{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:08:08Z","timestamp":1784992088602,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","award":["2005-35200-15218"],"award-info":[{"award-number":["2005-35200-15218"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","award":["2009-35200-05171"],"award-info":[{"award-number":["2009-35200-05171"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1093\/jn\/nxab416","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T20:11:23Z","timestamp":1638562283000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Placental Iron Content Is Lower than Previously Estimated and Is Associated with Maternal Iron Status in Women at Greater Risk of Gestational Iron Deficiency and Anemia"],"prefix":"10.1016","volume":"152","author":[{"given":"Alexa","family":"Barad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4394-344X","authenticated-orcid":false,"given":"Ronnie","family":"Guillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva K","family":"Pressman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Katzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Darrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly O","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/nxab416_bib1","unstructured":"Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron metabolism in man. Oxford (UK): Blackwell Scientific Publications; 1979."},{"issue":"3","key":"10.1093\/jn\/nxab416_bib2","doi-asserted-by":"crossref","DOI":"10.1152\/ajplegacy.1958.193.3.615","article-title":"Iron metabolism in the pregnant rabbit; iron transport across the placenta.","volume":"193","author":"Bothwell","year":"1958","journal-title":"Am J Physiol."},{"issue":"3","key":"10.1093\/jn\/nxab416_bib3","article-title":"Iron metabolism and placental transfer of iron in the term rhesus monkey (Macaca mulatta): a compartmental analysis.","volume":"7","author":"van\u00a0Dijk","year":"1977","journal-title":"EurJ Obstet Gynecol Reprod Biol."},{"key":"10.1093\/jn\/nxab416_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fphys.2016.00028","article-title":"Placental adaptation: what can we learn from birthweight:placental weight ratio?.","volume":"7","author":"Hayward","year":"2016","journal-title":"Front Physiol."},{"issue":"5","key":"10.1093\/jn\/nxab416_bib5","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/9.5.613","article-title":"Iron content of intact placentas and cords.","volume":"9","author":"McCoy","year":"1961","journal-title":"Am J Clin Nutr."},{"issue":"Suppl 6","key":"10.1093\/jn\/nxab416_bib6","doi-asserted-by":"crossref","first-page":"1567S","DOI":"10.3945\/ajcn.117.155812","article-title":"Iron homeostasis during pregnancy.","volume":"106","author":"Fisher","year":"2017","journal-title":"Am J Clin Nutr."},{"issue":"10","key":"10.1093\/jn\/nxab416_bib7","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201600069R","article-title":"Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans.","volume":"30","author":"Best","year":"2016","journal-title":"FASEB J."},{"issue":"11","key":"10.1093\/jn\/nxab416_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2010.08.009","article-title":"Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents.","volume":"31","author":"Young","year":"2010","journal-title":"Placenta."},{"issue":"4","key":"10.1093\/jn\/nxab416_bib9","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.90793.2008","article-title":"Fetal iron status regulates maternal iron metabolism during pregnancy in the rat.","volume":"296","author":"Gambling","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"issue":"2","key":"10.1093\/jn\/nxab416_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI127341","article-title":"Effects of maternal iron status on placental and fetal iron homeostasis.","volume":"130","author":"Sangkhae","year":"2019","journal-title":"J Clin Invest."},{"issue":"10","key":"10.1093\/jn\/nxab416_bib11","doi-asserted-by":"crossref","DOI":"10.3945\/jn.114.191445","article-title":"Maternal inflammation at delivery affects assessment of maternal iron status.","volume":"144","author":"Lee","year":"2014","journal-title":"J Nutr."},{"issue":"4","key":"10.1093\/jn\/nxab416_bib12","doi-asserted-by":"crossref","DOI":"10.3945\/ajcn.115.126284","article-title":"Iron deficiency and anemia are prevalent in women with multiple gestations.","volume":"104","author":"Ru","year":"2016","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/jn\/nxab416_bib13","unstructured":"Institute of Medicine. Rasmussen KM, Yaktine ALeditors. Weight gain during pregnancy: reexamining the guidelines. Washington (DC): National Academies Press, National Academy of Sciences; 2009."