{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:49:43Z","timestamp":1788580183179,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":779,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency of Science Technology and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wilmar International Limited"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1093\/jn\/nxaa274","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T19:18:24Z","timestamp":1600456704000},"page":"3141-3151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Two Blends of Refined Rice Bran, Flaxseed, and Sesame Seed Oils Affect the Blood Lipid Profile of Chinese Adults with Borderline Hypercholesterolemia to a Similar Extent as Refined Olive Oil"],"prefix":"10.1016","volume":"150","author":[{"given":"Sumanto","family":"Haldar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long Hui","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shia Lyn","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg J","family":"Jacoby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Ponnalagu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Rong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwee Peng Rebecca","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiani Jeyakumar","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/nxaa274_bib1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease Study 2017.","volume":"392","author":"Roth","year":"2018","journal-title":"Lancet North Am Ed"},{"key":"10.1093\/jn\/nxaa274_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1885-5857(08)60118-8","article-title":"Cardiovascular risk factors: insights from Framingham Heart Study.","volume":"61","author":"O'Donnell","year":"2008","journal-title":"Revista Espanola de Cardiologia (English Edition)"},{"key":"10.1093\/jn\/nxaa274_bib3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study.","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet North Am Ed"},{"key":"10.1093\/jn\/nxaa274_bib4","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel.","volume":"38","author":"Ference","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1093\/jn\/nxaa274_bib5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/jama.2016.13985","article-title":"Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis.","volume":"316","author":"Silverman","year":"2016","journal-title":"JAMA"},{"key":"10.1093\/jn\/nxaa274_bib6","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/jn\/135.9.2075","article-title":"Mechanisms by which dietary fatty acids modulate plasma lipids.","volume":"135","author":"Fernandez","year":"2005","journal-title":"J Nutr"},{"key":"10.1093\/jn\/nxaa274_bib7","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.3390\/nu10111630","article-title":"Influence of bioactive nutrients on the atherosclerotic process: a review.","volume":"10","author":"Casas","year":"2018","journal-title":"Nutrients"},{"key":"10.1093\/jn\/nxaa274_bib8","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1080\/10408398.2018.1438349","article-title":"Comparison of blood lipid-lowering effects of olive oil and other plant oils: a systematic review and meta-analysis of 27 randomized placebocontrolled clinical trials.","volume":"59","author":"Ghobadi","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1093\/jn\/nxaa274_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jff.2017.02.014","article-title":"Contribution of ferulic acid, ? -oryzanol and tocotrienols to the cardiometabolic protective effects of rice bran.","volume":"32","author":"Perez-Ternero","year":"2017","journal-title":"J Funct Foods"},{"key":"10.1093\/jn\/nxaa274_bib10","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1021\/jf5063606","article-title":"Cholesterol-lowering activity of sesamin is associated with down-regulation on genes of sterol transporters involved in cholesterol absorption.","volume":"63","author":"Liang","year":"2015","journal-title":"J Agric Food Chem"},{"key":"10.1093\/jn\/nxaa274_bib11","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1177\/0148607115595980","article-title":"Functional roles of fatty acids and their effects on human health.","volume":"39","author":"Calder","year":"2015","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1093\/jn\/nxaa274_bib12","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s10616-012-9510-x","article-title":"?- Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and -1c expression.","volume":"65","author":"Fukumitsu","year":"2013","journal-title":"Cytotechnology"},{"key":"10.1093\/jn\/nxaa274_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11883-010-0137-0","article-title":"Alpha-linolenic acid: is it essential to cardiovascular health?","volume":"12","author":"Geleijnse","year":"2010","journal-title":"Curr Atheroscler Rep"},{"key":"10.1093\/jn\/nxaa274_bib14","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1003603","article-title":"n\u20133 Fatty acids and cardiovascular events after myocardial infarction.","volume":"363","author":"Kromhout","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1093\/jn\/nxaa274_bib15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3181\/0711-MR-311","article-title":"The importance of the omega-6\/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.","volume":"233","author":"Simopoulos","year":"2008","journal-title":"Exp BiolMed (Maywood)"},{"key":"10.1093\/jn\/nxaa274_bib16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1079\/PHN2005933","article-title":"The Mediterranean-style diet for the prevention of cardiovascular diseases.","volume":"9","author":"de Lorgeril","year":"2006","journal-title":"Public Health Nutr"},{"key":"10.1093\/jn\/nxaa274_bib17","doi-asserted-by":"crossref","DOI":"10.5772\/67407","article-title":"Importance of fatty acids in physiopathology of human body.","author":"Nagy","year":"2017"},{"key":"10.1093\/jn\/nxaa274_bib18","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.jacc.2011.06.063","article-title":"Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.","volume":"58","author":"Mozaffarian","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1093\/jn\/nxaa274_bib19","doi-asserted-by":"crossref","unstructured":"National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): final report. McLean (VA): International Medical Publishing; 2002.","DOI":"10.1001\/jama.285.19.2486"},{"key":"10.1093\/jn\/nxaa274_bib20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1079\/PHN2005898","article-title":"The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity.","volume":"9","author":"Hagstr\u00f6mer","year":"2006","journal-title":"Public Health Nutr"},{"key":"10.1093\/jn\/nxaa274_bib21","unstructured":"The IPAQ Group. Guidelines for data processing and analysis of the International Physical Activity Questionnaire (IPAQ)\u2014short and long forms. 2005 [cited 2020 May 20] [Internet]. Available from: https:\/\/sites.google.com\/site\/theipaq\/scoring-protocol."},{"key":"10.1093\/jn\/nxaa274_bib22","doi-asserted-by":"crossref","first-page":"e020167","DOI":"10.1136\/bmjopen-2017-020167","article-title":"Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women.","volume":"8","author":"Khaw","year":"2018","journal-title":"BMJ Open"},{"key":"10.1093\/jn\/nxaa274_bib23","first-page":"13","article-title":"nparLD: an R software package for the nonparametric analysis of longitudinal data in factorial experiments.","volume":"5","author":"Noguchi","year":"2012","journal-title":"J Stat Soft"},{"key":"10.1093\/jn\/nxaa274_bib24","doi-asserted-by":"crossref","first-page":"99c","DOI":"10.1093\/eurheartj\/ehz785","article-title":"Clinical review on triglycerides.","volume":"41","author":"Laufs","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1093\/jn\/nxaa274_bib25","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1210\/jc.2011-3213","article-title":"Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline.","volume":"97","author":"Berglund","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/jn\/nxaa274_bib26","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0140-6736(57)91998-0","article-title":"Prediction of serum-cholesterol responses of man to changes in fats in the diet.","volume":"270","author":"Keys","year":"1957","journal-title":"Lancet"},{"key":"10.1093\/jn\/nxaa274_bib27","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1001\/jama.2015.5941","article-title":"The 2015 US Dietary Guidelines: lifting the ban on total dietary fat.","volume":"313","author":"Mozaffarian","year":"2015","journal-title":"JAMA"},{"key":"10.1093\/jn\/nxaa274_bib28","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1194\/jlr.P085522","article-title":"Effects of oils and solid fats on blood lipids: a systematic review and network meta-analysis.","volume":"59","author":"Schwingshackl","year":"2018","journal-title":"J Lipid Res"},{"key":"10.1093\/jn\/nxaa274_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/bmj.314.7074.112","article-title":"Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies.","volume":"314","author":"Clarke","year":"1997","journal-title":"BMJ"},{"key":"10.1093\/jn\/nxaa274_bib30","doi-asserted-by":"crossref","first-page":"k2139","DOI":"10.1136\/bmj.k2139","article-title":"Dietary fat and cardiometabolic health: evidence, controversies, and consensus for guidance.","volume":"361","author":"Forouhi","year":"2018","journal-title":"BMJ"},{"key":"10.1093\/jn\/nxaa274_bib31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/ajcn.83.3.575","article-title":"Mediterranean-inspired diet lowers the ratio of serum phospholipid n\u20136 to n\u20133 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects.","volume":"83","author":"Ambring","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/nxaa274_bib32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/jama.284.3.311","article-title":"Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity.","volume":"284","author":"Stamler","year":"2000","journal-title":"JAMA"},{"key":"10.1093\/jn\/nxaa274_bib33","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3945\/ajcn.111.018846","article-title":"Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals.","volume":"94","author":"Tholstrup","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/nxaa274_bib34","first-page":"417","article-title":"Rice