{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:45:24Z","timestamp":1790797524920,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":597,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002946","name":"German Aerospace Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002946","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Federal Ministry of Economy and Technology","award":["50WB1535"],"award-info":[{"award-number":["50WB1535"]}]},{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Aeronautics and Space Administration Human Research Program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1093\/jn\/nxab036","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T03:31:16Z","timestamp":1612323076000},"page":"1527-1538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antioxidant Supplementation Does Not Affect Bone Turnover Markers During 60 Days of 6\u00b0 Head-Down Tilt Bed Rest: Results from an Exploratory Randomized Controlled Trial"],"prefix":"10.1016","volume":"151","author":[{"given":"Katharina","family":"Austermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Baecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-0180","authenticated-orcid":false,"given":"Sara R","family":"Zwart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-6803","authenticated-orcid":false,"given":"Rolf","family":"Fimmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-6269","authenticated-orcid":false,"given":"Jean-Pol","family":"Frippiat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-8088","authenticated-orcid":false,"given":"Peter","family":"Stehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-911X","authenticated-orcid":false,"given":"Martina","family":"Heer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1093\/jn\/nxab036_bib1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1152\/japplphysiol.00935.2015","article-title":"Long-duration bed rest as an analog to microgravity.","volume":"120","author":"Hargens","year":"2016","journal-title":"J Appl Physiol."},{"issue":"6","key":"10.1093\/jn\/nxab036_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jbspin.2011.04.007","article-title":"Pathophysiology of bone loss in disuse osteoporosis.","volume":"78","author":"Alexandre","year":"2011","journal-title":"Joint Bone Spine."},{"key":"10.1093\/jn\/nxab036_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling.","volume":"6","author":"Feng","year":"2011","journal-title":"Annu Rev Pathol Mech Dis."},{"issue":"8","key":"10.1093\/jn\/nxab036_bib4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1152\/japplphysiol.00919.2015","article-title":"FemHab: the effects of bed rest and hypoxia on oxidative stress in healthy women.","volume":"120","author":"Debevec","year":"2016","journal-title":"J Appl Physiol."},{"issue":"Suppl 5","key":"10.1093\/jn\/nxab036_bib5","doi-asserted-by":"crossref","first-page":"A15","DOI":"10.3357\/ASEM.BR07.2009","article-title":"Nutritional status assessment before, during, and after long-duration head-down bed rest.","volume":"80","author":"Zwart","year":"2009","journal-title":"Aviat Space Environ Med."},{"issue":"10","key":"10.1093\/jn\/nxab036_bib6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.molmed.2009.08.004","article-title":"Oxidative stress in bone remodelling and disease.","volume":"15","author":"Wauquier","year":"2009","journal-title":"Trends Mol Med."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3945\/ajcn.112.056465","article-title":"Iron status and its relations with oxidative damage and bone loss during long-duration space flight on the International Space Station.","volume":"98","author":"Zwart","year":"2013","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab036_bib8","first-page":"1","article-title":"Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis.","volume":"2014","author":"Cervellati","year":"2014","journal-title":"Biomed Res Int."},{"issue":"1\u20132","key":"10.1093\/jn\/nxab036_bib9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0009-8981(01)00766-5","article-title":"A duality in the roles of reactive oxygen species with respect to bone metabolism.","volume":"318","author":"Sontakke","year":"2002","journal-title":"Clin Chim Acta."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/bbrc.2001.5747","article-title":"Association between oxidative stress and bone mineral density.","volume":"288","author":"Basu","year":"2001","journal-title":"Biochem Biophys Res Commun."},{"key":"10.1093\/jn\/nxab036_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2474-8-124","article-title":"Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes.","volume":"8","author":"Sanchez-Rodriguez","year":"2007","journal-title":"BMC Musculoskelet Disord."