},{"issue":"1","key":"10.1093\/jn\/nxab416_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/pr.2015.183","article-title":"Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents.","volume":"79","author":"Lee","year":"2016","journal-title":"Pediatr Res."},{"issue":"2","key":"10.1093\/jn\/nxab416_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41390-018-0044-6","article-title":"Predictors of anemia and iron status at birth in neonates born to women carrying multiple fetuses.","volume":"84","author":"Ru","year":"2018","journal-title":"Pediatr Res."},{"issue":"11","key":"10.1093\/jn\/nxab416_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/nxy151","article-title":"Umbilical cord hepcidin concentrations are positively associated with the variance in iron status among multiple birth neonates.","volume":"148","author":"Ru","year":"2018","journal-title":"J Nutr."},{"issue":"3","key":"10.1093\/jn\/nxab416_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/nxy286","article-title":"Umbilical cord serum ferritin concentration is inversely associated with umbilical cord hemoglobin in neonates born to adolescents carrying singletons and women carrying multiples.","volume":"149","author":"Delaney","year":"2019","journal-title":"J Nutr."},{"issue":"Rr-3","key":"10.1093\/jn\/nxab416_bib18","first-page":"1","article-title":"Recommendations to prevent and control iron deficiency in the united states.","volume":"47","year":"1998","journal-title":"MMWR Recomm Rep."},{"key":"10.1093\/jn\/nxab416_bib19","unstructured":"Institute of Medicine. Earl R, Woteki CEeditors. Iron deficiency anemia: recommended guidelines for the prevention, detection, and management among US children and women of childbearing age. Washington (DC): National Academies Press, National Academy of Sciences; 1993."},{"key":"10.1093\/jn\/nxab416_bib20","unstructured":"World Health Organization. The management of nutrition in major emergencies. Geneva: WHO; 2000."},{"key":"10.1093\/jn\/nxab416_bib21","unstructured":"World Health Organization. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: WHO; 2020."},{"issue":"6","key":"10.1093\/jn\/nxab416_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/68.6.1241","article-title":"Serum transferrin receptor: a specific marker of iron deficiency in pregnancy.","volume":"68","author":"Akesson","year":"1998","journal-title":"Am J Clin Nutr."},{"issue":"9","key":"10.1093\/jn\/nxab416_bib23","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2002-10-3071","article-title":"The quantitative assessment of body iron.","volume":"101","author":"Cook","year":"2003","journal-title":"Blood."},{"key":"10.1093\/jn\/nxab416_bib24","unstructured":"Orkin SHN, Ginsburg D, Nathan DG, Look AT, Fisher DE, Lux S. Nathan and Oski's hematology of infancy and childhood. 8th ed. Philadelphia (PA): Saunders Elsevier; 2014."},{"key":"10.1093\/jn\/nxab416_bib25","article-title":"Elemental content of the placenta: a comparison between two high-risk obstetrical populations, adult women carrying multiples and adolescents carrying singletons.","volume":"158","author":"de\u00a0Angelis","year":"2017","journal-title":"Environ Res."},{"issue":"3","key":"10.1093\/jn\/nxab416_bib26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1530\/REP-14-0053","article-title":"Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status.","volume":"148","author":"Cao","year":"2014","journal-title":"Reproduction."},{"issue":"7","key":"10.1093\/jn\/nxab416_bib27","doi-asserted-by":"crossref","DOI":"10.3945\/jn.110.135798","article-title":"Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents.","volume":"141","author":"Jaacks","year":"2011","journal-title":"J Nutr."},{"issue":"1","key":"10.1093\/jn\/nxab416_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0143-4004(05)80235-8","article-title":"Placental water content and distribution.","volume":"15","author":"Barker","year":"1994","journal-title":"Placenta."},{"issue":"1\u20133","key":"10.1093\/jn\/nxab416_bib29","article-title":"Human placenta as a \u2018dual\u2019 biomarker for monitoring fetal and maternal environment with special reference to potentially toxic trace elements. Part 2: essential minor, trace and other (non-essential) elements in human placenta.","volume":"280","author":"Iyengar","year":"2001","journal-title":"Sci Total Environ."},{"key":"10.1093\/jn\/nxab416_bib30","unstructured":"Harrell FE Jr., Harrel miscellaneous: package \u2018Hmisc\u2019\u00a0[Internet]. [cited 2021 Mar 21].\u00a0Available\u00a0fromhttps:\/\/cran.r-project.org\/web\/packages\/Hmisc\/Hmisc.pdf"},{"key":"10.1093\/jn\/nxab416_bib31","unstructured":"Lenth RV, Buerkner P, Herve M, Love J, Reibl H, Singmann H. Estimated marginal means \u2018emmeans\u2019. [Internet]. 