{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:01:37Z","timestamp":1793196097562,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Topsector Agri & Food","award":["TKI-AF 12083"],"award-info":[{"award-number":["TKI-AF 12083"]}]},{"name":"TNO roadmap Nutrition & Health"},{"DOI":"10.13039\/100015765","name":"Cereal Partners Worldwide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015765","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dutch Bakery Center"},{"name":"GoodMills Innovation GmbH"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1093\/jn\/nxaa312","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T19:15:10Z","timestamp":1602011710000},"page":"491-502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults"],"prefix":"10.1016","volume":"151","author":[{"given":"Mara P H","family":"van Trijp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Schutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik","family":"Esser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-657X","authenticated-orcid":false,"given":"Suzan","family":"Wopereis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke P M","family":"Hoevenaars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-3542","authenticated-orcid":false,"given":"Guido J E J","family":"Hooiveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-6217","authenticated-orcid":false,"given":"Lydia A","family":"Afman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1093\/jn\/nxaa312_bib1","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1371\/journal.pmed.0040261","article-title":"Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review.","volume":"4","author":"de Munter","year":"2007","journal-title":"PLoS Med."},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.ejcn.1601283","article-title":"Cereal grains and coronary heart disease.","volume":"56","author":"Truswell","year":"2002","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/ajcn\/83.1.124","article-title":"Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults.","volume":"83","author":"Sahyoun","year":"2006","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxaa312_bib4","doi-asserted-by":"crossref","first-page":"585876","DOI":"10.1155\/2013\/585876","article-title":"Increasing whole grain intake as part of prevention and treatment of nonalcoholic fatty liver disease.","volume":"2013","author":"Ross","year":"2013","journal-title":"Int J Endocrinol"},{"issue":"6","key":"10.1093\/jn\/nxaa312_bib5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1177\/1082013211433079","article-title":"Bioactive compounds in cereal grains\u2014occurrence, structure, technological significance and nutritional benefits\u2014a review.","volume":"18","author":"Bart\u0142omiej","year":"2012","journal-title":"Food Sci Technol Int."},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1467-3010.2004.00418.x","article-title":"Nutritional aspects of cereals.","volume":"29","author":"McKevith","year":"2004","journal-title":"Nutr Bull."},{"issue":"6","key":"10.1093\/jn\/nxaa312_bib7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/ajcn\/nqy204","article-title":"A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects.","volume":"108","author":"Schutte","year":"2018","journal-title":"Am J Clin Nutr."},{"issue":"11","key":"10.1093\/jn\/nxaa312_bib8","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3945\/jn.116.230508","article-title":"A whole-grain diet reduces cardiovascular risk factors in overweight and obese adults: a randomized controlled trial.","volume":"146","author":"Kirwan","year":"2016","journal-title":"J Nutr."},{"issue":"4","key":"10.1093\/jn\/nxaa312_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3945\/ajcn.2010.29417","article-title":"Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial.","volume":"92","author":"Tighe","year":"2010","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"10.1093\/jn\/nxaa312_bib10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3945\/ajcn.115.109165","article-title":"Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies.","volume":"102","author":"Holl\u00e6nder","year":"2015","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S0954422410000041","article-title":"New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?","volume":"23","author":"Fardet","year":"2010","journal-title":"Nutr Res Rev."},{"issue":"6","key":"10.1093\/jn\/nxaa312_bib12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"The impact of dietary fiber on gut microbiota in host health and disease.","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe."},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/19490976.2017.1290756","article-title":"Dietary fiber and prebiotics and the gastrointestinal microbiota.","volume":"8","author":"Holscher","year":"2017","journal-title":"Gut microbes."