{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:32:49Z","timestamp":1789201969455,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701000"],"award-info":[{"award-number":["2021YFC2701000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1000506"],"award-info":[{"award-number":["2016YFC1000506"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2018RU002"],"award-info":[{"award-number":["2018RU002"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070323"],"award-info":[{"award-number":["82070323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Suzhou Science, Education and Health Project","award":["KJXW2019067"],"award-info":[{"award-number":["KJXW2019067"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1093\/jn\/nxac050","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T12:10:28Z","timestamp":1646136628000},"page":"1496-1506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["RBC Folate and Serum Folate, Vitamin B-12, and Homocysteine in Chinese Couples Prepregnancy in the Shanghai Preconception Cohort"],"prefix":"10.1016","volume":"152","author":[{"given":"Mengru","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/nxac050_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mam.2016.11.001","article-title":"Effects of altered parental folate and one-carbon nutrient status on offspring growth and metabolism","volume":"53","author":"Crott","year":"2017","journal-title":"Mol Aspects Med"},{"issue":"21","key":"10.1093\/jn\/nxac050_bib2","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.2008.742","article-title":"Contributions of total daily intake of folic acid to serum folate concentrations","volume":"300","author":"Yeung","year":"2008","journal-title":"JAMA"},{"issue":"7093","key":"10.1093\/jn\/nxac050_bib3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1136\/bmj.314.7093.1545","article-title":"Socioeconomic determinants of health: the contribution of nutrition to inequalities in health","volume":"314","author":"James","year":"1997","journal-title":"BMJ"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"Jacques","year":"1996","journal-title":"Circulation"},{"key":"10.1093\/jn\/nxac050_bib5","series-title":"Serum and red blood cell folate concentrations for assessing folate status in populations [Internet]. Vitamin and Mineral Nutrition Information System","year":"2015"},{"issue":"15","key":"10.1093\/jn\/nxac050_bib6","first-page":"421","article-title":"Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines","volume":"64","author":"Cordero","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"9","key":"10.1093\/jn\/nxac050_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/CIRCULATIONAHA.116.022126","article-title":"Effect of folic acid food fortification in Canada on congenital heart disease subtypes","volume":"134","author":"Liu","year":"2016","journal-title":"Circulation"},{"issue":"4","key":"10.1093\/jn\/nxac050_bib8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/eurheartj\/ehp479","article-title":"Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case\u2013control study in the northern Netherlands","volume":"31","author":"van Beynum","year":"2010","journal-title":"Eur Heart J"},{"issue":"7591","key":"10.1093\/jn\/nxac050_bib9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/bmj.39079.618287.0B","article-title":"Folic acid supplements and risk of facial clefts: national population based case-control study","volume":"334","author":"Wilcox","year":"2007","journal-title":"BMJ"},{"key":"10.1093\/jn\/nxac050_bib10","series-title":"Guideline: optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects","year":"2015"},{"key":"10.1093\/jn\/nxac050_bib11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mam.2016.11.007","article-title":"One-carbon metabolism and epigenetics","volume":"54","author":"Friso","year":"2017","journal-title":"Mol Aspects Med"},{"issue":"5","key":"10.1093\/jn\/nxac050_bib12","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/ajcn\/nqz184","article-title":"Folate status in the US population 20 y after the introduction of folic acid fortification","volume":"110","author":"Pfeiffer","year":"2019","journal-title":"Am J Clin Nutr"},{"issue":"5\u20136","key":"10.1093\/jn\/nxac050_bib13","doi-asserted-by":"crossref","first-page":"684","DOI":"10.17269\/s41997-018-0085-y","article-title":"Red blood cell folate levels in Canadian Inuit women of childbearing years: influence of food security, body mass index, smoking, education, and vitamin use","volume":"109","author":"Duncan","year":"2018","journal-title":"Can J Public Health"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib14","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1038\/ncomms3889","article-title":"Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes","volume":"4","author":"Lambrot","year":"2013","journal-title":"Nat Commun"},{"issue":"2","key":"10.1093\/jn\/nxac050_bib15","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.fertnstert.2018.10.017","article-title":"Does