{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:46:41Z","timestamp":1791254801780,"version":"4.1.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Cancer Institute at the National Institutes of Health","award":["R01CA207228"],"award-info":[{"award-number":["R01CA207228"]}]},{"name":"National Cancer Institute at the National Institutes of Health","award":["R01CA207228-S1"],"award-info":[{"award-number":["R01CA207228-S1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lung cancer mortality is reduced via low-dose computed tomography screening and treatment of early-stage disease. Evidence-based smoking cessation treatment in the lung screening setting can further reduce mortality. We report the results of a cessation trial from the National Cancer Institute\u2019s Smoking Cessation at Lung Examination collaboration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eligible patients (n\u2009=\u2009818) aged 50-80 years were randomly assigned (May 2017-January 2021) to the intensive vs minimal arms (8 vs 3 phone sessions plus 8 vs 2\u2009weeks of nicotine patches, respectively). Bio-verified (primary) and self-reported 7-day abstinence rates were assessed at 3, 6, and 12 months post random assignment. Logistic regression analyses evaluated the effects of study arm. All statistical tests were 2-sided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Participants reported 48.0 (SD\u2009=\u200917.2) pack-years, and 51.6% were not ready to quit in less than 30\u2009days. Self-reported 3-month quit rates were statistically significantly higher in the intensive vs minimal arm (14.3% vs 7.9%; odds ratio [OR]\u2009=\u20092.00, 95% confidence interval [CI] = 1.26 to 3.18). Bio-verified abstinence was lower but with similar relative differences between arms (9.1% vs 3.9%; OR\u2009=\u20092.70, 95% CI\u2009=\u20091.44 to 5.08). Compared with the minimal arm, the intensive arm was more effective among those with greater nicotine dependence (OR\u2009=\u20093.47, 95% CI\u2009=\u20091.55 to 7.76), normal screening results (OR\u2009=\u20092.58, 95% CI\u2009=\u20091.32 to 5.03), high engagement in counseling (OR\u2009=\u20093.03, 95% CI\u2009=\u20091.50 to 6.14), and patch use (OR\u2009=\u20092.81, 95% CI\u2009=\u20091.39 to 5.68). Abstinence rates did not differ statistically significantly between arms at 6 months (OR\u2009=\u20091.2, 95% CI\u2009=\u20090.68 to 2.11) or 12 months (OR\u2009=\u20091.4, 95% CI\u2009=\u20090.82 to 2.42).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Delivering intensive telephone counseling and nicotine replacement with lung screening is an effective strategy to increase short-term smoking cessation. Methods to maintain short-term effects are needed. Even with modest quit rates, integrating cessation treatment into lung screening programs may have a large impact on tobacco-related mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djac127","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T04:06:50Z","timestamp":1657598810000},"page":"1410-1419","source":"Crossref","is-referenced-by-count":45,"title":["A Randomized Trial of Telephone-Based Smoking Cessation Treatment in the Lung Cancer Screening Setting"],"prefix":"10.1093","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-0413","authenticated-orcid":false,"given":"Kathryn L","family":"Taylor","sequence":"first","affiliation":[{"name":"Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi 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