{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:20:56Z","timestamp":1787988056020,"version":"build-2784847793"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Ovarian Cancer Association Consortium"},{"DOI":"10.13039\/100001282","name":"Ovarian Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001282","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Ovarian Cancer Study"},{"DOI":"10.13039\/100000182","name":"U.S. Army Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["DAMD17-01-1-0729"],"award-info":[{"award-number":["DAMD17-01-1-0729"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health & Medical Research Council of Australia","award":["199600"],"award-info":[{"award-number":["199600"]}]},{"name":"National Health & Medical Research Council of Australia","award":["400413"],"award-info":[{"award-number":["400413"]}]},{"name":"National Health & Medical Research Council of Australia","award":["400281"],"award-info":[{"award-number":["400281"]}]},{"name":"Cancer Councils of New South Wales"},{"name":"South Australia and Tasmania and Cancer Foundation of Western Australia"},{"name":"Australian Ovarian Cancer Study"},{"DOI":"10.13039\/100011928","name":"Ovarian Cancer Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022084","name":"Peter MacCallum Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"University of Erlangen-Nuremberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"crossref"}]},{"name":"United States National Institutes of Health","award":["R01-CA063678"],"award-info":[{"award-number":["R01-CA063678"]}]},{"name":"United States National Institutes of Health","award":["R01-CA074850"],"award-info":[{"award-number":["R01-CA074850"]}]},{"name":"United States National Institutes of Health","award":["R01-CA080742"],"award-info":[{"award-number":["R01-CA080742"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-CA112523"],"award-info":[{"award-number":["R01-CA112523"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-CA87538"],"award-info":[{"award-number":["R01-CA87538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research"},{"name":"Programme of Clinical Biomedical Research"},{"DOI":"10.13039\/100008658","name":"German Cancer Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-CA58598"],"award-info":[{"award-number":["R01-CA58598"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01-CN-55424"],"award-info":[{"award-number":["N01-CN-55424"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01-PC-67001"],"award-info":[{"award-number":["N01-PC-67001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020156","name":"Lon V Smith Foundation","doi-asserted-by":"publisher","award":["LVS-39420"],"award-info":[{"award-number":["LVS-39420"]}],"id":[{"id":"10.13039\/100020156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00004\/01"],"award-info":[{"award-number":["MC_UU_00004\/01"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00004\/01"],"award-info":[{"award-number":["MC_UU_00004\/01"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01CA17054"],"award-info":[{"award-number":["P01CA17054"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA14089"],"award-info":[{"award-number":["P30CA14089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA61132"],"award-info":[{"award-number":["R01CA61132"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01PC67010"],"award-info":[{"award-number":["N01PC67010"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03CA113148"],"award-info":[{"award-number":["R03CA113148"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03CA115195"],"award-info":[{"award-number":["R03CA115195"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01CN025403"],"award-info":[{"award-number":["N01CN025403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004802","name":"California Cancer Research Program","doi-asserted-by":"crossref","award":["00-01389\u2009V-20170"],"award-info":[{"award-number":["00-01389\u2009V-20170"]}],"id":[{"id":"10.13039\/100004802","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004802","name":"California Cancer Research Program","doi-asserted-by":"crossref","award":["2II0200"],"award-info":[{"award-number":["2II0200"]}],"id":[{"id":"10.13039\/100004802","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K05-CA154337"],"award-info":[{"award-number":["K05-CA154337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored the association between lifetime ovulatory years (LOY) and EOC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>LOY was calculated using 12 algorithms. Odds ratios (ORs) and 95% confidence intervals (CIs) estimated the association between LOY or LOY components and EOC among 26\u200a204 control participants and 21\u200a267 case patients from 25 studies. To assess whether LOY components act through ovulation suppression alone, we compared beta coefficients obtained from regression models with expected estimates assuming 1 year of ovulation suppression has the same effect regardless of source.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>LOY was associated with increased EOC risk (OR per year increase = 1.014, 95% CI = 1.009 to 1.020 to OR per year increase = 1.044, 95% CI = 1.041 to 1.048). Individual LOY components, except age at menarche, also associated with EOC. The estimated model coefficient for oral contraceptive use and pregnancies were 4.45 times and 12- to 15-fold greater than expected, respectively. LOY was associated with high-grade serous, low-grade serous, endometrioid, and clear cell histotypes (ORs per year increase = 1.054, 1.040, 1.065, and 1.098, respectively) but not mucinous tumors. Estimated coefficients of LOY components were close to expected estimates for high-grade serous but larger than expected for low-grade serous, endometrioid, and clear cell histotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LOY is positively associated