{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:29:53Z","timestamp":1780968593080,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":1054,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Japan Milk Promotion Board"},{"name":"Japan Dairy Council"},{"name":"Grants-in-Aid for Scientific Research","award":["B #10470114"],"award-info":[{"award-number":["B #10470114"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["B #14370147"],"award-info":[{"award-number":["B #14370147"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["B #18390201"],"award-info":[{"award-number":["B #18390201"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["C#18590619"],"award-info":[{"award-number":["C#18590619"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["B# 23390180"],"award-info":[{"award-number":["B# 23390180"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["C#23590824"],"award-info":[{"award-number":["C#23590824"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Dairy Association"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1093\/jn\/nxz292","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T12:11:04Z","timestamp":1573128664000},"page":"599-605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Natto Intake is Inversely Associated with Osteoporotic Fracture Risk in Postmenopausal Japanese Women"],"prefix":"10.1016","volume":"150","author":[{"given":"Akane","family":"Kojima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoyo","family":"Ikehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyasu","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Kajita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuho","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyasu","family":"Kouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadanobu","family":"Kagamimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Iki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/nxz292_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jama.297.4.387","article-title":"Risk of subsequent fracture after low-trauma fracture in men and women.","volume":"297","author":"Center","year":"2007","journal-title":"J Am Med Assoc"},{"key":"10.1093\/jn\/nxz292_bib2","first-page":"937","article-title":"A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: Morbidity, subsequent fractures, and mortality.","volume":"10","author":"Nazrun","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"10.1093\/jn\/nxz292_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11914-003-0011-x","article-title":"Burden of osteoporosis and fractures.","volume":"1","author":"Keen","year":"2003","journal-title":"Curr Osteoporos Rep"},{"key":"10.1093\/jn\/nxz292_bib4","doi-asserted-by":"crossref","first-page":"e968490","DOI":"10.4161\/19381972.2014.968490","article-title":"Vitamin K: An old vitamin in a new perspective.","volume":"6","author":"Gr\u00f6ber","year":"2015","journal-title":"Dermatoendocrinol"},{"key":"10.1093\/jn\/nxz292_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3945\/an.113.003855","article-title":"Menaquinones, bacteria, and the food supply: The relevance of dairy and fermented food products to Vitamin K requirements.","volume":"4","author":"Walther","year":"2013","journal-title":"Adv Nutr"},{"key":"10.1093\/jn\/nxz292_bib6","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3177\/jnsv.53.464","article-title":"Vitamin K content of foods and dietary vitamin K intake in Japanese young women.","volume":"53","author":"Kamao","year":"2007","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1093\/jn\/nxz292_bib7","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/jn\/136.5.1323","article-title":"Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study.","volume":"136","author":"Ikeda","year":"2006","journal-title":"J Nutr"},{"key":"10.1093\/jn\/nxz292_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00198-011-1594-1","article-title":"Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study.","volume":"23","author":"Fujita","year":"2012","journal-title":"Osteoporos Int"},{"key":"10.1093\/jn\/nxz292_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0899-9007(00)00554-2","article-title":"Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk.","volume":"17","author":"Kaneki","year":"2001","journal-title":"Nutrition"},{"key":"10.1093\/jn\/nxz292_bib10","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00198-019-04844-8","article-title":"Estimates of hip fracture incidence in Japan using the National Health Insurance Claim Database in 2012\u20132015.","volume":"30","author":"Tamaki","year":"2019","journal-title":"Osteoporos Int"},{"key":"10.1093\/jn\/nxz292_bib11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ije\/dyu084","article-title":"Cohort profile: The Japanese Population-based Osteoporosis (JPOS) Cohort Study.","volume":"44","author":"Iki","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1093\/jn\/nxz292_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.maturitas.2013.08.007","article-title":"Age