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib12","first-page":"689","article-title":"Is there a role of free oxygen radicals in primary male osteoporosis?.","volume":"23","author":"Yalin","year":"2005","journal-title":"Clin Exp Rheumatol."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib13","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3945\/ajcn.110.005926","article-title":"Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study.","volume":"93","author":"Farina","year":"2011","journal-title":"Am J Clin Nutr."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib14","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jbmr.285","article-title":"Associations between dietary flavonoid intakes and bone health in a Scottish population.","volume":"26","author":"Hardcastle","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"11","key":"10.1093\/jn\/nxab036_bib15","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1210\/jc.2012-2121","article-title":"Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women.","volume":"97","author":"Hoeg","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"Suppl 1","key":"10.1093\/jn\/nxab036_bib16","doi-asserted-by":"crossref","first-page":"423S","DOI":"10.3945\/ajcn.113.071464","article-title":"Soy foods, isoflavones, and the health of postmenopausal women.","volume":"100","author":"Messina","year":"2014","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3945\/ajcn.113.064691","article-title":"Intake and serum concentrations of \u03b1-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.","volume":"99","author":"Micha\u00eblsson","year":"2014","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab036_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.foodres.2015.10.017","article-title":"The role of polyphenols on bone metabolism in osteoporosis.","volume":"77","author":"\u0110udari\u0107","year":"2015","journal-title":"Food Res Int."},{"key":"10.1093\/jn\/nxab036_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.plipres.2015.03.001","article-title":"Pros and cons of fatty acids in bone biology.","volume":"58","author":"Wauquier","year":"2015","journal-title":"Prog Lipid Res."},{"issue":"3","key":"10.1093\/jn\/nxab036_bib20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF02555114","article-title":"Effects of ascorbic acid on alkaline phosphatase activity and hormone responsiveness in the osteoblastic osteosarcoma cell line UMR-106.","volume":"39","author":"Sugimoto","year":"1986","journal-title":"Calcif Tissue Int."},{"issue":"6","key":"10.1093\/jn\/nxab036_bib21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/jbmr.5650090610","article-title":"Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells.","volume":"9","author":"Franceschi","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"6","key":"10.1093\/jn\/nxab036_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20061453","article-title":"The molecular mechanism of vitamin E as a bone-protecting agent: a review on current evidence.","volume":"20","author":"Wong","year":"2019","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj2690175","article-title":"Regulation of procollagen synthesis and processing during ascorbate-induced extracellular matrix accumulation in vitro.","volume":"269","author":"Chan","year":"1990","journal-title":"Biochem J."},{"issue":"6","key":"10.1093\/jn\/nxab036_bib24","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s11101-017-9529-x","article-title":"Molecular signaling mechanisms behind polyphenol-induced bone anabolism. Phytochemistry Rev.","volume":"16","author":"Torre","year":"2017","journal-title":"Phytochemistry Rev"},{"issue":"4","key":"10.1093\/jn\/nxab036_bib25","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3390\/nu7042499","article-title":"Increased intake of selected vegetables, herbs and fruit may reduce bone turnover in post-menopausal women.","volume":"7","author":"Gunn","year":"2015","journal-title":"Nutrients."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/01635581.2014.847964","article-title":"High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study.","volume":"66","author":"Hutchins-Wiese","year":"2014","journal-title":"Nutr Cancer."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib27","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1359\/jbmr.091041","article-title":"Capacity of omega-3 fatty acids or eicosapentaenoic acid to counteract weightlessness-induced bone loss by inhibiting NF-kappaB activation: from cells to bed rest to astronauts.","volume":"25","author":"Zwart","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"6","key":"10.1093\/jn\/nxab036_bib28","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1017\/S000711451100119X","article-title":"Comparative effects of dried plum and dried apple on bone in postmenopausal women.","volume":"106","author":"Hooshmand","year":"2011","journal-title":"Br J Nutr."