with nonmucinous EOC. Differences between estimated and expected model coefficients for LOY components suggest factors beyond ovulation underlie the associations between LOY components and EOC in general and for non-HGSOC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jnci\/djad011","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T14:52:36Z","timestamp":1674485556000},"page":"539-551","source":"Crossref","is-referenced-by-count":27,"title":["Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis"],"prefix":"10.1093","volume":"115","author":[{"given":"Zhuxuan","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Mori","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health , Pittsburgh, PA, USA"},{"name":"Department of Biostatistics, University of Pittsburgh School of Public Health , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Irvin","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Jordan","sequence":"additional","affiliation":[{"name":"The School of Public Health, The University of Queensland , Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja K H","family":"Aben","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud University Medical Center , Nijmegen, The Netherlands"},{"name":"Netherlands Comprehensive Cancer Organisation , Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-0110","authenticated-orcid":false,"given":"Hoda","family":"Anton-Culver","sequence":"additional","affiliation":[{"name":"Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine , Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa V","family":"Bandera","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey , New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias W","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-European Metropolitan Region of Nuremberg (EMN), Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen , Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Berchuck","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center , Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Brooks-Wilson","sequence":"additional","affiliation":[{"name":"Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer , Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Chang-Claude","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg, Germany"},{"name":"Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf , Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S","family":"Cook","sequence":"additional","affiliation":[{"name":"Epidemiology, School of Public Health, University of Colorado , Aurora, CO, USA"},{"name":"Community Health Sciences, University of Calgary , Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA, USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara L","family":"Cushing-Haugen","sequence":"additional","affiliation":[{"name":"Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif B","family":"Ekici","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Comprehensive Cancer Center Erlangen-EMN, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU) , Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Fasching","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-European Metropolitan Region of Nuremberg (EMN), Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen , Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e T","family":"Fortner","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A","family":"Gayther","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core, Cedars-Sinai Medical Center , Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Gentry-Maharaj","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit, Institute of Clinical Trials & Methodology, University College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-9099","authenticated-orcid":false,"given":"Graham G","family":"Giles","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria , Melbourne, Victoria, Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne , Melbourne, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University , Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L","family":"Goode","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic , Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc T","family":"Goodman","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center , Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly R","family":"Harris","sequence":"additional","affiliation":[{"name":"Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center , Seattle, WA, USA"},{"name":"Department of Epidemiology, University of Washington , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hein","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-European Metropolitan Region of Nuremberg (EMN), Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen , Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3751-3929","authenticated-orcid":false,"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambertus A","family":"Kiemeney","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud University Medical Center , Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"K\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center , Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-4218","authenticated-orcid":false,"given":"Joanne","family":"Kotsopoulos","sequence":"additional","affiliation":[{"name":"Women\u2019s College Research Institute, Women\u2019s College Hospital, University of Toronto , Toronto, ON, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto , Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhu D","family":"Le","sequence":"additional","affiliation":[{"name":"Cancer Control Research, BC Cancer , Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice W","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Health Science, California State University , Fullerton, Fullerton, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-6314","authenticated-orcid":false,"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute , Nagoya, Japan"},{"name":"Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine , Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Stanford University School of Medicine , Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health, University of Toronto , Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-1732","authenticated-orcid":false,"given":"Usha","family":"Menon","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit, Institute of Clinical Trials & Methodology, University College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L","family":"Milne","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria , Melbourne, Victoria, Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne , Melbourne, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University , Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten B","family":"Moysich","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control, Roswell Park Cancer Institute , Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste Leigh","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Michigan School of Public Health , Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm C","family":"Pike","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, NY, USA"},{"name":"Department of Population Health and Public Health Sciences, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center , Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qin","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey , New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0005-7798","authenticated-orcid":false,"given":"Susan J","family":"Ramus","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, University of New South Wales Medicine and Health, University of New South Wales Sydney , Sydney, New South Wales, Australia"},{"name":"Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie J","family":"Riggan","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center , Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H","family":"Rothstein","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY, USA"},{"name":"Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joellen M","family":"Schildkraut","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University , Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0085-1190","authenticated-orcid":false,"given":"Weiva","family":"Sieh","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY, USA"},{"name":"Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Sutphen","sequence":"additional","affiliation":[{"name":"Epidemiology Center, College of Medicine, University of South Florida , Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA, USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J","family":"Thompson","sequence":"additional","affiliation":[{"name":"Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center , Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Titus","sequence":"additional","affiliation":[{"name":"Muskie School of Public Policy, Public Health , Portland, ME, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2598-087X","authenticated-orcid":false,"given":"Anne M","family":"van Altena","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Radboud University Medical Center , Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"White","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington , Seattle, WA, USA"},{"name":"Fred Hutchinson Cancer Research Center , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S","family":"Whittemore","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Stanford University School of Medicine , Stanford, CA, USA"},{"name":"Department of Biomedical Data Science, Stanford University School of Medicine , Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Population Health and Public Health Sciences, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center , Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-3727","authenticated-orcid":false,"given":"Argyrios","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine , Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Pittsburgh School of Public Health , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Songer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-0836","authenticated-orcid":false,"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M","family":"Webb","sequence":"additional","affiliation":[{"name":"The School of Public Health, The University of Queensland , Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AOCS Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-3941","authenticated-orcid":false,"given":"Harvey A","family":"Risch","sequence":"additional","affiliation":[{"name":"Chronic Disease Epidemiology, Yale School of Public Health , New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-1534","authenticated-orcid":false,"given":"Francesmary","family":"Modugno","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh School of Public Health , Pittsburgh, PA, USA"},{"name":"Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA"},{"name":"Women\u2019s Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"issue":"12","key":"2024012311464546700_djad011-B1","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/ijc.30910","article-title":"Timing of births and oral contraceptive use influences ovarian cancer risk","volume":"141","author":"Wu","year":"2017","journal-title":"Int J Cancer"},{"issue":"6","key":"2024012311464546700_djad011-B2","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1158\/1055-9965.EPI-07-0089","article-title":"Different risk factor profiles for mucinous and nonmucinous ovarian cancer: results from the Danish MALOVA