},{"key":"10.1093\/jn\/nxaa312_bib14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.3389\/fmicb.2015.01481","article-title":"Microbial metabolism shifts towards an adverse profile with supplementary iron in the TIM-2 in vitro model of the human colon.","volume":"6","author":"Kortman","year":"2016","journal-title":"Front Microbiol"},{"issue":"10","key":"10.1093\/jn\/nxaa312_bib15","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.3390\/ijms19103097","article-title":"In vitro fermentation of selected prebiotics and their effects on the composition and activity of the adult gut microbiota.","volume":"19","author":"Fehlbaum","year":"2018","journal-title":"IJMS"},{"issue":"33","key":"10.1093\/jn\/nxaa312_bib16","article-title":"The effects of intact cereal grain fibers, including wheat bran on the gut microbiota composition of healthy adults: a systematic review.","volume":"6","author":"Jefferson","year":"2019","journal-title":"Front Nutr."},{"issue":"12","key":"10.1093\/jn\/nxaa312_bib17","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ejcn.2013.207","article-title":"Bifidogenic effect of whole-grain wheat during a 12-week energy-restricted dietary intervention in postmenopausal women.","volume":"67","author":"Christensen","year":"2013","journal-title":"Eur J Clin Nutr."},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1017\/S0007114507793923","article-title":"Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study.","volume":"99","author":"Costabile","year":"2008","journal-title":"Br J Nutr."},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3945\/ajcn.114.088120","article-title":"Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber.","volume":"101","author":"Vitaglione","year":"2015","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"10.1093\/jn\/nxaa312_bib20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3945\/ajcn.116.146928","article-title":"Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults.","volume":"105","author":"Vanegas","year":"2017","journal-title":"Am J Clin Nutr."},{"issue":"5","key":"10.1093\/jn\/nxaa312_bib21","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3945\/jn.112.172668","article-title":"Intake of whole-grain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome.","volume":"143","author":"Lappi","year":"2013","journal-title":"J Nutr."},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3945\/jn.114.202176","article-title":"Increased whole grain consumption does not affect blood biochemistry, body composition, or gut microbiology in healthy, low-habitual whole grain consumers.","volume":"145","author":"Ampatzoglou","year":"2015","journal-title":"J Nutr."},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3390\/nu9020173","article-title":"The effects of moderate whole grain consumption on fasting glucose and lipids, gastrointestinal symptoms, and microbiota.","volume":"9","author":"Cooper","year":"2017","journal-title":"Nutrients"},{"issue":"5","key":"10.1093\/jn\/nxaa312_bib24","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1017\/S000711450783902X","article-title":"Wholegrain foods made from a novel high-amylose barley variety (Himalaya 292) improve indices of bowel health in human subjects.","volume":"99","author":"Bird","year":"2008","journal-title":"Br J Nutr."},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1079\/PNS2002221","article-title":"Why whole grains are protective: biological mechanisms.","volume":"62","author":"Slavin","year":"2003","journal-title":"Proc Nutr Soc."},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1113\/JP272613","article-title":"Systemic availability and metabolism of colonic\u2010derived short\u2010chain fatty acids in healthy subjects: a stable isotope study.","volume":"595","author":"Boets","year":"2017","journal-title":"J Physiol."},{"issue":"10","key":"10.1093\/jn\/nxaa312_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrendo.2015.128","article-title":"Short-chain fatty acids in control of body weight and insulin sensitivity.","volume":"11","author":"Canfora","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"10.1093\/jn\/nxaa312_bib28","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/db14-1213","article-title":"Short-chain fatty acids protect against high-fat diet-induced obesity via a PPAR\u03b3-dependent switch from lipogenesis to fat oxidation.","volume":"64","author":"den Besten","year":"2015","journal-title":"Diabetes."},{"issue":"5","key":"10.1093\/jn\/nxaa312_bib29","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2337\/db16-0924","article-title":"Butyrate regulates liver mitochondrial function, efficiency, and dynamic, in insulin resistant obese mice.","volume":"66","author":"Mollica","year":"2017","journal-title":"Diabetes."},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.15403\/jgld.2014.1121.271.kby","article-title":"A multi-strain probiotic reduces the fatty liver index, cytokines and aminotransferase levels in NAFLD patients: evidence from a randomized clinical trial.","volume":"27","author":"Kobyliak","year":"2018","journal-title":"J Gastrointestin Liver Dis."},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10620-011-1887-4","article-title":"Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis.","volume":"57","author":"Malaguarnera","year":"2012","journal-title":"Dig Dis Sci."