{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:17:17Z","timestamp":1791310637150,"version":"4.3.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNCI Journal of the National Cancer Institute"],"published-print":{"date-parts":[[2003,5,21]]},"DOI":"10.1093\/jnci\/95.10.723","type":"journal-article","created":{"date-parts":[[2003,5,20]],"date-time":"2003-05-20T20:17:25Z","timestamp":1053461845000},"page":"723-732","source":"Crossref","is-referenced-by-count":122,"title":["p16\/Cyclin-Dependent Kinase Inhibitor 2A Deficiency in Human Melanocyte Senescence, Apoptosis, and Immortalization: Possible Implications for Melanoma Progression"],"prefix":"10.1093","volume":"95","author":[{"given":"E. V.","family":"Sviderskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. C.","family":"Gray-Schopfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. P.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Evans-Whipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kipling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wynford-Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"2","key":"1_6236271","first-page":"F115","volume":"1378","author":"Ruas","year":"1998","journal-title":"Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"issue":"1","key":"2_10747089","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S0959-437X(99)80004-5","volume":"9","author":"Sharpless","year":"1999","journal-title":"Current opinion in genetics &amp; development","ISSN":"https:\/\/id.crossref.org\/issn\/0959-437X","issn-type":"print"},{"issue":"1","key":"3_11061707","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1006\/excr.2000.5149","volume":"264","author":"Rocco","year":"2001","journal-title":"Experimental cell research","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4827","issn-type":"print"},{"issue":"10","key":"4_11343861","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/35096061","volume":"2","author":"Sherr","year":"2001","journal-title":"Nature reviews. Molecular cell biology","ISSN":"https:\/\/id.crossref.org\/issn\/1471-0072","issn-type":"print"},{"issue":"6","key":"5_16118270","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/0092-8674(95)90214-7","volume":"83","author":"Quelle","year":"1995","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"6456","key":"6_14538309","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/366704a0","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"17","key":"7_23393936","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.1093\/emboj\/17.17.5001","volume":"17","author":"Stott","year":"1998","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"5","key":"8_5818299","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0092-8674(00)80452-3","volume":"91","author":"Kamijo","year":"1997","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"6","key":"9_5943731","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0092-8674(00)81400-2","volume":"92","author":"Pomerantz","year":"1998","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"6","key":"10_5943732","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0092-8674(00)81401-4","volume":"92","author":"Zhang","year":"1998","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"24 Suppl QA","key":"11_15463183","first-page":"15","volume":"8","author":"Sansoni","year":"1994","journal-title":"Medline Rows With NULL issns Will Point To This"},{"issue":"6851","key":"12_11309493","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/35092592","volume":"413","author":"Sharpless","year":"2001","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"6851","key":"13_11309492","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/35092584","volume":"413","author":"Krimpenfort","year":"2001","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"2","key":"14_16864065","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/sj.onc.1201178","volume":"15","author":"Zindy","year":"1997","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"issue":"1","key":"15_10832148","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/(SICI)1096-9896(199901)187:1<100::AID-PATH236>3.0.CO;2-T","volume":"187","author":"Wynford-Thomas","year":"1999","journal-title":"The Journal of pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3417","issn-type":"print"},{"issue":"6809","key":"16_10558219","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/35041694","volume":"408","author":"DePinho","year":"2000","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"5","key":"17_16705955","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"8","key":"18_16359013","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1093\/carcin\/17.8.1567","volume":"17","author":"England","year":"1996","journal-title":"Carcinogenesis","ISSN":"https:\/\/id.crossref.org\/issn\/0143-3334","issn-type":"print"},{"issue":"2","key":"19_5904640","first-page":"139","volume":"9","author":"Vogt","year":"1998","journal-title":"Cell Growth &amp; Differentiation","ISSN":"https:\/\/id.crossref.org\/issn\/1044-9523","issn-type":"print"},{"issue":"20","key":"20_11326776","doi-asserted-by":"publisher","first-page":"6748","DOI":"10.1128\/MCB.21.20.6748-6757.2001","volume":"21","author":"Wei","year":"2001","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"1","key":"21_16188180","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0092-8674(00)81079-X","volume":"85","author":"Serrano","year":"1996","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"4","key":"22_15572550","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1091\/mbc.5.4.497","volume":"5","author":"Medrano","year":"1994","journal-title":"Molecular Biology of the Cell","ISSN":"https:\/\/id.crossref.org\/issn\/1059-1524","issn-type":"print"},{"issue":"1","key":"23_6143715","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/jidsp.1998.9","volume":"3","author":"Haddad","year":"1998","journal-title":"The journal of investigative dermatology. Symposium proceedings \/ the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0024","issn-type":"print"},{"issue":"1","key":"24_10405706","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.2000.tb06637.x","volume":"908","author":"BANDYOPADHYAY","year":"2000","journal-title":"Annals of the New York Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"issue":"8","key":"25_11359822","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/S0531-5565(01)00098-5","volume":"36","author":"Bandyopadhyay","year":"2001","journal-title":"Experimental gerontology","ISSN":"https:\/\/id.crossref.org\/issn\/0531-5565","issn-type":"print"},{"issue":"6","key":"26_8659274","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1073\/pnas.79.6.2018","volume":"79","author":"Eisinger","year":"1982","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"5","key":"27_13341886","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/1523-1747.ep12264638","volume":"83","author":"Gilchrest","year":"1984","journal-title":"Journal of Investigative Dermatology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-202X","issn-type":"print"},{"issue":"3","key":"28_10049802","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/00002371-199210000-00012","volume":"12","author":"Graeven","year":"1992","journal-title":"Journal of immunotherapy (Hagerstown, Md. : 1997)","ISSN":"https:\/\/id.crossref.org\/issn\/1524-9557","issn-type":"print"},{"issue":"4","key":"29_17133740","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1034\/j.1600-0749.2002.02036.x","volume":"15","author":"Bennett","year":"2002","journal-title":"Pigment cell research \/ sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society","ISSN":"https:\/\/id.crossref.org\/issn\/0893-5785","issn-type":"print"},{"issue":"3","key":"30_16004536","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/ng0795-351","volume":"10","author":"Gruis","year":"1995","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"12","key":"31_23363103","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1093\/emboj\/21.12.2936","volume":"21","author":"Brookes","year":"2002","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"23","key":"32_17316924","doi-asserted-by":"publisher","first-page":"8135","DOI":"10.1128\/MCB.22.23.8135-8143.2002","volume":"22","author":"Huot","year":"2002","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"2","key":"33_17580029","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/00008390-200304000-00010","volume":"13","author":"Pavel","year":"2003","journal-title":"Melanoma research","ISSN":"https:\/\/id.crossref.org\/issn\/0960-8931","issn-type":"print"},{"issue":"6808","key":"34_10551131","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/35040500","volume":"408","author":"Blackburn","year":"2000","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"5349","key":"35_5874358","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1126\/science.279.5349.349","volume":"279","author":"Bodnar","year":"1998","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"6706","key":"36_6228284","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/23962","volume":"396","author":"Kiyono","year":"1998","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"4","key":"37_11067219","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1101\/gad.859201","volume":"15","author":"Ramirez","year":"2001","journal-title":"Genes &amp; Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"issue":"6","key":"38_5832313","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/1523-1747.ep12340980","volume":"109","author":"Smit","year":"1997","journal-title":"Journal of Investigative Dermatology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-202X","issn-type":"print"},{"issue":"1","key":"39_13722031","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1242\/jcs.77.1.167","volume":"77","author":"Bennett","year":"1985","journal-title":"Journal of Cell Science","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9533","issn-type":"print"},{"issue":"1","key":"41_16667616","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/1523-1747.ep12285621","volume":"108","author":"Sviderskaya","year":"1997","journal-title":"Journal of Investigative