study","volume":"16","author":"Soegaard","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"24","key":"2024012311464546700_djad011-B3","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1200\/JCO.2016.66.8178","article-title":"Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium","volume":"34","author":"Wentzensen","year":"2016","journal-title":"J Clin Oncol"},{"issue":"6","key":"2024012311464546700_djad011-B4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3961\/jpmph.16.066","article-title":"The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer: a systematic review and meta-analysis","volume":"49","author":"Sung","year":"2016","journal-title":"J Prev Med Public Health"},{"issue":"6","key":"2024012311464546700_djad011-B5","doi-asserted-by":"crossref","first-page":"e200421","DOI":"10.1001\/jamaoncol.2020.0421","article-title":"Association between breastfeeding and ovarian cancer risk","volume":"6","author":"Babic","year":"2020","journal-title":"JAMA Oncol"},{"issue":"7716","key":"2024012311464546700_djad011-B6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0140-6736(71)92335-X","article-title":"Incessant ovulation\u2014a factor in ovarian neoplasia?","volume":"2","author":"Fathalla","year":"1971","journal-title":"Lancet"},{"issue":"2","key":"2024012311464546700_djad011-B7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/oxfordjournals.aje.a113523","article-title":"Events of reproductive life and the incidence of epithelial ovarian cancer","volume":"117","author":"Risch","year":"1983","journal-title":"Am J Epidemiol"},{"issue":"9","key":"2024012311464546700_djad011-B8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/aje\/kwv308","article-title":"Lifetime number of ovulatory cycles and risks of ovarian and endometrial cancer among postmenopausal women","volume":"183","author":"Yang","year":"2016","journal-title":"Am J Epidemiol"},{"issue":"6","key":"2024012311464546700_djad011-B9","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/oxfordjournals.aje.a115076","article-title":"Personal and environmental characteristics related to epithelial ovarian cancer. I. Reproductive and menstrual events and oral contraceptive use","volume":"128","author":"Wu","year":"1988","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2024012311464546700_djad011-B10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/aje\/kwp314","article-title":"Risk factors for epithelial ovarian cancer by histologic subtype","volume":"171","author":"Gates","year":"2010","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2024012311464546700_djad011-B11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1158\/1055-9965.EPI-06-0688","article-title":"Incessant ovulation, mucin 1 immunity, and risk for ovarian cancer","volume":"16","author":"Terry","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"7","key":"2024012311464546700_djad011-B12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/aje\/kwg177","article-title":"Reproductive factors and epithelial ovarian cancer risk by histologic type: a multiethnic case-control study","volume":"158","author":"Tung","year":"2003","journal-title":"Am J Epidemiol"},{"issue":"5","key":"2024012311464546700_djad011-B13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10552-017-0853-7","article-title":"Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women","volume":"28","author":"Peres","year":"2017","journal-title":"Cancer Causes Control"},{"issue":"5","key":"2024012311464546700_djad011-B14","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1158\/0008-5472.CAN-19-2850","article-title":"The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the Ovarian Cancer Cohort Consortium (OC3)","volume":"80","author":"Trabert","year":"2020","journal-title":"Cancer Res"},{"issue":"3","key":"2024012311464546700_djad011-B15","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ygyno.2022.04.001","article-title":"Lifetime ovulations and epithelial ovarian cancer risk and survival: a systematic review and meta-analysis","volume":"165","author":"Fu","year":"2022","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2024012311464546700_djad011-B16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/ijc.23017","article-title":"Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer","volume":"122","author":"Merritt","year":"2008","journal-title":"Int J Cancer"},{"issue":"9","key":"2024012311464546700_djad011-B17","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ng.424","article-title":"A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2","volume":"41","author":"Song","year":"2009","journal-title":"Nat Genet"},{"issue":"9","key":"2024012311464546700_djad011-B18","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1158\/1055-9965.EPI-06-0272","article-title":"PGR +331 A\/G and increased risk of epithelial ovarian cancer","volume":"15","author":"Risch","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"12","key":"2024012311464546700_djad011-B19","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s10552-012-0076-x","article-title":"Sun exposure and risk of epithelial ovarian cancer","volume":"23","author":"Bodelon","year":"2012","journal-title":"Cancer Causes Control"},{"issue":"6","key":"2024012311464546700_djad011-B20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/1097-0215(20011120)95:6<370::AID-IJC1065>3.0.CO;2-T","article-title":"Low-dose oral contraceptives: protective effect on ovarian cancer risk","volume":"95","author":"Royar","year":"2001","journal-title":"Int J Cancer"},{"issue":"4","key":"2024012311464546700_djad011-B21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1677\/ERC-08-0104","article-title":"Association of two common single-nucleotide polymorphisms in the CYP19A1 locus and ovarian cancer risk","volume":"15","author":"Goodman","year":"2008","journal-title":"Endocr Relat Cancer"},{"issue":"2","key":"2024012311464546700_djad011-B22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/EDE.0b013e3182456ad3","article-title":"Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, or