at menopause and determinants of hysterectomy and menopause in a multi-ethnic community: The Hilo Women's Health Study.","volume":"76","author":"Sievert","year":"2013","journal-title":"Maturitas"},{"key":"10.1093\/jn\/nxz292_bib13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s001980170073","article-title":"Bone mineral density of the spine, hip and distal forearm in representative samples of the Japanese female population: Japanese population-based osteoporosis (JPOS) study.","volume":"12","author":"Iki","year":"2001","journal-title":"Osteoporos Int"},{"key":"10.1093\/jn\/nxz292_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1620\/tjem.207.217","article-title":"Development of a food-frequency questionnaire to measure the dietary calcium intake of adult Japanese women.","volume":"207","author":"Sato","year":"2005","journal-title":"Tohoku J Exp Med"},{"key":"10.1093\/jn\/nxz292_bib15","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1359\/jbmr.2000.15.5.872","article-title":"Diet- or warfarin-induced vitamin K insufficiency elevates circulating undercarboxylated osteocalcin without altering skeletal status in growing female rats.","volume":"15","author":"Haffa","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1093\/jn\/nxz292_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbacli.2015.08.002","article-title":"Long-term warfarin therapy and biomarkers for osteoporosis and atherosclerosis.","volume":"12","author":"Namba","year":"2015","journal-title":"BBA Clin"},{"key":"10.1093\/jn\/nxz292_bib17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3143\/geriatrics.48.633","article-title":"Japanese guidelines for the management of stroke 2009.","volume":"48","author":"Uchiyama","year":"2011","journal-title":"Japanese J Geriatr"},{"key":"10.1093\/jn\/nxz292_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00198-011-1600-7","article-title":"Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study.","volume":"23","author":"Iki","year":"2012","journal-title":"Osteoporos Int"},{"key":"10.1093\/jn\/nxz292_bib19","first-page":"489","article-title":"Interrelationship between glucose metabolism and undercarboxylated osteocalcin: A cross-sectional study in a community-dwelling population.","volume":"24","author":"Yano","year":"2015","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1093\/jn\/nxz292_bib20","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4103\/2230-8210.192914","article-title":"Bone turnover markers: Emerging tool in the management of osteoporosis.","volume":"20","author":"Shetty","year":"2016","journal-title":"Indian J Endocrinol Metab"},{"key":"10.1093\/jn\/nxz292_bib21","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3177\/jnsv.61.471","article-title":"Low-dose daily intake of vitamin K2 (menaquinone-7) improves osteocalcin ?-carboxylation: A double-blind, randomized controlled trials.","volume":"61","author":"Inaba","year":"2015","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1093\/jn\/nxz292_bib22","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1017\/S0007114511001425","article-title":"Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation.","volume":"106","author":"Brug\u00e8","year":"2011","journal-title":"Br J Nutr"},{"key":"10.1093\/jn\/nxz292_bib23","doi-asserted-by":"crossref","first-page":"16927","DOI":"10.1074\/jbc.M600896200","article-title":"Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells.","volume":"281","author":"Ichikawa","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1093\/jn\/nxz292_bib24","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00198-013-2325-6","article-title":"Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.","volume":"24","author":"Knapen","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.1093\/jn\/nxz292_bib25","first-page":"527","article-title":"Determinants of skeletal fragility and bone quality.","volume":"2","author":"Turner","year":"2002","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1093\/jn\/nxz292_bib26","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1371\/journal.pmed.0040027","article-title":"Bone quality: an empty term.","volume":"4","author":"Siev\u00e4nen","year":"2007","journal-title":"PLoS Med"},{"key":"10.1093\/jn\/nxz292_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1530\/EJE-16-0498","article-title":"Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women.","volume":"175","author":"R\u00f8nn","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"10.1093\/jn\/nxz292_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF03350919","article-title":"Bone microarchitecture as an important determinant of bone strength.","volume":"27","author":"Dalle Carbonare","year":"2004","journal-title":"J Endocrinol Invest"},{"key":"10.1093\/jn\/nxz292_bib29","first-page":"307","article-title":"The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis.","volume":"16","author":"Conly","year":"1992","journal-title":"Prog Food Nutr