{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:15:33Z","timestamp":1791220533729,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,2,18]]},"DOI":"10.1093\/jnci\/90.4.307","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:24:57Z","timestamp":1027722297000},"page":"307-315","source":"Crossref","is-referenced-by-count":56,"title":["Molecular Detection of Cancer Cells by Competitive Reverse Transcription-Polymerase Chain Reaction Analysis of Specific CD44 Variant RNAs"],"prefix":"10.1093","volume":"90","author":[{"given":"Isamu","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-ichiro","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Morisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Saya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritaka","family":"Suga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,2,18]]},"reference":[{"key":"key\n\t\t\t\t20170702064344_bib1","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0140-6736(91)92100-G","article-title":"Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction","volume":"338","author":"Smith","year":"1991","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib2","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1093\/jnci\/85.24.2008","article-title":"Detection of c-Ki-ras mutation by PCR\/RFLP analysis and diagnosis of pancreatic adenocarcinomas","volume":"85","author":"Urban","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t20170702064344_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jnci\/87.2.129","article-title":"Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors","volume":"87","author":"Fitzgerald","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t20170702064344_bib4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/bjc.1995.324","article-title":"The molecular detection of circulating tumour cells","volume":"72","author":"Johnson","year":"1995","journal-title":"Br J Cancer"},{"key":"key\n\t\t\t\t20170702064344_bib5","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/jnci\/87.14.1056","article-title":"Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.","volume":"87","author":"Mills","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t20170702064344_bib6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0140-6736(95)90922-2","article-title":"Genetic diagnosis of lymph-node metastasis in colorectal cancer","volume":"345","author":"Hayashi","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1126\/science.271.5249.659","article-title":"Molecular detection of primary bladder cancer by microsatellite analysis","volume":"271","author":"Mao","year":"1996","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702064344_bib8","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/nm0996-1033","article-title":"Microsatellite alterations in plasma DNA of small cell lung cancer patients","volume":"2","author":"Chen","year":"1996","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702064344_bib9","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nm0996-1035","article-title":"Microsatellite alterations in serum DNA of head and neck cancer patients","volume":"2","author":"Nawroz","year":"1996","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170702064344_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/(SICI)1097-0215(19970106)70:1<52::AID-IJC8>3.0.CO;2-5","article-title":"Increased analytical sensitivity of RT-PCR of PSA mRNA decreases diagnostic specificity of detection of prostatic cells in blood","volume":"70","author":"Henke","year":"1997","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t20170702064344_bib11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/jnci\/89.10.724","article-title":"Detection of telomerase activity in exfoliated cells in urine from patients with bladder cancer","volume":"89","author":"Kinoshita","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t20170702064344_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/359557a0","article-title":"Competitive PCR","volume":"359","author":"Siebert","year":"1992","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170702064344_bib13","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0092-8674(89)90638-7","article-title":"A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family","volume":"56","author":"Stamenkovic","year":"1989","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170702064344_bib14","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0092-8674(90)90694-A","article-title":"CD44 is the principal cell surface receptor for hyaluronate","volume":"61","author":"Aruffo","year":"1990","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170702064344_bib15","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.88.17.7877","article-title":"T-cell-receptor-independent activation of cytolytic activity of cytotoxic T lymphocytes mediated through CD44 and gp90MEL-14","volume":"88","author":"Seth","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702064344_bib16","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.1496383","article-title":"Participation in normal immune responses of a metastasis-inducing splice variant of CD44","volume":"257","author":"Arch","year":"1992","journal-title":"Science"},{"key":"key\n\t\t\t\t20170702064344_bib17","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1083\/jcb.118.4.971","article-title":"CD44H regulates tumor cell migration on hyaluronate-coated