acetaminophen and risk of ovarian cancer","volume":"23","author":"Lo-Ciganic","year":"2012","journal-title":"Epidemiology"},{"issue":"2","key":"2024012311464546700_djad011-B23","first-page":"99","article-title":"Gene-environment interactions and polymorphism studies of cancer risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II)","volume":"2","author":"Hamajima","year":"2001","journal-title":"Asian Pac J Cancer Prev"},{"issue":"7","key":"2024012311464546700_djad011-B24","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1158\/0008-5472.CAN-07-5165","article-title":"Genetic variation in the one-carbon transfer pathway and ovarian cancer risk","volume":"68","author":"Kelemen","year":"2008","journal-title":"Cancer Res"},{"issue":"3","key":"2024012311464546700_djad011-B25","first-page":"69","article-title":"The Melbourne Collaborative Cohort Study","volume":"156","author":"Giles","year":"2002","journal-title":"IARC Sci Publ"},{"issue":"4","key":"2024012311464546700_djad011-B26","doi-asserted-by":"crossref","first-page":"e10061","DOI":"10.1371\/journal.pone.0010061","article-title":"Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer","volume":"5","author":"Schildkraut","year":"2010","journal-title":"PLoS One"},{"issue":"13","key":"2024012311464546700_djad011-B27","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1158\/0008-5472.CAN-04-3885","article-title":"Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk","volume":"65","author":"Terry","year":"2005","journal-title":"Cancer Res"},{"issue":"1","key":"2024012311464546700_djad011-B28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1472-6874-11-40","article-title":"Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study","volume":"11","author":"Bandera","year":"2011","journal-title":"BMC Womens Health"},{"issue":"3","key":"2024012311464546700_djad011-B29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10689-012-9518-6","article-title":"Adequacy of family history taking in ovarian cancer patients: a population-based study","volume":"11","author":"van Altena","year":"2012","journal-title":"Fam Cancer"},{"issue":"5","key":"2024012311464546700_djad011-B30","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/sj.ki.5002374","article-title":"Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study","volume":"72","author":"Wetzels","year":"2007","journal-title":"Kidney Int"},{"issue":"1","key":"2024012311464546700_djad011-B31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2407-7-60","article-title":"Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study","volume":"7","author":"Garcia-Closas","year":"2007","journal-title":"BMC Cancer"},{"issue":"7","key":"2024012311464546700_djad011-B32","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/oxfordjournals.aje.a117296","article-title":"Parity, contraception, infertility, and the risk of epithelial ovarian cancer","volume":"140","author":"Risch","year":"1994","journal-title":"Am J Epidemiol"},{"issue":"7","key":"2024012311464546700_djad011-B33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/aje\/kwh284","article-title":"Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations","volume":"160","author":"McGuire","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"11","key":"2024012311464546700_djad011-B34","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/aje\/kwi322","article-title":"The Shanghai Women\u2019s Health Study: rationale, study design, and baseline characteristics","volume":"162","author":"Zheng","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"12","key":"2024012311464546700_djad011-B35","first-page":"2807","article-title":"BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases","volume":"104","author":"Pal","year":"2005","journal-title":"Cancer-Am Cancer Soc"},{"issue":"2","key":"2024012311464546700_djad011-B36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ygyno.2011.01.020","article-title":"Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer","volume":"121","author":"Zhang","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2024012311464546700_djad011-B37","first-page":"103","article-title":"Cancer risk estimates for family members of a population-based family registry for breast and ovarian cancer","volume":"9","author":"Ziogas","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"2024012311464546700_djad011-B38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jclinepi.2010.07.008","article-title":"Recruitment of newly diagnosed ovarian cancer patients proved challenging in a multicentre biobanking study","volume":"64","author":"Balogun","year":"2011","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"2024012311464546700_djad011-B39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.fertnstert.2004.03.013","article-title":"Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control study","volume":"82","author":"Pike","year":"2004","journal-title":"Fertil Steril"},{"issue":"3","key":"2024012311464546700_djad011-B40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/aje\/155.3.217","article-title":"Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies","volume":"155","author":"Ness","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"6","key":"2024012311464546700_djad011-B41","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/ijc.24091","article-title":"Markers of inflammation and risk of ovarian cancer in Los Angeles County","volume":"124","author":"Wu","year":"2009","journal-title":"Int J Cancer"},{"issue":"1","key":"2024012311464546700_djad011-B42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/aje\/kwh010","article-title":"VITamins And Lifestyle cohort study: study design and characteristics of supplement