the father matter? The association between the periconceptional paternal folate status and embryonic growth","volume":"111","author":"Hoek","year":"2019","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1093\/jn\/nxac050_bib16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/dmcn.12929","article-title":"Paternal transmission ofMTHFD1 G1958A variant predisposes to neural tube defects in the offspring","volume":"58","author":"Prasoona","year":"2016","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1186\/s12884-020-03154-w","article-title":"Effectiveness of community-based folate-oriented tertiary interventions on incidence of fetus and birth defects: a protocol for a single-blind cluster randomized controlled trial","volume":"20","author":"Li","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"issue":"11","key":"10.1093\/jn\/nxac050_bib18","doi-asserted-by":"crossref","first-page":"e031076","DOI":"10.1136\/bmjopen-2019-031076","article-title":"Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile","volume":"9","author":"Wang","year":"2019","journal-title":"BMJ Open"},{"issue":"6","key":"10.1093\/jn\/nxac050_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S2213-8587(21)00045-0","article-title":"Epidemiology and determinants of obesity in China","volume":"9","author":"Pan","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"21","key":"10.1093\/jn\/nxac050_bib20","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1001\/jama.1995.03530210052030","article-title":"Folate levels and neural tube defects. Implications for prevention","volume":"274","author":"Daly","year":"1995","journal-title":"JAMA"},{"issue":"2","key":"10.1093\/jn\/nxac050_bib21","doi-asserted-by":"crossref","first-page":"693S","DOI":"10.3945\/ajcn.2008.26947A","article-title":"How common is vitamin B-12 deficiency?","volume":"89","author":"Allen","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"Supplement_1","key":"10.1093\/jn\/nxac050_bib22","doi-asserted-by":"crossref","first-page":"2524S","DOI":"10.1093\/jn\/nxaa243","article-title":"Sulfur-containing amino acids and lipid metabolism","volume":"150","author":"Blachier","year":"2020","journal-title":"J Nutr"},{"issue":"10","key":"10.1093\/jn\/nxac050_bib23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/bdra.23024","article-title":"Does obesity modify the association of supplemental folic acid with folate status among nonpregnant women of childbearing age in the United States?","volume":"94","author":"Tinker","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3945\/jn.114.199117","article-title":"Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations","volume":"145","author":"Bird","year":"2015","journal-title":"J Nutr"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/nyas.13963","article-title":"Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues","volume":"1431","author":"Rogers","year":"2018","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"10.1093\/jn\/nxac050_bib26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ejcn.2017.60","article-title":"An overview of folate status in a population-based study from S\u00e3o Paulo, Brazil and the potential impact of 10 years of national folic acid fortification policy","volume":"71","author":"Steluti","year":"2017","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/jn\/nxac050_bib27","series-title":"National Diet and Nutrition Survey. Results from Years 7 and 8 (combined) of the Rolling Programme (2014\/2015 to 2015\/2016)","year":"2018"},{"key":"10.1093\/jn\/nxac050_bib28","series-title":"A focus on nutrition: key findings of the 2008\/09 New Zealand Adult Nutrition Survey","year":"2011"},{"issue":"6","key":"10.1093\/jn\/nxac050_bib29","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3945\/ajcn.115.107151","article-title":"Impact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 in Irish adults","volume":"101","author":"Hopkins","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/nxac050_bib30","series-title":"National Nutrition Health Survey (2013\u20132016) in Taiwan","year":"2019"},{"issue":"6","key":"10.1093\/jn\/nxac050_bib31","doi-asserted-by":"crossref","first-page":"957S","DOI":"10.3945\/jn.112.173021","article-title":"Dietary supplement use and smoking are important correlates of biomarkers of water-soluble vitamin status after adjusting for sociodemographic and lifestyle variables in a representative sample of U.S. adults","volume":"143","author":"Pfeiffer","year":"2013","journal-title":"J Nutr"},{"issue":"3","key":"10.1093\/jn\/nxac050_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/1462220031000094330","article-title":"Tobacco smoke exposure and decreased serum and red blood cell folate levels: data from the Third National Health and Nutrition Examination Survey","volume":"5","author":"Mannino","year":"2003","journal-title":"Nicotin Tob