substrate","volume":"118","author":"Thomas","year":"1992","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170702064344_bib18","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1016\/S0021-9258(18)42893-1","article-title":"Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain","volume":"267","author":"Jackson","year":"1992","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170702064344_bib19","doi-asserted-by":"crossref","first-page":"12160","DOI":"10.1073\/pnas.89.24.12160","article-title":"Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons","volume":"89","author":"Screaton","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170702064344_bib20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/j.1460-2075.1991.tb07955.x","article-title":"The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells","volume":"10","author":"Stamenkovic","year":"1991","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170702064344_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0140-6736(93)90126-2","article-title":"CD44 and cancer","volume":"341","author":"Jackson","year":"1993","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/0140-6736(93)91670-H","article-title":"CD44 and cancer screening","volume":"342","author":"Fox","year":"1993","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib23","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/bjc.1996.364","article-title":"Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer","volume":"74","author":"Gotley","year":"1996","journal-title":"Br J Cancer"},{"key":"key\n\t\t\t\t20170702064344_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0092-8674(91)90403-L","article-title":"A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells","volume":"65","author":"G\u00fcnthert","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170702064344_bib25","first-page":"5292","article-title":"CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines","volume":"51","author":"Hofmann","year":"1991","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170702064344_bib26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/mc.2940070403","article-title":"Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase","volume":"7","author":"Tanabe","year":"1993","journal-title":"Mol Carcinog"},{"key":"key\n\t\t\t\t20170702064344_bib27","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0140-6736(93)92879-X","article-title":"De-novo expression of CD44 and survival in gastric cancer","volume":"342","author":"Mayer","year":"1993","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib28","first-page":"4754","article-title":"Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression","volume":"53","author":"Wielenga","year":"1993","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170702064344_bib29","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/S0140-6736(94)90290-9","article-title":"Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins","volume":"344","author":"Mulder","year":"1994","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0140-6736(95)90320-8","article-title":"Effect of CD44v6 on survival in colorectal carcinoma","volume":"345","author":"Koretz","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0140-6736(95)90521-9","article-title":"CD44 variant exon epitopes in primary breast cancer and length of survival","volume":"345","author":"Kaufmann","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib32","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0140-6736(95)92018-8","article-title":"CD44 isoforms in prognosis of breast cancer","volume":"345","author":"Friedrichs","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib33","first-page":"19","article-title":"Are CD44 variant isoforms involved in human tumour progression?","volume":"24","author":"G\u00fcnthert","year":"1995","journal-title":"Cancer Surv"},{"key":"key\n\t\t\t\t20170702064344_bib34","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/ijc.2910640512","article-title":"CD44 expression patterns in breast and colon tumors: a PCR-based study of splice variants","volume":"64","author":"Rodriguez","year":"1995","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t20170702064344_bib35","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/0959-8049(95)00252-E","article-title":"CD44 in colon cancer","volume":"31A","author":"Herrlich","year":"1995","journal-title":"Eur J Cancer"},{"key":"key\n\t\t\t\t20170702064344_bib36","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(95)90491-3","article-title":"Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins","volume":"345","author":"Finke","year":"1995","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib37","first-page":"450","article-title":"Expression of CD44 isoforms\u2014a new histopathologic parameter in colorectal carcinoma?","volume":"121","author":"Finke","year":"1996","journal-title":"Zentralbl Chir"},{"key":"key\n\t\t\t\t20170702064344_bib38","first-page":"1519","article-title":"Analysis of anomalous CD44 gene expression in human breast, bladder, and colon cancer and correlation of observed mRNA and protein isoforms","volume":"149","author":"Woodman","year":"1996","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170702064344_bib39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/(SICI)1097-0215(19960621)69:3<218::AID-IJC12>3.0.CO;2-3","article-title":"CD44 standard and variant isoform expression in human epidermal skin tumors is not correlated with tumor aggressiveness but down-regulated during proliferation and tumor de-differentiation","volume":"69","author":"Seelentag","year":"1996","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t20170702064344_bib40","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1200\/JCO.1996.14.4.1122","article-title":"Expression