{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:31:52Z","timestamp":1792625512722,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1093\/jn\/nxab337","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T19:15:04Z","timestamp":1631819704000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Does the Amount of Stable Isotope Dose Influence Retinol Kinetic Responses and Predictions of Vitamin A Total Body Stores by the Retinol Isotope Dilution Method in Theoretical Children and Adults?"],"prefix":"10.1016","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8169-9313","authenticated-orcid":false,"given":"Michael H","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-4911","authenticated-orcid":false,"given":"Veronica","family":"Lopez-Teros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne Balmer","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/nxab337_bib1","first-page":"99","article-title":"Method for the assessment of vitamin A liver stores.","volume":"31","author":"Bausch","year":"1977","journal-title":"Acta Vitaminol Enzymol."},{"key":"10.1093\/jn\/nxab337_bib2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ajcn\/49.4.713","article-title":"Vitamin A concentrations in liver determined by isotope dilution assay with tetradeuterated vitamin A and by biopsy in generally healthy adult humans.","volume":"49","author":"Furr","year":"1989","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab337_bib3","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.3945\/jn.116.233676","article-title":"A retinol isotope dilution equation predicts both group and individual total body vitamin A stores in adults based on data from an early postdosing blood sample.","volume":"146","author":"Green","year":"2016","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/jn\/nxz225","article-title":"Use of model-based compartmental analysis and a super-child design to study whole-body retinol kinetics and vitamin A total body stores in children from 3 lower-income countries.","volume":"150","author":"Ford","year":"2020","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3945\/jn.112.165506","article-title":"Vitamin A-fortified milk increases total body vitamin A stores in Mexican preschoolers.","volume":"143","author":"Lopez-Teros","year":"2013","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib6","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3945\/ajcn.114.087379","article-title":"Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a community-based, randomized placebo-controlled trial.","volume":"100","author":"Gannon","year":"2014","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab337_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ajcn\/nqy382","article-title":"South African preschool children habitually consuming sheep liver and exposed to vitamin A supplementation and fortification have hypervitaminotic A liver stores: a cohort study.","volume":"110","author":"van\u00a0Stuijvenberg","year":"2019","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab337_bib8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/jn\/nxz321","article-title":"Better predictions of vitamin A total body stores by the retinol isotope dilution method are possible with deeper understanding of the mathematics and by applying compartmental modeling.","volume":"150","author":"Green","year":"2020","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib9","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/jn\/nxab061","article-title":"Use of model-based compartmental analysis and theoretical data to further explore choice of sampling time for assessing vitamin A status in groups and individual human subjects by the retinol isotope dilution method.","volume":"151","author":"Green","year":"2021","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/nxab310","article-title":"Influence of vitamin A status on the choice of sampling time for application of the retinol isotope dilution method in theoretical children.","author":"Lopez-Teros","year":"2021","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/jn\/nxaa407","article-title":"Development of a compartmental model to investigate the influence of inflammation on predictions of vitamin A total body stores by retinol isotope dilution in theoretical humans.","volume":"151","author":"Green","year":"2021","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib12","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/ajcn\/77.3.681","article-title":"Population-based plasma kinetics of an oral dose of [2H4]retinyl acetate among preschool-aged, Peruvian children.","volume":"77","author":"Haskell","year":"2003","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab337_bib13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3945\/jn.114.208132","article-title":"Comparisons among equations used for retinol isotope dilution in the assessment of total body stores and total liver reserves.","volume":"145","author":"Gannon","year":"2015","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib14","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/jn\/nxaa048","article-title":"The \u201csuper-child\u201d approach is applied to estimate retinol kinetics and vitamin A total body stores in Mexican preschoolers.","volume":"150","author":"Lopez-Teros","year":"2020","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib15","doi-asserted-by":"crossref","first-page":"nzy071","DOI":"10.1093\/cdn\/nzy071","article-title":"A population-based (super-child) approach for predicting vitamin A total body stores and retinol kinetics in children is validated by the application of model-based compartmental analysis to theoretical data.","volume":"2","author":"Ford","year":"2018","journal-title":"Curr Dev Nutr."