users","volume":"159","author":"White","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"2","key":"2024012311464546700_djad011-B43","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/ijc.23448","article-title":"Consortium analysis of 7 candidate SNPs for ovarian cancer","volume":"123","author":"Ramus","year":"2008","journal-title":"Int J Cancer"},{"issue":"6","key":"2024012311464546700_djad011-B44","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.annepidem.2011.02.010","article-title":"Age at menopause: imputing age at menopause for women with a hysterectomy with application to risk of postmenopausal breast cancer","volume":"21","author":"Rosner","year":"2011","journal-title":"Ann Epidemiol"},{"issue":"2","key":"2024012311464546700_djad011-B45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/sysbio\/syt100","article-title":"Missing data estimation in morphometrics: how much is too much?","volume":"63","author":"Clavel","year":"2014","journal-title":"Syst Biol"},{"issue":"1","key":"2024012311464546700_djad011-B46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/02664763.2016.1158246","article-title":"Missing data methods for arbitrary missingness with small samples","volume":"44","author":"McNeish","year":"2017","journal-title":"J Appl Stat"},{"issue":"3","key":"2024012311464546700_djad011-B47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1536867X0400400301","article-title":"Multiple imputation of missing values","volume":"4","author":"Royston","year":"2004","journal-title":"Stata J"},{"key":"2024012311464546700_djad011-B48","volume-title":"Applied Missing Data Analysis","author":"Enders","year":"2010"},{"key":"2024012311464546700_djad011-B49","doi-asserted-by":"crossref","first-page":"59S","DOI":"10.1016\/S0021-9681(87)80009-7","article-title":"Age-related factors in cancers of the breast, ovary, and endometrium","volume":"40(S2)","author":"Pike","year":"1987","journal-title":"Journal of Chronic Diseases"},{"issue":"3","key":"2024012311464546700_djad011-B50","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/oxfordjournals.aje.a113207","article-title":"An epidemiologic study of epithelial carcinoma of the ovary","volume":"114","author":"Hildreth","year":"1981","journal-title":"Am J Epidemiol"},{"issue":"2","key":"2024012311464546700_djad011-B51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ije\/12.2.161","article-title":"Incessant ovulation and ovarian cancer: a critical approach","volume":"12","author":"La Vecchia","year":"1983","journal-title":"Int J Epidemiol"},{"issue":"10","key":"2024012311464546700_djad011-B52","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/oxfordjournals.aje.a116426","article-title":"Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. I. Methods. Collaborative Ovarian Cancer Group","volume":"136","author":"Whittemore","year":"1992","journal-title":"Am J Epidemiol"},{"issue":"14","key":"2024012311464546700_djad011-B53","first-page":"4047","article-title":"Epithelial ovarian cancer and the ability to conceive","volume":"49","author":"Whittemore","year":"1989","journal-title":"Cancer Res"},{"issue":"3","key":"2024012311464546700_djad011-B54","first-page":"245","article-title":"Univariate and multivariate analysis of risk factors for ovarian cancer: case-control study, Mexico City","volume":"26","author":"Bernal","year":"1995","journal-title":"Arch Med Res"},{"issue":"13","key":"2024012311464546700_djad011-B55","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/jnci\/89.13.932","article-title":"Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer","volume":"89","author":"Schildkraut","year":"1997","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"2024012311464546700_djad011-B56","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1158\/1055-9965.EPI-07-0596","article-title":"Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup","volume":"17","author":"Schildkraut","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"22","key":"2024012311464546700_djad011-B57","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1093\/jnci\/90.22.1729","article-title":"Relationship between number of ovulatory cycles and accumulation of mutant p53 in epithelial ovarian cancer","volume":"90","author":"Webb","year":"1998","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"2024012311464546700_djad011-B58","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1023\/A:1020678100977","article-title":"Ovulation and ovarian cancer: a comparison of two methods for calculating lifetime ovulatory cycles (United States)","volume":"13","author":"Moorman","year":"2002","journal-title":"Cancer Causes Control"},{"issue":"2","key":"2024012311464546700_djad011-B59","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ijc.10927","article-title":"Ovulation and risk of epithelial ovarian cancer","volume":"104","author":"Purdie","year":"2003","journal-title":"Int J Cancer"},{"issue":"4","key":"2024012311464546700_djad011-B60","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/01.ede.0000164557.81694.63","article-title":"Mathematical models of ovarian cancer incidence","volume":"16","author":"Rosner","year":"2005","journal-title":"Epidemiology"},{"issue":"4","key":"2024012311464546700_djad011-B61","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/aje\/kwi046","article-title":"Effect of anovulation factors on pre- and postmenopausal ovarian cancer risk: revisiting the incessant ovulation hypothesis","volume":"161","author":"Tung","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2024012311464546700_djad011-B62","doi-asserted-by":"crossref","first-page":"83.e1","DOI":"10.1016\/j.ajog.2006.06.088","article-title":"Lifetime ovulatory cycles and ovarian cancer risk in 2 Italian case-control studies","volume":"196","author":"Pelucchi","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"2024012311464546700_djad011-B63","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.contraception.2012.02.019","article-title":"Reproductive