of a CD44 variant containing exons 8 to 10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients","volume":"14","author":"Yamaguchi","year":"1996","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t20170702064344_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/(SICI)1097-0142(19960101)77:1<25::AID-CNCR6>3.0.CO;2-M","article-title":"Progression in gastric carcinoma relative to the ratio of CD44 epithelial variant transcript to CD44 hematopoietic variant transcript","volume":"77","author":"Miwa","year":"1996","journal-title":"Cancer"},{"key":"key\n\t\t\t\t20170702064344_bib42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/bjs.1800840328","article-title":"Expression of CD44 splice variants in colorectal cancer","volume":"84","author":"Wong","year":"1997","journal-title":"Br J Surg"},{"key":"key\n\t\t\t\t20170702064344_bib43","first-page":"2281","article-title":"Regulation of CD44v6-containing isoforms during proliferation of normal and malignant epithelial cells","volume":"57","author":"Soukka","year":"1997","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170702064344_bib44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0140-6736(93)90490-8","article-title":"Expression of CD44R1 adhesion molecule in colon carcinomas and metastases","volume":"341","author":"Tanabe","year":"1993","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib45","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1349-7006.1996.tb03139.x","article-title":"Increased expression of CD44 variants in differentiated thyroid cancers","volume":"87","author":"Takano","year":"1996","journal-title":"Jpn J Cancer Res"},{"key":"key\n\t\t\t\t20170702064344_bib46","first-page":"2223","article-title":"CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas","volume":"11","author":"Takahashi","year":"1995","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170702064344_bib47","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0140-6736(92)93077-Z","article-title":"Significance of CD44 gene products for cancer diagnosis and disease evaluation","volume":"340","author":"Matsumura","year":"1992","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170702064344_bib48","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/bmj.308.6929.619","article-title":"Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells","volume":"308","author":"Matsumura","year":"1994","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20170702064344_bib49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/path.1711770104","article-title":"Unusual retention of introns in CD44 gene transcripts in bladder cancer provides new diagnostic and clinical oncological opportunities","volume":"177","author":"Matsumura","year":"1995","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20170702064344_bib50","first-page":"4273","article-title":"Abnormal retention of intron 9 in CD44 gene transcripts in human gastrointestinal tumors","volume":"55","author":"Yoshida","year":"1995","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170702064344_bib51","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/jcp.49.4.300","article-title":"Detection of exfoliated carcinoma cells in colonic luminal washings by identification of deranged patterns of expression of the CD44 gene","volume":"49","author":"Yoshida","year":"1996","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t20170702064344_bib52","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0025-7125(16)31265-2","article-title":"Pleural effusions","volume":"61","author":"Light","year":"1977","journal-title":"Med Clin North Am"},{"key":"key\n\t\t\t\t20170702064344_bib53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0272-5231(21)01157-6","article-title":"Pleural effusion in lung cancer","volume":"14","author":"Sahn","year":"1993","journal-title":"Clin Chest Med"},{"key":"key\n\t\t\t\t20170702064344_bib54","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-114-4-271","article-title":"Thoracoscopy for the diagnosis of pleural disease","volume":"114","author":"Menzies","year":"1991","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20170702064344_bib55","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0022-5347(17)61391-0","article-title":"Urinary cytology and the clinical diagnosis of urinary tract malignancy: a clinicopathologic study of 1,400 patients","volume":"106","author":"Sarnacki","year":"1971","journal-title":"J Urol"},{"key":"key\n\t\t\t\t20170702064344_bib56","first-page":"2495","article-title":"Morphological and clinical observations of patients with early bladder cancer treated with total cystectomy","volume":"36","author":"Farrow","year":"1976","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170702064344_bib57","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/1097-0142(19840401)53:7<1555::AID-CNCR2820530723>3.0.CO;2-G","article-title":"Urinary cytology and bladder cancer. The cellular features of transitional cell neoplasms","volume":"53","author":"Murphy","year":"1984","journal-title":"Cancer"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/90\/4\/307\/18048834\/90-4-307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T03:41:48Z","timestamp":1682221308000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article-lookup\/doi\/10.1093\/jnci\/90.4.307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2,18]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1998,2,18]]},"published-print":{"date-parts":[[1998,2,18]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/90.4.307","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2,18]]}}}