Dermatology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-202X","issn-type":"print"},{"issue":"12","key":"42_5686293","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1093\/nar\/18.12.3587","volume":"18","author":"Morgenstern","year":"1990","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"17","key":"43_5000649","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.1073\/pnas.85.17.6460","volume":"85","author":"Danos","year":"1988","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"8","key":"44_13995246","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1128\/MCB.6.8.2895","volume":"6","author":"Miller","year":"1986","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"34","key":"45_10051708","doi-asserted-by":"crossref","first-page":"24675","DOI":"10.1016\/S0021-9258(18)35817-4","volume":"267","author":"Imokawa","year":"1992","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"46_11098778","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1046\/j.1523-1747.2001.01290.x","volume":"116","author":"Hachiya","year":"2001","journal-title":"Journal of Investigative Dermatology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-202X","issn-type":"print"},{"issue":"6492","key":"47_15591186","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/371072a0","volume":"371","author":"Morgenbesser","year":"1994","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"22","key":"48_23311446","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1002\/j.1460-2075.1996.tb01006.x","volume":"15","author":"Macleod","year":"1996","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"8","key":"49_16703216","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/sj.onc.1200897","volume":"14","author":"Gorospe","year":"1997","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"issue":"24","key":"50_16535844","doi-asserted-by":"publisher","first-page":"13742","DOI":"10.1073\/pnas.93.24.13742","volume":"93","author":"Alcorta","year":"1996","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"10","key":"51_16545837","first-page":"2097","volume":"13","author":"Bond","year":"1996","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"issue":"5","key":"52_15461113","first-page":"1455","volume":"9","author":"Montano","year":"1994","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"issue":"1","key":"53_15548640","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00008390-199402000-00006","volume":"4","author":"Albino","year":"1994","journal-title":"Melanoma research","ISSN":"https:\/\/id.crossref.org\/issn\/0960-8931","issn-type":"print"},{"issue":"5","key":"54_10425980","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1290\/1071-2690(2000)036<0309:PAIHVM>2.0.CO;2","volume":"36","author":"Le Poole","year":"2000","journal-title":"In vitro cellular &amp; developmental biology. Animal","ISSN":"https:\/\/id.crossref.org\/issn\/1071-2690","issn-type":"print"},{"issue":"5","key":"55_15862803","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/1523-1747.ep12606981","volume":"104","author":"Zepter","year":"1995","journal-title":"Journal of Investigative Dermatology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-202X","issn-type":"print"},{"issue":"4","key":"56_10755299","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1128\/MCB.19.4.3103","volume":"19","author":"Bond","year":"1999","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"6","key":"57_16966627","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1093\/jnci\/94.6.446","volume":"94","author":"Sviderskaya","year":"2002","journal-title":"JNCI Journal of the National Cancer Institute","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"issue":"6892","key":"58_17120961","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nature00766","volume":"417","author":"Davies","year":"2002","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"24","key":"59_5471316","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1093\/jnci\/81.24.1893","volume":"81","author":"Clark","year":"1989","journal-title":"JNCI Journal of the National Cancer Institute","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"issue":"5","key":"60_10561905","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/00008390-200010000-00001","volume":"10","author":"Easty","year":"2000","journal-title":"Melanoma research","ISSN":"https:\/\/id.crossref.org\/issn\/0960-8931","issn-type":"print"},{"issue":"2","key":"61_11052793","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/00001622-200103000-00008","volume":"13","author":"Halachmi","year":"2001","journal-title":"Current opinion in oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1040-8746","issn-type":"print"}],"container-title":["JNCI Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnci\/article-pdf\/95\/10\/723\/9835165\/723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T04:12:33Z","timestamp":1623039153000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article-lookup\/doi\/10.1093\/jnci\/95.10.723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,21]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,5,21]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/95.10.723","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5,21]]}}}