},{"key":"10.1093\/jn\/nxab337_bib16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/jn\/nxy095","article-title":"Duration of retinol isotope dilution studies with compartmental modeling affects model complexity, kinetic parameters, and calculated vitamin A stores in US women.","volume":"148","author":"Gannon","year":"2018","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib17","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.3945\/jn.117.256974","article-title":"Use of a \u201csuper-child\u201d approach to assess the vitamin A equivalence ofMoringa oleifera leaves, develop a compartmental model for vitamin A kinetics, and estimate vitamin A total body stores in young Mexican children.","volume":"147","author":"Lopez-Teros","year":"2017","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib18","unstructured":"Institute of Medicine. Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington (DC): National Academies Press; 2001."},{"key":"10.1093\/jn\/nxab337_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0020-708X(68)90022-7","article-title":"Nomenclature for tracer kinetics.","volume":"19","author":"Brownell","year":"1968","journal-title":"Int J Appl Radiat Isot."},{"key":"10.1093\/jn\/nxab337_bib20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0955-2863(98)00026-6","article-title":"Deuterium enrichment of retinol in humans determined by gas chromatography electron capture negative chemical ionization mass spectrometry.","volume":"9","author":"Tang","year":"1998","journal-title":"J Nutr Biochem."},{"key":"10.1093\/jn\/nxab337_bib21","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/jn\/130.11.2844","article-title":"Vitamin A status assessment in rats with13C4-retinyl acetate and gas chromatography\/combustion\/isotope ratio mass spectrometry.","volume":"130","author":"Tanumihardjo","year":"2000","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0021-9673(94)00969-G","article-title":"High-precision gas chromatography-combustion isotope ratio mass spectrometry at low signal levels.","volume":"689","author":"Goodman","year":"1995","journal-title":"J Chromatogr A."},{"key":"10.1093\/jn\/nxab337_bib23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1194\/jlr.D040204","article-title":"An LC\/MS\/MS method for stable isotope dilution studies of \u03b2-carotene bioavailability, bioconversion, and vitamin A status in humans.","volume":"55","author":"Oxley","year":"2014","journal-title":"J Lipid Res."},{"key":"10.1093\/jn\/nxab337_bib24","unstructured":"Haskell MJ, Ribaya-Mercado JD, Vitamin A Tracer Task Force. Handbook on vitamin A tracer dilution methods to assess status and evaluate intervention programs. HarvestPlus Technical Monograph 5. Washington (DC)."},{"issue":"2_suppl","key":"10.1093\/jn\/nxab337_bib25","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1177\/0379572116630642","article-title":"Current capabilities and limitations of stable isotope techniques and applied mathematical equations in determining whole-body vitamin A status.","volume":"37","author":"Lietz","year":"2016","journal-title":"Food Nutr Bull."},{"key":"10.1093\/jn\/nxab337_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-4899-1959-5_13","article-title":"Development of a compartmental model describing the dynamics of vitamin A metabolism in men.","volume":"445","author":"von\u00a0Reinersdorff","year":"1998","journal-title":"Adv Exp Med Biol."},{"key":"10.1093\/jn\/nxab337_bib27","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/jn\/nxaa446","article-title":"Determination of vitamin A total body stores in children from dried serum spots: application in a low- and middle-income country community setting.","volume":"151","author":"Oxley","year":"2021","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/jn\/138.5.971","article-title":"Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores.","volume":"138","author":"Cifelli","year":"2008","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib29","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.3945\/jn.116.233486","article-title":"Plasma retinol kinetics and \u03b2-carotene bioefficacy are quantified by model-based compartmental analysis in healthy young adults with low vitamin A stores.","volume":"146","author":"Green","year":"2016","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib30","unstructured":"Berman M, Weiss MF. SAAM Manual. Washington (DC): US Government Printing Office; 1978. DHEW Publication No.: (NIH) 78\u2013180."