},{"issue":"6","key":"10.1093\/jn\/nxab036_bib29","first-page":"467","article-title":"Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly. J Nutr.","volume":"14","author":"Ruiz-Ramos","year":"2010","journal-title":"Health Aging."},{"key":"10.1093\/jn\/nxab036_bib30","article-title":"Guidelines for standardization of bed rest studies in the spaceflight context.","author":"Orlov","year":"2014"},{"issue":"1","key":"10.1093\/jn\/nxab036_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-45600-6","article-title":"Healthy adiposity and extended lifespan in obese mice fed a diet supplemented with a polyphenol-rich plant extract.","volume":"9","author":"Aires","year":"2019","journal-title":"Sci Rep."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1152\/japplphysiol.00018.2018","article-title":"A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: result from a randomized study.","volume":"126","author":"Damiot","year":"2019","journal-title":"J Appl Physiol."},{"key":"10.1093\/jn\/nxab036_bib33","series-title":"Dietary reference intakes (DRIs): elements and vitamins.","article-title":"Food and Nutrition Board of the Institute of Medicine, National Academies.","year":"2011"},{"key":"10.1093\/jn\/nxab036_bib34","unstructured":"German Nutrition Society, Austrian Nutrition Society, Swiss Society for Nutrition Research, Swiss Nutrition Association. Reference values for nutrient intake. 2013, German Nutrition Society, Austrian Nutrition Society, Swiss Society for Nutrition Research and Swiss Nutrition Association, Bonn, Germany."},{"issue":"Suppl 6","key":"10.1093\/jn\/nxab036_bib35","first-page":"S1","article-title":"A collection of Physical Activity Questionnaires for health-related research.","volume":"29","author":"Pereira","year":"1997","journal-title":"Med Sci Sports Exerc."},{"key":"10.1093\/jn\/nxab036_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0065-2776(08)60791-9","article-title":"Neutrophil-derived proteins: selling cytokines by the pound.","volume":"73","author":"Cassatella","year":"1999","journal-title":"Adv Immunol"},{"issue":"6","key":"10.1093\/jn\/nxab036_bib37","first-page":"428","article-title":"White blood cells, neutrophils, and reactive oxygen metabolites among asymptomatic subjects.","volume":"3","author":"Kotani","year":"2012","journal-title":"Int J Prev Med."},{"issue":"3","key":"10.1093\/jn\/nxab036_bib38","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1152\/jappl.1984.57.3.619","article-title":"Physiological responses to prolonged bed rest and fluid immersion in humans.","volume":"57","author":"Greenleaf","year":"1984","journal-title":"J Appl Physiol."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib39","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1210\/jc.2017-02267","article-title":"Metabolic inflexibility is an early marker of bed-rest-induced glucose intolerance even when fat mass is stable.","volume":"103","author":"Rudwill","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1093\/jn\/nxab036_bib40","unstructured":"European Food Safety Authority. Tolerable upper intake levels for vitamins and minerals. Scientific Committee on Food, Scientific Panel on Dietetic Products, Scientific Committee on Food, Scientific Panel on Dietetic Products, Nutrition and Allergies, 2006, The European Food and Safety Authority, Parma, Italy."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib41","first-page":"33","article-title":"Skeletal responses to space flight and the bed rest analog: a review.","volume":"7","author":"Leblanc","year":"2007","journal-title":"J Musculoskelet Neuronal Interact."},{"issue":"Suppl 4","key":"10.1093\/jn\/nxab036_bib42","doi-asserted-by":"crossref","first-page":"301S","DOI":"10.1016\/8756-3282(94)00045-2","article-title":"Calcium absorption, endogenous excretion, and endocrine changes during and after long-term bed rest.","volume":"16","author":"LeBlanc","year":"1995","journal-title":"Bone."},{"issue":"4","key":"10.1093\/jn\/nxab036_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu11040871","article-title":"Putative effects of nutritive polyphenols on bone metabolism in vivo-evidence from human studies.","volume":"11","author":"Austermann","year":"2019","journal-title":"Nutrients."