Res"},{"issue":"3","key":"10.1093\/jn\/nxac050_bib33","first-page":"485","article-title":"Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption","volume":"92","author":"Gl\u00f3ria","year":"1997","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"10.1093\/jn\/nxac050_bib34","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1093\/jn\/133.11.3630","article-title":"Geographical, seasonal and gender differences in folate status among Chinese adults","volume":"133","author":"Hao","year":"2003","journal-title":"J Nutr"},{"issue":"5","key":"10.1093\/jn\/nxac050_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1017\/S0007114518003677","article-title":"Effect of alcohol consumption on food energy intake: a systematic review and meta-analysis","volume":"121","author":"Kwok","year":"2019","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib36","doi-asserted-by":"crossref","first-page":"18100","DOI":"10.1038\/s41598-021-97635-3","article-title":"The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis","volume":"11","author":"Yang","year":"2021","journal-title":"Sci Rep"},{"issue":"6","key":"10.1093\/jn\/nxac050_bib37","doi-asserted-by":"crossref","first-page":"C1889","DOI":"10.1152\/ajpcell.2000.279.6.C1889","article-title":"Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency","volume":"279","author":"Said","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1093\/jn\/nxac050_bib38","first-page":"470656","article-title":"Folate intake and markers of folate status in women of reproductive age, pregnant and lactating women: a meta-analysis","author":"Berti","year":"2012","journal-title":"J Nutr Metab"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3945\/ajcn.113.062752","article-title":"Biomarker responses to folic acid intervention in healthy adults: a meta-analysis of randomized controlled trials","volume":"99","author":"Duffy","year":"2014","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1093\/jn\/nxac050_bib40","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3945\/jn.113.183970","article-title":"Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women","volume":"144","author":"Abbenhardt","year":"2014","journal-title":"J Nutr"},{"issue":"1","key":"10.1093\/jn\/nxac050_bib41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/nyas.13574","article-title":"Should vitamin B status be considered in assessing risk of neural tube defects?","volume":"1414","author":"Molloy","year":"2018","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1093\/jn\/nxac050_bib42","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1542\/peds.2008-1173","article-title":"Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification","volume":"123","author":"Molloy","year":"2009","journal-title":"Pediatrics"},{"issue":"3","key":"10.1093\/jn\/nxac050_bib43","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/ajcn\/nqy340","article-title":"Vitamin B-12 and liver activity and expression of methionine synthase are decreased in fetuses with neural tube defects","volume":"109","author":"Fofou-Caillierez","year":"2019","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1093\/jn\/nxac050_bib44","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.3390\/nu7042663","article-title":"Assessing the association between natural food folate intake and blood folate concentrations: a systematic review and Bayesian meta-analysis of trials and observational studies","volume":"7","author":"Marchetta","year":"2015","journal-title":"Nutrients"},{"key":"10.1093\/jn\/nxac050_bib45","first-page":"401","article-title":"Study on dietary folate nutrition status pre-pregnancy population","volume":"13","author":"Ji","year":"2018","journal-title":"Chinese Journal of Evidence-Based Pediatrics"},{"issue":"6","key":"10.1093\/jn\/nxac050_bib46","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.amepre.2019.01.004","article-title":"Accuracy of self-reported height, weight, and BMI over time in emerging adults","volume":"56","author":"Lipsky","year":"2019","journal-title":"Am J Prev Med"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622006459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622006459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jn\/advance-article-pdf\/doi\/10.1093\/jn\/nxac050\/43390884\/nxac050.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/6\/1496\/43989489\/nxac050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jn\/article-pdf\/152\/6\/1496\/43989489\/nxac050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T21:42:20Z","timestamp":1686692540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622006459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0022316622006459"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxac050","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RBC Folate and Serum Folate, Vitamin B-12, and Homocysteine in Chinese Couples Prepregnancy in the Shanghai Preconception Cohort","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxac050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}