{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:31:47Z","timestamp":1791855107744,"version":"4.3.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Institutes of Health to the Children\u2019s Oncology Group","award":["U10CA180886-06S1"],"award-info":[{"award-number":["U10CA180886-06S1"]}]},{"name":"National Institutes of Health to the Children\u2019s Oncology Group","award":["U10CA98543"],"award-info":[{"award-number":["U10CA98543"]}]},{"name":"National Institutes of Health to the Children\u2019s Oncology Group","award":["U10CA98413"],"award-info":[{"award-number":["U10CA98413"]}]},{"name":"National Institutes of Health to the Children\u2019s Oncology Group","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}]},{"name":"NCTN Network Group Operations Center Grant","award":["U10CA180899"],"award-info":[{"award-number":["U10CA180899"]}]},{"name":"NCTN Statistics and Data Center","award":["UG1CA189955"],"award-info":[{"award-number":["UG1CA189955"]}]},{"name":"NCORP Grant for Cancer Control Studies"},{"name":"Clinical Oncology Research Program grant","award":["U10CA095861"],"award-info":[{"award-number":["U10CA095861"]}]},{"name":"National Cancer Institute Division of Cancer Prevention to COG"},{"name":"St. Baldrick\u2019s Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with B-acute lymphoblastic leukemia (B-ALL) are at risk for chemotherapy-induced peripheral neuropathy (CIPN). Children\u2019s Oncology Group AALL0932 randomized reduction in vincristine and dexamethasone (every 4 weeks vs 12 weeks during maintenance in the average-risk subset of National Cancer Institute standard-B-ALL (SR AR B-ALL). We longitudinally measured CIPN, overall and by treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AALL0932 standard-B-ALL patients aged 3\u2009years and older were evaluated at T1-T4 (end consolidation, maintenance month 1, maintenance month 18, 12 months posttherapy). Physical and occupational therapists (PT\/OT) measured motor CIPN (hand and ankle strength, dorsiflexion and plantarflexion range of motion), sensory CIPN (finger and toe vibration and touch), function (dexterity [Purdue Pegboard], and walking efficiency [Six-Minute Walk]). Proxy-reported function (Pediatric Outcome Data Collection Instrument) and quality of life (Pediatric Quality of Life Inventory) were assessed. Age- and sex-matched z scores and proportion impaired were measured longitudinally and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Consent and data were obtained from 150 participants (mean age = 5.1\u2009years [SD\u2009=\u20091.7], 48.7% female). Among participants with completed evaluations, 81.8% had CIPN at T1 (74.5% motor, 34.1% sensory). When examining severity of PT\/OT outcomes, only handgrip strength (P\u2009&amp;lt;\u2009.001) and walking efficiency (P\u2009=\u2009.02) improved from T1-T4, and only dorsiflexion range of motion (46.7% vs 14.7%; P\u2009=\u2009.008) and handgrip strength (22.2% vs 37.1%; P\u2009=\u2009.03) differed in vincristine and dexamethasone every 4 weeks vs vincristine and dexamethasone 12 weeks at T4. Proxy-reported outcomes improved from T1 to T4 (P\u2009&amp;lt;\u2009.001), and most did not differ between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CIPN is prevalent early in B-ALL therapy and persists at least 12 months posttherapy. Most outcomes did not differ between treatment groups despite reduction in vincristine frequency. Children with B-ALL should be monitored for CIPN, even with reduced vincristine frequency.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jnci\/djac095","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T19:16:56Z","timestamp":1651864616000},"page":"1167-1175","source":"Crossref","is-referenced-by-count":27,"title":["Persistence of Chemotherapy-Induced Peripheral Neuropathy Despite Vincristine Reduction in Childhood B-Acute Lymphoblastic Leukemia"],"prefix":"10.1093","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5243-3284","authenticated-orcid":false,"given":"Rozalyn L","family":"Rodwin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine , New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Kairalla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida , Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Hibbitts","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida , Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St. Jude Children\u2019s Research Hospital , Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira K","family":"Whitley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine , New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E","family":"Mohrmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis Children\u2019s Hospital , St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven J","family":"Schore","sequence":"additional","affiliation":[{"name":"Division of Oncology, Center for Cancer and Blood Disorders, Children\u2019s National Medical Center , Washington, DC, USA"},{"name":"Cancer Biology Research Program, George Washington University School of Medicine and Health Sciences , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Raetz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, NYU Langone Medical Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-3870","authenticated-orcid":false,"given":"Naomi J","family":"Winick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-3957","authenticated-orcid":false,"given":"Stephen P","family":"Hunger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mignon L","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Benioff Children\u2019s Hospital, and the Helen Diller Family Comprehensive Cancer Institute, University of California, San Francisco , San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn J","family":"Hockenberry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine , Houston, TX, USA"},{"name":"School of Nursing, Duke University , Durham, NC, 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