},{"issue":"2","key":"10.1093\/jn\/nxab036_bib44","first-page":"1","article-title":"Blueberry juice antioxidants protect osteogenic activity against oxidative stress and improve long-term activation of the mineralization process in human osteoblast-like SaOS-2 cells: involvement of SIRT1.","volume":"9","author":"Domazetovic","year":"2020","journal-title":"Antioxidants (Basel)."},{"key":"10.1093\/jn\/nxab036_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2020.00071","article-title":"Evaluation of an antioxidant and anti-inflammatory cocktail against human hypoactivity-induced skeletal muscle deconditioning.","volume":"11","author":"Arc-Chagnaud","year":"2020","journal-title":"Front Physiol."},{"issue":"12","key":"10.1093\/jn\/nxab036_bib46","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/bies.950181215","article-title":"Human physiology in space.","volume":"18","author":"Vernikos","year":"1996","journal-title":"Bioessays."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib47","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1189\/jlb.0309167","article-title":"Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?.","volume":"86","author":"Gu\u00e9guinou","year":"2009","journal-title":"J Leukoc Biol."},{"issue":"2","key":"10.1093\/jn\/nxab036_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jlb.65.2.179","article-title":"Leukocyte subsets and neutrophil function after short-term spaceflight.","volume":"65","author":"Stowe","year":"1999","journal-title":"J Leukoc Biol."},{"issue":"99 (Suppl 3)","key":"10.1093\/jn\/nxab036_bib49","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1017\/S0007114508006867","article-title":"Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?.","author":"Williamson","year":"2008","journal-title":"Br J Nutr."},{"issue":"12","key":"10.1093\/jn\/nxab036_bib50","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1210\/jc.2014-2799","article-title":"Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial.","volume":"99","author":"Ornstrup","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib51","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3945\/ajcn.2009.28001","article-title":"Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial.","volume":"90","author":"Wong","year":"2009","journal-title":"Am J Clin Nutr."},{"issue":"2","key":"10.1093\/jn\/nxab036_bib52","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3945\/jn.115.219238","article-title":"Long-term supplementation of green tea extract does not modify adiposity or bone mineral density in a randomized trial of overweight and obese postmenopausal women.","volume":"146","author":"Dostal","year":"2016","journal-title":"J Nutr."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jocd.2010.11.003","article-title":"The soy isoflavones for reducing bone loss study: 3-yr effects on pQCT bone mineral density and strength measures in postmenopausal women.","volume":"14","author":"Shedd-Wise","year":"2011","journal-title":"J Clin Densitom."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib54","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s00198-011-1750-7","article-title":"The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study.","volume":"23","author":"Tai","year":"2012","journal-title":"Osteoporos Int."},{"issue":"8","key":"10.1093\/jn\/nxab036_bib55","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1017\/S0007114510004861","article-title":"Supplementation with a low-moderate dose of n-3 long-chain PUFA has no short-term effect on bone resorption in human adults.","volume":"105","author":"Appleton","year":"2011","journal-title":"Br J Nutr."},{"issue":"6","key":"10.1093\/jn\/nxab036_bib56","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/13697137.2017.1384952","article-title":"Effects of omega-3 fatty acids on bone turnover markers in postmenopausal women: systematic review and meta-analysis.","volume":"20","author":"Shen","year":"2017","journal-title":"Climacteric."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib57","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3945\/ajcn.2009.28306","article-title":"The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women.","volume":"91","author":"Alekel","year":"2010","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"10.1093\/jn\/nxab036_bib58","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2015-3767","article-title":"Effect of hesperidin with and without a calcium (Calcilock) supplement on bone health in postmenopausal women.","volume":"101","author":"Martin","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"10.1093\/jn\/nxab036_bib59","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbmr.2927","article-title":"Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial.","volume":"32","author":"Sathyapalan","year":"2016","journal-title":"J Bone Miner Res."