factors in relation to ovarian cancer: a case-control study in Northern Vietnam","volume":"86","author":"Le","year":"2012","journal-title":"Contraception"},{"issue":"3","key":"2024012311464546700_djad011-B64","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3390\/cancers4030701","article-title":"Ovarian cancer stroma: pathophysiology and the roles in cancer development","volume":"4","author":"Furuya","year":"2012","journal-title":"Cancers (Basel)"},{"issue":"12","key":"2024012311464546700_djad011-B65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122113","article-title":"Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment","volume":"17","author":"Rojas","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2024012311464546700_djad011-B66","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/oxfordjournals.aje.a008937","article-title":"Differences in risk factors for epithelial ovarian cancer by histologic type. Results of a case-control study","volume":"144","author":"Risch","year":"1996","journal-title":"Am J Epidemiol"},{"issue":"4","key":"2024012311464546700_djad011-B67","first-page":"717","article-title":"Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis","volume":"71","author":"Cramer","year":"1983","journal-title":"J Natl Cancer Inst"},{"issue":"23","key":"2024012311464546700_djad011-B68","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/jnci\/90.23.1774","article-title":"Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone","volume":"90","author":"Risch","year":"1998","journal-title":"J Natl Cancer Inst"},{"issue":"17","key":"2024012311464546700_djad011-B69","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/jnci\/91.17.1459","article-title":"Possible role of ovarian epithelial inflammation in ovarian cancer","volume":"91","author":"Ness","year":"1999","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"2024012311464546700_djad011-B70","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3390\/cancers10110433","article-title":"Cell origins of high-grade serous ovarian cancer","volume":"10","author":"Kim","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"3","key":"2024012311464546700_djad011-B71","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2024012311464546700_djad011-B72","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/IGC.0b013e318199009c","article-title":"The fallopian tube: primary site of most pelvic high-grade serous carcinomas","volume":"19","author":"Salvador","year":"2009","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"2024012311464546700_djad011-B73","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ygyno.2013.12.015","article-title":"Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma","volume":"132","author":"Bahar-Shany","year":"2014","journal-title":"Gynecol Oncol"},{"issue":"11","key":"2024012311464546700_djad011-B74","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1093\/carcin\/bgv132","article-title":"Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: Initiation of fimbria carcinogenesis","volume":"36","author":"Huang","year":"2015","journal-title":"Carcinogenesis"},{"issue":"4","key":"2024012311464546700_djad011-B75","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/path.4807","article-title":"Haemoglobin in pelvic fluid rescues fallopian tube epithelial cells from reactive oxygen species stress and apoptosis","volume":"240","author":"Huang","year":"2016","journal-title":"J Pathol"},{"key":"2024012311464546700_djad011-B76","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ebiom.2019.01.061","article-title":"IGF-axis confers transformation and regeneration of fallopian tube fimbria epithelium upon ovulation","volume":"41","author":"Hsu","year":"2019","journal-title":"EBioMedicine"},{"issue":"3","key":"2024012311464546700_djad011-B77","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/cancers13030468","article-title":"Ovulatory follicular fluid facilitates the full transformation process for the development of high-grade serous carcinoma","volume":"13","author":"Hsu","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"5","key":"2024012311464546700_djad011-B78","first-page":"271","article-title":"Effect of progestin on the ovarian epithelium of macaques: cancer prevention through apoptosis?","volume":"5","author":"Rodriguez","year":"1998","journal-title":"J Soc Gynecol Investig"},{"issue":"1","key":"2024012311464546700_djad011-B79","article-title":"Mucinous cancer of the ovary: overview and current status","volume":"10","author":"Babaier","year":"2020","journal-title":"Diagnostics (Basel)"},{"issue":"1 pt 2","key":"2024012311464546700_djad011-B80","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1006\/gyno.2002.6706","article-title":"The different etiologies of mucinous and nonmucinous epithelial ovarian cancers","volume":"88","author":"Purdie","year":"2003","journal-title":"Gynecol Oncol"}],"container-title":["JNCI: Journal of the National Cancer Institute"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnci\/advance-article-pdf\/doi\/10.1093\/jnci\/djad011\/49725655\/djad011.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/115\/5\/539\/50206917\/djad011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnci\/article-pdf\/115\/5\/539\/50206917\/djad011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T11:48:04Z","timestamp":1706010484000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnci\/article\/115\/5\/539\/6998214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,23]]},"references-count":80,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,1,23]]},"published-print":{"date-parts":[[2023,5,8]]}},"URL":"https:\/\/doi.org\/10.1093\/jnci\/djad011","relation":{},"ISSN":["0027-8874","1460-2105"],"issn-type":[{"value":"0027-8874","type":"print"},{"value":"1460-2105","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,1,23]]}}}