2021; [cited 2021 Mar 21]. Available from: https:\/\/cran.r-project.org\/web\/packages\/emmeans\/emmeans.pdf."},{"issue":"7","key":"10.1093\/jn\/nxab416_bib32","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1093\/jn\/nxab093","article-title":"Serum erythroferrone during pregnancy is related to erythropoietin but does not predict the risk of anemia.","volume":"151","author":"Delaney","year":"2021","journal-title":"J Nutr."},{"issue":"9","key":"10.1093\/jn\/nxab416_bib33","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1093\/jn\/nxab156","article-title":"Umbilical cord erythroferrone is inversely associated with hepcidin, but does not capture the most variability in iron status of neonates born to teens carrying singletons and women carrying multiples.","volume":"151","author":"Delaney","year":"2021","journal-title":"J Nutr."},{"issue":"1","key":"10.1093\/jn\/nxab416_bib34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/AOG.0b013e3181809c0d","article-title":"ACOG practice bulletin no. 95: anemia in pregnancy.","volume":"112","year":"2008","journal-title":"Obstet Gynecol."},{"issue":"11","key":"10.1093\/jn\/nxab416_bib35","doi-asserted-by":"crossref","first-page":"e112216","DOI":"10.1371\/journal.pone.0112216","article-title":"Iron status and reproduction in US women: National Health and Nutrition Examination Survey, 1999\u20132006.","volume":"9","author":"Miller","year":"2014","journal-title":"PLoS One."},{"issue":"1","key":"10.1093\/jn\/nxab416_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2399\/prn.17.0251002","article-title":"The association between anemia prevalence, maternal age and parity in term pregnancies in our city.","volume":"25","author":"Kavak","year":"2017","journal-title":"Perinat J."},{"key":"10.1093\/jn\/nxab416_bib37","unstructured":"Institute of Medicine. Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington (DC): National Academies Press, National Academy of Sciences; 2001."},{"issue":"1","key":"10.1093\/jn\/nxab416_bib38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejogrb.2008.02.012","article-title":"Change in iron transporter expression in human term placenta with different maternal iron status.","volume":"140","author":"Li","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"issue":"5","key":"10.1093\/jn\/nxab416_bib39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3109\/03014460903563434","article-title":"Teen motherhood in cross-cultural perspective.","volume":"37","author":"Kramer","year":"2010","journal-title":"Ann Hum Biol."},{"key":"10.1093\/jn\/nxab416_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jtemb.2019.03.006","article-title":"Placental levels of metals and associated factors in urban and sub-urban areas of Seville (Spain).","volume":"54","author":"Cerrillos","year":"2019","journal-title":"J Trace Elem Med Biol."},{"issue":"3","key":"10.1093\/jn\/nxab416_bib41","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1039\/c8mt00331a","article-title":"Maternal, placental and cordonal metallomic profiles in gestational diabetes mellitus.","volume":"11","author":"Roverso","year":"2019","journal-title":"Metallomics."},{"issue":"S3","key":"10.1093\/jn\/nxab416_bib42","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2458-13-S3-S2","article-title":"The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysis.","volume":"13","author":"Kozuki","year":"2013","journal-title":"BMC Public Health."},{"issue":"14","key":"10.1093\/jn\/nxab416_bib43","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1113\/jphysiol.2009.173013","article-title":"Placental efficiency and adaptation: endocrine regulation.","volume":"587","author":"Fowden","year":"2009","journal-title":"J Physiol."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622005776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622005776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jn\/advance-article-pdf\/doi\/10.1093\/jn\/nxab416\/42249158\/nxab416.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/3\/737\/42686540\/nxab416.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/3\/737\/42686540\/nxab416.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T21:39:36Z","timestamp":1686692376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622005776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022316622005776"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxab416","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental Iron Content Is Lower than Previously Estimated and Is Associated with Maternal Iron Status in Women at Greater Risk of Gestational Iron Deficiency and Anemia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxab416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}