{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:19:24Z","timestamp":1791674364526,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Ministry of Health","award":["RF-2009-1536040"],"award-info":[{"award-number":["RF-2009-1536040"]}]},{"name":"Hologic-Genprobe"},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The study presents cross-sectional accuracy of E6 and E7 (E6\/E7) mRNA detection and p16\/ki67 dual staining, alone or in combination with cytology and human papillomavirus (HPV)16\/18 genotyping, as a triage test in HPV DNA-positive women and their impact on cervical intraepithelial neoplasia (CIN2+) overdiagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women aged 25-64 years were recruited. HPV DNA-positive women were triaged with cytology and tested for E6\/E7 mRNA and p16\/ki67. Cytology positive women were referred to colposcopy, and negatives were randomly assigned to immediate colposcopy or to 1-year HPV retesting. Lesions found within 24\u2009months since recruitment were included. All P values were 2-sided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>40\u2009509 women were recruited, and 3147 (7.8%) tested HPV DNA positive; 174 CIN2+ were found: sensitivity was 61.0% (95% confidence interval [CI] = 53.6 to 68.0), 94.4% (95% CI = 89.1 to 97.3), and 75.2% (95% CI = 68.1 to 81.6) for cytology, E6\/E7 mRNA, and p16\/ki67, respectively. Immediate referral was 25.6%, 66.8%, and 28.3%, respectively. Overall referral was 65.3%, 78.3%, and 63.3%, respectively. Cytology or p16\/ki67, when combined with HPV16\/18 typing, reached higher sensitivity with a small impact on referral. Among the 2306 HPV DNA-positive and cytology-negative women, relative CIN2+ detection in those randomly assigned at 1-year retesting vs immediate colposcopy suggests a -28% CIN2+ regression (95% CI = -57% to +20%); regression was higher in E6\/E7 mRNA-negatives (Pinteraction = .29). HPV clearance at 1\u2009year in E6\/E7 mRNA and in p16\/ki67 negative women was about 2 times higher than in positive women (Pinteraction &amp;lt; .001 for both).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>p16\/ki67 showed good performance as a triage test. E6\/E7 mRNA showed the highest sensitivity, at the price of too high a positivity rate to be efficient for triage. However, when negative, it showed a good prognostic value for clearance and CIN2+ regression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djaa105","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T15:12:04Z","timestamp":1596208324000},"page":"292-300","source":"Crossref","is-referenced-by-count":88,"title":["p16\/ki67 and E6\/E7 mRNA Accuracy and Prognostic Value in Triaging HPV DNA-Positive Women"],"prefix":"10.1093","volume":"113","author":[{"given":"Paolo","family":"Giorgi Rossi","sequence":"first","affiliation":[{"name":"Epidemiology Unit, Azienda Unit\u00e0 Sanitaria Locale\u2013IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Carozzi","sequence":"additional","affiliation":[{"name":"ISPRO Oncological Network, Prevention and Research Institute, Regional Laboratory of Cancer Prevention Unit, Florence, 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