},{"issue":"5","key":"10.1093\/jn\/nxab036_bib60","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00198-011-1731-x","article-title":"Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial.","volume":"23","author":"Shen","year":"2012","journal-title":"Osteoporos Int."},{"issue":"3","key":"10.1093\/jn\/nxab036_bib61","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/ajcn\/87.3.761","article-title":"Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study.","volume":"87","author":"Brink","year":"2008","journal-title":"Am J Clin Nutr."},{"issue":"7","key":"10.1093\/jn\/nxab036_bib62","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1007\/s00198-016-3524-8","article-title":"The effect of two doses of dried plum on bone density and bone biomarkers in osteopenic postmenopausal women: a randomized, controlled trial.","volume":"27","author":"Hooshmand","year":"2016","journal-title":"Osteoporos Int."},{"issue":"2","key":"10.1093\/jn\/nxab036_bib63","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1017\/S002966510800699X","article-title":"Biomarkers of bone health and osteoporosis risk.","volume":"67","author":"Eastell","year":"2008","journal-title":"Proc Nutr Soc."},{"issue":"2","key":"10.1093\/jn\/nxab036_bib64","first-page":"117","article-title":"Laboratory aspects and clinical utility of bone turnover markers.","volume":"29","author":"Bhattoa","year":"2018","journal-title":"EJIFCC."},{"key":"10.1093\/jn\/nxab036_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40364-017-0097-4","article-title":"Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives.","volume":"5","author":"Kuo","year":"2017","journal-title":"Biomark Res."},{"issue":"2","key":"10.1093\/jn\/nxab036_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu9020179","article-title":"Antiosteoporotic activity of genistein aglycone in postmenopausal women: evidence from a post-hoc analysis of a multicenter randomized controlled trial.","volume":"9","author":"Arcoraci","year":"2017","journal-title":"Nutrients."},{"issue":"12","key":"10.1093\/jn\/nxab036_bib67","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1210\/jc.2008-1087","article-title":"Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study.","volume":"93","author":"Marini","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"10.1093\/jn\/nxab036_bib68","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/ijms11041321","article-title":"Bioavailability of the polyphenols: status and controversies.","volume":"11","author":"D'Archivio","year":"2010","journal-title":"Int J Mol Sci."},{"issue":"7","key":"10.1093\/jn\/nxab036_bib69","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/nure.12114","article-title":"Dietary factors affecting polyphenol bioavailability.","volume":"72","author":"Bohn","year":"2014","journal-title":"Nutr Rev."},{"issue":"3\u20134","key":"10.1093\/jn\/nxab036_bib70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1024\/0300-9831\/a000199","article-title":"Effects of omega-3 polyunsaturated fatty acid supplementation on bone turnover in older women.","volume":"84","author":"Dong","year":"2014","journal-title":"Int J Vitam Nutr Res."},{"issue":"3","key":"10.1093\/jn\/nxab036_bib71","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0271-5317(95)00002-X","article-title":"Biochemical profile of osteoporotic patients on essential fatty acid supplementation.","volume":"15","author":"van Papendorp","year":"1995","journal-title":"Nutr Res."},{"issue":"7","key":"10.1093\/jn\/nxab036_bib72","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3109\/09637486.2014.931361","article-title":"The effect of olive oil on osteoporosis prevention.","volume":"65","author":"Garc\u00eda-Mart\u00ednez","year":"2014","journal-title":"Int J Food Sci Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622002012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622002012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/151\/6\/1527\/38444254\/nxab036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/151\/6\/1527\/38444254\/nxab036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T03:29:05Z","timestamp":1697772545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622002012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":72,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0022316622002012"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxab036","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antioxidant Supplementation Does Not Affect Bone Turnover Markers During 60 Days of 6\u00b0 Head-Down Tilt Bed Rest: Results from an Exploratory Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxab036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}