{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:33:14Z","timestamp":1777519994673,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903312"],"award-info":[{"award-number":["81903312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1093\/jn\/nxab404","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T12:11:48Z","timestamp":1643285508000},"page":"1052-1058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Plasma Alkylresorcinol Metabolite, a Biomarker for Whole-Grain Intake, Is Inversely Associated with Risk of Nonalcoholic Fatty Liver Disease in a Case-Control Study of Chinese Adults"],"prefix":"10.1016","volume":"152","author":[{"given":"Taoping","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangkai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixiao","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-1224","authenticated-orcid":false,"given":"Liegang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1093\/jn\/nxab404_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014meta-analytic assessment of prevalence, incidence, and outcomes.","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology."},{"issue":"2","key":"10.1093\/jn\/nxab404_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12072-020-10023-3","article-title":"The epidemiology of NAFLD in Mainland China with analysis by adjusted gross regional domestic product: a meta-analysis.","volume":"14","author":"Wu","year":"2020","journal-title":"Hepatol Int."},{"issue":"4","key":"10.1093\/jn\/nxab404_bib4","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016\u20132030.","volume":"69","author":"Estes","year":"2018","journal-title":"J Hepatol."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib5","doi-asserted-by":"crossref","first-page":"22100","DOI":"10.3402\/fnr.v58.22100","article-title":"The HEALTHGRAIN definition of \u2018whole grain","volume":"58","author":"van der Kamp","year":"2014","journal-title":"Food Nutr Res."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/10408390802248734","article-title":"Health benefits of whole grain phytochemicals.","volume":"50","author":"Okarter","year":"2010","journal-title":"Crit Rev Food Sci Nutr."},{"issue":"5","key":"10.1093\/jn\/nxab404_bib7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/ajcn\/80.5.1237","article-title":"Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-y weight gain among men.","volume":"80","author":"Koh-Banerjee","year":"2004","journal-title":"Am J Clin Nutr."},{"issue":"5","key":"10.1093\/jn\/nxab404_bib8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3945\/ajcn.2009.29106","article-title":"Whole- and refined-grain intakes are differentially associated with abdominal visceral and subcutaneous adiposity in healthy adults: the Framingham Heart Study.","volume":"92","author":"McKeown","year":"2010","journal-title":"Am J Clin Nutr."},{"issue":"11","key":"10.1093\/jn\/nxab404_bib9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10654-013-9852-5","article-title":"Whole grain and refined grain consumption and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies.","volume":"28","author":"Aune","year":"2013","journal-title":"Eur J Epidemiol."},{"key":"10.1093\/jn\/nxab404_bib10","doi-asserted-by":"crossref","first-page":"m2206","DOI":"10.1136\/bmj.m2206","article-title":"Intake of whole grain foods and risk of type 2 diabetes: results from three prospective cohort studies.","volume":"370","author":"Hu","year":"2020","journal-title":"BMJ."},{"key":"10.1093\/jn\/nxab404_bib11","doi-asserted-by":"crossref","first-page":"i2716","DOI":"10.1136\/bmj.i2716","article-title":"Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies.","volume":"353","author":"Aune","year":"2016","journal-title":"BMJ."},{"issue":"8","key":"10.1093\/jn\/nxab404_bib12","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00394-014-0679-y","article-title":"The impact of cereal grain consumption on the development and severity of non-alcoholic fatty liver disease.","volume":"53","author":"Georgoulis","year":"2014","journal-title":"Eur J Nutr."},{"issue":"2","key":"10.1093\/jn\/nxab404_bib13","first-page":"102","article-title":"Vegetarian diet, food substitution, and nonalcoholic fatty liver.","volume":"30","author":"Chiu","year":"2018","journal-title":"Ci Ji Yi Xue Za Zhi."},{"issue":"14","key":"10.1093\/jn\/nxab404_bib14","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/jnci\/djr189","article-title":"Dealing with dietary measurement error in nutritional cohort studies.","volume":"103","author":"Freedman","year":"2011","journal-title":"J Natl Cancer Inst."},{"issue":"4","key":"10.1093\/jn\/nxab404_bib15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/ajcn\/87.4.797","article-title":"Are alkylresorcinols accurate biomarkers for whole grain intake?.","volume":"87","author":"van Dam","year":"2008","journal-title":"Am J Clin Nutr."