},{"key":"10.1093\/jn\/nxab337_bib31","doi-asserted-by":"crossref","unstructured":"Wastney ME, Patterson BH, Linares OA, Greif PC, Boston RC. Chapter 6 \u2013 WinSAAM. In: Investigating biological systems using modeling: strategies and software. San Diego (CA): Academic Press; 1999, pp. 95\u2013138.","DOI":"10.1016\/B978-0-08-092645-2.50010-9"},{"key":"10.1093\/jn\/nxab337_bib32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0026-0495(03)00144-6","article-title":"WinSAAM: a Windows-based compartmental modeling system.","volume":"52","author":"Stefanovski","year":"2003","journal-title":"Metabolism."},{"key":"10.1093\/jn\/nxab337_bib33","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1152\/physrev.1991.71.4.951","article-title":"Vitamin A metabolism: new perspectives on absorption, transport, and storage.","volume":"71","author":"Blomhoff","year":"1991","journal-title":"Physiol Rev."},{"key":"10.1093\/jn\/nxab337_bib34","unstructured":"Green MH, Green JB. Dynamics and control of plasma retinol. In: Blomhoff R, editor. Vitamin A in Health and Disease. New York (NY): Marcel Dekker; 1994, pp. 119\u201333."},{"key":"10.1093\/jn\/nxab337_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/nu3010063","article-title":"Vitamin A metabolism: an update.","volume":"3","author":"D'Ambrosio","year":"2011","journal-title":"Nutrients."},{"key":"10.1093\/jn\/nxab337_bib36","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/S0021-9258(19)44224-5","article-title":"The effects of chylomicron vitamin A on the metabolism of retinol-binding protein in the rat.","volume":"248","author":"Smith","year":"1973","journal-title":"J Biol Chem."},{"key":"10.1093\/jn\/nxab337_bib37","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1177\/1535370219877132","article-title":"Liver retinol estimated by13C-retinol isotope dilution at 7 versus 14 days in Burkinabe schoolchildren.","volume":"244","author":"Bationo","year":"2019","journal-title":"Exp Biol Med."},{"issue":"9","key":"10.1093\/jn\/nxab337_bib38","doi-asserted-by":"crossref","first-page":"1816S","DOI":"10.3945\/jn.115.229708","article-title":"Biomarkers of nutrition for development (BOND) \u2013 vitamin A review.","volume":"146","author":"Tanumihardjo","year":"2016","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib39","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/ajcn\/nqy190","article-title":"Serum retinyl esters are positively correlated with analyzed total liver vitamin A reserves collected from US adults at time of death.","volume":"108","author":"Olsen","year":"2018","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab337_bib40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0083-6729(06)75007-5","article-title":"Use of model-based compartmental analysis to study vitamin A kinetics and metabolism.","volume":"75","author":"Cifelli","year":"2007","journal-title":"Vitam Horm."},{"key":"10.1093\/jn\/nxab337_bib41","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0076-6879(90)90035-Y","article-title":"Experimental and kinetic methods for studying vitamin A dynamics in vivo.","volume":"190","author":"Green","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1093\/jn\/nxab337_bib42","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/jn\/109.5.787","article-title":"Effects of retinoic acid on the mobilization of vitamin A from the liver in rats.","volume":"109","author":"Keilson","year":"1979","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib43","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/jn\/109.5.778","article-title":"Response of plasma levels of vitamin A to a dose of vitamin A as an indicator of hepatic vitamin A reserves in rats.","volume":"109","author":"Loerch","year":"1979","journal-title":"J Nutr."},{"key":"10.1093\/jn\/nxab337_bib44","first-page":"G509","article-title":"Vitamin A metabolism in rat liver: a kinetic model.","volume":"264","author":"Green","year":"1993","journal-title":"Am J Physiol."},{"key":"10.1093\/jn\/nxab337_bib45","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3945\/jn.117.254441","article-title":"Should we restrict vitamin A intake, a minor contributor to plasma retinol turnover, when using retinol isotope dilution equations to estimate an individual's vitamin A status, or should vitamin A balance be maintained?.","volume":"147","author":"Ford","year":"2017","journal-title":"J Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622005004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622005004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/advance-article-pdf\/doi\/10.1093\/jn\/nxab337\/40424096\/nxab337.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/1\/86\/43698677\/nxab337.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/1\/86\/43698677\/nxab337.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T21:36:37Z","timestamp":1686692197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622005004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0022316622005004"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxab337","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does the Amount of Stable Isotope Dose Influence Retinol Kinetic Responses and Predictions of Vitamin A Total Body Stores by the Retinol Isotope Dilution Method in Theoretical Children and Adults?","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxab337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}