},{"issue":"12","key":"10.1093\/jn\/nxaa312_bib32","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/1751-2980.12561","article-title":"Treatment efficacy of a probiotic preparation for non-alcoholic steatohepatitis: a pilot trial.","volume":"18","author":"Manzhalii","year":"2017","journal-title":"J Dig Dis."},{"issue":"9","key":"10.1093\/jn\/nxaa312_bib33","first-page":"1090","article-title":"Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial.","volume":"15","author":"Aller","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci."},{"issue":"12","key":"10.1093\/jn\/nxaa312_bib34","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/jn\/nxz177","article-title":"Whole grain wheat consumption affects postprandial inflammatory response in a randomized controlled trial in overweight and obese adults with mild hypercholesterolemia in the Graandioos study.","volume":"149","author":"Hoevenaars","year":"2019","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxaa312_bib35","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.12688\/f1000research.9227.2","article-title":"NG-Tax, a highly accurate and validated pipeline for analysis of 16S rRNA amplicons from complex biomes.","volume":"5","author":"Ramiro-Garcia","year":"2018","journal-title":"F1000Res"},{"key":"10.1093\/jn\/nxaa312_bib36","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3389\/fgene.2019.01366","article-title":"NG-Tax 2.0: a semantic framework for high-throughput amplicon analysis.","volume":"10","author":"Poncheewin","year":"2019","journal-title":"Front Genet"},{"key":"10.1093\/jn\/nxaa312_bib37","series-title":"R: A language and environment for statistical computing.","year":"2007"},{"issue":"4","key":"10.1093\/jn\/nxaa312_bib38","doi-asserted-by":"crossref","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40168-017-0237-y","article-title":"Normalization and microbial differential abundance strategies depend upon data characteristics.","volume":"5","author":"Weiss","year":"2017","journal-title":"Microbiome"},{"key":"10.1093\/jn\/nxaa312_bib40","series-title":"vegan: Community Ecology Package. R package version 2.5-2.","author":"Oksanen","year":"2018"},{"key":"10.1093\/jn\/nxaa312_bib41","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences.","volume":"31","author":"Langille","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1093\/jn\/nxaa312_bib42","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1038\/ismej.2014.63","article-title":"Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men.","volume":"8","author":"Salonen","year":"2014","journal-title":"ISME J"},{"key":"10.1093\/jn\/nxaa312_bib43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/ismej.2010.118","article-title":"Dominant and diet-responsive groups of bacteria within the human colonic microbiota.","volume":"5","author":"Walker","year":"2011","journal-title":"ISME J"},{"key":"10.1093\/jn\/nxaa312_bib44","series-title":"Bergey\u2019s manual of systematic bacteriology. Vol. 3.","author":"Vos","year":"2011"},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-6496(03)00207-1","article-title":"The cellulolytic microflora of the human colon: evidence of microcrystalline cellulose-degrading bacteria in methane-excreting subjects.","volume":"46","author":"Robert","year":"2003","journal-title":"FEMS Microbiol Ecol."},{"issue":"4","key":"10.1093\/jn\/nxaa312_bib46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4161\/gmic.19897","article-title":"Microbial degradation of complex carbohydrates in the gut.","volume":"3","author":"Flint","year":"2012","journal-title":"Gut Microbes."},{"issue":"11","key":"10.1093\/jn\/nxaa312_bib47","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.3945\/jn.117.250647","article-title":"Whole-grain rye and wheat affect some markers of gut health without altering the fecal microbiota in healthy overweight adults: a 6-week randomized trial.","volume":"147","author":"Vuholm","year":"2017","journal-title":"J Nutr."},{"issue":"7","key":"10.1093\/jn\/nxaa312_bib48","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cgh.2013.02.015","article-title":"Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease.","volume":"11","author":"Raman","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib49","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1038\/srep08096","article-title":"Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease.","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci Rep"},{"issue":"6","key":"10.1093\/jn\/nxaa312_bib50","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s12072-019-09987-8","article-title":"Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study.","volume":"13","author":"Iino","year":"2019","journal-title":"Hepatol Int."