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Artificial intelligence has shown promise in endoscopy, but few cystoscopic applications have been reported. We report a Cystoscopy Artificial Intelligence Diagnostic System (CAIDS) for BCa diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 69 204 images from 10 729 consecutive patients from 6 hospitals were collected and divided into training, internal validation, and external validation sets. The CAIDS was built using a pyramid scene parsing network and transfer learning. A subset (n\u2009=\u2009260) of the validation sets was used for a performance comparison between the CAIDS and urologists for complex lesion detection. The diagnostic accuracy, sensitivity, specificity, and positive and negative predictive values and 95% confidence intervals (CIs) were calculated using the Clopper-Pearson method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The diagnostic accuracies of the CAIDS were 0.977 (95% CI\u2009=\u20090.974 to 0.979) in the internal validation set and 0.990 (95% CI\u2009=\u20090.979 to 0.996), 0.982 (95% CI\u2009=\u20090.974 to 0.988), 0.978 (95% CI\u2009=\u20090.959 to 0.989), and 0.991 (95% CI\u2009=\u20090.987 to 0.994) in different external validation sets. In the CAIDS vs urologists\u2019 comparisons, the CAIDS showed high accuracy and sensitivity (accuracy\u2009=\u20090.939, 95% CI\u2009=\u20090.902 to 0.964; sensitivity\u2009=\u20090.954, 95% CI\u2009=\u20090.902 to 0.983) with a short latency of 12\u2009seconds, much more accurate and quicker than the expert urologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CAIDS achieved accurate BCa detection with a short latency. The CAIDS may provide many clinical benefits, from increasing the diagnostic accuracy for BCa, even for commonly misdiagnosed cases such as flat cancerous tissue (carcinoma in situ), to reducing the operation time for cystoscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jnci\/djab179","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T10:49:38Z","timestamp":1630579778000},"page":"220-227","source":"Crossref","is-referenced-by-count":74,"title":["An Artificial Intelligence System for the Detection of Bladder Cancer via Cystoscopy: A Multicenter Diagnostic Study"],"prefix":"10.1093","volume":"114","author":[{"given":"Shaoxu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, 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