bran oil decreases total and LDL cholesterol in humans: a systematic review and meta-analysis of randomized controlled clinical trials.","volume":"48","author":"Jolfaie","year":"2016","journal-title":"HormMetab Res"},{"key":"10.1093\/jn\/nxaa274_bib35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/01.ATV.14.4.549","article-title":"Rice bran oil consumption and plasma lipid levels in moderately hypercholesterolemic humans.","volume":"14","author":"Lichtenstein","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1093\/jn\/nxaa274_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5264\/eiyogakuzashi.28.3","article-title":"Influence of blending of edible fats and oils on human serum cholesterol level (part 1).","volume":"28","author":"Suzuki","year":"1970","journal-title":"Jpn J Nutr Diet"},{"key":"10.1093\/jn\/nxaa274_bib37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jacl.2015.12.011","article-title":"A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients.","volume":"10","author":"Devarajan","year":"2016","journal-title":"J Clin Lipidol"},{"key":"10.1093\/jn\/nxaa274_bib38","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.amjmed.2016.02.044","article-title":"A blend of sesame and rice bran oils lowers hyperglycemia and improves the lipids.","volume":"129","author":"Devarajan","year":"2016","journal-title":"Am J Med"},{"key":"10.1093\/jn\/nxaa274_bib39","first-page":"1059","article-title":"Olive and sesame oil effect on lipid profile in hypercholesterolemic patients, which better?","volume":"4","author":"Namayandeh","year":"2013","journal-title":"Int J Prev Med"},{"key":"10.1093\/jn\/nxaa274_bib40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.clnu.2010.11.005","article-title":"Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus.","volume":"30","author":"Sankar","year":"2011","journal-title":"Clin Nutr"},{"key":"10.1093\/jn\/nxaa274_bib41","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3945\/ajcn.2009.27469","article-title":"Meta-analysis of the effects of flaxseed interventions on blood lipids.","volume":"90","author":"Pan","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/nxaa274_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clnu.2015.11.003","article-title":"Metabolic response to omega-3 fatty acid supplementation in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial.","volume":"36","author":"Soleimani","year":"2017","journal-title":"Clin Nutr"},{"key":"10.1093\/jn\/nxaa274_bib43","first-page":"1679","article-title":"Additive effect of linseed oil supplementation on the lipid profiles of older adults.","volume":"10","author":"Avelino","year":"2015","journal-title":"Clin Intervent Aging"},{"key":"10.1093\/jn\/nxaa274_bib44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12937-015-0023-2","article-title":"Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study.","volume":"14","author":"Kawakami","year":"2015","journal-title":"Nutr J"},{"key":"10.1093\/jn\/nxaa274_bib45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1017\/S0007114510003697","article-title":"Higholeic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects.","volume":"105","author":"Gillingham","year":"2011","journal-title":"Br J Nutr"},{"key":"10.1093\/jn\/nxaa274_bib46","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3945\/ajcn.113.081133","article-title":"DHA-enriched high\u2013oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the Canola Oil Multicenter Randomized Controlled Trial.","volume":"100","author":"Jones","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/nxaa274_bib47","doi-asserted-by":"crossref","first-page":"g2272","DOI":"10.1136\/bmj.g2272","article-title":"Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys.","volume":"348","author":"Micha","year":"2014","journal-title":"BMJ"},{"key":"10.1093\/jn\/nxaa274_bib48","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3945\/ajcn.115.113548","article-title":"Best (but oft-forgotten) practices: the multiple problems of multiplicity\u2014whether and how to correct for many statistical tests.","volume":"102","author":"Streiner","year":"2015","journal-title":"Am J Clin Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622023938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622023938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/150\/12\/3141\/34835010\/nxaa274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/150\/12\/3141\/34835010\/nxaa274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T22:24:35Z","timestamp":1686695075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622023938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0022316622023938"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxaa274","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two Blends of Refined Rice Bran, Flaxseed, and Sesame Seed Oils Affect the Blood Lipid Profile of Chinese Adults with Borderline Hypercholesterolemia to a Similar Extent as Refined Olive Oil","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxaa274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}