},{"issue":"6","key":"10.1093\/jn\/nxaa312_bib51","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.cmet.2017.05.002","article-title":"Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses.","volume":"25","author":"Korem","year":"2017","journal-title":"Cell Metab"},{"issue":"11","key":"10.1093\/jn\/nxaa312_bib52","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1136\/gutjnl-2016-313271","article-title":"Prebiotic inulin-type fructans induce specific changes in the human gut microbiota.","volume":"66","author":"Vandeputte","year":"2017","journal-title":"Gut."},{"issue":"9","key":"10.1093\/jn\/nxaa312_bib53","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3390\/nu9091021","article-title":"Effects of probiotics, prebiotics, and synbiotics on human health.","volume":"9","author":"Markowiak","year":"2017","journal-title":"Nutrients"},{"issue":"6","key":"10.1093\/jn\/nxaa312_bib54","doi-asserted-by":"crossref","first-page":"e00130","DOI":"10.1128\/mSystems.00130-17","article-title":"Colonic butyrate-producing communities in humans: an overview using omics data.","volume":"2","author":"Vital","year":"2017","journal-title":"mSystems"},{"issue":"3","key":"10.1093\/jn\/nxaa312_bib55","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1574-6941.2011.01085.x","article-title":"Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species.","volume":"76","author":"Mu\u00f1oz-Tamayo","year":"2011","journal-title":"FEMS Microbiol Ecol."},{"issue":"25","key":"10.1093\/jn\/nxaa312_bib56","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1021\/acs.jafc.8b01891","article-title":"Effects of whole-grain rice and wheat on composition of gut microbiota and short-chain fatty acids in rats.","volume":"66","author":"Han","year":"2018","journal-title":"J Agric Food Chem."},{"issue":"S2","key":"10.1093\/jn\/nxaa312_bib57","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1017\/S0007114514002244","article-title":"Impact of whole grains on the gut microbiota: the next frontier for oats?","volume":"112","author":"Rose","year":"2014","journal-title":"Br J Nutr"},{"issue":"3-4","key":"10.1093\/jn\/nxaa312_bib58","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.foodchem.2012.09.074","article-title":"Contents of dietary fibre components and their relation to associated bioactive components in whole grain wheat samples from the HEALTHGRAIN diversity screen.","volume":"136","author":"Andersson","year":"2013","journal-title":"Food Chem"},{"issue":"5","key":"10.1093\/jn\/nxaa312_bib59","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1021\/jf801280f","article-title":"Content and molecular-weight distribution of dietary fiber components in whole-grain rye flour and bread.","volume":"57","author":"Andersson","year":"2009","journal-title":"J Agric Food Chem."},{"issue":"4","key":"10.1093\/jn\/nxaa312_bib60","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/ajcn\/nqaa026","article-title":"Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: a randomized crossover trial.","volume":"111","author":"Eriksen","year":"2020","journal-title":"Am J Clin Nutr."},{"issue":"10","key":"10.1093\/jn\/nxaa312_bib61","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3390\/nu10101499","article-title":"Impact of diet-modulated butyrate production on intestinal barrier function and inflammation.","volume":"10","author":"Bach Knudsen","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1093\/jn\/nxaa312_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2009.01514.x","article-title":"Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine.","volume":"294","author":"Louis","year":"2009","journal-title":"FEMS Microbiol Lett."},{"key":"10.1093\/jn\/nxaa312_bib63","doi-asserted-by":"crossref","first-page":"32002","DOI":"10.1038\/srep32002","article-title":"Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease.","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1093\/jn\/nxaa312_bib64","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/hep.28572","article-title":"Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach.","volume":"65","author":"Del Chierico","year":"2017","journal-title":"Hepatology."},{"issue":"4","key":"10.1093\/jn\/nxaa312_bib65","first-page":"275","article-title":"An altered fecal microbiota profile in patients with non-alcoholic fatty liver disease (NAFLD) associated with obesity.","volume":"111","author":"Nistal","year":"2019","journal-title":"Rev Esp Enferm Dig."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622000608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622000608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/151\/3\/491\/36547339\/nxaa312.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/151\/3\/491\/36547339\/nxaa312.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T21:02:40Z","timestamp":1686690160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622000608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0022316622000608"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxaa312","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxaa312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 American Society for Nutrition. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}