},{"issue":"4","key":"10.1093\/jn\/nxab404_bib16","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/ije\/dys105","article-title":"Review and evaluation of innovative technologies for measuring diet in nutritional epidemiology.","volume":"41","author":"Illner","year":"2012","journal-title":"Int J Epidemiol."},{"issue":"5","key":"10.1093\/jn\/nxab404_bib17","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3945\/ajcn.2009.28290","article-title":"Plasma pharmacokinetics of alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intake.","volume":"90","author":"S\u00f6derholm","year":"2009","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib18","doi-asserted-by":"crossref","first-page":"djt352","DOI":"10.1093\/jnci\/djt352","article-title":"Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer.","volume":"106","author":"Kyr\u00f8","year":"2014","journal-title":"J Natl Cancer Inst."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1158\/1055-9965.EPI-13-0878","article-title":"Plasma alkylresorcinol metabolites as biomarkers for whole-grain intake and their association with prostate cancer: a Swedish nested case-control study.","volume":"23","author":"Drake","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3945\/ajcn.116.133496","article-title":"Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and risk of type 2 diabetes in Scandinavian men and women.","volume":"104","author":"Biskup","year":"2016","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2337\/dc17-1570","article-title":"Plasma alkylresorcinol metabolite, a biomarker of whole-grain wheat and rye intake, and risk of type 2 diabetes and impaired glucose regulation in a Chinese population.","volume":"41","author":"Sun","year":"2018","journal-title":"Diabetes Care."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/CEJ.0b013e328333d12a","article-title":"Plasma levels of alkylresorcinols and incidence of endometrial cancer.","volume":"19","author":"Olsen","year":"2010","journal-title":"Eur J Cancer Prev."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1753-4887.2004.tb00029.x","article-title":"Dietary alkylresorcinols: absorption, bioactivities, and possible use as biomarkers of whole-grain wheat- and rye-rich foods.","volume":"62","author":"Ross","year":"2004","journal-title":"Nutr Rev."},{"issue":"14","key":"10.1093\/jn\/nxab404_bib24","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1021\/jf0340456","article-title":"Alkylresorcinols in cereals and cereal products.","volume":"51","author":"Ross","year":"2003","journal-title":"J Agric Food Chem."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1017\/S0007114509992315","article-title":"Plasma alkylresorcinol metabolites as potential biomarkers of whole-grain wheat and rye cereal fibre intakes in women.","volume":"103","author":"Aubertin-Leheudre","year":"2010","journal-title":"Br J Nutr."},{"issue":"4","key":"10.1093\/jn\/nxab404_bib26","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/ajcn\/87.4.832","article-title":"Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: plasma concentration and intake estimated from dietary records.","volume":"87","author":"Landberg","year":"2008","journal-title":"Am J Clin Nutr."},{"issue":"2","key":"10.1093\/jn\/nxab404_bib27","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3390\/cancers2020513","article-title":"Responsiveness of urinary and plasma alkylresorcinol metabolites to rye intake in Finnish women.","volume":"2","author":"Aubertin-Leheudre","year":"2010","journal-title":"Cancers."},{"issue":"5","key":"10.1093\/jn\/nxab404_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1586\/17474124.2015.1007955","article-title":"Role of ultrasound in the diagnosis and treatment of nonalcoholic fatty liver disease and its complications.","volume":"9","author":"Ballestri","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib29","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut-off points of body mass index and waist circumference in Chinese adults.","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed Environ Sci."},{"key":"10.1093\/jn\/nxab404_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.metabol.2017.12.011","article-title":"A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: a randomized-controlled trial.","volume":"82","author":"Malin","year":"2018","journal-title":"Metabolism."},{"issue":"5","key":"10.1093\/jn\/nxab404_bib31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/ajcn\/nqy169","article-title":"Diets rich in whole grains increase betainized compounds associated with glucose metabolism.","volume":"108","author":"K\u00e4rkk\u00e4inen","year":"2018","journal-title":"Am J Clin Nutr."},{"issue":"2","key":"10.1093\/jn\/nxab404_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/advances\/nmy092","article-title":"Food groups and risk of overweight, obesity, and weight gain: a systematic review and dose-response meta-analysis of prospective studies.","volume":"10","author":"Schlesinger","year":"2019","journal-title":"Adv Nutr."