T09:13:13Z","timestamp":1516266793000},"page":"157-167","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Metabolites of Vitamin D3 and Their Biologic Activity"],"prefix":"10.1016","volume":"99","author":[{"given":"G.","family":"Ponchon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.F.","family":"Deluca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/99.2.157_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0083-6729(08)60039-4","article-title":"Mechanism of action and metabolic fate of vitamin D.","volume":"25","author":"DeLuca","year":"1967","journal-title":"Vitamins Hormones"},{"key":"10.1093\/jn\/99.2.157_bib2","series-title":"Ciba Found. Symp. Bone Struct. Metab.","first-page":"161","article-title":"Metabolic studies on vitamin D.","author":"Kodicek","year":"1956"},{"key":"10.1093\/jn\/99.2.157_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0003-9861(64)90349-2","article-title":"Biologically active forms of vitamin D3 in kidney and intestine.","volume":"108","author":"Norman","year":"1964","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1093\/jn\/99.2.157_bib4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0022-2275(20)38950-1","article-title":"Biologically active metabolite of vitamin D3 from bone, liver, and blood serum.","volume":"7","author":"Lund","year":"1966","journal-title":"J. Lipid Res."},{"key":"10.1093\/jn\/99.2.157_bib5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0003-9861(67)90511-5","article-title":"Formation of vitamin D esters in vivo.","volume":"120","author":"Lund","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1093\/jn\/99.2.157_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0003-9861(68)90310-X","article-title":"Synthesis, biological activity and metabolism of 22, 23-3H-vitamin D4.","volume":"124","author":"DeLuca","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1093\/jn\/99.2.157_bib7","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0003-9861(67)90510-3","article-title":"Biological activity of a vitamin D metabolite.","volume":"120","author":"Morii","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1093\/jn\/99.2.157_bib8","first-page":"801","article-title":"25-Hydroxycholecalciferol: a biologically active metabolite of cholecalciferol.","author":"Blunt","year":"1968","journal-title":"Chem. Commun"},{"key":"10.1093\/jn\/99.2.157_bib9","first-page":"3317","article-title":"25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3.","volume":"7","author":"Blunt","year":"1968","journal-title":"Bio-chemistry"},{"key":"10.1093\/jn\/99.2.157_bib10","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1021\/bi00871a007","article-title":"The synthesis of [1,2-3H]-vitamin D3 and the tissue localization of a 0.25 \u03bcg (10 IU) dose per rat.","volume":"5","author":"Neville","year":"1966","journal-title":"Biochemistry"},{"key":"10.1093\/jn\/99.2.157_bib11","unstructured":"U.S. Pharmacopeia, vol. 15 1955 p. 889."},{"key":"10.1093\/jn\/99.2.157_bib12","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1152\/ajplegacy.1963.204.5.833","article-title":"Citrate and action of vitamin D on calcium and phosphorus metabolism.","volume":"204","author":"Guroff","year":"1963","journal-title":"Amer. J. Physiol."},{"key":"10.1093\/jn\/99.2.157_bib13","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification.","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1093\/jn\/99.2.157_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0021-9258(18)64756-8","article-title":"The separation of complex lipide mixtures by the use of silicic acid chromatography.","volume":"233","author":"Hirsch","year":"1958","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/99.2.157_bib15","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1021\/ac60094a004","article-title":"Devices for gradient elution in chromatography.","volume":"26","author":"Bock","year":"1954","journal-title":"Anal. Chem."},{"key":"10.1093\/jn\/99.2.157_bib16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0003-2697(67)90016-4","article-title":"Improved solubilization procedures for liquid scintillation counting of biological materials.","volume":"18","author":"Hansen","year":"1967","journal-title":"Anal. Biochem."},{"key":"10.1093\/jn\/99.2.157_bib17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0003-2697(61)80010-9","article-title":"Determination of C14 and H3 in biological samples by Sch\u00f4niger combustion and liquid scintillation techniques.","volume":"2","author":"Kelly","year":"1961","journal-title":"Anal. Biochem."},{"key":"10.1093\/jn\/99.2.157_bib18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(67)90018-8","article-title":"External standardization in liquid scintillation counting of homogeneous samples labeled with 1, 2 or 3 isotopes.","volume":"18","author":"DeWachter","year":"1967","journal-title":"Anal. Biochem."},{"key":"10.1093\/jn\/99.2.157_bib19","first-page":"501","article-title":"Le precalciferol\u2014ses relations d'\u00e9quilibre avec le calciferol.","volume":"16","author":"Velluz","year":"1949","journal-title":"Bull. Soc. Chim. France, 5-serie"},{"key":"10.1093\/jn\/99.2.157_bib20","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1016\/S0021-9258(18)93278-3","article-title":"The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo.","volume":"243","author":"Haussier","year":"1968","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/99.2.157_bib21","doi-asserted-by":"crossref","DOI":"10.3181\/00379727-131-33962","article-title":"Ethanol-induced artifacts in the metabolism of 3H-vitamin D3.","author":"Ponchon","year":"1969","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1093\/jn\/99.2.157_bib22","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1021\/bi00905a044","article-title":"The preparation of H3 vitamin D3 and D3 and their localization in the rat.","volume":"2","author":"Norman","year":"1963","journal-title":"Biochemistry"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623052999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623052999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/99\/2\/157\/24058189\/jn0990020157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T20:12:00Z","timestamp":1686859920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623052999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,10]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1969,10]]}},"alternative-id":["S0022316623052999"],"URL":"https:\/\/doi.org\/10.1093\/jn\/99.2.157","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1969,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolites of Vitamin D3 and Their Biologic Activity","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/99.2.157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1969 American Institute of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}