Sci"},{"key":"10.1093\/jn\/nxz292_bib30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.11138\/ccmbm\/2017.14.1.200","article-title":"Vitamin K and bone.","volume":"14","author":"Fusaro","year":"2017","journal-title":"Clin Cases Min Bone Metab"},{"key":"10.1093\/jn\/nxz292_bib31","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/jbmr.3114","article-title":"Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.","volume":"32","author":"Guss","year":"2017","journal-title":"J Bone Min Res"},{"key":"10.1093\/jn\/nxz292_bib32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bone.2019.06.010","article-title":"The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength.","volume":"127","author":"Guss","year":"2019","journal-title":"Bone"},{"key":"10.1093\/jn\/nxz292_bib33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3945\/ajcn.110.008359","article-title":"Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial 1 \u2013 4.","volume":"93","author":"Wong","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/jn\/nxz292_bib34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/sj.ejcn.1602748","article-title":"Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials.","volume":"62","author":"Ma","year":"2008","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/jn\/nxz292_bib35","unstructured":"Food Safety Commission of Japan. Daizu-isoflavonewo Fukumu Tokutei-hokenyo-syokuhinno Anzensei-hyoukano Kihontekina Kangaekata (Basic concept of safety evaluation of specified health food containing soy isoflavones). Version current 2006 (Japanese). [accessed 16 June 2019]. [Internet]. Available from: https:\/\/www.mhlw.go.jp\/houdou\/2006\/02\/dl\/h0202-1b.pdf."},{"key":"10.1093\/jn\/nxz292_bib36","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/jn\/130.7.1695","article-title":"Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans.","volume":"130","author":"Izumi","year":"2000","journal-title":"J Nutr"},{"key":"10.1093\/jn\/nxz292_bib37","unstructured":"United States Department of Agriculture. USDA Database for the Isoflavone Content of Selected Foods. U.S. Department of Agriculture; 2015;1\u2013156."},{"key":"10.1093\/jn\/nxz292_bib38","doi-asserted-by":"crossref","first-page":"839","DOI":"10.7326\/0003-4819-146-12-200706190-00005","article-title":"Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women.","volume":"146","author":"Marini","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1093\/jn\/nxz292_bib39","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/jama.2016.14403","article-title":"Trends in dietary supplement use among US adults from 1999-2012.","volume":"316","author":"Kantor","year":"2016","journal-title":"JAMA"},{"key":"10.1093\/jn\/nxz292_bib40","doi-asserted-by":"crossref","first-page":"S226","DOI":"10.1038\/ejcn.2009.83","article-title":"Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study.","volume":"63","author":"Skeie","year":"2009","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/jn\/nxz292_bib41","unstructured":"Japan Ministry of Health, Labour and Welfare. National Nutrition Survey. Version 2001 (Japanese). [Internet]. Available from: https:\/\/www.mhlw.go.jp\/houdou\/2002\/12\/h1211-1b2.html (accessed 16 June 2019)."},{"key":"10.1093\/jn\/nxz292_bib42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s001980050288","article-title":"Validity of self-report of fractures: results from a prospective study in men and women across Europe. EPOS Study Group. European Prospective Osteoporosis Study Group.","volume":"11","author":"Ismail","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.1093\/jn\/nxz292_bib43","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10654-007-9163-9","article-title":"Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registry.","volume":"22","author":"Siggeirsdottir","year":"2007","journal-title":"Eur J Epidemiol"}],"updated-by":[{"DOI":"10.1093\/jn\/nxaa443","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000}},{"DOI":"10.1093\/jn\/nxaa460","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000}}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662202079X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662202079X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/150\/3\/599\/32537202\/nxz292.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/150\/3\/599\/32537202\/nxz292.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T22:12:38Z","timestamp":1686694358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002231662202079X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S002231662202079X"],"URL":"https:\/\/doi.org\/10.1093\/jn\/nxz292","relation":{"erratum":[{"id-type":"doi","id":"10.1093\/jn\/nxaa443","asserted-by":"object"},{"id-type":"doi","id":"10.1093\/jn\/nxaa460","asserted-by":"object"}]},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natto Intake is Inversely Associated with Osteoporotic Fracture Risk in Postmenopausal Japanese Women","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/nxz292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}