},{"issue":"10170","key":"10.1093\/jn\/nxab404_bib33","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0140-6736(18)31809-9","article-title":"Carbohydrate quality and human health: a series of systematic reviews and meta-analyses.","volume":"393","author":"Reynolds","year":"2019","journal-title":"Lancet North Am Ed."},{"issue":"Suppl 1","key":"10.1093\/jn\/nxab404_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/nutrit\/nuz079","article-title":"Emerging science on whole grain intake and inflammation.","volume":"78","author":"Sang","year":"2020","journal-title":"Nutr Rev."},{"key":"10.1093\/jn\/nxab404_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/585876","article-title":"Increasing whole grain intake as part of prevention and treatment of nonalcoholic fatty liver disease.","volume":"2013","author":"Ross","year":"2013","journal-title":"Int J Endocrinol."},{"issue":"4","key":"10.1093\/jn\/nxab404_bib36","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1017\/S0007114515001701","article-title":"Whole-grain products and whole-grain types are associated with lower all-cause and cause-specific mortality in the Scandinavian HELGA cohort.","volume":"114","author":"Johnsen","year":"2015","journal-title":"Br J Nutr."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib37","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2105\/AJPH.89.3.322","article-title":"Is whole grain intake associated with reduced total and cause-specific death rates in older women? The Iowa Women's Health Study.","volume":"89","author":"Jacobs","year":"1999","journal-title":"Am J Public Health."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib38","first-page":"233","article-title":"Whole-Grain foods in health and disease.","volume":"19","author":"Marquart","year":"2002","journal-title":"Kents Technol Cereals."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib39","first-page":"439","article-title":"The transition of Chinese dietary guidelines and food guide pagoda.","volume":"20","author":"Ge","year":"2011","journal-title":"Asia Pac J Clin Nutr."},{"issue":"3","key":"10.1093\/jn\/nxab404_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S2213-8587(14)70134-2","article-title":"Obesity, inflammation, and the gut microbiota.","volume":"3","author":"Cox","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"7","key":"10.1093\/jn\/nxab404_bib41","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD.","volume":"13","author":"Leung","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol."},{"issue":"1","key":"10.1093\/jn\/nxab404_bib42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3945\/ajcn.2009.28521","article-title":"Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation.","volume":"91","author":"Priebe","year":"2010","journal-title":"Am J Clin Nutr."},{"issue":"5","key":"10.1093\/jn\/nxab404_bib43","doi-asserted-by":"crossref","first-page":"G1068","DOI":"10.1152\/ajpgi.00249.2010","article-title":"Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine.","volume":"299","author":"Kathirvel","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"issue":"2","key":"10.1093\/jn\/nxab404_bib44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/1440-1681.12514","article-title":"Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice.","volume":"43","author":"Naowaboot","year":"2016","journal-title":"Clin Exp Pharmacol Physiol."},{"issue":"7","key":"10.1093\/jn\/nxab404_bib45","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/liv.13435","article-title":"The Mediterranean dietary pattern as the diet of choice for non-alcoholic fatty liver disease: evidence and plausible mechanisms.","volume":"37","author":"Zelber-Sagi","year":"2017","journal-title":"Liver Int."},{"issue":"5","key":"10.1093\/jn\/nxab404_bib46","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/jn\/137.5.1137","article-title":"Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins.","volume":"137","author":"Linko-Parvinen","year":"2007","journal-title":"J Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622006010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622006010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jn\/advance-article-pdf\/doi\/10.1093\/jn\/nxab404\/42884710\/nxab404.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/4\/1052\/43190398\/nxab404.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/4\/1052\/43190398\/nxab404.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T21:49:45Z","timestamp":1735249785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622006010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0022316622006010"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxab404","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma Alkylresorcinol Metabolite, a Biomarker for Whole-Grain Intake, Is Inversely Associated with Risk of Nonalcoholic Fatty Liver Disease in a Case-Control Study of Chinese Adults","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxab404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}